Abstract:
:The activities of sialyl-, fucosyl- and galactosyltransferase were measured in membrane preparations from bovine eyes. Radioactive sugars from CMP-N-neuraminic acid, GDP-fucose and UDP-galactose were incorporated into the endogenous and exogenous acceptors. The enzymatic activities of all three glycosyltransferases were found to be high in the neural retina and retinal pigment epithelium, moderate in the cornea and uvea, and low in the lens and sclera, except for a high galactosyltransferase activity in the cornea.
journal_name
Ophthalmic Resjournal_title
Ophthalmic researchauthors
Unoki K,Uehara F,Muramatsu Tdoi
10.1159/000267045subject
Has Abstractpub_date
1990-01-01 00:00:00pages
342-50issue
6eissn
0030-3747issn
1423-0259journal_volume
22pub_type
杂志文章abstract::Low intensity diffuse white fluorescent light (1,000 lx for 2 h) exclusively induced photoreceptor damage in the inferior retina of albino rats; the temporal retina showed extensive damage, whereas the nasal retina revealed threshold lesions prior to recovery. To expand our morphological data, further experiments were...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267881
更新日期:1996-01-01 00:00:00
abstract::Metabolic changes in the rabbit lens have been studied by means of nuclear magnetic resonance spectroscopy. These changes have been induced by prolonged topical treatment with dexamethasone. Our results demonstrate an increase in sorbitol, sorbitol-3-phosphate, fructose-3-phosphate, glycerol-3-phosphate and glucose-6-...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000055646
更新日期:2001-03-01 00:00:00
abstract:PURPOSE:The aim of this study was to investigate the effects of quercetin on vascular endothelial growth factor (VEGF)-induced choroidal and retinal angiogenesis in vitro using a rhesus macaque choroid-retinal endothelial (RF/6A) cell line. METHODS:RF/6A cells were cultured in Dulbecco's modified Eagle's medium contai...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000369824
更新日期:2015-01-01 00:00:00
abstract::Epinephrine (1, 3 and 10 micrograms/kg) was found to increase retinal and choroidal blood flow (22, 49 and 67%) when it was administered intravenously. The increase in retinal and choroidal blood flow coincided well with the increase in systemic blood pressure (44, 65 and 96%, respectively). When epinephrine (2%) was ...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000266728
更新日期:1988-01-01 00:00:00
abstract::Cannabinoid receptor involvement in the intraocular-pressure (IOP)-lowering effect of the cannabinoids has not been determined. These receptors bind four structural classes of agonists: the classical and the nonclassical cannabinoids, the aminoalkylindoles and the arachidonylethanolamides (the endogenous ligands). We ...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267984
更新日期:1997-01-01 00:00:00
abstract::This study developed a modified monolayer culture technique for expansion of retinal progenitor cells in vitro. Using this method, spheres collected by low centrifugation from free floating cultures were re-seeded onto poly-D-lysine pre-coated flasks, and cultured in the retinal progenitor cells medium (including fibr...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000134927
更新日期:2008-10-01 00:00:00
abstract::Lipid peroxidation was induced with porcine retinal homogenates using ferric iron or UV light. A number of lipid and aqueous-soluble antioxidants were tested and their protective effects measured after 60 min of exposure. The iron system produced up to 5 times more lipid hydroperoxides as quantified by the fluorescenc...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267103
更新日期:1991-01-01 00:00:00
abstract::We measured prostaglandin E2 (PGE2) and prostacyclin levels in the vitreous bodies of 5 eyes of patients with diabetic retinopathy complicated by rhegmatogenous retinal detachment (RRD) and compared them with the corresponding levels in 9 nondiabetic eyes with the same condition as well as with 10 control eyes of dece...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000266995
更新日期:1990-01-01 00:00:00
abstract::The antioxidants sodium benzoate and 2,3-dihydroxybenzoic acid reduced the inflammatory response in experimental phacoanaphylactic endophthalmitis. The 2,3-dihydroxybenzoic acid was by far the more effective antiphlogistic agent. The molecular mechanisms that may have contributed to the observed difference in antiphlo...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265483
更新日期:1987-01-01 00:00:00
abstract::Ocular pneumoplethysmography was performed before and after 1,737 carotid endarterectomies, 82% of which were performed for carotid lesions of hemodynamic consequence. Preoperative ocular hypoperfusion without ischemia was associated with at least transient postoperative ocular hyperemia. A difference in ocular volume...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000055558
更新日期:1999-01-01 00:00:00
abstract:PURPOSE:Retinal gene therapy trials are currently ongoing in a small number of inherited retinal disorders and this number is expected to rise significantly. The aim of this study was to analyze the psychological aspects of patients with RPE65 deficiency awaiting potential enrollment in gene therapy trials. METHODS:Fi...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000435887
更新日期:2015-01-01 00:00:00
abstract:AIMS:Staphylococcus epidermidis is considered a commensal bacterium; however, it is frequently isolated from ocular infections showing a multidrug resistance. Ciprofloxacin-resistant strains have been isolated from ocular infections; however, resistance to quinolone, such as gatifloxacin and moxifloxacin, is not often ...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000219684
更新日期:2009-01-01 00:00:00
abstract::Equine recurrent uveitis (ERU) is an autoimmune disease that occurs with a high prevalence (10%) in horses. ERU represents the only reliable spontaneous model for human autoimmune uveitis. We already identified and characterized novel autoantigens (malate dehydrogenase, recoverin, CRALBP) by analyzing the autoantibody...
journal_title:Ophthalmic research
pub_type: 杂志文章,评审
doi:10.1159/000119867
更新日期:2008-01-01 00:00:00
abstract::Dragomirescu et al. [1983] described a 2-chamber flow system for the incubation of lenses with an inserted photometer to measure changes in lens transparency. Mester et al. [1984] applied the method to simulate conditions occurring during vitrectomy, which occasionally leads to reversible lens opacification. Using Sch...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265357
更新日期:1985-01-01 00:00:00
abstract:INTRODUCTION:Diabetic Retinopathy (DR) is one of the major vision-threatening causes worldwide. Searching for an individualized therapeutic strategy to prevent its progress is challenging. OBJECTIVE:This work aimed to investigate the association of angiogenesis-inducer vascular endothelial growth factor (VEGF) gene fa...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000511087
更新日期:2020-08-24 00:00:00
abstract::Cataract is the leading cause of blindness worldwide. It is a multifactorial disease primarily associated with oxidative stress produced by free radicals. The protection offered by various antioxidants in cataract development is well established. Polyphenolic compounds present in green tea (Camellia sinensis) are repo...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000063881
更新日期:2002-07-01 00:00:00
abstract:OBJECTIVE:In this study, we used a rat model of retinal detachment (RD) to investigate the effects of transient receptor potential mucolipin 1 (TRPML1) on photoreceptor cells and the underlying mechanism. METHODS:An RD model was established by subretinal injection of sodium hyaluronate, and mucolipin synthetic agonist...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000512104
更新日期:2020-10-07 00:00:00
abstract:PURPOSE:To examine melanocortin receptor (from MC-1 to MC-5) mRNA and the effect of alpha-melanocyte-stimulating hormone (alpha-MSH) on interleukin 8 (IL-8) and monocyte chemotactic protein 1 (MCP-1) expression in a human retinal pigment epithelial cell line (ARPE-19) stimulated with IL-1beta or tumor necrosis factor a...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000087699
更新日期:2005-09-01 00:00:00
abstract:AIMS:To investigate whether allogeneic limbal mesenchymal stem cell (LMSC) therapy affects corneal healing after a severe chemical burn and whether the route of administration of LMSCs differs in its therapeutic effect in this respect. METHODS:A total of 60 Sprague-Dawley rats with clinically proven alkali injury were...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000368659
更新日期:2015-01-01 00:00:00
abstract::Age-related lens opacity is the major cause of loss of vision affecting more than half of the world's blind. The development of cataract is associated with changes in the structure of the lens. The lens consists largely of closely packed fibre cells forming a transparent syncytium. The main intrinsic polypeptide (MIP)...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267974
更新日期:1996-01-01 00:00:00
abstract:PURPOSE:To compare the effects between intravitreal and periocular injections of adenoviral vectored pigment epithelium-derived factor (AdPEDF) on suppressing established choroidal neovascularization (CNV) in rats. METHODS:Sixty-eight female BN rats (136 eyes) aged 6-8 weeks were involved in this study. The CNV animal...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000342979
更新日期:2013-01-01 00:00:00
abstract:PURPOSE:Osthole is an agent isolated from Cnidium monnieri (L.) Cusson and has been used to treat several disorders. Corneal neovascularization is a sight-threatening condition associated with several inflammatory or infectious ocular disorders. In this study, we investigated the anti-angiogenic effects of osthole on c...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000505976
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Myopia has become a worldwide public health issue, which is occurring at a younger age, leading to an increased risk of high myopia. Ocular complications associated with high myopia can lead to irreversible vision loss. It is urgent and critical to explore effective treatment to slow or even stop the progres...
journal_title:Ophthalmic research
pub_type: meta分析
doi:10.1159/000510779
更新日期:2020-08-11 00:00:00
abstract::Diabetic macular edema is a common condition frequently encountered by ophthalmologists. In this piece we briefly review its definition, pathogenesis, clinical aspects, imaging, and treatment. ...
journal_title:Ophthalmic research
pub_type: 杂志文章,评审
doi:10.1159/000458535
更新日期:2017-01-01 00:00:00
abstract::Soluble dextran polymer derivatives (CMDBSs) are originally synthesized as heparin-like plasma substitutes. Some of them mimic heparin in its interactions and stabilize, protect and facilitate actions of heparin binding growth factors. The wound healing activity of one specific CMDBS was studied in a model of corneal ...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267497
更新日期:1994-01-01 00:00:00
abstract::To determine the conditions under which anesthetized pigs can be used in acute noninvasive investigations of ocular hydro- and hemodynamics, the intraocular pressure (IOP) of adult pigs was recorded under the following conditions: (1) after intravenous injection of propofol plus ketamine; (2) during inhalation of isof...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000317060
更新日期:2011-01-01 00:00:00
abstract:PURPOSE:To investigate the possible roles of various cytokines or growth factors in the pathogenesis of exudative age-related macular degeneration (AMD) by comparing aqueous humor levels of 14 cytokines between eyes with polypoidal choroidal vasculopathy (PCV) and those with neovascular AMD. METHODS:Forty eyes from 40...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000365487
更新日期:2015-01-01 00:00:00
abstract::The crystalline lens capsules of eye bank eyes, intraocular lens (IOL)-inserted eyes and those of monkey and rabbit eyes were observed in vivo and/or in vitro through a specular microscope or Scheimpflug slit images in combination with new image-processing techniques and scanning electron microscopy. Shagreen patterns...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000266575
更新日期:1988-01-01 00:00:00
abstract:PURPOSE:This study was performed to examine the location, width, and insertional shape of rectus extraocular muscles (EOMs), and to elucidate the symmetry of the insertional anatomy of rectus EOMs in the left and right eyes. METHODS:EOMs were dissected from their origin to the insertion point in 100 intact orbits of 5...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000272021
更新日期:2010-01-01 00:00:00
abstract::This study examined and characterized the distribution and kinetics of the inflammatory cell response to pseudomonas ocular challenge in susceptible C57BL/6J and resistant DBA/2J mice. Initially, in the cornea, the number of neutrophilic leukocytes (PMNs), macrophages/monocytes or lymphocytes was 2-2.5 times greater i...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267142
更新日期:1992-01-01 00:00:00