Abstract:
:Metabolic changes in the rabbit lens have been studied by means of nuclear magnetic resonance spectroscopy. These changes have been induced by prolonged topical treatment with dexamethasone. Our results demonstrate an increase in sorbitol, sorbitol-3-phosphate, fructose-3-phosphate, glycerol-3-phosphate and glucose-6-phosphate levels and a decrease in glutathione sulphate (GSH) and myo-inositol levels, in agreement with what was observed in lenses from streptozocin-diabetic rats before lens opacity. The hyperglycaemia can only partially explain all these observed biochemical variations. The lack of increase in the intermediates of pentose cycle, such as sedoheptulose-7-phosphate, seems to support the hypothesis of an inhibition of glucose-6-phosphate dehydrogenase by dexamethasone treatment. Finally dexamethasone treatment induces a decrease in GSH. The decreasing or the loss of GSH has been suggested as a possible pathogenic mechanism in the cataract formation.
journal_name
Ophthalmic Resjournal_title
Ophthalmic researchauthors
Pescosolido N,Miccheli A,Manetti C,Iannetti GD,Feher J,Cavallotti Cdoi
10.1159/000055646subject
Has Abstractpub_date
2001-03-01 00:00:00pages
68-74issue
2eissn
0030-3747issn
1423-0259pii
55646journal_volume
33pub_type
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更新日期:1985-01-01 00:00:00
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更新日期:2005-09-01 00:00:00
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更新日期:1990-01-01 00:00:00
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