Abstract:
:We studied lens opacification of rabbit lenses in culture. Opacification was produced by maintaining rabbit lenses in medium containing calcium concentrations as high as 10 mmol/l and the opacity was measured using LASER spectroscopy. Increasing calcium caused significant opacification in lens cortex while the transparency in lens nucleus was unchanged by these concentrations. The cortical opacity was inhibited by low temperature and acrylamide. The maximum inhibition of opacity occurred at a concentration of 1% acrylamide and a temperature of 4 degrees C. The opacification due to a phase separation in nuclear cells was unaffected by these concentrations of calcium.
journal_name
Ophthalmic Resjournal_title
Ophthalmic researchauthors
Clark JI,Danford MEdoi
10.1159/000265380subject
Has Abstractpub_date
1985-01-01 00:00:00pages
246-50issue
4eissn
0030-3747issn
1423-0259journal_volume
17pub_type
杂志文章abstract:PURPOSE:To describe the characteristics of macular lesions after eye trauma using spectral-domain optical coherence tomography (OCT). METHODS:We retrospectively reviewed and described 2-dimensional (2D) and 3-dimensional (3D) spectral-domain OCT characteristics of 24 consecutive eyes of 24 cases that were identified w...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000325732
更新日期:2012-01-01 00:00:00
abstract:PURPOSE:The purpose of our study was to investigate the profiles of inflammatory cytokines and the macrophage polarization gene in a choroidal neovascularization (CNV) mouse model before and after intravitreal aflibercept treatment. METHODS:The CNV mouse model was conducted by laser photocoagulation. A total of 58 cyt...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000513588
更新日期:2020-12-04 00:00:00
abstract::The turnover and migration of synthesized glycoproteins in the cultured retinal pigment epithelium have been studied. Quantitative study indicated that half-time of 3H-fucosylglycoproteins was 11.6 days. Autoradiography was performed several times after incubation of 3H-fucose. Retinal pigment epithelium constantly sy...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265423
更新日期:1986-01-01 00:00:00
abstract::The high-voltage electron microscope (HVEM) permits examination of sections much thicker (up to 1 micron) than those usually used in transmission electron microscopy, which are approximately 70 nm in thickness. Two examples of the utility of the HVEM in research on the ultrastructure of the retinal pigment epithelium ...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265457
更新日期:1986-01-01 00:00:00
abstract:PURPOSE:To investigate therapeutic ocular surface medium (TOSM), a potential physiological tear replacement therapy, for persistent epithelial defect (PED). METHODS:11 eyes of 10 patients with PED for ≥ 2 weeks without improvement despite conventional treatment were enrolled in a prospective pilot study of TOSM over 1...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000355065
更新日期:2014-01-01 00:00:00
abstract::The rate of reepithelialization of the rabbit cornea, receiving isotonic NaCl solution and acetylcysteine (Mucomyst) solution at 10 and 20% concentrations, following a superficial epithelial ulcer was studied by fluorescein staining, photography and light microscopy. Acetylcysteine solution does not seem to retard nor...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265198
更新日期:1982-01-01 00:00:00
abstract::The ultrastructure of optic nerve axons was examined in several mammals (human, cat, rat, sheep, ox, pig, guinea pig, rabbit). Human material was obtained from normotensive, glaucoma-free eyes and from eyes with a history of glaucoma and raised intra-ocular pressure (IOP). We describe accumulations of organelles (prin...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267739
更新日期:1995-01-01 00:00:00
abstract::Results of a comparative study of accommodative capability of eyes in individuals exposed to various doses of ionizing radiation and in a control group are presented. The mean values for ranges of accommodation in the control group were consonant with previous data. However, the range of accommodation was found to be ...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000063879
更新日期:2002-07-01 00:00:00
abstract::The refractive indices in various rat retinal layers, based on the total dry mass concentration, ranged from 1.369 to 1.385. The ratios of the refractive indices of neighboring retinal layers were near unity. This finding suggests that light passes through the rat retina without much refraction. ...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267223
更新日期:1993-01-01 00:00:00
abstract::The polyamines putrescine, spermidine and spermine have been proposed to be a part of the acute phase inflammatory response. They have been shown to be useful markers for cellular kinetics and change with various pathological conditions. The hypothesis that aqueous humor polyamines could be used to follow the time cou...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267165
更新日期:1992-01-01 00:00:00
abstract::The purpose of this study was to compare the variability of the amplitude ratios and latencies of the electro-oculogram (EOG) light peak (LP) in three different recording conditions: Arden ratio (dark trough (DT): 12 min), modified Arden ratio (DT: 15 min) and light peak/dark baseline ratio (LP/BL: 35 min of dark adap...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267320
更新日期:1993-01-01 00:00:00
abstract:OBJECTIVE:Acute corneal permeability change after instillation of benzalkonium chloride (BAC) was evaluated using a newly developed in vivo corneal transepithelial electric resistance (TER) measurement method. METHOD:Corneal TER was measured by Ag/AgCl electrodes placed in the anterior aqueous chamber and on the corne...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000109986
更新日期:2007-01-01 00:00:00
abstract::During the process of terminal differentiation, the fibre cells in the eye lens undergo many changes that are reminiscent of apoptotic/necrotic changes. Mitochondria, for instance, undergo permeability transition and nuclear degradation is accompanied by chromatin condensation, disintegration of the nucleolus, dissolu...
journal_title:Ophthalmic research
pub_type: 杂志文章,评审
doi:10.1159/000055530
更新日期:1999-01-01 00:00:00
abstract::The development and extension of fibrovascular or fibroglial membranes onto the retinal surface are a major cause of visual loss in diabetic patients with proliferative retinopathy and in patients suffering from retinal detachment with proliferative vitreoretinopathy. The pathogenesis of these proliferative diseases, ...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267115
更新日期:1991-01-01 00:00:00
abstract::Cannabinoid receptor involvement in the intraocular-pressure (IOP)-lowering effect of the cannabinoids has not been determined. These receptors bind four structural classes of agonists: the classical and the nonclassical cannabinoids, the aminoalkylindoles and the arachidonylethanolamides (the endogenous ligands). We ...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267984
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND/AIM:Corneal epithelial defects may heal slowly in patients with diabetes, limbal stem cell deficiency, extensive chemical burns or anesthetized corneas. Studies have shown that erythropoietin, a glycoprotein hormone that promotes red blood cell proliferation and inhibits apoptosis of erythroid progenitors, m...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000351627
更新日期:2013-01-01 00:00:00
abstract::Dry eye is the most prominent pathology among those involving the ocular surface: a decrease of the aqueous (less frequent) or the lipid (more frequent) component of the tear film is the cause of the diminished stability of tears that is observed in this pathology. Dry eye shows a clear distribution linked to both sex...
journal_title:Ophthalmic research
pub_type: 杂志文章,评审
doi:10.1159/000489093
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Genipin (GP) is a safe method for corneal crosslinking, even for very thin corneas. However, there have been no reports on the optimal GP concentration range to use in vivo for corneal crosslinking. OBJECTIVES:To investigate the safety of corneal crosslinking after a 24-h incubation with different concentra...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000499571
更新日期:2019-01-01 00:00:00
abstract::Tear hyperosmolarity is known to cause ocular surface inflammation in dry eye syndrome. Benzalkonium chloride (BAK), an eyedrop preservative, is known to induce dry eye in long-term-treated patients. Analyzing the modulation of the proinflammatory potential of hyperosmolarity in the presence of BAK on the conjunctiva ...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000448117
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:To determine the effect of placing a pneumatic suction ring on intraocular pressure (IOP) in the cat and to design an improved method to generate a stable elevation of IOP. METHODS:A pneumatic suction ring was applied to the eye in cats while the IOP was monitored. Three groups of animals (10 per group) were u...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000055680
更新日期:2001-09-01 00:00:00
abstract:AIMS:Experimental retinal research has gained great importance due to the ophthalmic pharmacotherapy era. An increasing number of drugs are constantly released into the market for the treatment of retinal diseases. In this review, animal species, animal models and toxicity assays in retinal research are discussed. MET...
journal_title:Ophthalmic research
pub_type: 杂志文章,评审
doi:10.1159/000312817
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Mesopic conditions elicit both rod and cone responses, and they are more commonly encountered in daily life than are scotopic conditions; yet visual function outcome measures of mesopic visual acuity (VA) or contrast sensitivity (CS) are rarely evaluated. OBJECTIVE:In retinitis pigmentosa (RP), we explored ...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000503931
更新日期:2020-01-01 00:00:00
abstract:PURPOSE:To evaluate the role of initial visual acuity (VA) as a potential prognostic factor for final VA in patients with branch retinal vein occlusion (BRVO). METHODS:A retrospective data analysis involving 163 patients with macular edema secondary to BRVO treated according to the recommendations of the Branch Vein O...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000321701
更新日期:2011-01-01 00:00:00
abstract::Cataractous lens images taken with different camera types for retroillumination photography were compared. Images taken by conventional photo slitlamp and fundus cameras were not suitable for image analysis. Retroillumination photography with a conventional fundus camera with additional polarizing filters seemed to be...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267063
更新日期:1990-01-01 00:00:00
abstract::The effects of optical defocusing with convex lenses on the amplitudes of pattern reversal visual-evoked response (PVER) were investigated. With the large check size and high-contrast pattern, PVER amplitudes showed a linear decrease in response to initial defocusing up to +5 to +6 dptr. As the degree of defocus incre...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267051
更新日期:1990-01-01 00:00:00
abstract::The seasonal variation in the incidence of retinal detachment over the period from 1981 to 1987 inclusive was investigated. Highly significant associations were observed between this variation and both sunshine and temperature. Hence, it is suggested that heat or cold may be important additional factors in the develop...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267026
更新日期:1990-01-01 00:00:00
abstract::Ocular pneumoplethysmography was performed before and after 1,737 carotid endarterectomies, 82% of which were performed for carotid lesions of hemodynamic consequence. Preoperative ocular hypoperfusion without ischemia was associated with at least transient postoperative ocular hyperemia. A difference in ocular volume...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000055558
更新日期:1999-01-01 00:00:00
abstract::Lipid peroxidation was induced with porcine retinal homogenates using ferric iron or UV light. A number of lipid and aqueous-soluble antioxidants were tested and their protective effects measured after 60 min of exposure. The iron system produced up to 5 times more lipid hydroperoxides as quantified by the fluorescenc...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267103
更新日期:1991-01-01 00:00:00
abstract::Indirect measurement in vivo of nuclear color of 64 cataractous eyes was made using a method of image analysis of photographed lenses developed by the authors. The grade of yellow of lens color was characterized by its dominant wavelength and excitation purity in the CIE chromaticity diagram. The differences were smal...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265345
更新日期:1985-01-01 00:00:00
abstract:PURPOSE:To analyze a multiflash multifocal electroretinogram in 20 patients with open-angle glaucoma (OAG). METHODS:The stimulation sequence consisted of a binary m-sequence (L(max) 200 cd/m(2), L(min) <1 cd/m(2)). Each m-sequence stimulus was followed by three global flashes (luminance: 400 cd/m(2)) at an interval of...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000048333
更新日期:2002-03-01 00:00:00