Abstract：
PURPOSE:To establish a retinal blood flow database in normal human eyes using the Canon Laser Blood Flowmeter (CLBF). METHOD:Fourteen healthy subjects (7 males, 7 females) between the ages of 24 and 33 underwent birectional laser Doppler velocimetry (BLDV) in one eye using the CLBF. Measurements consisting of blood vessel diameter (D) in micrometers, velocity (V) in millimeters per second, and flow (F) in microliters per minute were recorded at sites along the major retinal veins. Four to six veins were measured in each eye. Total volumetric blood flow was calculated as the sum of the venous flow rates in the major veins. RESULTS:Total retinal blood flow could be reliably determined on 5 of the subjects (1 male, 4 females). Venous blood vessel diameter ranged from 84 to 177 microm. The correlations between D and F, as well as D and V were found to be significant. Specifically, the correlation coefficient between D and F was 0.885 (p < or = 0.001), while the log-log regression coefficient was 3.35 +/- 0.23 (p < or = 0.001). The correlation coefficient between D and V was 0.694 (p < or = 0.001), while the log-log regression coefficient was 1.43 +/- 0.27 (p < or = 0.001). Total venous blood flow showed a mean of 64.9 +/- (SD) 12.8 microl/min (range: 50.9-80.6 microl/min). Venous blood flow averaged 44.1 +/- 4.5 microl/min temporally and 20.8 +/- 9.2 microl/min nasally, showing a temporal retinal blood flow approximately twice that of the nasal retina (p < 0.001). On the other hand, venous blood flow averaged 30.6 +/- 9.8 microl/min superiorly and 34.3 +/- 8.0 microl/min inferiorly. These values showed no statistical difference. CONCLUSION:The average total retinal blood flow in 5 healthy subjects using the CLBF was 64.9 +/- 12.8 microl/min. Venous blood flow at the temporal retina was about twice that of the nasal retina, whereas flow at the superior and inferior retina showed no statistical difference. Our findings are comparable with studies done using a different BLDV system.
journal_name
Ophthalmic Resjournal_title
Ophthalmic researchauthors
Garcia JP Jr,Garcia PT,Rosen RBdoi
10.1159/000065600subject
Has Abstractpub_date
2002-09-01 00:00:00pages
295-9issue
5eissn
0030-3747issn
1423-0259pii
65600journal_volume
34pub_type
杂志文章abstract：:The aqueous humors of 100 freshly enucleated rabbit eyes were assessed within 10 min postmortem by taking samples in the last stage of corneal dissection following the Dikstein-Maurice procedure. Aqueous levels of partial pressure of carbon dioxide (pCO2) averaged 58.2 +/- 8.5 mm Hg to give calculated tCO2 and bicarbo...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000267269
更新日期：1993-01-01 00:00:00
abstract：:The binding of fluorescein and 6-carboxyfluorescein by normal, diabetic and in vitro glycosylated human serum proteins was analyzed by absorption and fluorescence spectroscopy, gel filtration and equilibrium dialysis. The absorption spectra of bound fluorochromes showed red shifts and hypochromic changes, and fluoroch...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000265219
更新日期：1982-01-01 00:00:00
abstract：:The refractive indices in various rat retinal layers, based on the total dry mass concentration, ranged from 1.369 to 1.385. The ratios of the refractive indices of neighboring retinal layers were near unity. This finding suggests that light passes through the rat retina without much refraction. ...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000267223
更新日期：1993-01-01 00:00:00
abstract：:Exposure of mice to hyperbaric oxygen leads to an inhibition of the mitotic activity in the germinative epithelium of the lens. This is followed by an eventual development of cataracts. Cataracts have also been observed in human beings treated with hyperbaric oxygen for different afflictions. The lens damage and catar...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000266579
更新日期：1988-01-01 00:00:00
abstract：PURPOSE:To study the ability to appreciate qualitative features that indicate disease activity in patients with neovascular age-related macular degeneration (AMD) and to analyze the differences in automated retinal thickness measurement, using 1 time domain optical coherence tomography (TD-OCT) and 2 different spectral...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000325027
更新日期：2011-01-01 00:00:00
abstract：:In a search for a pharmacologic adjuvant in the management of posttraumatic proliferative vitreoretinopathy (PVR), we investigated the effect of intravitreal injection of prinomastat (AG3340) on an experimental model. Posterior penetrating eye trauma was created in one eye each of 24 New Zealand white rabbits. One wee...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000055636
更新日期：2001-01-01 00:00:00
abstract：:We examined 304 conjunctiva in 152 subjects by clinical, cytologic, and bacteriologic methods. Bacteriologic samples were evaluated after a 48-hour incubation. Bacterial growth was found in 8 (20.5%) of 39 patients with clinically normal conjunctiva and no polymorphonuclear leukocytes (PMNs), and in 8 (61.5%) of 13 su...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000267086
更新日期：1991-01-01 00:00:00
abstract：PURPOSE:To determine the effect of placing a pneumatic suction ring on intraocular pressure (IOP) in the cat and to design an improved method to generate a stable elevation of IOP. METHODS:A pneumatic suction ring was applied to the eye in cats while the IOP was monitored. Three groups of animals (10 per group) were u...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000055680
更新日期：2001-09-01 00:00:00
abstract：PURPOSE:The purpose of this study was to evaluate the anatomical and functional findings in patients with vitreomacular traction (VMT) combined with epiretinal membrane (ERM) in the same eye. METHODS:In this retrospective, cross-sectional study, we studied 65 patients with VMT and ERM. In 36 of them, ERM/VMT had a 'un...
journal_title：Ophthalmic research
pub_type： 杂志文章,多中心研究
doi：10.1159/000446658
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:The lens is the ocular structure most susceptible to oxidative damage. Antioxidants, micronutrients and phytochemicals have been extensively studied for their possible effects to prevent or delay the progression of various eye diseases. OBJECTIVES:A brief overview of the updated literature on the role of an...
journal_title：Ophthalmic research
pub_type： 杂志文章,评审
doi：10.1159/000316477
更新日期：2010-01-01 00:00:00
abstract：:The possible multiple effect of galactose diet and X-irradiation on cataract development in mice was investigated by scanning electron microscopy. X-ray cataracts were induced by maintaining animals either on a normal or 50% galactose diet. No detectable changes in lens morphology were seen in animals fed galactose al...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000265280
更新日期：1983-01-01 00:00:00
abstract：BACKGROUND:The aim of this work was to evaluate the narrow anterior chamber angle (ACA) in Chinese patients by anterior segment optical coherence tomography (As-OCT). METHODS:Eighty right eyes of 80 consecutive patients with a shallow peripheral anterior chamber but no peripheral anterior synechia were enrolled in thi...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000448523
更新日期：2017-01-01 00:00:00
abstract：:A method for microscopical observation and quantification of corneal neovascularization in the living mouse is described. Measurements of the corneal vasculature were made on still-mode video-pictures of the cornea. The validity of the method was shown by the high correlation between the morphometric measurements and ...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000267097
更新日期：1991-01-01 00:00:00
abstract：:The specific activities of the four investigated enzymes of the carbohydrate metabolism decrease with ageing. In the old tissue, phosphoglyceratemutase and enolase sustain changes in their molecular weight, and their substrate affinity is modified. ...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000265275
更新日期：1983-01-01 00:00:00
abstract：PURPOSE:To propose a new noncontact tonometer based on corneal photoelasticity. METHOD:In this study, we experimented with 18 enucleated porcine eyes. The anterior chamber was infused with a physiological solution. A circular polarizing filter was attached to an ophthalmic surgical microscope. Color fringe changes at ...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000320600
更新日期：2011-01-01 00:00:00
abstract：PURPOSE:This study was performed to examine the location, width, and insertional shape of rectus extraocular muscles (EOMs), and to elucidate the symmetry of the insertional anatomy of rectus EOMs in the left and right eyes. METHODS:EOMs were dissected from their origin to the insertion point in 100 intact orbits of 5...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000272021
更新日期：2010-01-01 00:00:00
abstract：:Metabolic changes in the rabbit lens have been studied by means of nuclear magnetic resonance spectroscopy. These changes have been induced by prolonged topical treatment with dexamethasone. Our results demonstrate an increase in sorbitol, sorbitol-3-phosphate, fructose-3-phosphate, glycerol-3-phosphate and glucose-6-...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000055646
更新日期：2001-03-01 00:00:00
abstract：:The influence of nonselective and selective alpha-adrenergic agonists on intraocular pressure (IOP) was studied in isolated arterially perfused rabbit eyes. Drugs were given intra-arterially or topically. With either route of administration, no initial hypertensive phase was observed after l-epinephrine, l-norepinephr...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000265400
更新日期：1985-01-01 00:00:00
abstract：:Cellular events in the rat conjunctiva were studied at 1, 6 and 24 h following the topical application of leukotriene B4. A significant increase was noted in the number of eosinophils (p less than 0.01) and neutrophils (p less than 0.05) at 1 h and only in eosinophils at 6 h after leukotriene B4 application at the 2-m...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000266873
更新日期：1989-01-01 00:00:00
abstract：:Energy-dispersive X-ray analysis was used to obtain distribution profiles of Na, K, Cl, P and S in rapidly frozen-dried bulk specimens, and in cryosections of the normal rat lens. Na and Cl are highly concentrated in the capsule, and K and P, in the epithelial cells. Profiles of the entire radius of a lens show relati...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000265328
更新日期：1984-01-01 00:00:00
abstract：:Modulation sensitivity functions ( MSFs ) of retinal ganglion cells of the pigeon were determined by recording action potentials from their end branching in the optic tectum as response indicator. The inverse Fourier transformation of a MSF is taken to represent the receptive field sensitivity function approximating t...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000265299
更新日期：1984-01-01 00:00:00
abstract：:We measured prostaglandin E2 (PGE2) and prostacyclin levels in the vitreous bodies of 5 eyes of patients with diabetic retinopathy complicated by rhegmatogenous retinal detachment (RRD) and compared them with the corresponding levels in 9 nondiabetic eyes with the same condition as well as with 10 control eyes of dece...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000266995
更新日期：1990-01-01 00:00:00
abstract：PURPOSE:To determine whether docosahexaenoic acid (DHA) can reduce the retinal damage induced by transient retinal ischemia. METHODS:Retinal ischemia was induced by increasing intraocular pressure (IOP). Retinal circulation was restored by lowering IOP. An intraperitoneal injection of 1,000 mg/kg of DHA-ester (DHA-E) ...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000055669
更新日期：2001-07-01 00:00:00
abstract：:The high cytotoxicity of linoleic acid (LA) to cultured bovine lens epithelial cells is correlated with high uptake rates for the fatty acid (FA). Both, LA uptake and LA cytotoxicity strongly increase with the increasing LA-to-albumin molar ratio in the culture medium. Cellular uptake and cytotoxicity of LA can be com...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000055595
更新日期：2000-03-01 00:00:00
abstract：:The tear levels of cholesterol of 17 patients with chronic blepharitis and 17 healthy subjects were determined by the photometric method. The mean cholesterol level of the patients was determined to be 56.1 +/- 8.9 (SEM) mg/dl. No statistically significant difference between the tear cholesterol levels of the two grou...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000267034
更新日期：1990-01-01 00:00:00
abstract：:The antioxidants sodium benzoate and 2,3-dihydroxybenzoic acid reduced the inflammatory response in experimental phacoanaphylactic endophthalmitis. The 2,3-dihydroxybenzoic acid was by far the more effective antiphlogistic agent. The molecular mechanisms that may have contributed to the observed difference in antiphlo...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000265483
更新日期：1987-01-01 00:00:00
abstract：AIM:To develop a local approach to study rabbit lacrimal secretion in situ by administering specific secretagogues directly onto the lacrimal gland (LG). METHODS:After the rabbit has been anesthetized, the inferior bulbar conjunctiva and underlying connective tissue are blunt dissected. A polyethylene tube, for drug d...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000111159
更新日期：2008-01-01 00:00:00
abstract：:Vitamin E (d-alpha-tocopherol) and aspirin were evaluated for their effects on the phase separation temperature, Tc, of calf lens cytoplasm. Vitamin E and aspirin were added to nuclear homogenate and the change in Tc was measured. Aspirin had no measurable effect on Tc. Vitamin E lowered Tc at a rate of -22 degrees C ...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000265475
更新日期：1987-01-01 00:00:00
abstract：:In order to know the correlation of a drug with high affinity to melanin in the iris ciliary body with the amount of melanin contained in the iris ciliary tissues, an in vivo study was performed on pigmented rabbits with brown or blue irises and albino rabbits. The melanin concentrations in the iris ciliary bodies of ...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000267404
更新日期：1994-01-01 00:00:00
abstract：:Catalase activity was evaluated in Long Evans rat retina after ischemia and reperfusion. Ischemia was induced by ligation of the optic nerve and vessels. Rats were sacrificed after 15 and 120 min of reperfusion, respectively. Catalase activity was assessed by Claiborne's method and was expressed as U/mg of protein. In...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000267924
更新日期：1996-01-01 00:00:00
