Suppression of Retinal Neovascularization by Anti-CCR3 Treatment in an Oxygen-Induced Retinopathy Model in Mice.

abstract：BACKGROUND:The aim of this work was to compare the efficacy of intravitreal dexamethasone implant (Ozurdex) and intravitreal ranibizumab (Lucentis) in the treatment of macular edema (ME) caused by retinal vein occlusion (RVO). METHODS:Thirty-two ME cases treated with Ozurdex and 32 ME cases treated with ranibizumab we...

journal_title：Ophthalmic research

authors： Gu X,Yu X,Song S,Dai H

更新日期：2017-01-01 00:00:00

abstract：PURPOSE:Extensive clinical investigations of the biocompatibility of different intraocular lenses (IOLs) have been made in an effort to optimize the outcome of modern cataract surgery. The aim of this study was to add animal eye experimental implantation data regarding cellular reaction on the anterior surface of IOLs....

journal_title：Ophthalmic research

authors： Barbour W,Saika S,Miyamoto T,Ohnishi Y

更新日期：2005-09-01 00:00:00

abstract：:Calf water-soluble (WS) crystallins consist of high-molecular weight (HM), alpha-, beta H-, beta L-, beta s- and gamma-crystallins. alpha-Crystallin as a molecular chaperone forms a structure with a central hole, known as Carver's model. The only crystallins fitting into this central cavity are beta s- and gamma-cryst...

journal_title：Ophthalmic research

authors： Bours J

更新日期：1996-01-01 00:00:00

abstract：:Equine recurrent uveitis (ERU) is an autoimmune disease that occurs with a high prevalence (10%) in horses. ERU represents the only reliable spontaneous model for human autoimmune uveitis. We already identified and characterized novel autoantigens (malate dehydrogenase, recoverin, CRALBP) by analyzing the autoantibody...

journal_title：Ophthalmic research

authors： Deeg CA,Hauck SM,Amann B,Pompetzki D,Altmann F,Raith A,Schmalzl T,Stangassinger M,Ueffing M

更新日期：2008-01-01 00:00:00

abstract：:The aqueous humors of 100 freshly enucleated rabbit eyes were assessed within 10 min postmortem by taking samples in the last stage of corneal dissection following the Dikstein-Maurice procedure. Aqueous levels of partial pressure of carbon dioxide (pCO2) averaged 58.2 +/- 8.5 mm Hg to give calculated tCO2 and bicarbo...

journal_title：Ophthalmic research

authors： Doughty MJ

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Mesopic conditions elicit both rod and cone responses, and they are more commonly encountered in daily life than are scotopic conditions; yet visual function outcome measures of mesopic visual acuity (VA) or contrast sensitivity (CS) are rarely evaluated. OBJECTIVE:In retinitis pigmentosa (RP), we explored ...

journal_title：Ophthalmic research

authors： Bittner AK,Ferraz MC

更新日期：2020-01-01 00:00:00

abstract：:The crystalline lens capsules of eye bank eyes, intraocular lens (IOL)-inserted eyes and those of monkey and rabbit eyes were observed in vivo and/or in vitro through a specular microscope or Scheimpflug slit images in combination with new image-processing techniques and scanning electron microscopy. Shagreen patterns...

journal_title：Ophthalmic research

authors： Sasaki K,Kojima M,Hara T

更新日期：1988-01-01 00:00:00

abstract：PURPOSE:To compare the effects between intravitreal and periocular injections of adenoviral vectored pigment epithelium-derived factor (AdPEDF) on suppressing established choroidal neovascularization (CNV) in rats. METHODS:Sixty-eight female BN rats (136 eyes) aged 6-8 weeks were involved in this study. The CNV animal...

journal_title：Ophthalmic research

authors： Yan H,Cui J,Wang Y,Yu Y

更新日期：2013-01-01 00:00:00

abstract：:In order to know the correlation of a drug with high affinity to melanin in the iris ciliary body with the amount of melanin contained in the iris ciliary tissues, an in vivo study was performed on pigmented rabbits with brown or blue irises and albino rabbits. The melanin concentrations in the iris ciliary bodies of ...

journal_title：Ophthalmic research

authors： Fukuda M,Sasaki K

更新日期：1994-01-01 00:00:00

abstract：:The topographic distribution of enzyme activities in normal rat lenses and their changes occurring during naphthalene cataract development were investigated. Cataract formation was documented by slit images according to the Scheimpflug principle. Before the onset of visible changes and after the development of early v...

journal_title：Ophthalmic research

authors： Kojima M

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND/AIMS:By the release of antiangiogenic factors, Müller glial cells provide an angiostatic environment in the normal and ischemic retina. We determined whether Müller cells produce thrombospondin-1 (TSP-1), a known inhibitor of angiogenesis. METHODS:Secretion of TSP-1 by cultured Müller cells was determined w...

journal_title：Ophthalmic research

authors： Yafai Y,Eichler W,Iandiev I,Unterlauft JD,Jochmann C,Wiedemann P,Bringmann A

更新日期：2014-01-01 00:00:00

abstract：:HY-1 genotype chick lenses display epithelial hyperplasia and associated lens opacities. Membrane proteins from HY-1 and normal chick lenses were separated by isoelectric focusing, and 45Ca2+ binding capacities were determined. Markedly higher (congruent to 900-fold) binding of 45Ca2+ was observed in high molecular we...

journal_title：Ophthalmic research

authors： Odeigah PG,Patmore L

更新日期：1985-01-01 00:00:00

abstract：:The pineal organ of the pike is a functional photoreceptive organ in which a multiplicity of the cells of the receptor line (CRL i.e. typical and modified photoreceptors) was demonstrated. The CRL appeared to be (i) regionally distributed, (ii) photosensitive, and (iii) responsible for the storage of various indoles (...

journal_title：Ophthalmic research

authors： Falcón J

更新日期：1984-01-01 00:00:00

abstract：:Adult human lenses with focal opacities were processed for normal as well as freeze fracture electron microscopy. Cholesterol was demonstrated using filipin cytochemistry. Filipin cytochemistry in combination with freeze fracture revealed that the amount of cholesterol in the normal fibre membranes was fully comparabl...

journal_title：Ophthalmic research

authors： VanMarle J,Vrensen GF

更新日期：2000-11-01 00:00:00

abstract：PURPOSE:To investigate the effect of vitreomacular adhesion (VMA) on the outcome of antiangiogenic treatment for neovascular age-related macular degeneration (AMD). METHODS:Ninety-nine eyes of 83 patients were used in our cohort study. We prospectively evaluated best corrected visual acuity (BCVA) and central retinal ...

journal_title：Ophthalmic research

authors： Kanadani TCM,Dos Reis Veloso CE,Dorairaj S,Nehemy MB

更新日期：2017-01-01 00:00:00

abstract：:During the process of terminal differentiation, the fibre cells in the eye lens undergo many changes that are reminiscent of apoptotic/necrotic changes. Mitochondria, for instance, undergo permeability transition and nuclear degradation is accompanied by chromatin condensation, disintegration of the nucleolus, dissolu...

journal_title：Ophthalmic research

authors： Dahm R

更新日期：1999-01-01 00:00:00

abstract：:The development and extension of fibrovascular or fibroglial membranes onto the retinal surface are a major cause of visual loss in diabetic patients with proliferative retinopathy and in patients suffering from retinal detachment with proliferative vitreoretinopathy. The pathogenesis of these proliferative diseases, ...

journal_title：Ophthalmic research

authors： Fredj-Reygrobellet D,Baudouin C,Nègre F,Caruelle JP,Gastaud P,Lapalus P

更新日期：1991-01-01 00:00:00

abstract：:Low intensity diffuse white fluorescent light (1,000 lx for 2 h) exclusively induced photoreceptor damage in the inferior retina of albino rats; the temporal retina showed extensive damage, whereas the nasal retina revealed threshold lesions prior to recovery. To expand our morphological data, further experiments were...

journal_title：Ophthalmic research

authors： de Raad S,Szczesny PJ,Munz K,Remé CE

更新日期：1996-01-01 00:00:00

abstract：:The ophthalmic examination of patients with hypertrophic cardiomyopathy treated with high doses of verapamil over a considerable period of time showed no evidence of a side effect of the drug, thus proving its ocular safety. This could be verified by densitometric image analysis of Scheimpflug photographs of the eyes....

journal_title：Ophthalmic research

authors： Hockwin O,Dragomirescu V,Laser H,Ohrloff C,Kozamanoglu K,Kremer F

更新日期：1984-01-01 00:00:00

abstract：AIMS:Biomaterials are widely used in ophthalmology, and biodegradable polymers have been evaluated for use in surgery, tissue engineering and targeted drug delivery. We examined the tissue reactions attributable to 3 biodegradable polymers in the rat eye. METHODS:Inion GTR™ membrane [a blend of 85:15 poly(L-lactide-co...

journal_title：Ophthalmic research

authors： Rönkkö S,Kaarniranta K,Kalesnykas G,Uusitalo H

更新日期：2011-01-01 00:00:00

abstract：:Substance P (SP) immunoreactivity was demonstrated using the indirect immunofluorescence technique in one normal and one retinoblastomatous human retina. In the normal retina SP immunoreaction was located in nerve fibres but not in the neurons in the inner plexiform layer. A similar location was observed in the histol...

journal_title：Ophthalmic research

authors： Tarkkanen A,Tervo T,Tervo K,Eränkö L,Eränkö O,Cuello AC

更新日期：1983-01-01 00:00:00

abstract：:The purpose of this study was to determine the expression of metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in the aqueous humour of patients with exfoliation syndrome (XFS). XFS and control samples were analysed for their MMP content by zymography and for their tissue inhibitors by ELISA. In XFS eyes, ...

journal_title：Ophthalmic research

authors： Gartaganis SP,Georgakopoulos CD,Mela EK,Exarchou A,Ziouti N,Assouti M,Vynios DH

更新日期：2002-05-01 00:00:00

abstract：:Exposure of mice to hyperbaric oxygen leads to an inhibition of the mitotic activity in the germinative epithelium of the lens. This is followed by an eventual development of cataracts. Cataracts have also been observed in human beings treated with hyperbaric oxygen for different afflictions. The lens damage and catar...

journal_title：Ophthalmic research

authors： Varma SD,Richards RD

更新日期：1988-01-01 00:00:00

abstract：:The aim of the present study was to investigate biochemical and morphological changes in rat lenses following long-term UV B irradiation. After an irradiation period of 156 days with follow-up documentation by means of Scheimpflug photography, section-related biochemical analyses of the lenses as well as histological ...

journal_title：Ophthalmic research

authors： Schmidt J,Schmitt C,Kojima M,Hockwin O

更新日期：1992-01-01 00:00:00

abstract：:The tear levels of cholesterol of 17 patients with chronic blepharitis and 17 healthy subjects were determined by the photometric method. The mean cholesterol level of the patients was determined to be 56.1 +/- 8.9 (SEM) mg/dl. No statistically significant difference between the tear cholesterol levels of the two grou...

journal_title：Ophthalmic research

authors： Saatçi AO,Irkeç M,Unlü N

更新日期：1990-01-01 00:00:00

abstract：:We examined 304 conjunctiva in 152 subjects by clinical, cytologic, and bacteriologic methods. Bacteriologic samples were evaluated after a 48-hour incubation. Bacterial growth was found in 8 (20.5%) of 39 patients with clinically normal conjunctiva and no polymorphonuclear leukocytes (PMNs), and in 8 (61.5%) of 13 su...

journal_title：Ophthalmic research

authors： Ugomori S,Hayasaka S,Setogawa T

更新日期：1991-01-01 00:00:00

abstract：:Toxoplasma gondii is an extremely successful opportunistic parasite which infects approximately one third of the human population worldwide. The impact of this parasite on human health becomes particularly manifest in congenital damage with infection and subsequent inflammation of neuronal tissues including the retina...

journal_title：Ophthalmic research

authors： Pleyer U,Schlüter D,Mänz M

更新日期：2014-01-01 00:00:00

abstract：:Cellular immune responses in retinal autoimmunity have scarcely been studied in rabbits. An effective isolation of rabbit peripheral blood lymphocytes is difficult to achieve and requires specific conditions. This hampers especially the assay of antigen-induced lymphocyte transformation. We have improved the lymphocyt...

journal_title：Ophthalmic research

authors： Broekhuyse RM,Van Vugt AH

更新日期：1989-01-01 00:00:00

abstract：PURPOSE:To examine melanocortin receptor (from MC-1 to MC-5) mRNA and the effect of alpha-melanocyte-stimulating hormone (alpha-MSH) on interleukin 8 (IL-8) and monocyte chemotactic protein 1 (MCP-1) expression in a human retinal pigment epithelial cell line (ARPE-19) stimulated with IL-1beta or tumor necrosis factor a...

journal_title：Ophthalmic research

authors： Cui HS,Hayasaka S,Zhang XY,Chi ZL,Hayasaka Y

更新日期：2005-09-01 00:00:00

abstract：PURPOSE:To investigate therapeutic ocular surface medium (TOSM), a potential physiological tear replacement therapy, for persistent epithelial defect (PED). METHODS:11 eyes of 10 patients with PED for ≥ 2 weeks without improvement despite conventional treatment were enrolled in a prospective pilot study of TOSM over 1...

journal_title：Ophthalmic research

authors： Watson SL,Geerling G,Dart JK

更新日期：2014-01-01 00:00:00