Hypotensive effects after topical and intra-arterial administration of alpha-adrenergic agonists in isolated perfused rabbit eyes.

abstract：BACKGROUND:Mesopic conditions elicit both rod and cone responses, and they are more commonly encountered in daily life than are scotopic conditions; yet visual function outcome measures of mesopic visual acuity (VA) or contrast sensitivity (CS) are rarely evaluated. OBJECTIVE:In retinitis pigmentosa (RP), we explored ...

journal_title：Ophthalmic research

authors： Bittner AK,Ferraz MC

更新日期：2020-01-01 00:00:00

abstract：PURPOSE:To evaluate the role of initial visual acuity (VA) as a potential prognostic factor for final VA in patients with branch retinal vein occlusion (BRVO). METHODS:A retrospective data analysis involving 163 patients with macular edema secondary to BRVO treated according to the recommendations of the Branch Vein O...

journal_title：Ophthalmic research

authors： Rehak J,Dusek L,Chrapek O,Fric E,Rehak M

更新日期：2011-01-01 00:00:00

abstract：PURPOSE:To characterize the 1-year progression of retinal thickness (RT) increase occurring in eyes with subclinical macular edema in type 2 diabetes. METHODS:Forty-eight type 2 diabetic eyes/patients with mild nonproliferative diabetic retinopathy (NPDR; levels 20 and 35 in the Early Treatment Diabetic Retinopathy St...

journal_title：Ophthalmic research

authors： Tejerina AN,Vujosevic S,Varano M,Egan C,Sivaprasad S,Menon G,Massin P,Verbraak FD,Lund-Andersen H,Martinez JP,Jurgens I,Smets E,Coriat C,Wiedemann P,Ágoas V,Querques G,Holz FG,Nunes S,Alves D,Neves C,Santos T,Ri

更新日期：2015-01-01 00:00:00

abstract：:Cholinergic agents used to lower intraocular pressure in the medical management of glaucoma act on muscarinic receptors in the eye. Recently, subtypes of muscarinic receptors have been recognized in many tissues including the eye. To localize the M3 muscarinic receptor subtype and m3 messenger RNA (mRNA) in the human ...

journal_title：Ophthalmic research

authors： Gupta N,Drance SM,McAllister R,Prasad S,Rootman J,Cynader MS

更新日期：1994-01-01 00:00:00

abstract：:Previous research from this laboratory showed that human lacrimal fluid peroxidase has cyclic variations during the menstrual cycle, correlated with plasma levels of 17beta-oestradiol. In the present investigation, variations of enzyme activity and total protein content during the oestrous cycle of young adult female ...

journal_title：Ophthalmic research

authors： Madia F,Liberati V,de Feo G,Marcozzi G

更新日期：2001-05-01 00:00:00

abstract：PURPOSE:To analyze a multiflash multifocal electroretinogram in 20 patients with open-angle glaucoma (OAG). METHODS:The stimulation sequence consisted of a binary m-sequence (L(max) 200 cd/m(2), L(min) <1 cd/m(2)). Each m-sequence stimulus was followed by three global flashes (luminance: 400 cd/m(2)) at an interval of...

journal_title：Ophthalmic research

authors： Palmowski AM,Allgayer R,Heinemann-Vernaleken B,Ruprecht KW

更新日期：2002-03-01 00:00:00

abstract：:Indirect measurement in vivo of nuclear color of 64 cataractous eyes was made using a method of image analysis of photographed lenses developed by the authors. The grade of yellow of lens color was characterized by its dominant wavelength and excitation purity in the CIE chromaticity diagram. The differences were smal...

journal_title：Ophthalmic research

authors： Sasaki K,Hiiragi M,Sakamoto Y,Shibata T

更新日期：1985-01-01 00:00:00

abstract：:Small RNA (microRNA or miRNA) is a kind of small noncoding single-stranded RNA that regulates complementary mRNA at the posttranscriptional level in eukaryotic organisms. As important regulatory factors, miRNAs play an important role in the occurrence and development of glaucoma and widely participate in regulating bi...

journal_title：Ophthalmic research

authors： Guo R,Shen W,Su C,Jiang S,Wang J

更新日期：2017-01-01 00:00:00

abstract：PURPOSE:In this investigation the authors studied the effect of dapiprazole, an alpha-adrenergic blocking agent, on aqueous humor dynamics in patients affected with pigmentary glaucoma. METHODS:Dapiprazole 0.5% eye drops were administered 3 times daily as adjunctive therapy to 16 pigmentary glaucoma patients in additi...

journal_title：Ophthalmic research

authors： Mastropasqua L,Carpineto P,Ciancaglini M,Lobefalo L,Costagliola C,Gallenga PE

更新日期：1996-01-01 00:00:00

abstract：:During the process of terminal differentiation, the fibre cells in the eye lens undergo many changes that are reminiscent of apoptotic/necrotic changes. Mitochondria, for instance, undergo permeability transition and nuclear degradation is accompanied by chromatin condensation, disintegration of the nucleolus, dissolu...

journal_title：Ophthalmic research

authors： Dahm R

更新日期：1999-01-01 00:00:00

abstract：INTRODUCTION:Retinitis pigmentosa (RP) is an inherited retinal disorder, characterized by photoreceptor degeneration inducing progressive vision loss. This study evaluates its impact on quality of life (QOL) and emotional states of patients affected by RP. METHODS:A cross-sectional study was conducted on 60 RP patient...

journal_title：Ophthalmic research

authors： Azoulay L,Chaumet-Riffaud P,Jaron S,Roux C,Sancho S,Berdugo N,Audo I,Sahel JA,Mohand-Saïd S

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:Diabetic Retinopathy (DR) is one of the major vision-threatening causes worldwide. Searching for an individualized therapeutic strategy to prevent its progress is challenging. OBJECTIVE:This work aimed to investigate the association of angiogenesis-inducer vascular endothelial growth factor (VEGF) gene fa...

journal_title：Ophthalmic research

authors： Abdelghany AA,Toraih EA,Mohamed AA,Lashine RM,Saleh MH,Nafie MS,Fawzy MS

更新日期：2020-08-24 00:00:00

abstract：:The aim of the present study was to investigate biochemical and morphological changes in rat lenses following long-term UV B irradiation. After an irradiation period of 156 days with follow-up documentation by means of Scheimpflug photography, section-related biochemical analyses of the lenses as well as histological ...

journal_title：Ophthalmic research

authors： Schmidt J,Schmitt C,Kojima M,Hockwin O

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:The aim of this study was to evaluate the characteristics of corneal endothelial cells and central corneal thickness (CCT) in patients with diabetes mellitus (DM), comparing them with those of healthy subjects (controls) and to determine potential factors affecting the corneal parameters in patients with DM. M...

journal_title：Ophthalmic research

authors： Papadakou P,Chatziralli I,Papathanassiou M,Lambadiari V,Siganos CS,Theodossiadis P,Kozobolis V

更新日期：2020-01-01 00:00:00

abstract：:We hypothesize that the differential susceptibility to photic injury among different strains of rat retinas may depend on the levels of phospholipid hydroperoxide glutathione peroxidase (PHGPX) activity, one of the endogenous antioxidant enzymes in the retina. The retinas of four inbred strains of albino rat (Fischer,...

journal_title：Ophthalmic research

authors： Wang L,Lam TT,Lam KW,Tso MO

更新日期：1994-01-01 00:00:00

abstract：:The aqueous humors of 100 freshly enucleated rabbit eyes were assessed within 10 min postmortem by taking samples in the last stage of corneal dissection following the Dikstein-Maurice procedure. Aqueous levels of partial pressure of carbon dioxide (pCO2) averaged 58.2 +/- 8.5 mm Hg to give calculated tCO2 and bicarbo...

journal_title：Ophthalmic research

authors： Doughty MJ

更新日期：1993-01-01 00:00:00

abstract：:The refractive indices in various rat retinal layers, based on the total dry mass concentration, ranged from 1.369 to 1.385. The ratios of the refractive indices of neighboring retinal layers were near unity. This finding suggests that light passes through the rat retina without much refraction. ...

journal_title：Ophthalmic research

authors： Chen E

更新日期：1993-01-01 00:00:00

abstract：:To determine the conditions under which anesthetized pigs can be used in acute noninvasive investigations of ocular hydro- and hemodynamics, the intraocular pressure (IOP) of adult pigs was recorded under the following conditions: (1) after intravenous injection of propofol plus ketamine; (2) during inhalation of isof...

journal_title：Ophthalmic research

authors： Buehner E,Pietsch UC,Bringmann A,Foja C,Wiedemann P,Uhlmann S

更新日期：2011-01-01 00:00:00

abstract：:The ophthalmic examination of patients with hypertrophic cardiomyopathy treated with high doses of verapamil over a considerable period of time showed no evidence of a side effect of the drug, thus proving its ocular safety. This could be verified by densitometric image analysis of Scheimpflug photographs of the eyes....

journal_title：Ophthalmic research

authors： Hockwin O,Dragomirescu V,Laser H,Ohrloff C,Kozamanoglu K,Kremer F

更新日期：1984-01-01 00:00:00

abstract：:Inflammation is substantially contributing to the development and worsening of diabetic retinopathy in general and diabetic macular edema (DME) in particular, which provides the rationale to treat DME with corticosteroids. While anti-vascular endothelial growth factor (VEGF) agents are mostly chosen as a first-line tr...

journal_title：Ophthalmic research

authors： Zur D,Iglicki M,Loewenstein A

更新日期：2019-01-01 00:00:00

abstract：:The topographic distribution of enzyme activities in normal rat lenses and their changes occurring during naphthalene cataract development were investigated. Cataract formation was documented by slit images according to the Scheimpflug principle. Before the onset of visible changes and after the development of early v...

journal_title：Ophthalmic research

authors： Kojima M

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVE:The pathogenesis of Behçet's disease (BD) may be related to excessive production of reactive oxygen species, activated neutrophils, and T lymphocytes. The goal of this prospective study was to investigate whether there is any relationship among the oxidant/antioxidant system and nitric oxide (NO) and malondia...

journal_title：Ophthalmic research

authors： Aydin E,Sögüt S,Ozyurt H,Ozugurlu F,Akyol O

更新日期：2004-05-01 00:00:00

abstract：PURPOSE:To study the ability to appreciate qualitative features that indicate disease activity in patients with neovascular age-related macular degeneration (AMD) and to analyze the differences in automated retinal thickness measurement, using 1 time domain optical coherence tomography (TD-OCT) and 2 different spectral...

journal_title：Ophthalmic research

authors： Querques G,Forte R,Berboucha E,Martinelli D,Coscas G,Soubrane G,Souied EH

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Genipin (GP) is a safe method for corneal crosslinking, even for very thin corneas. However, there have been no reports on the optimal GP concentration range to use in vivo for corneal crosslinking. OBJECTIVES:To investigate the safety of corneal crosslinking after a 24-h incubation with different concentra...

journal_title：Ophthalmic research

authors： Song W,Tang Y,Qiao J,Li H,Rong B,Yang S,Wu Y,Yan X

更新日期：2019-01-01 00:00:00

abstract：:Diabetic macular edema is a common condition frequently encountered by ophthalmologists. In this piece we briefly review its definition, pathogenesis, clinical aspects, imaging, and treatment. ...

journal_title：Ophthalmic research

authors： Moisseiev E,Loewenstein A

更新日期：2017-01-01 00:00:00

abstract：:The development and extension of fibrovascular or fibroglial membranes onto the retinal surface are a major cause of visual loss in diabetic patients with proliferative retinopathy and in patients suffering from retinal detachment with proliferative vitreoretinopathy. The pathogenesis of these proliferative diseases, ...

journal_title：Ophthalmic research

authors： Fredj-Reygrobellet D,Baudouin C,Nègre F,Caruelle JP,Gastaud P,Lapalus P

更新日期：1991-01-01 00:00:00

abstract：:The pathology of rainbow trout lenses incubated in various media and at various temperatures was examined by electron microscopy. After incubation at 0 degrees C for 5 h, no changes were observed in transparency and cytology. Irreversible warm cataract occurred at 37 degrees C, which corresponds to the body temperatur...

journal_title：Ophthalmic research

authors： Uga S,Ishikawa S,Hikida M,Iwata S

更新日期：1986-01-01 00:00:00

abstract：AIM:To investigate the diagnostic efficacy and clinical application value of plasma endothelin-1 for diabetic retinopathy using receiver operating characteristic (ROC) curve analysis. METHODS:This was a prospective investigational study. Funduscopy and fundus fluorescein angiography were used as gold standards for the...

journal_title：Ophthalmic research

authors： Zhu H,Shi CH

更新日期：2007-01-01 00:00:00

abstract：:The ultrastructure of optic nerve axons was examined in several mammals (human, cat, rat, sheep, ox, pig, guinea pig, rabbit). Human material was obtained from normotensive, glaucoma-free eyes and from eyes with a history of glaucoma and raised intra-ocular pressure (IOP). We describe accumulations of organelles (prin...

journal_title：Ophthalmic research

authors： Holländer H,Makarov F,Stefani FH,Stone J

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:To assess the cytotoxic properties of voriconazole and sulfobutylether-β-cyclodextrin (SBECD) on cultured primary human corneal epithelial cells. METHODS:Human corneal epithelial cells were cultured and exposed to various concentrations of SBECD (0.016-32 mg/ml) and voriconazole (0.001-2 mg/ml). Cellular cy...

journal_title：Ophthalmic research

authors： Sobolewska B,Guerel G,Hofmann J,Tarek B,Bartz-Schmidt KU,Yoeruek E

更新日期：2015-01-01 00:00:00