Ocular toxoplasmosis: recent aspects of pathophysiology and clinical implications.

Abstract:

:Toxoplasma gondii is an extremely successful opportunistic parasite which infects approximately one third of the human population worldwide. The impact of this parasite on human health becomes particularly manifest in congenital damage with infection and subsequent inflammation of neuronal tissues including the retina. Although advances in our understanding could be achieved in ocular toxoplasmosis, large gaps still exist on factors influencing the epidemiology and pathophysiology of this potentially blinding disease. We are only at the beginning of understanding the complex biology of this parasite and its mechanisms of invasion, virulence and interaction with the host's immune response. Since it is a preventable cause of blindness, it is necessary to assess factors that have the potential to control this disease in the future. This mini review will focus on recent advances in postnatal acquired ocular infection and the factors that may influence its prevalence and functional outcome.

journal_name

Ophthalmic Res

journal_title

Ophthalmic research

authors

Pleyer U,Schlüter D,Mänz M

doi

10.1159/000363141

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

116-23

issue

3

eissn

0030-3747

issn

1423-0259

pii

000363141

journal_volume

52

pub_type

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