Correlation of phospholipid hydroperoxide glutathione peroxidase activity to the sensitivity of rat retinas to photic injury.

abstract：BACKGROUND:Mesopic conditions elicit both rod and cone responses, and they are more commonly encountered in daily life than are scotopic conditions; yet visual function outcome measures of mesopic visual acuity (VA) or contrast sensitivity (CS) are rarely evaluated. OBJECTIVE:In retinitis pigmentosa (RP), we explored ...

journal_title：Ophthalmic research

authors： Bittner AK,Ferraz MC

更新日期：2020-01-01 00:00:00

abstract：:The tear levels of cholesterol of 17 patients with chronic blepharitis and 17 healthy subjects were determined by the photometric method. The mean cholesterol level of the patients was determined to be 56.1 +/- 8.9 (SEM) mg/dl. No statistically significant difference between the tear cholesterol levels of the two grou...

journal_title：Ophthalmic research

authors： Saatçi AO,Irkeç M,Unlü N

更新日期：1990-01-01 00:00:00

abstract：:The eyes of 200 rats (Mol:SPRD, Moellegaard Ltd., Skensvet, Denmark), 8 weeks of age and of both sexes, were examined routinely with a photo-slitlamp microscope (Zeiss) and opthalmoscope (Heine) 3-4 times in the course of four different 12-week toxicity studies. The animals were kept under constant lighting conditions...

journal_title：Ophthalmic research

authors： Wegener A,Jochims K

更新日期：1994-01-01 00:00:00

abstract：:The influence of nonselective and selective alpha-adrenergic agonists on intraocular pressure (IOP) was studied in isolated arterially perfused rabbit eyes. Drugs were given intra-arterially or topically. With either route of administration, no initial hypertensive phase was observed after l-epinephrine, l-norepinephr...

journal_title：Ophthalmic research

authors： van Pinxteren PC

更新日期：1985-01-01 00:00:00

abstract：AIMS:The purpose of this paper was to determine the lacrimal concentration of IL-1α and MMP-9 in patients with active ocular rosacea before and after systemic treatment with azithromycin or doxycycline. METHODS:After 4 weeks of therapy with azithromycin (500 mg/day, 3 days a week PO) or doxycycline (200 mg/day PO), la...

journal_title：Ophthalmic research

authors： Lam-Franco L,Perfecto-Avalos Y,Patiño-Ramírez BE,Rodríguez García A

更新日期：2018-01-01 00:00:00

abstract：:The specific activities of the four investigated enzymes of the carbohydrate metabolism decrease with ageing. In the old tissue, phosphoglyceratemutase and enolase sustain changes in their molecular weight, and their substrate affinity is modified. ...

journal_title：Ophthalmic research

authors： Ohrloff C,Berdjis H,Hockwin O,Bours J

更新日期：1983-01-01 00:00:00

abstract：PURPOSE:To describe the characteristics of macular lesions after eye trauma using spectral-domain optical coherence tomography (OCT). METHODS:We retrospectively reviewed and described 2-dimensional (2D) and 3-dimensional (3D) spectral-domain OCT characteristics of 24 consecutive eyes of 24 cases that were identified w...

journal_title：Ophthalmic research

authors： Yu W,Zheng L,Zhang Z,Dai R,Dong F

更新日期：2012-01-01 00:00:00

abstract：:We measured prostaglandin E2 (PGE2) and prostacyclin levels in the vitreous bodies of 5 eyes of patients with diabetic retinopathy complicated by rhegmatogenous retinal detachment (RRD) and compared them with the corresponding levels in 9 nondiabetic eyes with the same condition as well as with 10 control eyes of dece...

journal_title：Ophthalmic research

authors： Naveh N,Belkin M,Ben-Chaim O,Weissman C,Treister G

更新日期：1990-01-01 00:00:00

abstract：:Cataractous lens images taken with different camera types for retroillumination photography were compared. Images taken by conventional photo slitlamp and fundus cameras were not suitable for image analysis. Retroillumination photography with a conventional fundus camera with additional polarizing filters seemed to be...

journal_title：Ophthalmic research

authors： Sakamoto Y,Rankov G,Sasaki K

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the effect of C constant for ray tracing-assisted intraocular lens (IOL) power calculation in the patients with different refractive power, we compared the refractive outcome of ray-tracing method based on C constant and conventional IOL calculation formula. METHODS:215 eyes which underwent phaco...

journal_title：Ophthalmic research

authors： Chang P,Zhang F,Wang J,Zhao Y

更新日期：2020-04-20 00:00:00

abstract：PURPOSE:To evaluate diabetic retinopathy (DR) progression in patients with diabetes mellitus type 2 in 2 populations of different ethnicity. METHODS:A prospective observational study was designed to follow eyes/patients with mild nonproliferative DR, for 2 years or until the development of central-involved macular ede...

journal_title：Ophthalmic research

authors： Ribeiro L,Pappuru R,Lobo C,Alves D,Cunha-Vaz J

更新日期：2018-01-01 00:00:00

abstract：PURPOSE:To evaluate the role of initial visual acuity (VA) as a potential prognostic factor for final VA in patients with branch retinal vein occlusion (BRVO). METHODS:A retrospective data analysis involving 163 patients with macular edema secondary to BRVO treated according to the recommendations of the Branch Vein O...

journal_title：Ophthalmic research

authors： Rehak J,Dusek L,Chrapek O,Fric E,Rehak M

更新日期：2011-01-01 00:00:00

abstract：PURPOSE:The aim of the present study was to characterize the development of after-cataract in the rabbit by measuring its wet weight, protein, DNA and glycosaminoglycan (GAG) contents and using Scheimpflug and slitlamp analysis. Further, aqueous humor (AqH) leukocytes, protein and lens epithelial cell proliferation act...

journal_title：Ophthalmic research

authors： Wallentin N,Lundgren B,Holmén JB,Lundberg C

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVE:In this study, we used a rat model of retinal detachment (RD) to investigate the effects of transient receptor potential mucolipin 1 (TRPML1) on photoreceptor cells and the underlying mechanism. METHODS:An RD model was established by subretinal injection of sodium hyaluronate, and mucolipin synthetic agonist...

journal_title：Ophthalmic research

authors： Yan Y,Wang Y,Ding J,Lu L,Ke G,Dong K

更新日期：2020-10-07 00:00:00

abstract：:The aim of the study was to examine the effects of nonsteroidal anti-inflammatory drugs (NSAIDs)/acetylsalicylic acid (ASA) on human lens epithelial cells (HLECs) during oxidative stress. HLECs were exposed to H2O2 in the absence or presence of indomethacin, diclofenac, celecoxib (NSAIDs) or ASA for 24 h. HLECs were a...

journal_title：Ophthalmic research

authors： Petersen A,Carlsson T,Karlsson JO,Zetterberg M

更新日期：2008-01-01 00:00:00

abstract：:Calf water-soluble (WS) crystallins consist of high-molecular weight (HM), alpha-, beta H-, beta L-, beta s- and gamma-crystallins. alpha-Crystallin as a molecular chaperone forms a structure with a central hole, known as Carver's model. The only crystallins fitting into this central cavity are beta s- and gamma-cryst...

journal_title：Ophthalmic research

authors： Bours J

更新日期：1996-01-01 00:00:00

abstract：PURPOSE:The purpose of our study was to investigate the profiles of inflammatory cytokines and the macrophage polarization gene in a choroidal neovascularization (CNV) mouse model before and after intravitreal aflibercept treatment. METHODS:The CNV mouse model was conducted by laser photocoagulation. A total of 58 cyt...

journal_title：Ophthalmic research

authors： Wang C,Zhang R,Zhang Q,Jin H,Wei C,Wu C,Mei L,Liu Y,Zhang P

更新日期：2020-12-04 00:00:00

abstract：:The main objective of this study was to determine the intraocular concentration of fluorescein after applying five eye drops with only 1-min intervals in human eyes. The concentration of fluorescein in corea and aqueous was studied with fluorophotometry in 11 healthy volunteers. Five 10-microliter drops of 2% fluoresc...

journal_title：Ophthalmic research

authors： Lindén C,Alm A

更新日期：1997-01-01 00:00:00

abstract：AIMS:To investigate whether allogeneic limbal mesenchymal stem cell (LMSC) therapy affects corneal healing after a severe chemical burn and whether the route of administration of LMSCs differs in its therapeutic effect in this respect. METHODS:A total of 60 Sprague-Dawley rats with clinically proven alkali injury were...

journal_title：Ophthalmic research

authors： Acar U,Pinarli FA,Acar DE,Beyazyildiz E,Sobaci G,Ozgermen BB,Sonmez AA,Delibasi T

更新日期：2015-01-01 00:00:00

abstract：:Lenticular S-adenosylmethionine synthetase has been partially purified and characterized. Lower levels of S-adenosylmethionine synthetase were detected by a sensitive radioactive assay procedure in the lenticular extract obtained from the pooled lenses of alloxan-treated rats 96 days of age as compared to the nontreat...

journal_title：Ophthalmic research

authors： Ahmad SS,Ahmad SI,Rahman MA

更新日期：1982-01-01 00:00:00

abstract：AIM:Ultraviolet (UV) B irradiation induces gene expression that leads to skin cancer. Among the transcription factors induced by UVB radiation exposure, the cyclic AMP response element-binding protein (CREB) is significant. Since several factors downstream of CREB signaling are known to be involved in pterygium pathoge...

journal_title：Ophthalmic research

authors： Nubile M,Curcio C,Lanzini M,Calienno R,Iezzi M,Mastropasqua A,Di Nicola M,Mastropasqua L

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:The aim of this work was to compare the efficacy of intravitreal dexamethasone implant (Ozurdex) and intravitreal ranibizumab (Lucentis) in the treatment of macular edema (ME) caused by retinal vein occlusion (RVO). METHODS:Thirty-two ME cases treated with Ozurdex and 32 ME cases treated with ranibizumab we...

journal_title：Ophthalmic research

authors： Gu X,Yu X,Song S,Dai H

更新日期：2017-01-01 00:00:00

abstract：PURPOSE:Osthole is an agent isolated from Cnidium monnieri (L.) Cusson and has been used to treat several disorders. Corneal neovascularization is a sight-threatening condition associated with several inflammatory or infectious ocular disorders. In this study, we investigated the anti-angiogenic effects of osthole on c...

journal_title：Ophthalmic research

authors： Zhang QY,Tao SY,Lu C,Li JJ,Li XM,Jiang Q,Yan B

更新日期：2020-01-01 00:00:00

abstract：:Dragomirescu et al. [1983] described a 2-chamber flow system for the incubation of lenses with an inserted photometer to measure changes in lens transparency. Mester et al. [1984] applied the method to simulate conditions occurring during vitrectomy, which occasionally leads to reversible lens opacification. Using Sch...

journal_title：Ophthalmic research

authors： Hockwin O,Dragomirescu V,Schwarz B

更新日期：1985-01-01 00:00:00

abstract：OBJECTIVES:To evaluate the efficacy of postenucleation saline wash and the effect of different antimicrobial agents on the microbial contamination of donor eyes. METHODS:Two hundred donor eyes were given saline wash and treated with any one of the following 5 randomly selected antimicrobial solutions: 1% povidone-iodi...

journal_title：Ophthalmic research

authors： Panda A,Saxena R,Vajpayee RB,Satpathy G,Angra SK,Sethi HS

更新日期：2006-01-01 00:00:00

abstract：AIM:To develop a local approach to study rabbit lacrimal secretion in situ by administering specific secretagogues directly onto the lacrimal gland (LG). METHODS:After the rabbit has been anesthetized, the inferior bulbar conjunctiva and underlying connective tissue are blunt dissected. A polyethylene tube, for drug d...

journal_title：Ophthalmic research

authors： Ding C,Rife L,Nakamura T,Wang YW,Kopp K,Schechter JE

更新日期：2008-01-01 00:00:00

abstract：:The possible multiple effect of galactose diet and X-irradiation on cataract development in mice was investigated by scanning electron microscopy. X-ray cataracts were induced by maintaining animals either on a normal or 50% galactose diet. No detectable changes in lens morphology were seen in animals fed galactose al...

journal_title：Ophthalmic research

authors： Kodama T,Reddy VN,Giblin F,Kinoshita JH,Harding C

更新日期：1983-01-01 00:00:00

abstract：:Small RNA (microRNA or miRNA) is a kind of small noncoding single-stranded RNA that regulates complementary mRNA at the posttranscriptional level in eukaryotic organisms. As important regulatory factors, miRNAs play an important role in the occurrence and development of glaucoma and widely participate in regulating bi...

journal_title：Ophthalmic research

authors： Guo R,Shen W,Su C,Jiang S,Wang J

更新日期：2017-01-01 00:00:00

abstract：PURPOSE:To characterize the 1-year progression of retinal thickness (RT) increase occurring in eyes with subclinical macular edema in type 2 diabetes. METHODS:Forty-eight type 2 diabetic eyes/patients with mild nonproliferative diabetic retinopathy (NPDR; levels 20 and 35 in the Early Treatment Diabetic Retinopathy St...

journal_title：Ophthalmic research

authors： Tejerina AN,Vujosevic S,Varano M,Egan C,Sivaprasad S,Menon G,Massin P,Verbraak FD,Lund-Andersen H,Martinez JP,Jurgens I,Smets E,Coriat C,Wiedemann P,Ágoas V,Querques G,Holz FG,Nunes S,Alves D,Neves C,Santos T,Ri

更新日期：2015-01-01 00:00:00

abstract：:Toxoplasma gondii is an extremely successful opportunistic parasite which infects approximately one third of the human population worldwide. The impact of this parasite on human health becomes particularly manifest in congenital damage with infection and subsequent inflammation of neuronal tissues including the retina...

journal_title：Ophthalmic research

authors： Pleyer U,Schlüter D,Mänz M

更新日期：2014-01-01 00:00:00