Ocular melanogenesis: the role of antioxidants.

abstract：:Cholinergic agents used to lower intraocular pressure in the medical management of glaucoma act on muscarinic receptors in the eye. Recently, subtypes of muscarinic receptors have been recognized in many tissues including the eye. To localize the M3 muscarinic receptor subtype and m3 messenger RNA (mRNA) in the human ...

journal_title：Ophthalmic research

authors： Gupta N,Drance SM,McAllister R,Prasad S,Rootman J,Cynader MS

更新日期：1994-01-01 00:00:00

abstract：PURPOSE:The aim of this study was to evaluate the choroidal thickness (CT) and its determinants in primary angle closure glaucoma (PACG) eyes with and without malignant glaucoma (MG). METHODS:In this cross-sectional study, we enrolled 25 patients with bilateral primary angle closure (PAC) diseases; 1 eye of each patie...

journal_title：Ophthalmic research

authors： Chen X,Guo X,Xu X,Xiao H,Liu X

更新日期：2018-01-01 00:00:00

abstract：PURPOSE:Abnormalities in electroretinograms (ERG), such as reduced amplitudes and delayed implicit times of a- and b-wave and oscillatory potentials (OPs), are one of the earliest features of diabetic retinopathy prior to obvious vascular changes in diabetic retinas. We have previously shown that serum levels of advanc...

journal_title：Ophthalmic research

authors： Maeda S,Matsui T,Ojima A,Suematsu M,Kaseda K,Higashimoto Y,Yamakawa R,Yamagishi S

更新日期：2015-01-01 00:00:00

abstract：:The possible multiple effect of galactose diet and X-irradiation on cataract development in mice was investigated by scanning electron microscopy. X-ray cataracts were induced by maintaining animals either on a normal or 50% galactose diet. No detectable changes in lens morphology were seen in animals fed galactose al...

journal_title：Ophthalmic research

authors： Kodama T,Reddy VN,Giblin F,Kinoshita JH,Harding C

更新日期：1983-01-01 00:00:00

abstract：:The activities of sialyl-, fucosyl- and galactosyltransferase were measured in membrane preparations from bovine eyes. Radioactive sugars from CMP-N-neuraminic acid, GDP-fucose and UDP-galactose were incorporated into the endogenous and exogenous acceptors. The enzymatic activities of all three glycosyltransferases we...

journal_title：Ophthalmic research

authors： Unoki K,Uehara F,Muramatsu T

更新日期：1990-01-01 00:00:00

abstract：:Local pO2 was measured close to the ciliary process of the rabbit eye using polarographic microelectrodes under microendoscopic observation. The experiments were performed in 5 anaesthetized New Zealand rabbits. Changes in local pO2, intraocular pressure (IOP) and blood flow velocity (BFV) were investigated after intr...

journal_title：Ophthalmic research

authors： Höper J,Funk RH

更新日期：1993-01-01 00:00:00

abstract：:We examined 304 conjunctiva in 152 subjects by clinical, cytologic, and bacteriologic methods. Bacteriologic samples were evaluated after a 48-hour incubation. Bacterial growth was found in 8 (20.5%) of 39 patients with clinically normal conjunctiva and no polymorphonuclear leukocytes (PMNs), and in 8 (61.5%) of 13 su...

journal_title：Ophthalmic research

authors： Ugomori S,Hayasaka S,Setogawa T

更新日期：1991-01-01 00:00:00

abstract：:The high-voltage electron microscope (HVEM) permits examination of sections much thicker (up to 1 micron) than those usually used in transmission electron microscopy, which are approximately 70 nm in thickness. Two examples of the utility of the HVEM in research on the ultrastructure of the retinal pigment epithelium ...

journal_title：Ophthalmic research

authors： Korte GE,Heriot W,Pollack A

更新日期：1986-01-01 00:00:00

abstract：PURPOSE:The purpose of this study was to evaluate the anatomical and functional findings in patients with vitreomacular traction (VMT) combined with epiretinal membrane (ERM) in the same eye. METHODS:In this retrospective, cross-sectional study, we studied 65 patients with VMT and ERM. In 36 of them, ERM/VMT had a 'un...

journal_title：Ophthalmic research

authors： Chatziralli I,Theodossiadis G,Datseris I,Parikakis E,Theodossiadis P

更新日期：2017-01-01 00:00:00

abstract：:Non-toxic concentrations of ceftazidime (CAZ), cefuzonam sodium (CZON) and cefmetazole sodium (CMZ) for intravitreal use were assessed by the electroretinogram in in vitro perfused eyecups of albino rabbits. None of the a-wave, the b-wave and the oscillatory potentials deteriorated with 300 microM CAZ, 300 microM CZON...

journal_title：Ophthalmic research

authors： Kitano K,Shirao Y,Kawasaki K

更新日期：1995-01-01 00:00:00

abstract：:Dry eye is the most prominent pathology among those involving the ocular surface: a decrease of the aqueous (less frequent) or the lipid (more frequent) component of the tear film is the cause of the diminished stability of tears that is observed in this pathology. Dry eye shows a clear distribution linked to both sex...

journal_title：Ophthalmic research

authors： Rusciano D,Pezzino S,Olivieri M,Cristaldi M,Gagliano C,Lupo G,Anfuso CD

更新日期：2018-01-01 00:00:00

abstract：:Ocular pneumoplethysmography was performed before and after 1,737 carotid endarterectomies, 82% of which were performed for carotid lesions of hemodynamic consequence. Preoperative ocular hypoperfusion without ischemia was associated with at least transient postoperative ocular hyperemia. A difference in ocular volume...

journal_title：Ophthalmic research

authors： Gee W,Reed JF 3rd

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND/AIM:Corneal epithelial defects may heal slowly in patients with diabetes, limbal stem cell deficiency, extensive chemical burns or anesthetized corneas. Studies have shown that erythropoietin, a glycoprotein hormone that promotes red blood cell proliferation and inhibits apoptosis of erythroid progenitors, m...

journal_title：Ophthalmic research

authors： Livny E,Livnat T,Yakimov M,Masoud M,Weinberger D,Bahar I

更新日期：2013-01-01 00:00:00

abstract：:The specific activities of the four investigated enzymes of the carbohydrate metabolism decrease with ageing. In the old tissue, phosphoglyceratemutase and enolase sustain changes in their molecular weight, and their substrate affinity is modified. ...

journal_title：Ophthalmic research

authors： Ohrloff C,Berdjis H,Hockwin O,Bours J

更新日期：1983-01-01 00:00:00

abstract：PURPOSE:In this investigation the authors studied the effect of dapiprazole, an alpha-adrenergic blocking agent, on aqueous humor dynamics in patients affected with pigmentary glaucoma. METHODS:Dapiprazole 0.5% eye drops were administered 3 times daily as adjunctive therapy to 16 pigmentary glaucoma patients in additi...

journal_title：Ophthalmic research

authors： Mastropasqua L,Carpineto P,Ciancaglini M,Lobefalo L,Costagliola C,Gallenga PE

更新日期：1996-01-01 00:00:00

abstract：:Results of a comparative study of accommodative capability of eyes in individuals exposed to various doses of ionizing radiation and in a control group are presented. The mean values for ranges of accommodation in the control group were consonant with previous data. However, the range of accommodation was found to be ...

journal_title：Ophthalmic research

authors： Sergienko NM,Fedirko P

更新日期：2002-07-01 00:00:00

abstract：:In an experimental study using freshly enucleated pig's eyes, we investigated the endothelial cell loss on the cut edge. Remote-control rotating trephine was found to be the least injuring when it was applied to fresh and preserved human corneas. Corneal culture does not seem to enhance endothelial cell damage due to ...

journal_title：Ophthalmic research

authors： Böhnke M,Draeger J,Niesmann U

更新日期：1982-01-01 00:00:00

abstract：:The topographic distribution of enzyme activities in normal rat lenses and their changes occurring during naphthalene cataract development were investigated. Cataract formation was documented by slit images according to the Scheimpflug principle. Before the onset of visible changes and after the development of early v...

journal_title：Ophthalmic research

authors： Kojima M

更新日期：1992-01-01 00:00:00

abstract：:Vitamin E (d-alpha-tocopherol) and aspirin were evaluated for their effects on the phase separation temperature, Tc, of calf lens cytoplasm. Vitamin E and aspirin were added to nuclear homogenate and the change in Tc was measured. Aspirin had no measurable effect on Tc. Vitamin E lowered Tc at a rate of -22 degrees C ...

journal_title：Ophthalmic research

authors： Eccarius S,Clark JI

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVE:Weak oxidants produced by activated human leukocytes are proven antimicrobial substances. We tested whether N-chlorotaurine (NCT, taurine chloramine), the chlorinated metabolite of the amino acid taurine, in addition to direct virucidal effects on viral suspensions, has the capability to prevent cell-to-cell ...

journal_title：Ophthalmic research

authors： Huemer HP,Nagl M,Irschick EU

更新日期：2010-01-01 00:00:00

abstract：PURPOSE:The aim of the present study was to characterize the development of after-cataract in the rabbit by measuring its wet weight, protein, DNA and glycosaminoglycan (GAG) contents and using Scheimpflug and slitlamp analysis. Further, aqueous humor (AqH) leukocytes, protein and lens epithelial cell proliferation act...

journal_title：Ophthalmic research

authors： Wallentin N,Lundgren B,Holmén JB,Lundberg C

更新日期：2002-01-01 00:00:00

abstract：:The turnover and migration of synthesized glycoproteins in the cultured retinal pigment epithelium have been studied. Quantitative study indicated that half-time of 3H-fucosylglycoproteins was 11.6 days. Autoradiography was performed several times after incubation of 3H-fucose. Retinal pigment epithelium constantly sy...

journal_title：Ophthalmic research

authors： Entani S,Yoshimura N,Chihara E,Tsukahara I

更新日期：1986-01-01 00:00:00

abstract：AIMS:Experimental retinal research has gained great importance due to the ophthalmic pharmacotherapy era. An increasing number of drugs are constantly released into the market for the treatment of retinal diseases. In this review, animal species, animal models and toxicity assays in retinal research are discussed. MET...

journal_title：Ophthalmic research

authors： Penha FM,Rodrigues EB,Maia M,Dib E,Fiod Costa E,Furlani BA,Nunes Moraes Filho M,Dreyfuss JL,Bottós J,Farah ME

更新日期：2010-01-01 00:00:00

abstract：PURPOSE:To evaluate the effect of transpupillary thermotherapy (TTT) on foveal thickness and macular function in eyes with choroidal neovascularization (CNV) associated with age-related macular degeneration. METHODS:Sixteen eyes with occult CNV and 6 eyes with classic CNV were treated with TTT. Optical coherence tomog...

journal_title：Ophthalmic research

authors： Ishikawa K,Terasaki H,Kobayashi C,Niwa Y,Piao CH,Ito Y,Kondo M,Miyake Y

更新日期：2005-01-01 00:00:00

abstract：:To study the mode of riboflavin metabolism in the lens in vivo, the uptake of 14C-labeled riboflavin and synthesis of ester forms from 14C-riboflavin were assayed in the single whole lens of the rats. 14C-riboflavin uptake increased in proportion to the substrate concentration in the incubation medium, reaching a plat...

journal_title：Ophthalmic research

authors： Ono S,Hirano H

更新日期：1983-01-01 00:00:00

abstract：PURPOSE:To compare tear film osmolarity (TFO) between patients with diabetes mellitus (DM) and normal healthy individuals. METHODS:In this prospective case-controlled study, the TFO in 46 normal subjects (control group) and 55 patients with DM (study group) was evaluated. TFO in milliosmole (mOsm) was measured by usin...

journal_title：Ophthalmic research

authors： Sağdık HM,Ugurbas SH,Can M,Tetikoğlu M,Ugurbas E,Uğurbaş SC,Alpay A,Uçar F

更新日期：2013-01-01 00:00:00

abstract：:Catalase activity was evaluated in Long Evans rat retina after ischemia and reperfusion. Ischemia was induced by ligation of the optic nerve and vessels. Rats were sacrificed after 15 and 120 min of reperfusion, respectively. Catalase activity was assessed by Claiborne's method and was expressed as U/mg of protein. In...

journal_title：Ophthalmic research

authors： Lewden O,Garcher C,Morales C,Javouhey A,Rochette L,Bron AM

更新日期：1996-01-01 00:00:00

abstract：INTRODUCTION:Diabetic Retinopathy (DR) is one of the major vision-threatening causes worldwide. Searching for an individualized therapeutic strategy to prevent its progress is challenging. OBJECTIVE:This work aimed to investigate the association of angiogenesis-inducer vascular endothelial growth factor (VEGF) gene fa...

journal_title：Ophthalmic research

authors： Abdelghany AA,Toraih EA,Mohamed AA,Lashine RM,Saleh MH,Nafie MS,Fawzy MS

更新日期：2020-08-24 00:00:00

abstract：:L-Timolol (0.4 mg/kg) reduced significantly retinal blood flow (17%), systemic blood pressure (18-20%) and heart rate (28%) in the rabbit. D-Timolol (4.0 mg/kg) increased retinal blood flow slightly (9%) and did not significantly affect systemic blood pressure or heart rate. Since D-timolol is effective in reducing in...

journal_title：Ophthalmic research

authors： Yan HY,Chiou GC

更新日期：1987-01-01 00:00:00

abstract：PURPOSE:To investigate the possible roles of various cytokines or growth factors in the pathogenesis of exudative age-related macular degeneration (AMD) by comparing aqueous humor levels of 14 cytokines between eyes with polypoidal choroidal vasculopathy (PCV) and those with neovascular AMD. METHODS:Forty eyes from 40...

journal_title：Ophthalmic research

authors： Sakurada Y,Nakamura Y,Yoneyama S,Mabuchi F,Gotoh T,Tateno Y,Sugiyama A,Kubota T,Iijima H

更新日期：2015-01-01 00:00:00