Effect of erythropoietin on healing of corneal epithelial defects in rabbits.

abstract：:The use of corneal tissue for ex vivo therapeutic evaluations is limited due to its rapid loss of viability after excision. Optimization of storage conditions may allow prolonged retention of physical tissue properties. In this study, we evaluated how storage in optimized organ culture (OC) medium at 37°C or phosphate...

journal_title：Ophthalmic research

authors： Thakur SS,Shrestha D,Rupenthal ID

更新日期：2019-01-01 00:00:00

abstract：PURPOSE:To investigate therapeutic ocular surface medium (TOSM), a potential physiological tear replacement therapy, for persistent epithelial defect (PED). METHODS:11 eyes of 10 patients with PED for ≥ 2 weeks without improvement despite conventional treatment were enrolled in a prospective pilot study of TOSM over 1...

journal_title：Ophthalmic research

authors： Watson SL,Geerling G,Dart JK

更新日期：2014-01-01 00:00:00

abstract：PURPOSE:The purpose of our study was to investigate the profiles of inflammatory cytokines and the macrophage polarization gene in a choroidal neovascularization (CNV) mouse model before and after intravitreal aflibercept treatment. METHODS:The CNV mouse model was conducted by laser photocoagulation. A total of 58 cyt...

journal_title：Ophthalmic research

authors： Wang C,Zhang R,Zhang Q,Jin H,Wei C,Wu C,Mei L,Liu Y,Zhang P

更新日期：2020-12-04 00:00:00

abstract：:In order to develop a more adequate ultraviolet (UV)-induced cataract model, a combination of l-buthionine sulfoximine (BSO) treatment was applied to experimental animals. A single administration of BSO 4 mmol/kg caused reduced glutathione concentration until experimental day 8. In the 0.067-J/cm2 UV-B irradiation exp...

journal_title：Ophthalmic research

authors： Hatano T,Kojima M

更新日期：1996-01-01 00:00:00

abstract：PURPOSE:To investigate the antiangiogenic effect of itraconazole for the prevention of experimentally induced corneal neovascularization and whether the efficacy depends on the route of administration. MATERIALS AND METHODS:Thirty-six rats were randomly divided into 6 groups with 6 rats in each group. Chemical cauteri...

journal_title：Ophthalmic research

authors： Goktas S,Sakarya R,Erdogan E,Sakarya Y,Ozcimen M,Dursunoglu D,Kocacan M,Alpfidan I,Erdogan E,Bukus A,Ivacık IS

更新日期：2014-01-01 00:00:00

abstract：PURPOSE:This study was aimed at determining the intraocular pharmacokinetics based on molecular physicochemical properties in a rabbit model. METHODS:The entire dataset was obtained from previous literature, and research articles regarding 70 molecular compounds were investigated. The intravitreal half-lives in rabbit...

journal_title：Ophthalmic research

authors： Kim HM,Park KH,Chung JY,Woo SJ

更新日期：2020-01-01 00:00:00

abstract：AIMS:Experimental retinal research has gained great importance due to the ophthalmic pharmacotherapy era. An increasing number of drugs are constantly released into the market for the treatment of retinal diseases. In this review, animal species, animal models and toxicity assays in retinal research are discussed. MET...

journal_title：Ophthalmic research

authors： Penha FM,Rodrigues EB,Maia M,Dib E,Fiod Costa E,Furlani BA,Nunes Moraes Filho M,Dreyfuss JL,Bottós J,Farah ME

更新日期：2010-01-01 00:00:00

abstract：:Cholinergic agents used to lower intraocular pressure in the medical management of glaucoma act on muscarinic receptors in the eye. Recently, subtypes of muscarinic receptors have been recognized in many tissues including the eye. To localize the M3 muscarinic receptor subtype and m3 messenger RNA (mRNA) in the human ...

journal_title：Ophthalmic research

authors： Gupta N,Drance SM,McAllister R,Prasad S,Rootman J,Cynader MS

更新日期：1994-01-01 00:00:00

abstract：PURPOSE:To study the ability to appreciate qualitative features that indicate disease activity in patients with neovascular age-related macular degeneration (AMD) and to analyze the differences in automated retinal thickness measurement, using 1 time domain optical coherence tomography (TD-OCT) and 2 different spectral...

journal_title：Ophthalmic research

authors： Querques G,Forte R,Berboucha E,Martinelli D,Coscas G,Soubrane G,Souied EH

更新日期：2011-01-01 00:00:00

abstract：:The ophthalmic examination of patients with hypertrophic cardiomyopathy treated with high doses of verapamil over a considerable period of time showed no evidence of a side effect of the drug, thus proving its ocular safety. This could be verified by densitometric image analysis of Scheimpflug photographs of the eyes....

journal_title：Ophthalmic research

authors： Hockwin O,Dragomirescu V,Laser H,Ohrloff C,Kozamanoglu K,Kremer F

更新日期：1984-01-01 00:00:00

abstract：:The effect of large intake of dietary ascorbic acid on heat-induced eye lens protein damage has been studied. Male guinea pigs of the Hartley strain were used. Ascorbic acid was administered to the experimental animals in the drinking water. The mean daily ascorbic acid intakes for the control and experimental animals...

journal_title：Ophthalmic research

authors： Tsao CS,Xu LF,Young M

更新日期：1990-01-01 00:00:00

abstract：:The effect of topical neutral formaldehyde on the blood-aqueous barrier of the rat was studied. Thirty minutes after irritation, the protein concentration of the aqueous humour had increased from the control value of 1.95 +/- 0.25 to 2.95 +/- 0.45 mg/ml (p less than 0.05). Extravasation of Evans blue dye from the iris...

journal_title：Ophthalmic research

authors： Krootila K,Uusitalo H,Lehtosalo JI,Palkama A

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:The aim of this study is to provide a quantitative evaluation of the blood-aqueous barrier (BAB) in patients with ocular blunt trauma and evaluate its association with intraocular pressure (IOP) elevation. METHODS:This is a prospective case-control study, and the following 3 groups were included: elevated I...

journal_title：Ophthalmic research

authors： Mao Z,Chen XB,Zhong YM,Guo XX,Liu X

更新日期：2016-07-01 00:00:00

abstract：PURPOSE:To evaluate the role of initial visual acuity (VA) as a potential prognostic factor for final VA in patients with branch retinal vein occlusion (BRVO). METHODS:A retrospective data analysis involving 163 patients with macular edema secondary to BRVO treated according to the recommendations of the Branch Vein O...

journal_title：Ophthalmic research

authors： Rehak J,Dusek L,Chrapek O,Fric E,Rehak M

更新日期：2011-01-01 00:00:00

abstract：:Naphthalene-induced rat cataract is a useful experimental cataract--however, because of its short survival period, studies using this model have been for limited purposes. Based on the consideration that the short survival might be caused by systemic toxicity of an overdose of naphthalene administration (1 g/kg body w...

journal_title：Ophthalmic research

authors： Nagata M,Murano H,Kojima M,Sasaki K

更新日期：1995-01-01 00:00:00

abstract：:Catalase activity was evaluated in Long Evans rat retina after ischemia and reperfusion. Ischemia was induced by ligation of the optic nerve and vessels. Rats were sacrificed after 15 and 120 min of reperfusion, respectively. Catalase activity was assessed by Claiborne's method and was expressed as U/mg of protein. In...

journal_title：Ophthalmic research

authors： Lewden O,Garcher C,Morales C,Javouhey A,Rochette L,Bron AM

更新日期：1996-01-01 00:00:00

abstract：:Cellular events in the rat conjunctiva were studied at 1, 6 and 24 h following the topical application of leukotriene B4. A significant increase was noted in the number of eosinophils (p less than 0.01) and neutrophils (p less than 0.05) at 1 h and only in eosinophils at 6 h after leukotriene B4 application at the 2-m...

journal_title：Ophthalmic research

authors： Trocmé SD,Gilbert CM,Allansmith MR,Bloch KJ,Abelson MB

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:Diabetic retinopathy (DR) is a severe ocular complication of diabetes. Kallistatin has multiple biological functions including anti-inflammation and antiangiogenesis. Our aim was to detect the level of kallistatin in the vitreous of proliferative DR (PDR) and its effect on proliferation, migration, and tube ...

journal_title：Ophthalmic research

authors： Xing Q,Zhang G,Kang L,Wu J,Chen H,Liu G,Zhu R,Guan H,Lu P

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the feasibility of a new technique for the implantation of ultrathin substrates containing stem cell-derived retinal pigment epithelium (RPE) cells into the subretinal space of retina-degenerate Royal College of Surgeon (RCS) rats. METHODS:A platform device was used for the implantation of 4-µm-t...

journal_title：Ophthalmic research

authors： Hu Y,Liu L,Lu B,Zhu D,Ribeiro R,Diniz B,Thomas PB,Ahuja AK,Hinton DR,Tai YC,Hikita ST,Johnson LV,Clegg DO,Thomas BB,Humayun MS

更新日期：2012-01-01 00:00:00

abstract：:The refractive indices in various rat retinal layers, based on the total dry mass concentration, ranged from 1.369 to 1.385. The ratios of the refractive indices of neighboring retinal layers were near unity. This finding suggests that light passes through the rat retina without much refraction. ...

journal_title：Ophthalmic research

authors： Chen E

更新日期：1993-01-01 00:00:00

abstract：:Oxidative stress plays a role in the pathogenesis of neurodegeneration in diabetic retinopathy (DR). However, whether an excellent reactive oxygen species scavenger, U83836E, inhibits the neurodegeneration in DR remains uncertain. This study is aimed at clarifying the effects of U83836E on DR. Two weeks after streptoz...

journal_title：Ophthalmic research

authors： Wang H,Zheng Z,Gong Y,Zhu B,Xu X

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the effect of C constant for ray tracing-assisted intraocular lens (IOL) power calculation in the patients with different refractive power, we compared the refractive outcome of ray-tracing method based on C constant and conventional IOL calculation formula. METHODS:215 eyes which underwent phaco...

journal_title：Ophthalmic research

authors： Chang P,Zhang F,Wang J,Zhao Y

更新日期：2020-04-20 00:00:00

abstract：:The eyes of 200 rats (Mol:SPRD, Moellegaard Ltd., Skensvet, Denmark), 8 weeks of age and of both sexes, were examined routinely with a photo-slitlamp microscope (Zeiss) and opthalmoscope (Heine) 3-4 times in the course of four different 12-week toxicity studies. The animals were kept under constant lighting conditions...

journal_title：Ophthalmic research

authors： Wegener A,Jochims K

更新日期：1994-01-01 00:00:00

abstract：:The main objective of this study was to determine the intraocular concentration of fluorescein after applying five eye drops with only 1-min intervals in human eyes. The concentration of fluorescein in corea and aqueous was studied with fluorophotometry in 11 healthy volunteers. Five 10-microliter drops of 2% fluoresc...

journal_title：Ophthalmic research

authors： Lindén C,Alm A

更新日期：1997-01-01 00:00:00

abstract：AIM:The aim of the current study is to evaluate the role of povidone iodine (PVI) in the management of experimental bacterial endophthalmitis in young rabbits. METHOD:Twenty white rabbits were used. Colony-forming units (CFU) of Staphylococcus epidermidis were injected intravitreally into the right eye of each animal....

journal_title：Ophthalmic research

authors： Brozou CG,Karabatakis V,Giannousis M,Mandraveli K,Karkavelas G,Alexiou-Daniel S

更新日期：2009-01-01 00:00:00

abstract：:This study examined and characterized the distribution and kinetics of the inflammatory cell response to pseudomonas ocular challenge in susceptible C57BL/6J and resistant DBA/2J mice. Initially, in the cornea, the number of neutrophilic leukocytes (PMNs), macrophages/monocytes or lymphocytes was 2-2.5 times greater i...

journal_title：Ophthalmic research

authors： Hazlett LD,Zucker M,Berk RS

更新日期：1992-01-01 00:00:00

abstract：:Extracellular recordings were performed on electrophysiologically identified achromatic neurons of the photosensitive pineal organ of the frog. The effects of iontophoretically applied aspartate and glutamate as well as one aspartate antagonist (D-alpha-aminoadipate) were observed on spontaneous activity and light-evo...

journal_title：Ophthalmic research

authors： Meissl H,George SR

更新日期：1984-01-01 00:00:00

abstract：:The development and extension of fibrovascular or fibroglial membranes onto the retinal surface are a major cause of visual loss in diabetic patients with proliferative retinopathy and in patients suffering from retinal detachment with proliferative vitreoretinopathy. The pathogenesis of these proliferative diseases, ...

journal_title：Ophthalmic research

authors： Fredj-Reygrobellet D,Baudouin C,Nègre F,Caruelle JP,Gastaud P,Lapalus P

更新日期：1991-01-01 00:00:00

abstract：:The binding of fluorescein and 6-carboxyfluorescein by normal, diabetic and in vitro glycosylated human serum proteins was analyzed by absorption and fluorescence spectroscopy, gel filtration and equilibrium dialysis. The absorption spectra of bound fluorochromes showed red shifts and hypochromic changes, and fluoroch...

journal_title：Ophthalmic research

authors： Rockey JH,Li W

更新日期：1982-01-01 00:00:00

abstract：AIM:To develop a local approach to study rabbit lacrimal secretion in situ by administering specific secretagogues directly onto the lacrimal gland (LG). METHODS:After the rabbit has been anesthetized, the inferior bulbar conjunctiva and underlying connective tissue are blunt dissected. A polyethylene tube, for drug d...

journal_title：Ophthalmic research

authors： Ding C,Rife L,Nakamura T,Wang YW,Kopp K,Schechter JE

更新日期：2008-01-01 00:00:00