Abstract:
:Non-toxic concentrations of ceftazidime (CAZ), cefuzonam sodium (CZON) and cefmetazole sodium (CMZ) for intravitreal use were assessed by the electroretinogram in in vitro perfused eyecups of albino rabbits. None of the a-wave, the b-wave and the oscillatory potentials deteriorated with 300 microM CAZ, 300 microM CZON or 500 microM CMZ. The oscillatory potentials were delayed and/or diminished at the concentration which did not change the a- and b-waves (500 microM and 1.0 mM for CAZ and CZON, 1.0 mM for CMZ). Thus, the oscillatory potentials were more vulnerable to these chemicals than the a- and b-waves. Not only the classical a- and b-waves, but also the oscillatory potentials should be examined in retinal toxicology studies by the electroretinogram.
journal_name
Ophthalmic Resjournal_title
Ophthalmic researchauthors
Kitano K,Shirao Y,Kawasaki Kdoi
10.1159/000267858subject
Has Abstractpub_date
1995-01-01 00:00:00pages
128-35eissn
0030-3747issn
1423-0259journal_volume
27 Suppl 1pub_type
杂志文章abstract:AIM:Ultraviolet (UV) B irradiation induces gene expression that leads to skin cancer. Among the transcription factors induced by UVB radiation exposure, the cyclic AMP response element-binding protein (CREB) is significant. Since several factors downstream of CREB signaling are known to be involved in pterygium pathoge...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000347124
更新日期:2013-01-01 00:00:00
abstract::Inflammation is substantially contributing to the development and worsening of diabetic retinopathy in general and diabetic macular edema (DME) in particular, which provides the rationale to treat DME with corticosteroids. While anti-vascular endothelial growth factor (VEGF) agents are mostly chosen as a first-line tr...
journal_title:Ophthalmic research
pub_type: 杂志文章,评审
doi:10.1159/000499540
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:To evaluate the role of initial visual acuity (VA) as a potential prognostic factor for final VA in patients with branch retinal vein occlusion (BRVO). METHODS:A retrospective data analysis involving 163 patients with macular edema secondary to BRVO treated according to the recommendations of the Branch Vein O...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000321701
更新日期:2011-01-01 00:00:00
abstract:PURPOSE:To investigate the effect of propolis, a natural resin produced by honeybees, in the treatment of alkali-injured rabbit eyes. METHOD:A corneal alkali burn was induced by applying filter paper immersed in 1 N NaOH on the central axis of the right corneas of 24 rabbits for 30 s. The animals were divided into thr...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000055581
更新日期:2000-01-01 00:00:00
abstract::The aim of the study was to examine the effects of nonsteroidal anti-inflammatory drugs (NSAIDs)/acetylsalicylic acid (ASA) on human lens epithelial cells (HLECs) during oxidative stress. HLECs were exposed to H2O2 in the absence or presence of indomethacin, diclofenac, celecoxib (NSAIDs) or ASA for 24 h. HLECs were a...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000113885
更新日期:2008-01-01 00:00:00
abstract::Dragomirescu et al. [1983] described a 2-chamber flow system for the incubation of lenses with an inserted photometer to measure changes in lens transparency. Mester et al. [1984] applied the method to simulate conditions occurring during vitrectomy, which occasionally leads to reversible lens opacification. Using Sch...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265357
更新日期:1985-01-01 00:00:00
abstract::Dry eye is the most prominent pathology among those involving the ocular surface: a decrease of the aqueous (less frequent) or the lipid (more frequent) component of the tear film is the cause of the diminished stability of tears that is observed in this pathology. Dry eye shows a clear distribution linked to both sex...
journal_title:Ophthalmic research
pub_type: 杂志文章,评审
doi:10.1159/000489093
更新日期:2018-01-01 00:00:00
abstract::The gut microbiome has important physiological functions and plays an indispensable role in the human body. Currently, there are an increasing number of studies revealing the close correlation between dysbiosis of the gut microbiome and a variety of autoimmune diseases, including autoimmune uveitis. This brief review ...
journal_title:Ophthalmic research
pub_type: 杂志文章,评审
doi:10.1159/000510212
更新日期:2020-07-16 00:00:00
abstract::The pathology of rainbow trout lenses incubated in various media and at various temperatures was examined by electron microscopy. After incubation at 0 degrees C for 5 h, no changes were observed in transparency and cytology. Irreversible warm cataract occurred at 37 degrees C, which corresponds to the body temperatur...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265427
更新日期:1986-01-01 00:00:00
abstract::The vibrating probe detects and measures currents around cells and organs. With its use, it is possible to demonstrate strong outward potassium currents at the equator of the lens and strong inward sodium currents at the optical poles. The addition of microelectrodes to the system permits one to define the nature of t...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000266570
更新日期:1988-01-01 00:00:00
abstract:PURPOSE:The aim of the present study was to characterize the development of after-cataract in the rabbit by measuring its wet weight, protein, DNA and glycosaminoglycan (GAG) contents and using Scheimpflug and slitlamp analysis. Further, aqueous humor (AqH) leukocytes, protein and lens epithelial cell proliferation act...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000048320
更新日期:2002-01-01 00:00:00
abstract::The use of corneal tissue for ex vivo therapeutic evaluations is limited due to its rapid loss of viability after excision. Optimization of storage conditions may allow prolonged retention of physical tissue properties. In this study, we evaluated how storage in optimized organ culture (OC) medium at 37°C or phosphate...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000493488
更新日期:2019-01-01 00:00:00
abstract::A technique for chronic implantation of a device for long-term continuous, quantitative monitoring of intraocular pressure (IOP) in experimental animals is presented. The methodology employed is straight forward and should be easily duplicated for experimental investigations where such monitoring might be useful. Cont...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265179
更新日期:1982-01-01 00:00:00
abstract::The possible multiple effect of galactose diet and X-irradiation on cataract development in mice was investigated by scanning electron microscopy. X-ray cataracts were induced by maintaining animals either on a normal or 50% galactose diet. No detectable changes in lens morphology were seen in animals fed galactose al...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265280
更新日期:1983-01-01 00:00:00
abstract:PURPOSE:In this investigation the authors studied the effect of dapiprazole, an alpha-adrenergic blocking agent, on aqueous humor dynamics in patients affected with pigmentary glaucoma. METHODS:Dapiprazole 0.5% eye drops were administered 3 times daily as adjunctive therapy to 16 pigmentary glaucoma patients in additi...
journal_title:Ophthalmic research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000267920
更新日期:1996-01-01 00:00:00
abstract::Modulation sensitivity functions ( MSFs ) of retinal ganglion cells of the pigeon were determined by recording action potentials from their end branching in the optic tectum as response indicator. The inverse Fourier transformation of a MSF is taken to represent the receptive field sensitivity function approximating t...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265299
更新日期:1984-01-01 00:00:00
abstract::We hypothesize that the differential susceptibility to photic injury among different strains of rat retinas may depend on the levels of phospholipid hydroperoxide glutathione peroxidase (PHGPX) activity, one of the endogenous antioxidant enzymes in the retina. The retinas of four inbred strains of albino rat (Fischer,...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267376
更新日期:1994-01-01 00:00:00
abstract:PURPOSE:To assess the natural variability in the diameter of small collagen fibrils in the lamellae of corneal stroma of healthy young rabbits. MATERIALS AND METHODS:The corneas of 6 young adult female New Zealand White rabbits (2.1 kg) were prepared for transmission electron microscopy (TEM) by fixation with a cacody...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000096228
更新日期:2006-01-01 00:00:00
abstract::We examined 304 conjunctiva in 152 subjects by clinical, cytologic, and bacteriologic methods. Bacteriologic samples were evaluated after a 48-hour incubation. Bacterial growth was found in 8 (20.5%) of 39 patients with clinically normal conjunctiva and no polymorphonuclear leukocytes (PMNs), and in 8 (61.5%) of 13 su...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267086
更新日期:1991-01-01 00:00:00
abstract:PURPOSE:To compare the effects between intravitreal and periocular injections of adenoviral vectored pigment epithelium-derived factor (AdPEDF) on suppressing established choroidal neovascularization (CNV) in rats. METHODS:Sixty-eight female BN rats (136 eyes) aged 6-8 weeks were involved in this study. The CNV animal...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000342979
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:In this study, we used a rat model of retinal detachment (RD) to investigate the effects of transient receptor potential mucolipin 1 (TRPML1) on photoreceptor cells and the underlying mechanism. METHODS:An RD model was established by subretinal injection of sodium hyaluronate, and mucolipin synthetic agonist...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000512104
更新日期:2020-10-07 00:00:00
abstract:PURPOSE:To investigate therapeutic ocular surface medium (TOSM), a potential physiological tear replacement therapy, for persistent epithelial defect (PED). METHODS:11 eyes of 10 patients with PED for ≥ 2 weeks without improvement despite conventional treatment were enrolled in a prospective pilot study of TOSM over 1...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000355065
更新日期:2014-01-01 00:00:00
abstract:INTRODUCTION:Retinitis pigmentosa (RP) is an inherited retinal disorder, characterized by photoreceptor degeneration inducing progressive vision loss. This study evaluates its impact on quality of life (QOL) and emotional states of patients affected by RP. METHODS:A cross-sectional study was conducted on 60 RP patient...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000435886
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy of bilateral lateral rectus muscle recession (BLR) to treat recurrent exotropia after bilateral medial rectus muscle resection (BMR). METHODS:Twenty-four patients who underwent BLR for recurrent exotropia and were followed up for more than 6 months were included in this retrospective s...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000494560
更新日期:2019-01-01 00:00:00
abstract::Although it is essential that intraocular pressure (IOP) be reduced in glaucoma treatment, it is also vitally important to provide sufficient blood flow to eye tissues so that healthy visual field is maintained. It is possible for an agent to reduce IOP and blood supply to the eye. In that case, glaucoma appears to be...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265445
更新日期:1986-01-01 00:00:00
abstract:OBJECTIVE:To assess changes of tear film function in patients with pterygium after pterygium excision combined with limbal-conjunctival autograft transplantation. METHODS:Sixty eyes of 60 patients were entered in the study. The Schirmer test, tear breakup time (BUT) and mucus fern test (MFT) were evaluated in the pati...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000321531
更新日期:2011-01-01 00:00:00
abstract::The polyamines putrescine, spermidine and spermine have been proposed to be a part of the acute phase inflammatory response. They have been shown to be useful markers for cellular kinetics and change with various pathological conditions. The hypothesis that aqueous humor polyamines could be used to follow the time cou...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267165
更新日期:1992-01-01 00:00:00
abstract::To investigate the binding of peanut-agglutinin (PNA) on porcine corneal tissue, several methods of tissue processing were used. In cryostat sections of postmortem tissue, PNA labeling of epithelial cell membranes was detected. In the stroma, a fibrillar structure parallel to the corneal surface was found. The anterio...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000266748
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVE:Weak oxidants produced by activated human leukocytes are proven antimicrobial substances. We tested whether N-chlorotaurine (NCT, taurine chloramine), the chlorinated metabolite of the amino acid taurine, in addition to direct virucidal effects on viral suspensions, has the capability to prevent cell-to-cell ...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000253846
更新日期:2010-01-01 00:00:00
abstract::This study was undertaken to characterize the mechanism of ocular irritation to YAG laser capsulotomy in rabbits. The blocking agents were administered intravitreally. (D-Arg1,D-Pro2,D-Trp7,9)-SP, a substance P antagonist, tended to reduce miosis but had no effect on intraocular pressure (IOP). It had less effect on m...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000266900
更新日期:1989-01-01 00:00:00