The effect of prinomastat (AG3340), a synthetic inhibitor of matrix metalloproteinases, on posttraumatic proliferative vitreoretinopathy.

abstract：PURPOSE:This study was aimed at determining the intraocular pharmacokinetics based on molecular physicochemical properties in a rabbit model. METHODS:The entire dataset was obtained from previous literature, and research articles regarding 70 molecular compounds were investigated. The intravitreal half-lives in rabbit...

journal_title：Ophthalmic research

authors： Kim HM,Park KH,Chung JY,Woo SJ

更新日期：2020-01-01 00:00:00

abstract：:VEGF is considered as an important factor in the pathogenesis of macular edema. VEGF induces the rupture of the blood retinal barrier and may also influence the retinal pigment epithelial (RPE) outer retinal barrier. The aim of this work was to analyze the influence of the VEGF receptor pathways in the modulation of t...

journal_title：Ophthalmic research

authors： Miyamoto N,de Kozak Y,Normand N,Courtois Y,Jeanny JC,Benezra D,Behar-Cohen F

更新日期：2008-01-01 00:00:00

abstract：:Two out of three normal eyes tested with frequent instillation of 30 microliters of drops of 0.5% bupranolol, a beta 1 + beta 2 blocking drug with some intrinsic sympathomimetic and local anesthetic activity, showed a miotic effect of the order of a 25% reduction of pupil area, as estimated by an open-loop iris-videor...

journal_title：Ophthalmic research

authors： Tsukahara S,Sasaki T,Yamabayashi S,Shimizu Y

更新日期：1986-01-01 00:00:00

abstract：:Local pO2 was measured close to the ciliary process of the rabbit eye using polarographic microelectrodes under microendoscopic observation. The experiments were performed in 5 anaesthetized New Zealand rabbits. Changes in local pO2, intraocular pressure (IOP) and blood flow velocity (BFV) were investigated after intr...

journal_title：Ophthalmic research

authors： Höper J,Funk RH

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND/AIMS:It has been suggested that eye makeup could interact with human meibum causing a decrease in the stability of the tear film. The aim of this pilot study was to measure makeup-human meibum interactions in vitro. METHODS:Human meibum-makeup interactions were quantified by measuring order-to-disorder lipi...

journal_title：Ophthalmic research

authors： Hunter M,Bhola R,Yappert MC,Borchman D,Gerlach D

更新日期：2015-01-01 00:00:00

abstract：:Dry eye is the most prominent pathology among those involving the ocular surface: a decrease of the aqueous (less frequent) or the lipid (more frequent) component of the tear film is the cause of the diminished stability of tears that is observed in this pathology. Dry eye shows a clear distribution linked to both sex...

journal_title：Ophthalmic research

authors： Rusciano D,Pezzino S,Olivieri M,Cristaldi M,Gagliano C,Lupo G,Anfuso CD

更新日期：2018-01-01 00:00:00

abstract：:The pathology of rainbow trout lenses incubated in various media and at various temperatures was examined by electron microscopy. After incubation at 0 degrees C for 5 h, no changes were observed in transparency and cytology. Irreversible warm cataract occurred at 37 degrees C, which corresponds to the body temperatur...

journal_title：Ophthalmic research

authors： Uga S,Ishikawa S,Hikida M,Iwata S

更新日期：1986-01-01 00:00:00

abstract：PURPOSE:To evaluate the corneal button of primary penetrating keratoplasty of patients diagnosed with congenital aniridia. The study took place at the Instituto Universitario Barraquer and the Centro de Oftalmología Barraquer. METHODS:A retrospective analysis of cases diagnosed with congenital aniridia was carried out...

journal_title：Ophthalmic research

authors： Bausili MM,Alvarez de Toledo J,Barraquer RI,Michael R,Tresserra F,de la Paz MF

更新日期：2016-01-01 00:00:00

abstract：:The main objective of this study was to determine the intraocular concentration of fluorescein after applying five eye drops with only 1-min intervals in human eyes. The concentration of fluorescein in corea and aqueous was studied with fluorophotometry in 11 healthy volunteers. Five 10-microliter drops of 2% fluoresc...

journal_title：Ophthalmic research

authors： Lindén C,Alm A

更新日期：1997-01-01 00:00:00

abstract：:The aqueous humors of 100 freshly enucleated rabbit eyes were assessed within 10 min postmortem by taking samples in the last stage of corneal dissection following the Dikstein-Maurice procedure. Aqueous levels of partial pressure of carbon dioxide (pCO2) averaged 58.2 +/- 8.5 mm Hg to give calculated tCO2 and bicarbo...

journal_title：Ophthalmic research

authors： Doughty MJ

更新日期：1993-01-01 00:00:00

abstract：:Diabetic macular edema is a common condition frequently encountered by ophthalmologists. In this piece we briefly review its definition, pathogenesis, clinical aspects, imaging, and treatment. ...

journal_title：Ophthalmic research

authors： Moisseiev E,Loewenstein A

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:Transient receptor potential canonical (TRPC) channels are involved in neovascularization repairing after vascular injury in many tissues. However, whether TRPCs play a regulatory role in the development of diabetic retinopathy (DR) has rarely been reported. In the present study, we selected TRPC1, 3, and 6 t...

journal_title：Ophthalmic research

authors： Lang HB,Xie RX,Huang ML,Fang LY,Tang YB,Zhang F

更新日期：2020-01-01 00:00:00

abstract：:The polyamines putrescine, spermidine and spermine have been proposed to be a part of the acute phase inflammatory response. They have been shown to be useful markers for cellular kinetics and change with various pathological conditions. The hypothesis that aqueous humor polyamines could be used to follow the time cou...

journal_title：Ophthalmic research

authors： Wickström K,Lundgren B,Törngren L,Ostberg C

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:Extensive clinical investigations of the biocompatibility of different intraocular lenses (IOLs) have been made in an effort to optimize the outcome of modern cataract surgery. The aim of this study was to add animal eye experimental implantation data regarding cellular reaction on the anterior surface of IOLs....

journal_title：Ophthalmic research

authors： Barbour W,Saika S,Miyamoto T,Ohnishi Y

更新日期：2005-09-01 00:00:00

abstract：:HY-1 genotype chick lenses display epithelial hyperplasia and associated lens opacities. Membrane proteins from HY-1 and normal chick lenses were separated by isoelectric focusing, and 45Ca2+ binding capacities were determined. Markedly higher (congruent to 900-fold) binding of 45Ca2+ was observed in high molecular we...

journal_title：Ophthalmic research

authors： Odeigah PG,Patmore L

更新日期：1985-01-01 00:00:00

abstract：:Cataract is the leading cause of blindness worldwide. It is a multifactorial disease primarily associated with oxidative stress produced by free radicals. The protection offered by various antioxidants in cataract development is well established. Polyphenolic compounds present in green tea (Camellia sinensis) are repo...

journal_title：Ophthalmic research

authors： Gupta SK,Halder N,Srivastava S,Trivedi D,Joshi S,Varma SD

更新日期：2002-07-01 00:00:00

abstract：:Soluble dextran polymer derivatives (CMDBSs) are originally synthesized as heparin-like plasma substitutes. Some of them mimic heparin in its interactions and stabilize, protect and facilitate actions of heparin binding growth factors. The wound healing activity of one specific CMDBS was studied in a model of corneal ...

journal_title：Ophthalmic research

authors： Fredj-Reygrobellet D,Hristova DL,Ettaiche M,Meddahi A,Jozefonwicz J,Barritault D

更新日期：1994-01-01 00:00:00

abstract：:We measured prostaglandin E2 (PGE2) and prostacyclin levels in the vitreous bodies of 5 eyes of patients with diabetic retinopathy complicated by rhegmatogenous retinal detachment (RRD) and compared them with the corresponding levels in 9 nondiabetic eyes with the same condition as well as with 10 control eyes of dece...

journal_title：Ophthalmic research

authors： Naveh N,Belkin M,Ben-Chaim O,Weissman C,Treister G

更新日期：1990-01-01 00:00:00

abstract：:A system for isolation of capillaries from the retina has been adapted to biochemical studies in vitro. Insulin receptors were identified in human and calf retinal blood vessels. Binding of 125I insulin by calf retinal blood vessels takes place through high affinity (low capacity) and low affinity (high capacity) rece...

journal_title：Ophthalmic research

authors： Cotlier E,Davidson C

更新日期：1983-01-01 00:00:00

abstract：:Cellular events in the rat conjunctiva were studied at 1, 6 and 24 h following the topical application of leukotriene B4. A significant increase was noted in the number of eosinophils (p less than 0.01) and neutrophils (p less than 0.05) at 1 h and only in eosinophils at 6 h after leukotriene B4 application at the 2-m...

journal_title：Ophthalmic research

authors： Trocmé SD,Gilbert CM,Allansmith MR,Bloch KJ,Abelson MB

更新日期：1989-01-01 00:00:00

abstract：PURPOSE:To evaluate the role of initial visual acuity (VA) as a potential prognostic factor for final VA in patients with branch retinal vein occlusion (BRVO). METHODS:A retrospective data analysis involving 163 patients with macular edema secondary to BRVO treated according to the recommendations of the Branch Vein O...

journal_title：Ophthalmic research

authors： Rehak J,Dusek L,Chrapek O,Fric E,Rehak M

更新日期：2011-01-01 00:00:00

abstract：:Low intensity diffuse white fluorescent light (1,000 lx for 2 h) exclusively induced photoreceptor damage in the inferior retina of albino rats; the temporal retina showed extensive damage, whereas the nasal retina revealed threshold lesions prior to recovery. To expand our morphological data, further experiments were...

journal_title：Ophthalmic research

authors： de Raad S,Szczesny PJ,Munz K,Remé CE

更新日期：1996-01-01 00:00:00

abstract：AIM:This study was done to evaluate the role of pentosidine in predicting the progression of diabetic retinopathy. PATIENTS AND METHODS:We included 30 subjects with insulin-dependent diabetes mellitus (type 1) and 10 healthy control individuals. A case control study was done. Full ophthalmological examination together...

journal_title：Ophthalmic research

authors： Salman AG,Mansour DE,Swelem AH,Al-Zawahary WM,Radwan AA

更新日期：2009-01-01 00:00:00

abstract：:In order to investigate the combined influence of age and light, the b-wave and oscillatory potentials (OPs) of the electroretinogram (ERG) were recorded in 1.5-, 7- and 12-month-old WAG/Rij rats, reared under homogenous low-intensity cyclic light exposure. Wistar albino rats of the same ages, reared under the same co...

journal_title：Ophthalmic research

authors： Cillino S,Guarneri R,Guarneri P,Pennica C,Chichi G,Piccoli F,Ponte F

更新日期：1993-01-01 00:00:00

abstract：:Vitamin E (d-alpha-tocopherol) and aspirin were evaluated for their effects on the phase separation temperature, Tc, of calf lens cytoplasm. Vitamin E and aspirin were added to nuclear homogenate and the change in Tc was measured. Aspirin had no measurable effect on Tc. Vitamin E lowered Tc at a rate of -22 degrees C ...

journal_title：Ophthalmic research

authors： Eccarius S,Clark JI

更新日期：1987-01-01 00:00:00

abstract：:Conventional Scheimpflug photography uses slits with a constant width of 80 microns. This parameter limits the resolution as sharp contours are imaged with a basic uncertainty. In order to reduce this basic uncertainty we developed an illumination slit with a width of 20 microns and less, using a green helium-neon las...

journal_title：Ophthalmic research

authors： Huebscher HJ,Möller DE,Seiler T

更新日期：1996-01-01 00:00:00

abstract：PURPOSE:To investigate therapeutic ocular surface medium (TOSM), a potential physiological tear replacement therapy, for persistent epithelial defect (PED). METHODS:11 eyes of 10 patients with PED for ≥ 2 weeks without improvement despite conventional treatment were enrolled in a prospective pilot study of TOSM over 1...

journal_title：Ophthalmic research

authors： Watson SL,Geerling G,Dart JK

更新日期：2014-01-01 00:00:00

abstract：PURPOSE:The aim of this study was to evaluate the choroidal thickness (CT) and its determinants in primary angle closure glaucoma (PACG) eyes with and without malignant glaucoma (MG). METHODS:In this cross-sectional study, we enrolled 25 patients with bilateral primary angle closure (PAC) diseases; 1 eye of each patie...

journal_title：Ophthalmic research

authors： Chen X,Guo X,Xu X,Xiao H,Liu X

更新日期：2018-01-01 00:00:00

abstract：:In corneal organ culture, a contamination of sterile culture media with endotoxin is frequently found. Thus, we investigated if the presence of endotoxin affects the viability of cultured porcine corneal endothelial cells. Endotoxin in high concentrations caused morphological cell changes in porcine corneal endothelia...

journal_title：Ophthalmic research

authors： Sobottka Ventura AC,Engelmann K,Böhnke M

更新日期：1999-01-01 00:00:00

abstract：:In order to develop a more adequate ultraviolet (UV)-induced cataract model, a combination of l-buthionine sulfoximine (BSO) treatment was applied to experimental animals. A single administration of BSO 4 mmol/kg caused reduced glutathione concentration until experimental day 8. In the 0.067-J/cm2 UV-B irradiation exp...

journal_title：Ophthalmic research

authors： Hatano T,Kojima M

更新日期：1996-01-01 00:00:00