Abstract:
:The refractive indices in various rat retinal layers, based on the total dry mass concentration, ranged from 1.369 to 1.385. The ratios of the refractive indices of neighboring retinal layers were near unity. This finding suggests that light passes through the rat retina without much refraction.
journal_name
Ophthalmic Resjournal_title
Ophthalmic researchauthors
Chen Edoi
10.1159/000267223subject
Has Abstractpub_date
1993-01-01 00:00:00pages
65-8issue
1eissn
0030-3747issn
1423-0259journal_volume
25pub_type
杂志文章abstract::This study is a first approach to identify UVA-related alterations in situ of bovine eye lens proteins from the water-soluble and urea-soluble fractions upon aging. The fractions were obtained from irradiated long-term organ culture lenses and analyzed by mini two-dimensional gel electrophoresis. This micropreparative...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000055613
更新日期:2000-09-01 00:00:00
abstract:OBJECTIVE:To assess changes of tear film function in patients with pterygium after pterygium excision combined with limbal-conjunctival autograft transplantation. METHODS:Sixty eyes of 60 patients were entered in the study. The Schirmer test, tear breakup time (BUT) and mucus fern test (MFT) were evaluated in the pati...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000321531
更新日期:2011-01-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy of bilateral lateral rectus muscle recession (BLR) to treat recurrent exotropia after bilateral medial rectus muscle resection (BMR). METHODS:Twenty-four patients who underwent BLR for recurrent exotropia and were followed up for more than 6 months were included in this retrospective s...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000494560
更新日期:2019-01-01 00:00:00
abstract::To determine the effect of interleukin-10 (IL-10) and transforming growth factor-beta (TGF-beta) on the down-regulation of MHC class II antigens, bovine retinal pigment epithelial (RPE) cells were incubated with interferon-gamma (IFN-gamma) in different concentrations. Subsequently, the IFN-gamma pretreated RPE cells ...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000055545
更新日期:1999-01-01 00:00:00
abstract::Photodocumented measurements of the lens thickness using an EAS-1000 Scheimpflug camera were performed in 261 cataract eyes (162 pure type) compared with 52 control eyes. The lens thickness in normal eyes usually increased with age by 0.015 mm annually. The cataractous lens, especially in the anterior subcapsular type...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267205
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVE:In this study, we used a rat model of retinal detachment (RD) to investigate the effects of transient receptor potential mucolipin 1 (TRPML1) on photoreceptor cells and the underlying mechanism. METHODS:An RD model was established by subretinal injection of sodium hyaluronate, and mucolipin synthetic agonist...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000512104
更新日期:2020-10-07 00:00:00
abstract:PURPOSE:To demonstrate the value of the laser-scanning optical-resolution (LSOR)-photoacoustic (PA) microscopy (PAM) system and the conventional multimodal imaging techniques in the evaluation of laser-induced retinal injury and choroidal neovascularization (CNV) in rats. METHODS:Different degrees of retinal injury we...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000502800
更新日期:2020-01-01 00:00:00
abstract::We studied lens opacification of rabbit lenses in culture. Opacification was produced by maintaining rabbit lenses in medium containing calcium concentrations as high as 10 mmol/l and the opacity was measured using LASER spectroscopy. Increasing calcium caused significant opacification in lens cortex while the transpa...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265380
更新日期:1985-01-01 00:00:00
abstract::Inflammation is substantially contributing to the development and worsening of diabetic retinopathy in general and diabetic macular edema (DME) in particular, which provides the rationale to treat DME with corticosteroids. While anti-vascular endothelial growth factor (VEGF) agents are mostly chosen as a first-line tr...
journal_title:Ophthalmic research
pub_type: 杂志文章,评审
doi:10.1159/000499540
更新日期:2019-01-01 00:00:00
abstract::Lenticular S-adenosylmethionine synthetase has been partially purified and characterized. Lower levels of S-adenosylmethionine synthetase were detected by a sensitive radioactive assay procedure in the lenticular extract obtained from the pooled lenses of alloxan-treated rats 96 days of age as compared to the nontreat...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265169
更新日期:1982-01-01 00:00:00
abstract:OBJECTIVE:Transient receptor potential canonical (TRPC) channels are involved in neovascularization repairing after vascular injury in many tissues. However, whether TRPCs play a regulatory role in the development of diabetic retinopathy (DR) has rarely been reported. In the present study, we selected TRPC1, 3, and 6 t...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000503724
更新日期:2020-01-01 00:00:00
abstract:AIMS:Biomaterials are widely used in ophthalmology, and biodegradable polymers have been evaluated for use in surgery, tissue engineering and targeted drug delivery. We examined the tissue reactions attributable to 3 biodegradable polymers in the rat eye. METHODS:Inion GTR™ membrane [a blend of 85:15 poly(L-lactide-co...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000322996
更新日期:2011-01-01 00:00:00
abstract:PURPOSE:Retinal gene therapy trials are currently ongoing in a small number of inherited retinal disorders and this number is expected to rise significantly. The aim of this study was to analyze the psychological aspects of patients with RPE65 deficiency awaiting potential enrollment in gene therapy trials. METHODS:Fi...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000435887
更新日期:2015-01-01 00:00:00
abstract::The gut microbiome has important physiological functions and plays an indispensable role in the human body. Currently, there are an increasing number of studies revealing the close correlation between dysbiosis of the gut microbiome and a variety of autoimmune diseases, including autoimmune uveitis. This brief review ...
journal_title:Ophthalmic research
pub_type: 杂志文章,评审
doi:10.1159/000510212
更新日期:2020-07-16 00:00:00
abstract:PURPOSE:To determine whether docosahexaenoic acid (DHA) can reduce the retinal damage induced by transient retinal ischemia. METHODS:Retinal ischemia was induced by increasing intraocular pressure (IOP). Retinal circulation was restored by lowering IOP. An intraperitoneal injection of 1,000 mg/kg of DHA-ester (DHA-E) ...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000055669
更新日期:2001-07-01 00:00:00
abstract:PURPOSE:To investigate whether different crush durations or a different fluorogold (FG) injection timing can affect the efficiency of FG retrograde labeling of retinal ganglion cells (RGCs) in the optic nerve (ON) crush model. METHODS:We performed the ON crush in rats with a clip at different durations or a jewel forc...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000357736
更新日期:2014-01-01 00:00:00
abstract::Equine recurrent uveitis (ERU) is an autoimmune disease that occurs with a high prevalence (10%) in horses. ERU represents the only reliable spontaneous model for human autoimmune uveitis. We already identified and characterized novel autoantigens (malate dehydrogenase, recoverin, CRALBP) by analyzing the autoantibody...
journal_title:Ophthalmic research
pub_type: 杂志文章,评审
doi:10.1159/000119867
更新日期:2008-01-01 00:00:00
abstract:PURPOSE:To evaluate the corneal button of primary penetrating keratoplasty of patients diagnosed with congenital aniridia. The study took place at the Instituto Universitario Barraquer and the Centro de Oftalmología Barraquer. METHODS:A retrospective analysis of cases diagnosed with congenital aniridia was carried out...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000444930
更新日期:2016-01-01 00:00:00
abstract:PURPOSE:To evaluate the effect of transpupillary thermotherapy (TTT) on foveal thickness and macular function in eyes with choroidal neovascularization (CNV) associated with age-related macular degeneration. METHODS:Sixteen eyes with occult CNV and 6 eyes with classic CNV were treated with TTT. Optical coherence tomog...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000083020
更新日期:2005-01-01 00:00:00
abstract::We examined 304 conjunctiva in 152 subjects by clinical, cytologic, and bacteriologic methods. Bacteriologic samples were evaluated after a 48-hour incubation. Bacterial growth was found in 8 (20.5%) of 39 patients with clinically normal conjunctiva and no polymorphonuclear leukocytes (PMNs), and in 8 (61.5%) of 13 su...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267086
更新日期:1991-01-01 00:00:00
abstract:PURPOSE:The purpose of our study was to investigate the profiles of inflammatory cytokines and the macrophage polarization gene in a choroidal neovascularization (CNV) mouse model before and after intravitreal aflibercept treatment. METHODS:The CNV mouse model was conducted by laser photocoagulation. A total of 58 cyt...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000513588
更新日期:2020-12-04 00:00:00
abstract::The pathology of rainbow trout lenses incubated in various media and at various temperatures was examined by electron microscopy. After incubation at 0 degrees C for 5 h, no changes were observed in transparency and cytology. Irreversible warm cataract occurred at 37 degrees C, which corresponds to the body temperatur...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265427
更新日期:1986-01-01 00:00:00
abstract:AIM:To investigate the diagnostic efficacy and clinical application value of plasma endothelin-1 for diabetic retinopathy using receiver operating characteristic (ROC) curve analysis. METHODS:This was a prospective investigational study. Funduscopy and fundus fluorescein angiography were used as gold standards for the...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000108123
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVES:To evaluate the efficacy of postenucleation saline wash and the effect of different antimicrobial agents on the microbial contamination of donor eyes. METHODS:Two hundred donor eyes were given saline wash and treated with any one of the following 5 randomly selected antimicrobial solutions: 1% povidone-iodi...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000095772
更新日期:2006-01-01 00:00:00
abstract:PURPOSE:To evaluate diabetic retinopathy (DR) progression in patients with diabetes mellitus type 2 in 2 populations of different ethnicity. METHODS:A prospective observational study was designed to follow eyes/patients with mild nonproliferative DR, for 2 years or until the development of central-involved macular ede...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000484666
更新日期:2018-01-01 00:00:00
abstract::This study developed a modified monolayer culture technique for expansion of retinal progenitor cells in vitro. Using this method, spheres collected by low centrifugation from free floating cultures were re-seeded onto poly-D-lysine pre-coated flasks, and cultured in the retinal progenitor cells medium (including fibr...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000134927
更新日期:2008-10-01 00:00:00
abstract:PURPOSE:To analyze chloroquine-induced morphological changes in the retinal pigment epithelium (RPE) and Bruch's membrane (BM). METHODS:Retina-choroid complexes of chloroquine-treated Long-Evans rats were analyzed by electron microscopy. RESULTS:Intercellular spaces between the RPE cells and BM were enlarged. Residua...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000090268
更新日期:2006-01-01 00:00:00
abstract::Ibudilast selectively vasodilates cerebral vessels without reducing blood pressure. We investigated the effect of the drug on retinal circulation in 8 patients with diabetes mellitus, using the video-densitometric image analysis of fluorescein angiography. We compared the build up time, the time constant of washout ra...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267168
更新日期:1992-01-01 00:00:00
abstract::Tear hyperosmolarity is known to cause ocular surface inflammation in dry eye syndrome. Benzalkonium chloride (BAK), an eyedrop preservative, is known to induce dry eye in long-term-treated patients. Analyzing the modulation of the proinflammatory potential of hyperosmolarity in the presence of BAK on the conjunctiva ...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000448117
更新日期:2017-01-01 00:00:00
abstract::Animal models are indispensable for pharmaceutical investigations. However, investigators often have difficulty choosing the appropriate modal for their research. To provide a comprehensive and convenient source of information about animal models of proliferative vitreoretinopathy (PVR), the current review sorted and ...
journal_title:Ophthalmic research
pub_type: 杂志文章,评审
doi:10.1159/000488492
更新日期:2018-01-01 00:00:00