The Effect of Diabetes Mellitus on Corneal Endothelial Cells and Central Corneal Thickness: A Case-Control Study.

abstract：BACKGROUND:To compare intraocular pressure (IOP) measurements obtained with the digital tonometer TGDc-01 'PRA' with those from a Goldmann applanation tonometer (GAT). METHODS:The IOP in 176 eyes of 88 healthy volunteers was measured prospectively in a sitting position. One single measurement, generated by the TGDc-01...

journal_title：Ophthalmic research

authors： Meyer MW,Gockeln R,Hoy L,Meyer A,Erb C

更新日期：2004-09-01 00:00:00

abstract：:Equine recurrent uveitis (ERU) is an autoimmune disease that occurs with a high prevalence (10%) in horses. ERU represents the only reliable spontaneous model for human autoimmune uveitis. We already identified and characterized novel autoantigens (malate dehydrogenase, recoverin, CRALBP) by analyzing the autoantibody...

journal_title：Ophthalmic research

authors： Deeg CA,Hauck SM,Amann B,Pompetzki D,Altmann F,Raith A,Schmalzl T,Stangassinger M,Ueffing M

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:To assess the cytotoxic properties of voriconazole and sulfobutylether-β-cyclodextrin (SBECD) on cultured primary human corneal epithelial cells. METHODS:Human corneal epithelial cells were cultured and exposed to various concentrations of SBECD (0.016-32 mg/ml) and voriconazole (0.001-2 mg/ml). Cellular cy...

journal_title：Ophthalmic research

authors： Sobolewska B,Guerel G,Hofmann J,Tarek B,Bartz-Schmidt KU,Yoeruek E

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:Primary open-angle glaucoma (POAG) is a chronic progressive optic neuropathy, leading to degeneration of retinal ganglion cells and characteristic morphological changes at the optic disc. In advanced stages of the disease, functional tests, such as standard automated perimetry (SAP), are the main diagnostic too...

journal_title：Ophthalmic research

authors： Leisser C,Palkovits S,Hirnschall N,Georgiev S,Findl O

更新日期：2020-01-01 00:00:00

abstract：:Net changes in the levels of lens calcium, magnesium, sodium, potassium, and water content were determined following exposure in vitro to iodoacetate, ouabain, lanthanum, cyanide, quercetin and cold temperature. The lens calcium content rose following inhibition of lens metabolism but did not change following specific...

journal_title：Ophthalmic research

authors： Delamere NA,Paterson CA

更新日期：1982-01-01 00:00:00

abstract：:The seasonal variation in the incidence of retinal detachment over the period from 1981 to 1987 inclusive was investigated. Highly significant associations were observed between this variation and both sunshine and temperature. Hence, it is suggested that heat or cold may be important additional factors in the develop...

journal_title：Ophthalmic research

authors： Al Samarrai AR

更新日期：1990-01-01 00:00:00

abstract：:To determine the conditions under which anesthetized pigs can be used in acute noninvasive investigations of ocular hydro- and hemodynamics, the intraocular pressure (IOP) of adult pigs was recorded under the following conditions: (1) after intravenous injection of propofol plus ketamine; (2) during inhalation of isof...

journal_title：Ophthalmic research

authors： Buehner E,Pietsch UC,Bringmann A,Foja C,Wiedemann P,Uhlmann S

更新日期：2011-01-01 00:00:00

abstract：:Photodocumented measurements of the lens thickness using an EAS-1000 Scheimpflug camera were performed in 261 cataract eyes (162 pure type) compared with 52 control eyes. The lens thickness in normal eyes usually increased with age by 0.015 mm annually. The cataractous lens, especially in the anterior subcapsular type...

journal_title：Ophthalmic research

authors： Shyn KH,Kim HC,Kim JC

更新日期：1992-01-01 00:00:00

abstract：:Ibudilast selectively vasodilates cerebral vessels without reducing blood pressure. We investigated the effect of the drug on retinal circulation in 8 patients with diabetes mellitus, using the video-densitometric image analysis of fluorescein angiography. We compared the build up time, the time constant of washout ra...

journal_title：Ophthalmic research

authors： Suzuki R,Sugihara I,Ishibashi T,Kurimoto S

更新日期：1992-01-01 00:00:00

abstract：AIMS:Biomaterials are widely used in ophthalmology, and biodegradable polymers have been evaluated for use in surgery, tissue engineering and targeted drug delivery. We examined the tissue reactions attributable to 3 biodegradable polymers in the rat eye. METHODS:Inion GTR™ membrane [a blend of 85:15 poly(L-lactide-co...

journal_title：Ophthalmic research

authors： Rönkkö S,Kaarniranta K,Kalesnykas G,Uusitalo H

更新日期：2011-01-01 00:00:00

abstract：:Diabetic macular edema is a common condition frequently encountered by ophthalmologists. In this piece we briefly review its definition, pathogenesis, clinical aspects, imaging, and treatment. ...

journal_title：Ophthalmic research

authors： Moisseiev E,Loewenstein A

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Diabetic retinopathy (DR) is a severe ocular complication of diabetes. Kallistatin has multiple biological functions including anti-inflammation and antiangiogenesis. Our aim was to detect the level of kallistatin in the vitreous of proliferative DR (PDR) and its effect on proliferation, migration, and tube ...

journal_title：Ophthalmic research

authors： Xing Q,Zhang G,Kang L,Wu J,Chen H,Liu G,Zhu R,Guan H,Lu P

更新日期：2017-01-01 00:00:00

abstract：PURPOSE:In this investigation the authors studied the effect of dapiprazole, an alpha-adrenergic blocking agent, on aqueous humor dynamics in patients affected with pigmentary glaucoma. METHODS:Dapiprazole 0.5% eye drops were administered 3 times daily as adjunctive therapy to 16 pigmentary glaucoma patients in additi...

journal_title：Ophthalmic research

authors： Mastropasqua L,Carpineto P,Ciancaglini M,Lobefalo L,Costagliola C,Gallenga PE

更新日期：1996-01-01 00:00:00

abstract：INTRODUCTION:This study aimed to evaluate the longitudinal changes in retinal layers thickness in patients treated with hydroxychloroquine and no signs of retinal toxicity. METHODS:Longitudinal retrospective study of patients taking hydroxychloroquine followed in a hydroxychloroquine retinal toxicity screening program...

journal_title：Ophthalmic research

authors： Godinho G,Madeira C,Falcão M,Penas S,Dinah-Bragança T,Brandão E,Carneiro Â,Santos-Silva R,Falcão-Reis F,Beato J

更新日期：2020-09-15 00:00:00

abstract：:The polyamines putrescine, spermidine and spermine have been proposed to be a part of the acute phase inflammatory response. They have been shown to be useful markers for cellular kinetics and change with various pathological conditions. The hypothesis that aqueous humor polyamines could be used to follow the time cou...

journal_title：Ophthalmic research

authors： Wickström K,Lundgren B,Törngren L,Ostberg C

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:To compare the effects between intravitreal and periocular injections of adenoviral vectored pigment epithelium-derived factor (AdPEDF) on suppressing established choroidal neovascularization (CNV) in rats. METHODS:Sixty-eight female BN rats (136 eyes) aged 6-8 weeks were involved in this study. The CNV animal...

journal_title：Ophthalmic research

authors： Yan H,Cui J,Wang Y,Yu Y

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND/AIMS:By the release of antiangiogenic factors, Müller glial cells provide an angiostatic environment in the normal and ischemic retina. We determined whether Müller cells produce thrombospondin-1 (TSP-1), a known inhibitor of angiogenesis. METHODS:Secretion of TSP-1 by cultured Müller cells was determined w...

journal_title：Ophthalmic research

authors： Yafai Y,Eichler W,Iandiev I,Unterlauft JD,Jochmann C,Wiedemann P,Bringmann A

更新日期：2014-01-01 00:00:00

abstract：:Non-toxic concentrations of ceftazidime (CAZ), cefuzonam sodium (CZON) and cefmetazole sodium (CMZ) for intravitreal use were assessed by the electroretinogram in in vitro perfused eyecups of albino rabbits. None of the a-wave, the b-wave and the oscillatory potentials deteriorated with 300 microM CAZ, 300 microM CZON...

journal_title：Ophthalmic research

authors： Kitano K,Shirao Y,Kawasaki K

更新日期：1995-01-01 00:00:00

abstract：:The antioxidants sodium benzoate and 2,3-dihydroxybenzoic acid reduced the inflammatory response in experimental phacoanaphylactic endophthalmitis. The 2,3-dihydroxybenzoic acid was by far the more effective antiphlogistic agent. The molecular mechanisms that may have contributed to the observed difference in antiphlo...

journal_title：Ophthalmic research

authors： Marak GE Jr,Rao NA,Sevanian A,Zdravkovich V,Till GO,Ward PA

更新日期：1987-01-01 00:00:00

abstract：PURPOSE:This study was aimed at determining the intraocular pharmacokinetics based on molecular physicochemical properties in a rabbit model. METHODS:The entire dataset was obtained from previous literature, and research articles regarding 70 molecular compounds were investigated. The intravitreal half-lives in rabbit...

journal_title：Ophthalmic research

authors： Kim HM,Park KH,Chung JY,Woo SJ

更新日期：2020-01-01 00:00:00

abstract：PURPOSE:To establish a retinal blood flow database in normal human eyes using the Canon Laser Blood Flowmeter (CLBF). METHOD:Fourteen healthy subjects (7 males, 7 females) between the ages of 24 and 33 underwent birectional laser Doppler velocimetry (BLDV) in one eye using the CLBF. Measurements consisting of blood ve...

journal_title：Ophthalmic research

authors： Garcia JP Jr,Garcia PT,Rosen RB

更新日期：2002-09-01 00:00:00

abstract：:Calf water-soluble (WS) crystallins consist of high-molecular weight (HM), alpha-, beta H-, beta L-, beta s- and gamma-crystallins. alpha-Crystallin as a molecular chaperone forms a structure with a central hole, known as Carver's model. The only crystallins fitting into this central cavity are beta s- and gamma-cryst...

journal_title：Ophthalmic research

authors： Bours J

更新日期：1996-01-01 00:00:00

abstract：:Topcon Tokyo manufactured the first series of SL-45 in 1980 and a second in 1982/83, which were completed in Bonn with all technical improvements developed so far. In 1987, the SL-45B was manufactured which included all previously added improvements. To compare both camera types, we carried out a test with 10 voluntee...

journal_title：Ophthalmic research

authors： Laser H,Berndt W,Leyendecker M,Kojima M,Hockwin O,Cheyne A

更新日期：1990-01-01 00:00:00

abstract：:Epinephrine (1, 3 and 10 micrograms/kg) was found to increase retinal and choroidal blood flow (22, 49 and 67%) when it was administered intravenously. The increase in retinal and choroidal blood flow coincided well with the increase in systemic blood pressure (44, 65 and 96%, respectively). When epinephrine (2%) was ...

journal_title：Ophthalmic research

authors： Chiou GC,Girgis Z,Chiou FY

更新日期：1988-01-01 00:00:00

abstract：INTRODUCTION:Retinitis pigmentosa (RP) is an inherited retinal disorder, characterized by photoreceptor degeneration inducing progressive vision loss. This study evaluates its impact on quality of life (QOL) and emotional states of patients affected by RP. METHODS:A cross-sectional study was conducted on 60 RP patient...

journal_title：Ophthalmic research

authors： Azoulay L,Chaumet-Riffaud P,Jaron S,Roux C,Sancho S,Berdugo N,Audo I,Sahel JA,Mohand-Saïd S

更新日期：2015-01-01 00:00:00

abstract：:We studied lens opacification of rabbit lenses in culture. Opacification was produced by maintaining rabbit lenses in medium containing calcium concentrations as high as 10 mmol/l and the opacity was measured using LASER spectroscopy. Increasing calcium caused significant opacification in lens cortex while the transpa...

journal_title：Ophthalmic research

authors： Clark JI,Danford ME

更新日期：1985-01-01 00:00:00

abstract：:We examined 304 conjunctiva in 152 subjects by clinical, cytologic, and bacteriologic methods. Bacteriologic samples were evaluated after a 48-hour incubation. Bacterial growth was found in 8 (20.5%) of 39 patients with clinically normal conjunctiva and no polymorphonuclear leukocytes (PMNs), and in 8 (61.5%) of 13 su...

journal_title：Ophthalmic research

authors： Ugomori S,Hayasaka S,Setogawa T

更新日期：1991-01-01 00:00:00

abstract：PURPOSE:To investigate the effect of propolis, a natural resin produced by honeybees, in the treatment of alkali-injured rabbit eyes. METHOD:A corneal alkali burn was induced by applying filter paper immersed in 1 N NaOH on the central axis of the right corneas of 24 rabbits for 30 s. The animals were divided into thr...

journal_title：Ophthalmic research

authors： Oztürk F,Kurt E,Cerçi M,Emiroglu L,Inan U,Türker M,Ilker S

更新日期：2000-01-01 00:00:00

abstract：INTRODUCTION:Diabetic Retinopathy (DR) is one of the major vision-threatening causes worldwide. Searching for an individualized therapeutic strategy to prevent its progress is challenging. OBJECTIVE:This work aimed to investigate the association of angiogenesis-inducer vascular endothelial growth factor (VEGF) gene fa...

journal_title：Ophthalmic research

authors： Abdelghany AA,Toraih EA,Mohamed AA,Lashine RM,Saleh MH,Nafie MS,Fawzy MS

更新日期：2020-08-24 00:00:00

abstract：PURPOSE:To investigate the effect of vitreomacular adhesion (VMA) on the outcome of antiangiogenic treatment for neovascular age-related macular degeneration (AMD). METHODS:Ninety-nine eyes of 83 patients were used in our cohort study. We prospectively evaluated best corrected visual acuity (BCVA) and central retinal ...

journal_title：Ophthalmic research

authors： Kanadani TCM,Dos Reis Veloso CE,Dorairaj S,Nehemy MB

更新日期：2017-01-01 00:00:00