Abstract:
:We examined the density and morphology of lens epithelial cells (LECs) in vivo in a group of normal volunteers and cataract patients by using a newly developed noncontact specular microscope. There was a statistically significant decrease in the cell density of LECs in a group of cataract patients over the age of 80 years. The coefficient of variation of the cell area and the number of large black spots that were observed in the enhanced specular images were not related to aging or cataract formation. Our data indicate that the cell density of LECs decreases after reaching the age of 80, but cataract formation does not affect the cell density or the coefficient of variation of the cell area until the age of 80.
journal_name
Ophthalmic Resjournal_title
Ophthalmic researchauthors
Oharazawa H,Ibaraki N,Matsui H,Ohara Kdoi
10.1159/000055694subject
Has Abstractpub_date
2001-11-01 00:00:00pages
363-6issue
6eissn
0030-3747issn
1423-0259pii
ore33363journal_volume
33pub_type
杂志文章abstract::Cataractous lens images taken with different camera types for retroillumination photography were compared. Images taken by conventional photo slitlamp and fundus cameras were not suitable for image analysis. Retroillumination photography with a conventional fundus camera with additional polarizing filters seemed to be...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267063
更新日期:1990-01-01 00:00:00
abstract::Using cuprolinic blue staining, we histochemically examined the ultrastructural localization of proteoglycans in the fibrous-type human posterior capsule opacification. This capsule opacification contained proteoglycans that showed positive staining with cuprolinic blue. Many cuprolinic-blue-positive filaments were pr...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267707
更新日期:1995-01-01 00:00:00
abstract::In a search for a pharmacologic adjuvant in the management of posttraumatic proliferative vitreoretinopathy (PVR), we investigated the effect of intravitreal injection of prinomastat (AG3340) on an experimental model. Posterior penetrating eye trauma was created in one eye each of 24 New Zealand white rabbits. One wee...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000055636
更新日期:2001-01-01 00:00:00
abstract::To study the mode of riboflavin metabolism in the lens in vivo, the uptake of 14C-labeled riboflavin and synthesis of ester forms from 14C-riboflavin were assayed in the single whole lens of the rats. 14C-riboflavin uptake increased in proportion to the substrate concentration in the incubation medium, reaching a plat...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265249
更新日期:1983-01-01 00:00:00
abstract::The seasonal variation in the incidence of retinal detachment over the period from 1981 to 1987 inclusive was investigated. Highly significant associations were observed between this variation and both sunshine and temperature. Hence, it is suggested that heat or cold may be important additional factors in the develop...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267026
更新日期:1990-01-01 00:00:00
abstract::The ophthalmic examination of patients with hypertrophic cardiomyopathy treated with high doses of verapamil over a considerable period of time showed no evidence of a side effect of the drug, thus proving its ocular safety. This could be verified by densitometric image analysis of Scheimpflug photographs of the eyes....
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265327
更新日期:1984-01-01 00:00:00
abstract::Ocular pneumoplethysmography was performed before and after 1,737 carotid endarterectomies, 82% of which were performed for carotid lesions of hemodynamic consequence. Preoperative ocular hypoperfusion without ischemia was associated with at least transient postoperative ocular hyperemia. A difference in ocular volume...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000055558
更新日期:1999-01-01 00:00:00
abstract::Cellular events in the rat conjunctiva were studied at 1, 6 and 24 h following the topical application of leukotriene B4. A significant increase was noted in the number of eosinophils (p less than 0.01) and neutrophils (p less than 0.05) at 1 h and only in eosinophils at 6 h after leukotriene B4 application at the 2-m...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000266873
更新日期:1989-01-01 00:00:00
abstract::Lenticular S-adenosylmethionine synthetase has been partially purified and characterized. Lower levels of S-adenosylmethionine synthetase were detected by a sensitive radioactive assay procedure in the lenticular extract obtained from the pooled lenses of alloxan-treated rats 96 days of age as compared to the nontreat...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265169
更新日期:1982-01-01 00:00:00
abstract:PURPOSE:To describe the characteristics of macular lesions after eye trauma using spectral-domain optical coherence tomography (OCT). METHODS:We retrospectively reviewed and described 2-dimensional (2D) and 3-dimensional (3D) spectral-domain OCT characteristics of 24 consecutive eyes of 24 cases that were identified w...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000325732
更新日期:2012-01-01 00:00:00
abstract:INTRODUCTION:Diabetic Retinopathy (DR) is one of the major vision-threatening causes worldwide. Searching for an individualized therapeutic strategy to prevent its progress is challenging. OBJECTIVE:This work aimed to investigate the association of angiogenesis-inducer vascular endothelial growth factor (VEGF) gene fa...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000511087
更新日期:2020-08-24 00:00:00
abstract:PURPOSE:To investigate whether different crush durations or a different fluorogold (FG) injection timing can affect the efficiency of FG retrograde labeling of retinal ganglion cells (RGCs) in the optic nerve (ON) crush model. METHODS:We performed the ON crush in rats with a clip at different durations or a jewel forc...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000357736
更新日期:2014-01-01 00:00:00
abstract:PURPOSE:To propose a new noncontact tonometer based on corneal photoelasticity. METHOD:In this study, we experimented with 18 enucleated porcine eyes. The anterior chamber was infused with a physiological solution. A circular polarizing filter was attached to an ophthalmic surgical microscope. Color fringe changes at ...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000320600
更新日期:2011-01-01 00:00:00
abstract:PURPOSE:Primary open-angle glaucoma (POAG) is a chronic progressive optic neuropathy, leading to degeneration of retinal ganglion cells and characteristic morphological changes at the optic disc. In advanced stages of the disease, functional tests, such as standard automated perimetry (SAP), are the main diagnostic too...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000501693
更新日期:2020-01-01 00:00:00
abstract:AIMS:To investigate whether allogeneic limbal mesenchymal stem cell (LMSC) therapy affects corneal healing after a severe chemical burn and whether the route of administration of LMSCs differs in its therapeutic effect in this respect. METHODS:A total of 60 Sprague-Dawley rats with clinically proven alkali injury were...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000368659
更新日期:2015-01-01 00:00:00
abstract:INTRODUCTION:The aim of this work was to describe the optical coherence tomography (OCT) angiography (OCTA) features in paediatric Leber-Coats disease. METHODS:Three children presenting with unilateral, clinically active Leber-Coats disease were evaluated using spectral domain OCT and OCTA. OCT angiograms were analyse...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000478783
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:To evaluate diabetic retinopathy (DR) progression in patients with diabetes mellitus type 2 in 2 populations of different ethnicity. METHODS:A prospective observational study was designed to follow eyes/patients with mild nonproliferative DR, for 2 years or until the development of central-involved macular ede...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000484666
更新日期:2018-01-01 00:00:00
abstract::To evaluate the effect of single or repeated topical applications of prostaglandin E2 (PGE2) to the cornea on the blood-aqueous barrier, we have measured the extent of flare in the anterior chamber of rabbit eyes at various time intervals. PGE2 was applied to the cornea for 4 min with the use of a glass cylinder in pi...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267895
更新日期:1996-01-01 00:00:00
abstract::Inflammation is substantially contributing to the development and worsening of diabetic retinopathy in general and diabetic macular edema (DME) in particular, which provides the rationale to treat DME with corticosteroids. While anti-vascular endothelial growth factor (VEGF) agents are mostly chosen as a first-line tr...
journal_title:Ophthalmic research
pub_type: 杂志文章,评审
doi:10.1159/000499540
更新日期:2019-01-01 00:00:00
abstract:AIM:The aim of the current study is to evaluate the role of povidone iodine (PVI) in the management of experimental bacterial endophthalmitis in young rabbits. METHOD:Twenty white rabbits were used. Colony-forming units (CFU) of Staphylococcus epidermidis were injected intravitreally into the right eye of each animal....
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000217721
更新日期:2009-01-01 00:00:00
abstract::Age-related lens opacity is the major cause of loss of vision affecting more than half of the world's blind. The development of cataract is associated with changes in the structure of the lens. The lens consists largely of closely packed fibre cells forming a transparent syncytium. The main intrinsic polypeptide (MIP)...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267974
更新日期:1996-01-01 00:00:00
abstract::The influence of nonselective and selective alpha-adrenergic agonists on intraocular pressure (IOP) was studied in isolated arterially perfused rabbit eyes. Drugs were given intra-arterially or topically. With either route of administration, no initial hypertensive phase was observed after l-epinephrine, l-norepinephr...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265400
更新日期:1985-01-01 00:00:00
abstract::Cataract is the leading cause of blindness worldwide. It is a multifactorial disease primarily associated with oxidative stress produced by free radicals. The protection offered by various antioxidants in cataract development is well established. Polyphenolic compounds present in green tea (Camellia sinensis) are repo...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000063881
更新日期:2002-07-01 00:00:00
abstract::To determine the effect of interleukin-10 (IL-10) and transforming growth factor-beta (TGF-beta) on the down-regulation of MHC class II antigens, bovine retinal pigment epithelial (RPE) cells were incubated with interferon-gamma (IFN-gamma) in different concentrations. Subsequently, the IFN-gamma pretreated RPE cells ...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000055545
更新日期:1999-01-01 00:00:00
abstract::Ibudilast selectively vasodilates cerebral vessels without reducing blood pressure. We investigated the effect of the drug on retinal circulation in 8 patients with diabetes mellitus, using the video-densitometric image analysis of fluorescein angiography. We compared the build up time, the time constant of washout ra...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267168
更新日期:1992-01-01 00:00:00
abstract:AIM/BACKGROUND:A 1-bp deletion (1147delA) in the SAG (also known as arrestin or S-antigen) gene is the most frequently seen mutation in Japanese patients suffering from Oguchi disease, a recessively inherited stationary night blindness. We investigated macular function in a patient with Oguchi disease with the 1147delA...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000325024
更新日期:2011-10-01 00:00:00
abstract:PURPOSE:To characterize the 1-year progression of retinal thickness (RT) increase occurring in eyes with subclinical macular edema in type 2 diabetes. METHODS:Forty-eight type 2 diabetic eyes/patients with mild nonproliferative diabetic retinopathy (NPDR; levels 20 and 35 in the Early Treatment Diabetic Retinopathy St...
journal_title:Ophthalmic research
pub_type: 杂志文章,多中心研究
doi:10.1159/000438793
更新日期:2015-01-01 00:00:00
abstract::Oxidative stress plays a role in the pathogenesis of neurodegeneration in diabetic retinopathy (DR). However, whether an excellent reactive oxygen species scavenger, U83836E, inhibits the neurodegeneration in DR remains uncertain. This study is aimed at clarifying the effects of U83836E on DR. Two weeks after streptoz...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000321952
更新日期:2011-01-01 00:00:00
abstract::Lipid peroxidation was induced with porcine retinal homogenates using ferric iron or UV light. A number of lipid and aqueous-soluble antioxidants were tested and their protective effects measured after 60 min of exposure. The iron system produced up to 5 times more lipid hydroperoxides as quantified by the fluorescenc...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267103
更新日期:1991-01-01 00:00:00
abstract::Equine recurrent uveitis (ERU) is an autoimmune disease that occurs with a high prevalence (10%) in horses. ERU represents the only reliable spontaneous model for human autoimmune uveitis. We already identified and characterized novel autoantigens (malate dehydrogenase, recoverin, CRALBP) by analyzing the autoantibody...
journal_title:Ophthalmic research
pub_type: 杂志文章,评审
doi:10.1159/000119867
更新日期:2008-01-01 00:00:00