Abstract:
PURPOSE:To evaluate the corneal button of primary penetrating keratoplasty of patients diagnosed with congenital aniridia. The study took place at the Instituto Universitario Barraquer and the Centro de Oftalmología Barraquer. METHODS:A retrospective analysis of cases diagnosed with congenital aniridia was carried out. We analyzed 13 corneal buttons of 11 eyes with congenital aniridia. We only included those patients who underwent penetrating keratoplasty for the first time. The corneal buttons were analyzed for histological characteristics of the presence of vascularization, the presence or not of Bowman's layer, the thickness of the stroma and Descemet's membrane, and endothelium layer alterations. RESULTS:We found alterations in the epithelium and stroma in all patients, although this loss of architecture was not seen in Descemet's membrane and the endothelial population. CONCLUSION:Patients with advanced congenital aniridic keratopathy may be good candidates for deep or superficial anterior lamellar keratoplasty for the preservation of normal endothelium and Descemet's membrane, along with limbal stem cell transplantation, to address epithelial and stromal pathology.
journal_name
Ophthalmic Resjournal_title
Ophthalmic researchauthors
Bausili MM,Alvarez de Toledo J,Barraquer RI,Michael R,Tresserra F,de la Paz MFdoi
10.1159/000444930subject
Has Abstractpub_date
2016-01-01 00:00:00pages
202-206issue
4eissn
0030-3747issn
1423-0259pii
000444930journal_volume
56pub_type
杂志文章abstract::The tear levels of cholesterol of 17 patients with chronic blepharitis and 17 healthy subjects were determined by the photometric method. The mean cholesterol level of the patients was determined to be 56.1 +/- 8.9 (SEM) mg/dl. No statistically significant difference between the tear cholesterol levels of the two grou...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267034
更新日期:1990-01-01 00:00:00
abstract::To study the mode of riboflavin metabolism in the lens in vivo, the uptake of 14C-labeled riboflavin and synthesis of ester forms from 14C-riboflavin were assayed in the single whole lens of the rats. 14C-riboflavin uptake increased in proportion to the substrate concentration in the incubation medium, reaching a plat...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265249
更新日期:1983-01-01 00:00:00
abstract:PURPOSE:The aim of this study was to evaluate the choroidal thickness (CT) and its determinants in primary angle closure glaucoma (PACG) eyes with and without malignant glaucoma (MG). METHODS:In this cross-sectional study, we enrolled 25 patients with bilateral primary angle closure (PAC) diseases; 1 eye of each patie...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000490914
更新日期:2018-01-01 00:00:00
abstract::The purpose of this study was to determine the expression of metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in the aqueous humour of patients with exfoliation syndrome (XFS). XFS and control samples were analysed for their MMP content by zymography and for their tissue inhibitors by ELISA. In XFS eyes, ...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000063661
更新日期:2002-05-01 00:00:00
abstract:PURPOSE:To establish a retinal blood flow database in normal human eyes using the Canon Laser Blood Flowmeter (CLBF). METHOD:Fourteen healthy subjects (7 males, 7 females) between the ages of 24 and 33 underwent birectional laser Doppler velocimetry (BLDV) in one eye using the CLBF. Measurements consisting of blood ve...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000065600
更新日期:2002-09-01 00:00:00
abstract:AIMS:To investigate whether allogeneic limbal mesenchymal stem cell (LMSC) therapy affects corneal healing after a severe chemical burn and whether the route of administration of LMSCs differs in its therapeutic effect in this respect. METHODS:A total of 60 Sprague-Dawley rats with clinically proven alkali injury were...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000368659
更新日期:2015-01-01 00:00:00
abstract::The effect of topical neutral formaldehyde on the blood-aqueous barrier of the rat was studied. Thirty minutes after irritation, the protein concentration of the aqueous humour had increased from the control value of 1.95 +/- 0.25 to 2.95 +/- 0.45 mg/ml (p less than 0.05). Extravasation of Evans blue dye from the iris...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265442
更新日期:1986-01-01 00:00:00
abstract::Net changes in the levels of lens calcium, magnesium, sodium, potassium, and water content were determined following exposure in vitro to iodoacetate, ouabain, lanthanum, cyanide, quercetin and cold temperature. The lens calcium content rose following inhibition of lens metabolism but did not change following specific...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265197
更新日期:1982-01-01 00:00:00
abstract::This study was undertaken to characterize the mechanism of ocular irritation to YAG laser capsulotomy in rabbits. The blocking agents were administered intravitreally. (D-Arg1,D-Pro2,D-Trp7,9)-SP, a substance P antagonist, tended to reduce miosis but had no effect on intraocular pressure (IOP). It had less effect on m...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000266900
更新日期:1989-01-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy of bilateral lateral rectus muscle recession (BLR) to treat recurrent exotropia after bilateral medial rectus muscle resection (BMR). METHODS:Twenty-four patients who underwent BLR for recurrent exotropia and were followed up for more than 6 months were included in this retrospective s...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000494560
更新日期:2019-01-01 00:00:00
abstract::The development and extension of fibrovascular or fibroglial membranes onto the retinal surface are a major cause of visual loss in diabetic patients with proliferative retinopathy and in patients suffering from retinal detachment with proliferative vitreoretinopathy. The pathogenesis of these proliferative diseases, ...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267115
更新日期:1991-01-01 00:00:00
abstract::The pathology of rainbow trout lenses incubated in various media and at various temperatures was examined by electron microscopy. After incubation at 0 degrees C for 5 h, no changes were observed in transparency and cytology. Irreversible warm cataract occurred at 37 degrees C, which corresponds to the body temperatur...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265427
更新日期:1986-01-01 00:00:00
abstract::In order to develop a more adequate ultraviolet (UV)-induced cataract model, a combination of l-buthionine sulfoximine (BSO) treatment was applied to experimental animals. A single administration of BSO 4 mmol/kg caused reduced glutathione concentration until experimental day 8. In the 0.067-J/cm2 UV-B irradiation exp...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267957
更新日期:1996-01-01 00:00:00
abstract:AIMS:Experimental retinal research has gained great importance due to the ophthalmic pharmacotherapy era. An increasing number of drugs are constantly released into the market for the treatment of retinal diseases. In this review, animal species, animal models and toxicity assays in retinal research are discussed. MET...
journal_title:Ophthalmic research
pub_type: 杂志文章,评审
doi:10.1159/000312817
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect of C constant for ray tracing-assisted intraocular lens (IOL) power calculation in the patients with different refractive power, we compared the refractive outcome of ray-tracing method based on C constant and conventional IOL calculation formula. METHODS:215 eyes which underwent phaco...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000507963
更新日期:2020-04-20 00:00:00
abstract::Soluble dextran polymer derivatives (CMDBSs) are originally synthesized as heparin-like plasma substitutes. Some of them mimic heparin in its interactions and stabilize, protect and facilitate actions of heparin binding growth factors. The wound healing activity of one specific CMDBS was studied in a model of corneal ...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267497
更新日期:1994-01-01 00:00:00
abstract::The high cytotoxicity of linoleic acid (LA) to cultured bovine lens epithelial cells is correlated with high uptake rates for the fatty acid (FA). Both, LA uptake and LA cytotoxicity strongly increase with the increasing LA-to-albumin molar ratio in the culture medium. Cellular uptake and cytotoxicity of LA can be com...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000055595
更新日期:2000-03-01 00:00:00
abstract:PURPOSE:Osthole is an agent isolated from Cnidium monnieri (L.) Cusson and has been used to treat several disorders. Corneal neovascularization is a sight-threatening condition associated with several inflammatory or infectious ocular disorders. In this study, we investigated the anti-angiogenic effects of osthole on c...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000505976
更新日期:2020-01-01 00:00:00
abstract:PURPOSE:To determine whether docosahexaenoic acid (DHA) can reduce the retinal damage induced by transient retinal ischemia. METHODS:Retinal ischemia was induced by increasing intraocular pressure (IOP). Retinal circulation was restored by lowering IOP. An intraperitoneal injection of 1,000 mg/kg of DHA-ester (DHA-E) ...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000055669
更新日期:2001-07-01 00:00:00
abstract::The vibrating probe detects and measures currents around cells and organs. With its use, it is possible to demonstrate strong outward potassium currents at the equator of the lens and strong inward sodium currents at the optical poles. The addition of microelectrodes to the system permits one to define the nature of t...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000266570
更新日期:1988-01-01 00:00:00
abstract::Equine recurrent uveitis (ERU) is an autoimmune disease that occurs with a high prevalence (10%) in horses. ERU represents the only reliable spontaneous model for human autoimmune uveitis. We already identified and characterized novel autoantigens (malate dehydrogenase, recoverin, CRALBP) by analyzing the autoantibody...
journal_title:Ophthalmic research
pub_type: 杂志文章,评审
doi:10.1159/000119867
更新日期:2008-01-01 00:00:00
abstract::The turnover and migration of synthesized glycoproteins in the cultured retinal pigment epithelium have been studied. Quantitative study indicated that half-time of 3H-fucosylglycoproteins was 11.6 days. Autoradiography was performed several times after incubation of 3H-fucose. Retinal pigment epithelium constantly sy...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265423
更新日期:1986-01-01 00:00:00
abstract::Cellular events in the rat conjunctiva were studied at 1, 6 and 24 h following the topical application of leukotriene B4. A significant increase was noted in the number of eosinophils (p less than 0.01) and neutrophils (p less than 0.05) at 1 h and only in eosinophils at 6 h after leukotriene B4 application at the 2-m...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000266873
更新日期:1989-01-01 00:00:00
abstract:OBJECTIVE:To evaluate a technique of autologous internal limiting membrane (ILM) fragment transplantation for the treatment of large, chronic, and/or refractory macular holes (MH). DESIGN:This was a 6-month prospective interventional case series. METHOD:Ten eyes of 10 patients with MH underwent pars plana vitretomy (...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000440767
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:To investigate the role of integrin-linked kinase (ILK) in endothelial cell migration, proliferation and tube formation in vitro. MATERIALS AND METHODS:Cultured RF/6A cells were knocked down for ILK using small interfering RNA (siRNA). Cellular ILK expression was quantified by real-time quantitative PCR and We...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000232971
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND/AIMS:It has been suggested that eye makeup could interact with human meibum causing a decrease in the stability of the tear film. The aim of this pilot study was to measure makeup-human meibum interactions in vitro. METHODS:Human meibum-makeup interactions were quantified by measuring order-to-disorder lipi...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000371852
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:The purpose of our study was to investigate the profiles of inflammatory cytokines and the macrophage polarization gene in a choroidal neovascularization (CNV) mouse model before and after intravitreal aflibercept treatment. METHODS:The CNV mouse model was conducted by laser photocoagulation. A total of 58 cyt...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000513588
更新日期:2020-12-04 00:00:00
abstract::To evaluate the possible role of nitric oxide in the pathogenesis of exogenous prostaglandin (PG) induced aqueous flare elevation, we examined the effect of NG-nitro-L-arginine methyl ester (L-NAME), an L-arginine analogue acting as a specific inhibitor of nitric oxide synthase, on the elevation of aqueous flare in pi...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267912
更新日期:1996-01-01 00:00:00
abstract::Epinephrine (1, 3 and 10 micrograms/kg) was found to increase retinal and choroidal blood flow (22, 49 and 67%) when it was administered intravenously. The increase in retinal and choroidal blood flow coincided well with the increase in systemic blood pressure (44, 65 and 96%, respectively). When epinephrine (2%) was ...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000266728
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVES:To evaluate the efficacy of postenucleation saline wash and the effect of different antimicrobial agents on the microbial contamination of donor eyes. METHODS:Two hundred donor eyes were given saline wash and treated with any one of the following 5 randomly selected antimicrobial solutions: 1% povidone-iodi...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000095772
更新日期:2006-01-01 00:00:00