Abstract:
OBJECTIVE:To evaluate the sensitivity and specificity of pseudoexfoliation syndrome diagnosis in pseudophakic patients and potential means of improving it. METHODS:This prospective, nonrandomized study comprised 41 consecutive patients (41 eyes) scheduled for cataract surgery at a tertiary medical center during 2016-2017. Preoperatively, all patients underwent a detailed slit-lamp examination, including gonioscopic assessment of the iridocorneal angle. The examination was performed by a glaucoma specialist who completed an assessment form documenting the presence/absence of clinical signs of pseudoexfoliation syndrome. It was repeated 1-2 weeks postoperatively by a second, masked, glaucoma specialist. RESULTS:Sixteen patients (39.0%) were diagnosed with pseudoexfoliation syndrome preoperatively: The diagnosis was confirmed postoperatively in 11/16 patients (68.8% sensitivity) and in an additional patient not diagnosed preoperatively (96% specificity). The ability to diagnose pseudoexfoliation syndrome postoperatively was significantly worse than preoperatively (Z=12.161, p <0.0001). Pupillary border deposits (75% of cases) and Sampaolesi line (83.3%) were the cornerstones of postoperative diagnosis; anterior capsular deposits were evident in only 41.6% of cases diagnosed postoperatively (31.3% of the originally diagnosed cases). CONCLUSIONS:Underdiagnosis of pseudoexfoliation syndrome is common in pseudophakic patients and may have significant implications for future management. Careful attention to pupillary border anatomy and meticulous gonioscopic assessment of the iridocorneal angle are essential for accurate diagnosis. Preoperative documentation of pseudoexfoliation syndrome could help prevent this diagnostic pitfall.
journal_name
Ophthalmic Resjournal_title
Ophthalmic researchauthors
Sternfeld A,Luski M,Sella R,Zahavi A,Geffen N,Pereg A,Megiddo E,Gaton Ddoi
10.1159/000508336subject
Has Abstractpub_date
2020-04-30 00:00:00eissn
0030-3747issn
1423-0259pii
000508336pub_type
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journal_title:Ophthalmic research
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journal_title:Ophthalmic research
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journal_title:Ophthalmic research
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journal_title:Ophthalmic research
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更新日期:1983-01-01 00:00:00
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doi:10.1159/000267997
更新日期:1997-01-01 00:00:00
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doi:10.1159/000267984
更新日期:1997-01-01 00:00:00
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更新日期:2020-01-01 00:00:00
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更新日期:2004-09-01 00:00:00
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更新日期:2015-01-01 00:00:00
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journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267924
更新日期:1996-01-01 00:00:00
abstract::Cholinergic agents used to lower intraocular pressure in the medical management of glaucoma act on muscarinic receptors in the eye. Recently, subtypes of muscarinic receptors have been recognized in many tissues including the eye. To localize the M3 muscarinic receptor subtype and m3 messenger RNA (mRNA) in the human ...
journal_title:Ophthalmic research
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更新日期:1994-01-01 00:00:00
abstract::In a search for a pharmacologic adjuvant in the management of posttraumatic proliferative vitreoretinopathy (PVR), we investigated the effect of intravitreal injection of prinomastat (AG3340) on an experimental model. Posterior penetrating eye trauma was created in one eye each of 24 New Zealand white rabbits. One wee...
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更新日期:2001-01-01 00:00:00
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更新日期:2015-01-01 00:00:00
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更新日期:1984-01-01 00:00:00