Postmortem evaluation of rabbit aqueous humor partial pressure of carbon dioxide, total carbon dioxide, bicarbonate, partial pressure of oxygen and ionized calcium levels.

abstract：:Rat lenses with experimentally induced cataract (either by naphthalene or by streptozotocin) were analyzed biochemically. Both noxae had some effects in common. Water-soluble protein and aldose reductase activity decreased, and glucose-6-phosphate dehydrogenase, phosphofructokinase and glutathione reductase activity i...

journal_title：Ophthalmic research

authors： Korte I,Hockwin O,Bours J,Wegener A

更新日期：1988-01-01 00:00:00

abstract：PURPOSE:To investigate the association between retinal neovascularization and the CC chemokine receptor-3 (CCR3) in a mouse model of oxygen-induced retinopathy (OIR). METHODS:An OIR model in C57BL/6J mice was used as a retinal neovascularization model. An enzyme-linked immunosorbent assay was performed to evaluate the...

journal_title：Ophthalmic research

authors： Hirahara S,Nozaki M,Ohbayashi M,Hasegawa N,Ozone D,Ogura Y

更新日期：2017-01-01 00:00:00

abstract：:The ultrastructure of optic nerve axons was examined in several mammals (human, cat, rat, sheep, ox, pig, guinea pig, rabbit). Human material was obtained from normotensive, glaucoma-free eyes and from eyes with a history of glaucoma and raised intra-ocular pressure (IOP). We describe accumulations of organelles (prin...

journal_title：Ophthalmic research

authors： Holländer H,Makarov F,Stefani FH,Stone J

更新日期：1995-01-01 00:00:00

abstract：:The development and extension of fibrovascular or fibroglial membranes onto the retinal surface are a major cause of visual loss in diabetic patients with proliferative retinopathy and in patients suffering from retinal detachment with proliferative vitreoretinopathy. The pathogenesis of these proliferative diseases, ...

journal_title：Ophthalmic research

authors： Fredj-Reygrobellet D,Baudouin C,Nègre F,Caruelle JP,Gastaud P,Lapalus P

更新日期：1991-01-01 00:00:00

abstract：:The rate of reepithelialization of the rabbit cornea, receiving isotonic NaCl solution and acetylcysteine (Mucomyst) solution at 10 and 20% concentrations, following a superficial epithelial ulcer was studied by fluorescein staining, photography and light microscopy. Acetylcysteine solution does not seem to retard nor...

journal_title：Ophthalmic research

authors： Petroutsos G,Guimaraes R,Giraud JP,Renard G,Pouliquen Y

更新日期：1982-01-01 00:00:00

abstract：BACKGROUND/AIMS:To evaluate the safety of suramin compared with mitomycin-C (MMC) as an adjunctive agent in trabeculectomy by determining its ciliary body toxicity at predetermined effective dosages in rabbit eyes. METHODS:Thirty-two New Zealand albino rabbits received either suramin (200, 300, 400, or 800 mg/ml) or M...

journal_title：Ophthalmic research

authors： Cetinkaya A,Akman A,Take G,Bilezikci B,Akova YA

更新日期：2009-01-01 00:00:00

abstract：:A technique for chronic implantation of a device for long-term continuous, quantitative monitoring of intraocular pressure (IOP) in experimental animals is presented. The methodology employed is straight forward and should be easily duplicated for experimental investigations where such monitoring might be useful. Cont...

journal_title：Ophthalmic research

authors： Flower RW,Maumenee AE,Michelson EA

更新日期：1982-01-01 00:00:00

abstract：:This study examined and characterized the distribution and kinetics of the inflammatory cell response to pseudomonas ocular challenge in susceptible C57BL/6J and resistant DBA/2J mice. Initially, in the cornea, the number of neutrophilic leukocytes (PMNs), macrophages/monocytes or lymphocytes was 2-2.5 times greater i...

journal_title：Ophthalmic research

authors： Hazlett LD,Zucker M,Berk RS

更新日期：1992-01-01 00:00:00

abstract：:Statistically significant differences were found to exist in the frequencies of abnormal cell types in cultured lenses depending on the composition of the nutrient media (Eagle's and Dulbecco's modified essential medium with fetal calf serum FCS) they were cultured on. Abnormal cell growth (epithelioid, fibroblast-lik...

journal_title：Ophthalmic research

authors： Veroman S,Viikmaa M

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVE:Transient receptor potential canonical (TRPC) channels are involved in neovascularization repairing after vascular injury in many tissues. However, whether TRPCs play a regulatory role in the development of diabetic retinopathy (DR) has rarely been reported. In the present study, we selected TRPC1, 3, and 6 t...

journal_title：Ophthalmic research

authors： Lang HB,Xie RX,Huang ML,Fang LY,Tang YB,Zhang F

更新日期：2020-01-01 00:00:00

abstract：PURPOSE:To evaluate the effect of transpupillary thermotherapy (TTT) on foveal thickness and macular function in eyes with choroidal neovascularization (CNV) associated with age-related macular degeneration. METHODS:Sixteen eyes with occult CNV and 6 eyes with classic CNV were treated with TTT. Optical coherence tomog...

journal_title：Ophthalmic research

authors： Ishikawa K,Terasaki H,Kobayashi C,Niwa Y,Piao CH,Ito Y,Kondo M,Miyake Y

更新日期：2005-01-01 00:00:00

abstract：:Animal models are indispensable for pharmaceutical investigations. However, investigators often have difficulty choosing the appropriate modal for their research. To provide a comprehensive and convenient source of information about animal models of proliferative vitreoretinopathy (PVR), the current review sorted and ...

journal_title：Ophthalmic research

authors： Hou H,Nudleman E,Weinreb RN

更新日期：2018-01-01 00:00:00

abstract：:The ophthalmic examination of patients with hypertrophic cardiomyopathy treated with high doses of verapamil over a considerable period of time showed no evidence of a side effect of the drug, thus proving its ocular safety. This could be verified by densitometric image analysis of Scheimpflug photographs of the eyes....

journal_title：Ophthalmic research

authors： Hockwin O,Dragomirescu V,Laser H,Ohrloff C,Kozamanoglu K,Kremer F

更新日期：1984-01-01 00:00:00

abstract：:Cholinergic agents used to lower intraocular pressure in the medical management of glaucoma act on muscarinic receptors in the eye. Recently, subtypes of muscarinic receptors have been recognized in many tissues including the eye. To localize the M3 muscarinic receptor subtype and m3 messenger RNA (mRNA) in the human ...

journal_title：Ophthalmic research

authors： Gupta N,Drance SM,McAllister R,Prasad S,Rootman J,Cynader MS

更新日期：1994-01-01 00:00:00

abstract：PURPOSE:To assess the natural variability in the diameter of small collagen fibrils in the lamellae of corneal stroma of healthy young rabbits. MATERIALS AND METHODS:The corneas of 6 young adult female New Zealand White rabbits (2.1 kg) were prepared for transmission electron microscopy (TEM) by fixation with a cacody...

journal_title：Ophthalmic research

authors： Doughty MJ,Bergmanson JP

更新日期：2006-01-01 00:00:00

abstract：:We examined the density and morphology of lens epithelial cells (LECs) in vivo in a group of normal volunteers and cataract patients by using a newly developed noncontact specular microscope. There was a statistically significant decrease in the cell density of LECs in a group of cataract patients over the age of 80 y...

journal_title：Ophthalmic research

authors： Oharazawa H,Ibaraki N,Matsui H,Ohara K

更新日期：2001-11-01 00:00:00

abstract：PURPOSE:To demonstrate the value of the laser-scanning optical-resolution (LSOR)-photoacoustic (PA) microscopy (PAM) system and the conventional multimodal imaging techniques in the evaluation of laser-induced retinal injury and choroidal neovascularization (CNV) in rats. METHODS:Different degrees of retinal injury we...

journal_title：Ophthalmic research

authors： Xiao M,Dai C,Li L,Zhou C,Wang F

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the effect of C constant for ray tracing-assisted intraocular lens (IOL) power calculation in the patients with different refractive power, we compared the refractive outcome of ray-tracing method based on C constant and conventional IOL calculation formula. METHODS:215 eyes which underwent phaco...

journal_title：Ophthalmic research

authors： Chang P,Zhang F,Wang J,Zhao Y

更新日期：2020-04-20 00:00:00

abstract：:Cellular immune responses in retinal autoimmunity have scarcely been studied in rabbits. An effective isolation of rabbit peripheral blood lymphocytes is difficult to achieve and requires specific conditions. This hampers especially the assay of antigen-induced lymphocyte transformation. We have improved the lymphocyt...

journal_title：Ophthalmic research

authors： Broekhuyse RM,Van Vugt AH

更新日期：1989-01-01 00:00:00

abstract：:Epinephrine (1, 3 and 10 micrograms/kg) was found to increase retinal and choroidal blood flow (22, 49 and 67%) when it was administered intravenously. The increase in retinal and choroidal blood flow coincided well with the increase in systemic blood pressure (44, 65 and 96%, respectively). When epinephrine (2%) was ...

journal_title：Ophthalmic research

authors： Chiou GC,Girgis Z,Chiou FY

更新日期：1988-01-01 00:00:00

abstract：PURPOSE:To establish a retinal blood flow database in normal human eyes using the Canon Laser Blood Flowmeter (CLBF). METHOD:Fourteen healthy subjects (7 males, 7 females) between the ages of 24 and 33 underwent birectional laser Doppler velocimetry (BLDV) in one eye using the CLBF. Measurements consisting of blood ve...

journal_title：Ophthalmic research

authors： Garcia JP Jr,Garcia PT,Rosen RB

更新日期：2002-09-01 00:00:00

abstract：PURPOSE:To investigate whether different crush durations or a different fluorogold (FG) injection timing can affect the efficiency of FG retrograde labeling of retinal ganglion cells (RGCs) in the optic nerve (ON) crush model. METHODS:We performed the ON crush in rats with a clip at different durations or a jewel forc...

journal_title：Ophthalmic research

authors： Huang TL,Huang SP,Chang CH,Lin KH,Sheu MM,Tsai RK

更新日期：2014-01-01 00:00:00

abstract：PURPOSE:The possibility of providing cultured corneal endothelial cells (CECs) for clinical transplantation has gained much attention. However, the worldwide need for human (h) donor corneas far exceeds supply. The pig (p) might provide an alternative source. The aim of this study was to compare the proliferative capac...

journal_title：Ophthalmic research

authors： Fujita M,Mehra R,Lee SE,Roh DS,Long C,Funderburgh JL,Ayares DL,Cooper DK,Hara H

更新日期：2013-01-01 00:00:00

abstract：PURPOSE:To investigate the effects, and their reversibility, of multiple oral voriconazole doses on a variety of visual tests in healthy male volunteers. METHODS:Single-center, double-blind, randomized, placebo-controlled, parallel-group study in 36 volunteers who received voriconazole (n=18, 400 mg every 12 h on day ...

journal_title：Ophthalmic research

authors： Zrenner E,Tomaszewski K,Hamlin J,Layton G,Wood N

更新日期：2014-01-01 00:00:00

abstract：:The eyes of 200 rats (Mol:SPRD, Moellegaard Ltd., Skensvet, Denmark), 8 weeks of age and of both sexes, were examined routinely with a photo-slitlamp microscope (Zeiss) and opthalmoscope (Heine) 3-4 times in the course of four different 12-week toxicity studies. The animals were kept under constant lighting conditions...

journal_title：Ophthalmic research

authors： Wegener A,Jochims K

更新日期：1994-01-01 00:00:00

abstract：AIM:Ultraviolet (UV) B irradiation induces gene expression that leads to skin cancer. Among the transcription factors induced by UVB radiation exposure, the cyclic AMP response element-binding protein (CREB) is significant. Since several factors downstream of CREB signaling are known to be involved in pterygium pathoge...

journal_title：Ophthalmic research

authors： Nubile M,Curcio C,Lanzini M,Calienno R,Iezzi M,Mastropasqua A,Di Nicola M,Mastropasqua L

更新日期：2013-01-01 00:00:00

abstract：:In order to develop a more adequate ultraviolet (UV)-induced cataract model, a combination of l-buthionine sulfoximine (BSO) treatment was applied to experimental animals. A single administration of BSO 4 mmol/kg caused reduced glutathione concentration until experimental day 8. In the 0.067-J/cm2 UV-B irradiation exp...

journal_title：Ophthalmic research

authors： Hatano T,Kojima M

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVE:Weak oxidants produced by activated human leukocytes are proven antimicrobial substances. We tested whether N-chlorotaurine (NCT, taurine chloramine), the chlorinated metabolite of the amino acid taurine, in addition to direct virucidal effects on viral suspensions, has the capability to prevent cell-to-cell ...

journal_title：Ophthalmic research

authors： Huemer HP,Nagl M,Irschick EU

更新日期：2010-01-01 00:00:00

abstract：:The purpose of this study was to determine the expression of metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in the aqueous humour of patients with exfoliation syndrome (XFS). XFS and control samples were analysed for their MMP content by zymography and for their tissue inhibitors by ELISA. In XFS eyes, ...

journal_title：Ophthalmic research

authors： Gartaganis SP,Georgakopoulos CD,Mela EK,Exarchou A,Ziouti N,Assouti M,Vynios DH

更新日期：2002-05-01 00:00:00

abstract：PURPOSE:The aim of this study was to evaluate the choroidal thickness (CT) and its determinants in primary angle closure glaucoma (PACG) eyes with and without malignant glaucoma (MG). METHODS:In this cross-sectional study, we enrolled 25 patients with bilateral primary angle closure (PAC) diseases; 1 eye of each patie...

journal_title：Ophthalmic research

authors： Chen X,Guo X,Xu X,Xiao H,Liu X

更新日期：2018-01-01 00:00:00