Abstract:
:Cellular events in the rat conjunctiva were studied at 1, 6 and 24 h following the topical application of leukotriene B4. A significant increase was noted in the number of eosinophils (p less than 0.01) and neutrophils (p less than 0.05) at 1 h and only in eosinophils at 6 h after leukotriene B4 application at the 2-micrograms dose. At the 200-ng dose, the eosinophil count was significantly elevated at 1 h only, and the number of neutrophils was not significantly changed at any time point. No significant increase in cell counts was observed at the 20-ng dose. In conclusion, certain doses of topically applied leukotriene B4 significantly increased the number of eosinophils and neutrophils in the rat conjunctiva.
journal_name
Ophthalmic Resjournal_title
Ophthalmic researchauthors
Trocmé SD,Gilbert CM,Allansmith MR,Bloch KJ,Abelson MBdoi
10.1159/000266873subject
Has Abstractpub_date
1989-01-01 00:00:00pages
297-302issue
4eissn
0030-3747issn
1423-0259journal_volume
21pub_type
杂志文章abstract:BACKGROUND:The lens is the ocular structure most susceptible to oxidative damage. Antioxidants, micronutrients and phytochemicals have been extensively studied for their possible effects to prevent or delay the progression of various eye diseases. OBJECTIVES:A brief overview of the updated literature on the role of an...
journal_title:Ophthalmic research
pub_type: 杂志文章,评审
doi:10.1159/000316477
更新日期:2010-01-01 00:00:00
abstract::The pathology of rainbow trout lenses incubated in various media and at various temperatures was examined by electron microscopy. After incubation at 0 degrees C for 5 h, no changes were observed in transparency and cytology. Irreversible warm cataract occurred at 37 degrees C, which corresponds to the body temperatur...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265427
更新日期:1986-01-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy of bilateral lateral rectus muscle recession (BLR) to treat recurrent exotropia after bilateral medial rectus muscle resection (BMR). METHODS:Twenty-four patients who underwent BLR for recurrent exotropia and were followed up for more than 6 months were included in this retrospective s...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000494560
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:To analyze chloroquine-induced morphological changes in the retinal pigment epithelium (RPE) and Bruch's membrane (BM). METHODS:Retina-choroid complexes of chloroquine-treated Long-Evans rats were analyzed by electron microscopy. RESULTS:Intercellular spaces between the RPE cells and BM were enlarged. Residua...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000090268
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:In this study, we used a rat model of retinal detachment (RD) to investigate the effects of transient receptor potential mucolipin 1 (TRPML1) on photoreceptor cells and the underlying mechanism. METHODS:An RD model was established by subretinal injection of sodium hyaluronate, and mucolipin synthetic agonist...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000512104
更新日期:2020-10-07 00:00:00
abstract::Oxidative stress plays a role in the pathogenesis of neurodegeneration in diabetic retinopathy (DR). However, whether an excellent reactive oxygen species scavenger, U83836E, inhibits the neurodegeneration in DR remains uncertain. This study is aimed at clarifying the effects of U83836E on DR. Two weeks after streptoz...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000321952
更新日期:2011-01-01 00:00:00
abstract::This study developed a modified monolayer culture technique for expansion of retinal progenitor cells in vitro. Using this method, spheres collected by low centrifugation from free floating cultures were re-seeded onto poly-D-lysine pre-coated flasks, and cultured in the retinal progenitor cells medium (including fibr...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000134927
更新日期:2008-10-01 00:00:00
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journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265224
更新日期:1982-01-01 00:00:00
abstract:PURPOSE:To characterize the 1-year progression of retinal thickness (RT) increase occurring in eyes with subclinical macular edema in type 2 diabetes. METHODS:Forty-eight type 2 diabetic eyes/patients with mild nonproliferative diabetic retinopathy (NPDR; levels 20 and 35 in the Early Treatment Diabetic Retinopathy St...
journal_title:Ophthalmic research
pub_type: 杂志文章,多中心研究
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更新日期:2015-01-01 00:00:00
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journal_title:Ophthalmic research
pub_type: 杂志文章,评审
doi:10.1159/000488492
更新日期:2018-01-01 00:00:00
abstract::To study the mode of riboflavin metabolism in the lens in vivo, the uptake of 14C-labeled riboflavin and synthesis of ester forms from 14C-riboflavin were assayed in the single whole lens of the rats. 14C-riboflavin uptake increased in proportion to the substrate concentration in the incubation medium, reaching a plat...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265249
更新日期:1983-01-01 00:00:00
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journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000266995
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:The aim of this work was to evaluate the narrow anterior chamber angle (ACA) in Chinese patients by anterior segment optical coherence tomography (As-OCT). METHODS:Eighty right eyes of 80 consecutive patients with a shallow peripheral anterior chamber but no peripheral anterior synechia were enrolled in thi...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000448523
更新日期:2017-01-01 00:00:00
abstract::We examined the density and morphology of lens epithelial cells (LECs) in vivo in a group of normal volunteers and cataract patients by using a newly developed noncontact specular microscope. There was a statistically significant decrease in the cell density of LECs in a group of cataract patients over the age of 80 y...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000055694
更新日期:2001-11-01 00:00:00
abstract::This study examined and characterized the distribution and kinetics of the inflammatory cell response to pseudomonas ocular challenge in susceptible C57BL/6J and resistant DBA/2J mice. Initially, in the cornea, the number of neutrophilic leukocytes (PMNs), macrophages/monocytes or lymphocytes was 2-2.5 times greater i...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267142
更新日期:1992-01-01 00:00:00
abstract:PURPOSE:To evaluate the effect of transpupillary thermotherapy (TTT) on foveal thickness and macular function in eyes with choroidal neovascularization (CNV) associated with age-related macular degeneration. METHODS:Sixteen eyes with occult CNV and 6 eyes with classic CNV were treated with TTT. Optical coherence tomog...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000083020
更新日期:2005-01-01 00:00:00
abstract::We investigated the effects of hyperthermia on the healing process of experimental Pseudomonas corneal ulceration (PCU). Hartley guinea pigs were used to develop animal models of PCU. As a heat source, disposable chemical pocket warmers were applied. The healing process of PCU was compared between the heat-treated cor...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000078780
更新日期:2004-07-01 00:00:00
abstract:OBJECTIVE:Acute corneal permeability change after instillation of benzalkonium chloride (BAC) was evaluated using a newly developed in vivo corneal transepithelial electric resistance (TER) measurement method. METHOD:Corneal TER was measured by Ag/AgCl electrodes placed in the anterior aqueous chamber and on the corne...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000109986
更新日期:2007-01-01 00:00:00
abstract::To evaluate the effect of single or repeated topical applications of prostaglandin E2 (PGE2) to the cornea on the blood-aqueous barrier, we have measured the extent of flare in the anterior chamber of rabbit eyes at various time intervals. PGE2 was applied to the cornea for 4 min with the use of a glass cylinder in pi...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267895
更新日期:1996-01-01 00:00:00
abstract::Results of a comparative study of accommodative capability of eyes in individuals exposed to various doses of ionizing radiation and in a control group are presented. The mean values for ranges of accommodation in the control group were consonant with previous data. However, the range of accommodation was found to be ...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000063879
更新日期:2002-07-01 00:00:00
abstract::Toxoplasma gondii is an extremely successful opportunistic parasite which infects approximately one third of the human population worldwide. The impact of this parasite on human health becomes particularly manifest in congenital damage with infection and subsequent inflammation of neuronal tissues including the retina...
journal_title:Ophthalmic research
pub_type: 杂志文章,评审
doi:10.1159/000363141
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:To assess the cytotoxic properties of voriconazole and sulfobutylether-β-cyclodextrin (SBECD) on cultured primary human corneal epithelial cells. METHODS:Human corneal epithelial cells were cultured and exposed to various concentrations of SBECD (0.016-32 mg/ml) and voriconazole (0.001-2 mg/ml). Cellular cy...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000371712
更新日期:2015-01-01 00:00:00
abstract::We examined 304 conjunctiva in 152 subjects by clinical, cytologic, and bacteriologic methods. Bacteriologic samples were evaluated after a 48-hour incubation. Bacterial growth was found in 8 (20.5%) of 39 patients with clinically normal conjunctiva and no polymorphonuclear leukocytes (PMNs), and in 8 (61.5%) of 13 su...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267086
更新日期:1991-01-01 00:00:00
abstract::HY-1 genotype chick lenses display epithelial hyperplasia and associated lens opacities. Membrane proteins from HY-1 and normal chick lenses were separated by isoelectric focusing, and 45Ca2+ binding capacities were determined. Markedly higher (congruent to 900-fold) binding of 45Ca2+ was observed in high molecular we...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265397
更新日期:1985-01-01 00:00:00
abstract:PURPOSE:To investigate whether different crush durations or a different fluorogold (FG) injection timing can affect the efficiency of FG retrograde labeling of retinal ganglion cells (RGCs) in the optic nerve (ON) crush model. METHODS:We performed the ON crush in rats with a clip at different durations or a jewel forc...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000357736
更新日期:2014-01-01 00:00:00
abstract::The binding of fluorescein and 6-carboxyfluorescein by normal, diabetic and in vitro glycosylated human serum proteins was analyzed by absorption and fluorescence spectroscopy, gel filtration and equilibrium dialysis. The absorption spectra of bound fluorochromes showed red shifts and hypochromic changes, and fluoroch...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265219
更新日期:1982-01-01 00:00:00
abstract::In a search for a pharmacologic adjuvant in the management of posttraumatic proliferative vitreoretinopathy (PVR), we investigated the effect of intravitreal injection of prinomastat (AG3340) on an experimental model. Posterior penetrating eye trauma was created in one eye each of 24 New Zealand white rabbits. One wee...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000055636
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:The aim of this study is to provide a quantitative evaluation of the blood-aqueous barrier (BAB) in patients with ocular blunt trauma and evaluate its association with intraocular pressure (IOP) elevation. METHODS:This is a prospective case-control study, and the following 3 groups were included: elevated I...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000445352
更新日期:2016-07-01 00:00:00
abstract:PURPOSE:To compare tear film osmolarity (TFO) between patients with diabetes mellitus (DM) and normal healthy individuals. METHODS:In this prospective case-controlled study, the TFO in 46 normal subjects (control group) and 55 patients with DM (study group) was evaluated. TFO in milliosmole (mOsm) was measured by usin...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000345770
更新日期:2013-01-01 00:00:00
abstract::The pineal organ of the pike is a functional photoreceptive organ in which a multiplicity of the cells of the receptor line (CRL i.e. typical and modified photoreceptors) was demonstrated. The CRL appeared to be (i) regionally distributed, (ii) photosensitive, and (iii) responsible for the storage of various indoles (...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265306
更新日期:1984-01-01 00:00:00