Effects of L-timolol, D-timolol, haloperidol and domperidone on rabbit retinal blood flow measured with laser Doppler method.

abstract：OBJECTIVE:To assess changes of tear film function in patients with pterygium after pterygium excision combined with limbal-conjunctival autograft transplantation. METHODS:Sixty eyes of 60 patients were entered in the study. The Schirmer test, tear breakup time (BUT) and mucus fern test (MFT) were evaluated in the pati...

journal_title：Ophthalmic research

authors： Wang S,Jiang B,Gu Y

更新日期：2011-01-01 00:00:00

abstract：:Adult human lenses with focal opacities were processed for normal as well as freeze fracture electron microscopy. Cholesterol was demonstrated using filipin cytochemistry. Filipin cytochemistry in combination with freeze fracture revealed that the amount of cholesterol in the normal fibre membranes was fully comparabl...

journal_title：Ophthalmic research

authors： VanMarle J,Vrensen GF

更新日期：2000-11-01 00:00:00

abstract：PURPOSE:To demonstrate the value of the laser-scanning optical-resolution (LSOR)-photoacoustic (PA) microscopy (PAM) system and the conventional multimodal imaging techniques in the evaluation of laser-induced retinal injury and choroidal neovascularization (CNV) in rats. METHODS:Different degrees of retinal injury we...

journal_title：Ophthalmic research

authors： Xiao M,Dai C,Li L,Zhou C,Wang F

更新日期：2020-01-01 00:00:00

abstract：:Cataract is the leading cause of blindness worldwide. It is a multifactorial disease primarily associated with oxidative stress produced by free radicals. The protection offered by various antioxidants in cataract development is well established. Polyphenolic compounds present in green tea (Camellia sinensis) are repo...

journal_title：Ophthalmic research

authors： Gupta SK,Halder N,Srivastava S,Trivedi D,Joshi S,Varma SD

更新日期：2002-07-01 00:00:00

abstract：PURPOSE:To determine whether docosahexaenoic acid (DHA) can reduce the retinal damage induced by transient retinal ischemia. METHODS:Retinal ischemia was induced by increasing intraocular pressure (IOP). Retinal circulation was restored by lowering IOP. An intraperitoneal injection of 1,000 mg/kg of DHA-ester (DHA-E) ...

journal_title：Ophthalmic research

authors： Miyauchi O,Mizota A,Adachi-Usami E,Nishikawa M

更新日期：2001-07-01 00:00:00

abstract：:The ophthalmic examination of patients with hypertrophic cardiomyopathy treated with high doses of verapamil over a considerable period of time showed no evidence of a side effect of the drug, thus proving its ocular safety. This could be verified by densitometric image analysis of Scheimpflug photographs of the eyes....

journal_title：Ophthalmic research

authors： Hockwin O,Dragomirescu V,Laser H,Ohrloff C,Kozamanoglu K,Kremer F

更新日期：1984-01-01 00:00:00

abstract：AIM:This study was done to evaluate the role of pentosidine in predicting the progression of diabetic retinopathy. PATIENTS AND METHODS:We included 30 subjects with insulin-dependent diabetes mellitus (type 1) and 10 healthy control individuals. A case control study was done. Full ophthalmological examination together...

journal_title：Ophthalmic research

authors： Salman AG,Mansour DE,Swelem AH,Al-Zawahary WM,Radwan AA

更新日期：2009-01-01 00:00:00

abstract：:The aim of the present study was to investigate biochemical and morphological changes in rat lenses following long-term UV B irradiation. After an irradiation period of 156 days with follow-up documentation by means of Scheimpflug photography, section-related biochemical analyses of the lenses as well as histological ...

journal_title：Ophthalmic research

authors： Schmidt J,Schmitt C,Kojima M,Hockwin O

更新日期：1992-01-01 00:00:00

abstract：:The gut microbiome has important physiological functions and plays an indispensable role in the human body. Currently, there are an increasing number of studies revealing the close correlation between dysbiosis of the gut microbiome and a variety of autoimmune diseases, including autoimmune uveitis. This brief review ...

journal_title：Ophthalmic research

authors： Fu X,Chen Y,Chen D

更新日期：2020-07-16 00:00:00

abstract：:To determine the effect of interleukin-10 (IL-10) and transforming growth factor-beta (TGF-beta) on the down-regulation of MHC class II antigens, bovine retinal pigment epithelial (RPE) cells were incubated with interferon-gamma (IFN-gamma) in different concentrations. Subsequently, the IFN-gamma pretreated RPE cells ...

journal_title：Ophthalmic research

authors： Enzmann V,Stadler M,Wiedemann P,Kohen L

更新日期：1999-01-01 00:00:00

abstract：:The ultrastructure of optic nerve axons was examined in several mammals (human, cat, rat, sheep, ox, pig, guinea pig, rabbit). Human material was obtained from normotensive, glaucoma-free eyes and from eyes with a history of glaucoma and raised intra-ocular pressure (IOP). We describe accumulations of organelles (prin...

journal_title：Ophthalmic research

authors： Holländer H,Makarov F,Stefani FH,Stone J

更新日期：1995-01-01 00:00:00

abstract：:The purpose of this study was to determine the expression of metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in the aqueous humour of patients with exfoliation syndrome (XFS). XFS and control samples were analysed for their MMP content by zymography and for their tissue inhibitors by ELISA. In XFS eyes, ...

journal_title：Ophthalmic research

authors： Gartaganis SP,Georgakopoulos CD,Mela EK,Exarchou A,Ziouti N,Assouti M,Vynios DH

更新日期：2002-05-01 00:00:00

abstract：:Toxoplasma gondii is an extremely successful opportunistic parasite which infects approximately one third of the human population worldwide. The impact of this parasite on human health becomes particularly manifest in congenital damage with infection and subsequent inflammation of neuronal tissues including the retina...

journal_title：Ophthalmic research

authors： Pleyer U,Schlüter D,Mänz M

更新日期：2014-01-01 00:00:00

abstract：AIMS:The purpose of this paper was to determine the lacrimal concentration of IL-1α and MMP-9 in patients with active ocular rosacea before and after systemic treatment with azithromycin or doxycycline. METHODS:After 4 weeks of therapy with azithromycin (500 mg/day, 3 days a week PO) or doxycycline (200 mg/day PO), la...

journal_title：Ophthalmic research

authors： Lam-Franco L,Perfecto-Avalos Y,Patiño-Ramírez BE,Rodríguez García A

更新日期：2018-01-01 00:00:00

abstract：AIMS:To evaluate the biologic effects of fluoroquinolone eye solutions without preservatives on cultured human corneal epithelial cells in vitro. METHODS:We studied the effect of diverse generations of topical fluoroquinolones such as ofloxacin 0.3%, levofloxacin 0.5%, tosufloxacin 0.3%, moxifloxacin 0.5% and gatiflox...

journal_title：Ophthalmic research

authors： Oum BS,Kim NM,Lee JS,Park YM

更新日期：2014-01-01 00:00:00

abstract：:Modulation sensitivity functions ( MSFs ) of retinal ganglion cells of the pigeon were determined by recording action potentials from their end branching in the optic tectum as response indicator. The inverse Fourier transformation of a MSF is taken to represent the receptive field sensitivity function approximating t...

journal_title：Ophthalmic research

authors： Pak MA

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:Myopia has become a worldwide public health issue, which is occurring at a younger age, leading to an increased risk of high myopia. Ocular complications associated with high myopia can lead to irreversible vision loss. It is urgent and critical to explore effective treatment to slow or even stop the progres...

journal_title：Ophthalmic research

authors： Wang S,Wang J,Wang N

更新日期：2020-08-11 00:00:00

abstract：:The high-voltage electron microscope (HVEM) permits examination of sections much thicker (up to 1 micron) than those usually used in transmission electron microscopy, which are approximately 70 nm in thickness. Two examples of the utility of the HVEM in research on the ultrastructure of the retinal pigment epithelium ...

journal_title：Ophthalmic research

authors： Korte GE,Heriot W,Pollack A

更新日期：1986-01-01 00:00:00

abstract：:Small RNA (microRNA or miRNA) is a kind of small noncoding single-stranded RNA that regulates complementary mRNA at the posttranscriptional level in eukaryotic organisms. As important regulatory factors, miRNAs play an important role in the occurrence and development of glaucoma and widely participate in regulating bi...

journal_title：Ophthalmic research

authors： Guo R,Shen W,Su C,Jiang S,Wang J

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:Transient receptor potential canonical (TRPC) channels are involved in neovascularization repairing after vascular injury in many tissues. However, whether TRPCs play a regulatory role in the development of diabetic retinopathy (DR) has rarely been reported. In the present study, we selected TRPC1, 3, and 6 t...

journal_title：Ophthalmic research

authors： Lang HB,Xie RX,Huang ML,Fang LY,Tang YB,Zhang F

更新日期：2020-01-01 00:00:00

abstract：PURPOSE:Abnormalities in electroretinograms (ERG), such as reduced amplitudes and delayed implicit times of a- and b-wave and oscillatory potentials (OPs), are one of the earliest features of diabetic retinopathy prior to obvious vascular changes in diabetic retinas. We have previously shown that serum levels of advanc...

journal_title：Ophthalmic research

authors： Maeda S,Matsui T,Ojima A,Suematsu M,Kaseda K,Higashimoto Y,Yamakawa R,Yamagishi S

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND/AIMS:To evaluate the safety of suramin compared with mitomycin-C (MMC) as an adjunctive agent in trabeculectomy by determining its ciliary body toxicity at predetermined effective dosages in rabbit eyes. METHODS:Thirty-two New Zealand albino rabbits received either suramin (200, 300, 400, or 800 mg/ml) or M...

journal_title：Ophthalmic research

authors： Cetinkaya A,Akman A,Take G,Bilezikci B,Akova YA

更新日期：2009-01-01 00:00:00

abstract：:Non-toxic concentrations of ceftazidime (CAZ), cefuzonam sodium (CZON) and cefmetazole sodium (CMZ) for intravitreal use were assessed by the electroretinogram in in vitro perfused eyecups of albino rabbits. None of the a-wave, the b-wave and the oscillatory potentials deteriorated with 300 microM CAZ, 300 microM CZON...

journal_title：Ophthalmic research

authors： Kitano K,Shirao Y,Kawasaki K

更新日期：1995-01-01 00:00:00

abstract：:Substance P (SP) immunoreactivity was demonstrated using the indirect immunofluorescence technique in one normal and one retinoblastomatous human retina. In the normal retina SP immunoreaction was located in nerve fibres but not in the neurons in the inner plexiform layer. A similar location was observed in the histol...

journal_title：Ophthalmic research

authors： Tarkkanen A,Tervo T,Tervo K,Eränkö L,Eränkö O,Cuello AC

更新日期：1983-01-01 00:00:00

abstract：:In order to investigate the combined influence of age and light, the b-wave and oscillatory potentials (OPs) of the electroretinogram (ERG) were recorded in 1.5-, 7- and 12-month-old WAG/Rij rats, reared under homogenous low-intensity cyclic light exposure. Wistar albino rats of the same ages, reared under the same co...

journal_title：Ophthalmic research

authors： Cillino S,Guarneri R,Guarneri P,Pennica C,Chichi G,Piccoli F,Ponte F

更新日期：1993-01-01 00:00:00

abstract：PURPOSE:To investigate the effects, and their reversibility, of multiple oral voriconazole doses on a variety of visual tests in healthy male volunteers. METHODS:Single-center, double-blind, randomized, placebo-controlled, parallel-group study in 36 volunteers who received voriconazole (n=18, 400 mg every 12 h on day ...

journal_title：Ophthalmic research

authors： Zrenner E,Tomaszewski K,Hamlin J,Layton G,Wood N

更新日期：2014-01-01 00:00:00

abstract：PURPOSE:Primary open-angle glaucoma (POAG) is a chronic progressive optic neuropathy, leading to degeneration of retinal ganglion cells and characteristic morphological changes at the optic disc. In advanced stages of the disease, functional tests, such as standard automated perimetry (SAP), are the main diagnostic too...

journal_title：Ophthalmic research

authors： Leisser C,Palkovits S,Hirnschall N,Georgiev S,Findl O

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:In this study, we used a rat model of retinal detachment (RD) to investigate the effects of transient receptor potential mucolipin 1 (TRPML1) on photoreceptor cells and the underlying mechanism. METHODS:An RD model was established by subretinal injection of sodium hyaluronate, and mucolipin synthetic agonist...

journal_title：Ophthalmic research

authors： Yan Y,Wang Y,Ding J,Lu L,Ke G,Dong K

更新日期：2020-10-07 00:00:00

abstract：:Conventional Scheimpflug photography uses slits with a constant width of 80 microns. This parameter limits the resolution as sharp contours are imaged with a basic uncertainty. In order to reduce this basic uncertainty we developed an illumination slit with a width of 20 microns and less, using a green helium-neon las...

journal_title：Ophthalmic research

authors： Huebscher HJ,Möller DE,Seiler T

更新日期：1996-01-01 00:00:00

abstract：PURPOSE:To investigate the possible roles of various cytokines or growth factors in the pathogenesis of exudative age-related macular degeneration (AMD) by comparing aqueous humor levels of 14 cytokines between eyes with polypoidal choroidal vasculopathy (PCV) and those with neovascular AMD. METHODS:Forty eyes from 40...

journal_title：Ophthalmic research

authors： Sakurada Y,Nakamura Y,Yoneyama S,Mabuchi F,Gotoh T,Tateno Y,Sugiyama A,Kubota T,Iijima H

更新日期：2015-01-01 00:00:00