Inhibition of lysosomal degradation in retinal pigment epithelium cells induces exocytosis of phagocytic residual material at the basolateral plasma membrane.

abstract：OBJECTIVE:Transient receptor potential canonical (TRPC) channels are involved in neovascularization repairing after vascular injury in many tissues. However, whether TRPCs play a regulatory role in the development of diabetic retinopathy (DR) has rarely been reported. In the present study, we selected TRPC1, 3, and 6 t...

journal_title：Ophthalmic research

authors： Lang HB,Xie RX,Huang ML,Fang LY,Tang YB,Zhang F

更新日期：2020-01-01 00:00:00

abstract：:A system for isolation of capillaries from the retina has been adapted to biochemical studies in vitro. Insulin receptors were identified in human and calf retinal blood vessels. Binding of 125I insulin by calf retinal blood vessels takes place through high affinity (low capacity) and low affinity (high capacity) rece...

journal_title：Ophthalmic research

authors： Cotlier E,Davidson C

更新日期：1983-01-01 00:00:00

abstract：PURPOSE:To evaluate the efficacy of bilateral lateral rectus muscle recession (BLR) to treat recurrent exotropia after bilateral medial rectus muscle resection (BMR). METHODS:Twenty-four patients who underwent BLR for recurrent exotropia and were followed up for more than 6 months were included in this retrospective s...

journal_title：Ophthalmic research

authors： Wang X,Chen X,Liu L

更新日期：2019-01-01 00:00:00

abstract：:Cataractous lens images taken with different camera types for retroillumination photography were compared. Images taken by conventional photo slitlamp and fundus cameras were not suitable for image analysis. Retroillumination photography with a conventional fundus camera with additional polarizing filters seemed to be...

journal_title：Ophthalmic research

authors： Sakamoto Y,Rankov G,Sasaki K

更新日期：1990-01-01 00:00:00

abstract：PURPOSE:To compare the effects between intravitreal and periocular injections of adenoviral vectored pigment epithelium-derived factor (AdPEDF) on suppressing established choroidal neovascularization (CNV) in rats. METHODS:Sixty-eight female BN rats (136 eyes) aged 6-8 weeks were involved in this study. The CNV animal...

journal_title：Ophthalmic research

authors： Yan H,Cui J,Wang Y,Yu Y

更新日期：2013-01-01 00:00:00

abstract：:The binding of fluorescein and 6-carboxyfluorescein by normal, diabetic and in vitro glycosylated human serum proteins was analyzed by absorption and fluorescence spectroscopy, gel filtration and equilibrium dialysis. The absorption spectra of bound fluorochromes showed red shifts and hypochromic changes, and fluoroch...

journal_title：Ophthalmic research

authors： Rockey JH,Li W

更新日期：1982-01-01 00:00:00

abstract：PURPOSE:This study was aimed at determining the intraocular pharmacokinetics based on molecular physicochemical properties in a rabbit model. METHODS:The entire dataset was obtained from previous literature, and research articles regarding 70 molecular compounds were investigated. The intravitreal half-lives in rabbit...

journal_title：Ophthalmic research

authors： Kim HM,Park KH,Chung JY,Woo SJ

更新日期：2020-01-01 00:00:00

abstract：:Animal models are indispensable for pharmaceutical investigations. However, investigators often have difficulty choosing the appropriate modal for their research. To provide a comprehensive and convenient source of information about animal models of proliferative vitreoretinopathy (PVR), the current review sorted and ...

journal_title：Ophthalmic research

authors： Hou H,Nudleman E,Weinreb RN

更新日期：2018-01-01 00:00:00

abstract：:The development and extension of fibrovascular or fibroglial membranes onto the retinal surface are a major cause of visual loss in diabetic patients with proliferative retinopathy and in patients suffering from retinal detachment with proliferative vitreoretinopathy. The pathogenesis of these proliferative diseases, ...

journal_title：Ophthalmic research

authors： Fredj-Reygrobellet D,Baudouin C,Nègre F,Caruelle JP,Gastaud P,Lapalus P

更新日期：1991-01-01 00:00:00

abstract：:A method for microscopical observation and quantification of corneal neovascularization in the living mouse is described. Measurements of the corneal vasculature were made on still-mode video-pictures of the cornea. The validity of the method was shown by the high correlation between the morphometric measurements and ...

journal_title：Ophthalmic research

authors： Falkvoll KH

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVE:The pathogenesis of Behçet's disease (BD) may be related to excessive production of reactive oxygen species, activated neutrophils, and T lymphocytes. The goal of this prospective study was to investigate whether there is any relationship among the oxidant/antioxidant system and nitric oxide (NO) and malondia...

journal_title：Ophthalmic research

authors： Aydin E,Sögüt S,Ozyurt H,Ozugurlu F,Akyol O

更新日期：2004-05-01 00:00:00

abstract：:Given the propensity of a large number of melanogenic pathways that can be modulated by cellular redox status, a causal role of the deficiency of ocular pigments such as melanin in the pathogenesis of age-related macular degeneration and evidence that melanin production does occur in the adult eye, it seems not improb...

journal_title：Ophthalmic research

authors： Sarangarajan R,Apte SP

更新日期：2004-11-01 00:00:00

abstract：:Dragomirescu et al. [1983] described a 2-chamber flow system for the incubation of lenses with an inserted photometer to measure changes in lens transparency. Mester et al. [1984] applied the method to simulate conditions occurring during vitrectomy, which occasionally leads to reversible lens opacification. Using Sch...

journal_title：Ophthalmic research

authors： Hockwin O,Dragomirescu V,Schwarz B

更新日期：1985-01-01 00:00:00

abstract：PURPOSE:To investigate the association between retinal neovascularization and the CC chemokine receptor-3 (CCR3) in a mouse model of oxygen-induced retinopathy (OIR). METHODS:An OIR model in C57BL/6J mice was used as a retinal neovascularization model. An enzyme-linked immunosorbent assay was performed to evaluate the...

journal_title：Ophthalmic research

authors： Hirahara S,Nozaki M,Ohbayashi M,Hasegawa N,Ozone D,Ogura Y

更新日期：2017-01-01 00:00:00

abstract：:The effects of inhibition of both glutathione synthesis and of glutathione reductase and catalase activities have been determined in the regulation of hydrogen peroxide (H2O2) in the anterior chamber of pigmented rabbits. Glutathione reductase inhibition using intravitreal 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) ...

journal_title：Ophthalmic research

authors： Costarides AP,Riley MV,Green K

更新日期：1991-01-01 00:00:00

abstract：:Using cuprolinic blue staining, we histochemically examined the ultrastructural localization of proteoglycans in the fibrous-type human posterior capsule opacification. This capsule opacification contained proteoglycans that showed positive staining with cuprolinic blue. Many cuprolinic-blue-positive filaments were pr...

journal_title：Ophthalmic research

authors： Ishibashi T,Araki H,Sugai S,Tawara A,Inomata H

更新日期：1995-01-01 00:00:00

abstract：PURPOSE:Extensive clinical investigations of the biocompatibility of different intraocular lenses (IOLs) have been made in an effort to optimize the outcome of modern cataract surgery. The aim of this study was to add animal eye experimental implantation data regarding cellular reaction on the anterior surface of IOLs....

journal_title：Ophthalmic research

authors： Barbour W,Saika S,Miyamoto T,Ohnishi Y

更新日期：2005-09-01 00:00:00

abstract：:Adult human lenses with focal opacities were processed for normal as well as freeze fracture electron microscopy. Cholesterol was demonstrated using filipin cytochemistry. Filipin cytochemistry in combination with freeze fracture revealed that the amount of cholesterol in the normal fibre membranes was fully comparabl...

journal_title：Ophthalmic research

authors： VanMarle J,Vrensen GF

更新日期：2000-11-01 00:00:00

abstract：AIM:To investigate the diagnostic efficacy and clinical application value of plasma endothelin-1 for diabetic retinopathy using receiver operating characteristic (ROC) curve analysis. METHODS:This was a prospective investigational study. Funduscopy and fundus fluorescein angiography were used as gold standards for the...

journal_title：Ophthalmic research

authors： Zhu H,Shi CH

更新日期：2007-01-01 00:00:00

abstract：:L-Timolol (0.4 mg/kg) reduced significantly retinal blood flow (17%), systemic blood pressure (18-20%) and heart rate (28%) in the rabbit. D-Timolol (4.0 mg/kg) increased retinal blood flow slightly (9%) and did not significantly affect systemic blood pressure or heart rate. Since D-timolol is effective in reducing in...

journal_title：Ophthalmic research

authors： Yan HY,Chiou GC

更新日期：1987-01-01 00:00:00

abstract：:To study the mode of riboflavin metabolism in the lens in vivo, the uptake of 14C-labeled riboflavin and synthesis of ester forms from 14C-riboflavin were assayed in the single whole lens of the rats. 14C-riboflavin uptake increased in proportion to the substrate concentration in the incubation medium, reaching a plat...

journal_title：Ophthalmic research

authors： Ono S,Hirano H

更新日期：1983-01-01 00:00:00

abstract：:The aim of the study was to examine the effects of nonsteroidal anti-inflammatory drugs (NSAIDs)/acetylsalicylic acid (ASA) on human lens epithelial cells (HLECs) during oxidative stress. HLECs were exposed to H2O2 in the absence or presence of indomethacin, diclofenac, celecoxib (NSAIDs) or ASA for 24 h. HLECs were a...

journal_title：Ophthalmic research

authors： Petersen A,Carlsson T,Karlsson JO,Zetterberg M

更新日期：2008-01-01 00:00:00

abstract：PURPOSE:To determine whether docosahexaenoic acid (DHA) can reduce the retinal damage induced by transient retinal ischemia. METHODS:Retinal ischemia was induced by increasing intraocular pressure (IOP). Retinal circulation was restored by lowering IOP. An intraperitoneal injection of 1,000 mg/kg of DHA-ester (DHA-E) ...

journal_title：Ophthalmic research

authors： Miyauchi O,Mizota A,Adachi-Usami E,Nishikawa M

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND:The aim of this study is to provide a quantitative evaluation of the blood-aqueous barrier (BAB) in patients with ocular blunt trauma and evaluate its association with intraocular pressure (IOP) elevation. METHODS:This is a prospective case-control study, and the following 3 groups were included: elevated I...

journal_title：Ophthalmic research

authors： Mao Z,Chen XB,Zhong YM,Guo XX,Liu X

更新日期：2016-07-01 00:00:00

abstract：:Cellular events in the rat conjunctiva were studied at 1, 6 and 24 h following the topical application of leukotriene B4. A significant increase was noted in the number of eosinophils (p less than 0.01) and neutrophils (p less than 0.05) at 1 h and only in eosinophils at 6 h after leukotriene B4 application at the 2-m...

journal_title：Ophthalmic research

authors： Trocmé SD,Gilbert CM,Allansmith MR,Bloch KJ,Abelson MB

更新日期：1989-01-01 00:00:00

abstract：PURPOSE:To assess the natural variability in the diameter of small collagen fibrils in the lamellae of corneal stroma of healthy young rabbits. MATERIALS AND METHODS:The corneas of 6 young adult female New Zealand White rabbits (2.1 kg) were prepared for transmission electron microscopy (TEM) by fixation with a cacody...

journal_title：Ophthalmic research

authors： Doughty MJ,Bergmanson JP

更新日期：2006-01-01 00:00:00

abstract：AIM:The aim of the current study is to evaluate the role of povidone iodine (PVI) in the management of experimental bacterial endophthalmitis in young rabbits. METHOD:Twenty white rabbits were used. Colony-forming units (CFU) of Staphylococcus epidermidis were injected intravitreally into the right eye of each animal....

journal_title：Ophthalmic research

authors： Brozou CG,Karabatakis V,Giannousis M,Mandraveli K,Karkavelas G,Alexiou-Daniel S

更新日期：2009-01-01 00:00:00

abstract：:The aqueous humors of 100 freshly enucleated rabbit eyes were assessed within 10 min postmortem by taking samples in the last stage of corneal dissection following the Dikstein-Maurice procedure. Aqueous levels of partial pressure of carbon dioxide (pCO2) averaged 58.2 +/- 8.5 mm Hg to give calculated tCO2 and bicarbo...

journal_title：Ophthalmic research

authors： Doughty MJ

更新日期：1993-01-01 00:00:00

abstract：:In a search for a pharmacologic adjuvant in the management of posttraumatic proliferative vitreoretinopathy (PVR), we investigated the effect of intravitreal injection of prinomastat (AG3340) on an experimental model. Posterior penetrating eye trauma was created in one eye each of 24 New Zealand white rabbits. One wee...

journal_title：Ophthalmic research

authors： Ozerdem U,Mach-Hofacre B,Keefe K,Pham T,Soules K,Appelt K,Freeman WR

更新日期：2001-01-01 00:00:00

abstract：:The effect of large intake of dietary ascorbic acid on heat-induced eye lens protein damage has been studied. Male guinea pigs of the Hartley strain were used. Ascorbic acid was administered to the experimental animals in the drinking water. The mean daily ascorbic acid intakes for the control and experimental animals...

journal_title：Ophthalmic research

authors： Tsao CS,Xu LF,Young M

更新日期：1990-01-01 00:00:00