Pentosidine - a new biochemical marker in diabetic retinopathy.

abstract：PURPOSE:This study was aimed at determining the intraocular pharmacokinetics based on molecular physicochemical properties in a rabbit model. METHODS:The entire dataset was obtained from previous literature, and research articles regarding 70 molecular compounds were investigated. The intravitreal half-lives in rabbit...

journal_title：Ophthalmic research

authors： Kim HM,Park KH,Chung JY,Woo SJ

更新日期：2020-01-01 00:00:00

abstract：:Conventional Scheimpflug photography uses slits with a constant width of 80 microns. This parameter limits the resolution as sharp contours are imaged with a basic uncertainty. In order to reduce this basic uncertainty we developed an illumination slit with a width of 20 microns and less, using a green helium-neon las...

journal_title：Ophthalmic research

authors： Huebscher HJ,Möller DE,Seiler T

更新日期：1996-01-01 00:00:00

abstract：:Cholinergic agents used to lower intraocular pressure in the medical management of glaucoma act on muscarinic receptors in the eye. Recently, subtypes of muscarinic receptors have been recognized in many tissues including the eye. To localize the M3 muscarinic receptor subtype and m3 messenger RNA (mRNA) in the human ...

journal_title：Ophthalmic research

authors： Gupta N,Drance SM,McAllister R,Prasad S,Rootman J,Cynader MS

更新日期：1994-01-01 00:00:00

abstract：PURPOSE:The aim of this study was to investigate the effects of quercetin on vascular endothelial growth factor (VEGF)-induced choroidal and retinal angiogenesis in vitro using a rhesus macaque choroid-retinal endothelial (RF/6A) cell line. METHODS:RF/6A cells were cultured in Dulbecco's modified Eagle's medium contai...

journal_title：Ophthalmic research

authors： Li F,Bai Y,Zhao M,Huang L,Li S,Li X,Chen Y

更新日期：2015-01-01 00:00:00

abstract：:The vibrating probe detects and measures currents around cells and organs. With its use, it is possible to demonstrate strong outward potassium currents at the equator of the lens and strong inward sodium currents at the optical poles. The addition of microelectrodes to the system permits one to define the nature of t...

journal_title：Ophthalmic research

authors： Patterson JW

更新日期：1988-01-01 00:00:00

abstract：:The polyamines putrescine, spermidine and spermine have been proposed to be a part of the acute phase inflammatory response. They have been shown to be useful markers for cellular kinetics and change with various pathological conditions. The hypothesis that aqueous humor polyamines could be used to follow the time cou...

journal_title：Ophthalmic research

authors： Wickström K,Lundgren B,Törngren L,Ostberg C

更新日期：1992-01-01 00:00:00

abstract：:The aim of the present study was to investigate biochemical and morphological changes in rat lenses following long-term UV B irradiation. After an irradiation period of 156 days with follow-up documentation by means of Scheimpflug photography, section-related biochemical analyses of the lenses as well as histological ...

journal_title：Ophthalmic research

authors： Schmidt J,Schmitt C,Kojima M,Hockwin O

更新日期：1992-01-01 00:00:00

abstract：:The ultrastructure of optic nerve axons was examined in several mammals (human, cat, rat, sheep, ox, pig, guinea pig, rabbit). Human material was obtained from normotensive, glaucoma-free eyes and from eyes with a history of glaucoma and raised intra-ocular pressure (IOP). We describe accumulations of organelles (prin...

journal_title：Ophthalmic research

authors： Holländer H,Makarov F,Stefani FH,Stone J

更新日期：1995-01-01 00:00:00

abstract：PURPOSE:Primary open-angle glaucoma (POAG) is a chronic progressive optic neuropathy, leading to degeneration of retinal ganglion cells and characteristic morphological changes at the optic disc. In advanced stages of the disease, functional tests, such as standard automated perimetry (SAP), are the main diagnostic too...

journal_title：Ophthalmic research

authors： Leisser C,Palkovits S,Hirnschall N,Georgiev S,Findl O

更新日期：2020-01-01 00:00:00

abstract：:Ibudilast selectively vasodilates cerebral vessels without reducing blood pressure. We investigated the effect of the drug on retinal circulation in 8 patients with diabetes mellitus, using the video-densitometric image analysis of fluorescein angiography. We compared the build up time, the time constant of washout ra...

journal_title：Ophthalmic research

authors： Suzuki R,Sugihara I,Ishibashi T,Kurimoto S

更新日期：1992-01-01 00:00:00

abstract：:Ocular pneumoplethysmography was performed before and after 1,737 carotid endarterectomies, 82% of which were performed for carotid lesions of hemodynamic consequence. Preoperative ocular hypoperfusion without ischemia was associated with at least transient postoperative ocular hyperemia. A difference in ocular volume...

journal_title：Ophthalmic research

authors： Gee W,Reed JF 3rd

更新日期：1999-01-01 00:00:00

abstract：:The aqueous humors of 100 freshly enucleated rabbit eyes were assessed within 10 min postmortem by taking samples in the last stage of corneal dissection following the Dikstein-Maurice procedure. Aqueous levels of partial pressure of carbon dioxide (pCO2) averaged 58.2 +/- 8.5 mm Hg to give calculated tCO2 and bicarbo...

journal_title：Ophthalmic research

authors： Doughty MJ

更新日期：1993-01-01 00:00:00

abstract：:A system for isolation of capillaries from the retina has been adapted to biochemical studies in vitro. Insulin receptors were identified in human and calf retinal blood vessels. Binding of 125I insulin by calf retinal blood vessels takes place through high affinity (low capacity) and low affinity (high capacity) rece...

journal_title：Ophthalmic research

authors： Cotlier E,Davidson C

更新日期：1983-01-01 00:00:00

abstract：PURPOSE:To establish a retinal blood flow database in normal human eyes using the Canon Laser Blood Flowmeter (CLBF). METHOD:Fourteen healthy subjects (7 males, 7 females) between the ages of 24 and 33 underwent birectional laser Doppler velocimetry (BLDV) in one eye using the CLBF. Measurements consisting of blood ve...

journal_title：Ophthalmic research

authors： Garcia JP Jr,Garcia PT,Rosen RB

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:Mesopic conditions elicit both rod and cone responses, and they are more commonly encountered in daily life than are scotopic conditions; yet visual function outcome measures of mesopic visual acuity (VA) or contrast sensitivity (CS) are rarely evaluated. OBJECTIVE:In retinitis pigmentosa (RP), we explored ...

journal_title：Ophthalmic research

authors： Bittner AK,Ferraz MC

更新日期：2020-01-01 00:00:00

abstract：:We measured prostaglandin E2 (PGE2) and prostacyclin levels in the vitreous bodies of 5 eyes of patients with diabetic retinopathy complicated by rhegmatogenous retinal detachment (RRD) and compared them with the corresponding levels in 9 nondiabetic eyes with the same condition as well as with 10 control eyes of dece...

journal_title：Ophthalmic research

authors： Naveh N,Belkin M,Ben-Chaim O,Weissman C,Treister G

更新日期：1990-01-01 00:00:00

abstract：AIM:The aim of the current study is to evaluate the role of povidone iodine (PVI) in the management of experimental bacterial endophthalmitis in young rabbits. METHOD:Twenty white rabbits were used. Colony-forming units (CFU) of Staphylococcus epidermidis were injected intravitreally into the right eye of each animal....

journal_title：Ophthalmic research

authors： Brozou CG,Karabatakis V,Giannousis M,Mandraveli K,Karkavelas G,Alexiou-Daniel S

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVE:Weak oxidants produced by activated human leukocytes are proven antimicrobial substances. We tested whether N-chlorotaurine (NCT, taurine chloramine), the chlorinated metabolite of the amino acid taurine, in addition to direct virucidal effects on viral suspensions, has the capability to prevent cell-to-cell ...

journal_title：Ophthalmic research

authors： Huemer HP,Nagl M,Irschick EU

更新日期：2010-01-01 00:00:00

abstract：PURPOSE:To propose a new noncontact tonometer based on corneal photoelasticity. METHOD:In this study, we experimented with 18 enucleated porcine eyes. The anterior chamber was infused with a physiological solution. A circular polarizing filter was attached to an ophthalmic surgical microscope. Color fringe changes at ...

journal_title：Ophthalmic research

authors： Hwang H,Kim M,Park C

更新日期：2011-01-01 00:00:00

abstract：PURPOSE:To describe the characteristics of macular lesions after eye trauma using spectral-domain optical coherence tomography (OCT). METHODS:We retrospectively reviewed and described 2-dimensional (2D) and 3-dimensional (3D) spectral-domain OCT characteristics of 24 consecutive eyes of 24 cases that were identified w...

journal_title：Ophthalmic research

authors： Yu W,Zheng L,Zhang Z,Dai R,Dong F

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the sensitivity and specificity of pseudoexfoliation syndrome diagnosis in pseudophakic patients and potential means of improving it. METHODS:This prospective, nonrandomized study comprised 41 consecutive patients (41 eyes) scheduled for cataract surgery at a tertiary medical center during 2016-2...

journal_title：Ophthalmic research

authors： Sternfeld A,Luski M,Sella R,Zahavi A,Geffen N,Pereg A,Megiddo E,Gaton D

更新日期：2020-04-30 00:00:00

abstract：:L-Timolol (0.4 mg/kg) reduced significantly retinal blood flow (17%), systemic blood pressure (18-20%) and heart rate (28%) in the rabbit. D-Timolol (4.0 mg/kg) increased retinal blood flow slightly (9%) and did not significantly affect systemic blood pressure or heart rate. Since D-timolol is effective in reducing in...

journal_title：Ophthalmic research

authors： Yan HY,Chiou GC

更新日期：1987-01-01 00:00:00

abstract：:We examined 304 conjunctiva in 152 subjects by clinical, cytologic, and bacteriologic methods. Bacteriologic samples were evaluated after a 48-hour incubation. Bacterial growth was found in 8 (20.5%) of 39 patients with clinically normal conjunctiva and no polymorphonuclear leukocytes (PMNs), and in 8 (61.5%) of 13 su...

journal_title：Ophthalmic research

authors： Ugomori S,Hayasaka S,Setogawa T

更新日期：1991-01-01 00:00:00

abstract：:We investigated the effects of hyperthermia on the healing process of experimental Pseudomonas corneal ulceration (PCU). Hartley guinea pigs were used to develop animal models of PCU. As a heat source, disposable chemical pocket warmers were applied. The healing process of PCU was compared between the heat-treated cor...

journal_title：Ophthalmic research

authors： Nanbu PN,Wakabayashi T,Yamashita R,Hayashi H,Hisano S,Oshika T

更新日期：2004-07-01 00:00:00

abstract：PURPOSE:The traditional medium for storing corneas in European Eye Banks is Gibco's MEM (Eagle's) with Earle's salts and Hepes containing 2% fetal calf serum, glutamine and antimycotics. Although serum-free MegaCell MEM has been reported to be more suitable for this purpose, it contains components of animal origin that...

journal_title：Ophthalmic research

authors： Smith VA,Johnson T

更新日期：2010-01-01 00:00:00

abstract：:Cataractous lens images taken with different camera types for retroillumination photography were compared. Images taken by conventional photo slitlamp and fundus cameras were not suitable for image analysis. Retroillumination photography with a conventional fundus camera with additional polarizing filters seemed to be...

journal_title：Ophthalmic research

authors： Sakamoto Y,Rankov G,Sasaki K

更新日期：1990-01-01 00:00:00

abstract：PURPOSE:To investigate therapeutic ocular surface medium (TOSM), a potential physiological tear replacement therapy, for persistent epithelial defect (PED). METHODS:11 eyes of 10 patients with PED for ≥ 2 weeks without improvement despite conventional treatment were enrolled in a prospective pilot study of TOSM over 1...

journal_title：Ophthalmic research

authors： Watson SL,Geerling G,Dart JK

更新日期：2014-01-01 00:00:00

abstract：:Cataract is the leading cause of blindness worldwide. It is a multifactorial disease primarily associated with oxidative stress produced by free radicals. The protection offered by various antioxidants in cataract development is well established. Polyphenolic compounds present in green tea (Camellia sinensis) are repo...

journal_title：Ophthalmic research

authors： Gupta SK,Halder N,Srivastava S,Trivedi D,Joshi S,Varma SD

更新日期：2002-07-01 00:00:00

abstract：:Calf water-soluble (WS) crystallins consist of high-molecular weight (HM), alpha-, beta H-, beta L-, beta s- and gamma-crystallins. alpha-Crystallin as a molecular chaperone forms a structure with a central hole, known as Carver's model. The only crystallins fitting into this central cavity are beta s- and gamma-cryst...

journal_title：Ophthalmic research

authors： Bours J

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the effect of C constant for ray tracing-assisted intraocular lens (IOL) power calculation in the patients with different refractive power, we compared the refractive outcome of ray-tracing method based on C constant and conventional IOL calculation formula. METHODS:215 eyes which underwent phaco...

journal_title：Ophthalmic research

authors： Chang P,Zhang F,Wang J,Zhao Y

更新日期：2020-04-20 00:00:00