Abstract:
:Small RNA (microRNA or miRNA) is a kind of small noncoding single-stranded RNA that regulates complementary mRNA at the posttranscriptional level in eukaryotic organisms. As important regulatory factors, miRNAs play an important role in the occurrence and development of glaucoma and widely participate in regulating biological processes of glaucoma-related genes. This article reviews the connection between the aqueous humor, trabecular meshwork, the apoptosis of retinal ganglion cells, and miRNA.
journal_name
Ophthalmic Resjournal_title
Ophthalmic researchauthors
Guo R,Shen W,Su C,Jiang S,Wang Jdoi
10.1159/000450957subject
Has Abstractpub_date
2017-01-01 00:00:00pages
194-199issue
3eissn
0030-3747issn
1423-0259pii
000450957journal_volume
57pub_type
杂志文章,评审abstract:PURPOSE:To evaluate the efficacy of bilateral lateral rectus muscle recession (BLR) to treat recurrent exotropia after bilateral medial rectus muscle resection (BMR). METHODS:Twenty-four patients who underwent BLR for recurrent exotropia and were followed up for more than 6 months were included in this retrospective s...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000494560
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND/AIMS:By the release of antiangiogenic factors, Müller glial cells provide an angiostatic environment in the normal and ischemic retina. We determined whether Müller cells produce thrombospondin-1 (TSP-1), a known inhibitor of angiogenesis. METHODS:Secretion of TSP-1 by cultured Müller cells was determined w...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000362371
更新日期:2014-01-01 00:00:00
abstract::Conventional Scheimpflug photography uses slits with a constant width of 80 microns. This parameter limits the resolution as sharp contours are imaged with a basic uncertainty. In order to reduce this basic uncertainty we developed an illumination slit with a width of 20 microns and less, using a green helium-neon las...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267967
更新日期:1996-01-01 00:00:00
abstract::Cellular immune responses in retinal autoimmunity have scarcely been studied in rabbits. An effective isolation of rabbit peripheral blood lymphocytes is difficult to achieve and requires specific conditions. This hampers especially the assay of antigen-induced lymphocyte transformation. We have improved the lymphocyt...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000266934
更新日期:1989-01-01 00:00:00
abstract:PURPOSE:Extensive clinical investigations of the biocompatibility of different intraocular lenses (IOLs) have been made in an effort to optimize the outcome of modern cataract surgery. The aim of this study was to add animal eye experimental implantation data regarding cellular reaction on the anterior surface of IOLs....
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000087100
更新日期:2005-09-01 00:00:00
abstract:AIM:Ultraviolet (UV) B irradiation induces gene expression that leads to skin cancer. Among the transcription factors induced by UVB radiation exposure, the cyclic AMP response element-binding protein (CREB) is significant. Since several factors downstream of CREB signaling are known to be involved in pterygium pathoge...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000347124
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:Transient receptor potential canonical (TRPC) channels are involved in neovascularization repairing after vascular injury in many tissues. However, whether TRPCs play a regulatory role in the development of diabetic retinopathy (DR) has rarely been reported. In the present study, we selected TRPC1, 3, and 6 t...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000503724
更新日期:2020-01-01 00:00:00
abstract::To determine the effect of interleukin-10 (IL-10) and transforming growth factor-beta (TGF-beta) on the down-regulation of MHC class II antigens, bovine retinal pigment epithelial (RPE) cells were incubated with interferon-gamma (IFN-gamma) in different concentrations. Subsequently, the IFN-gamma pretreated RPE cells ...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000055545
更新日期:1999-01-01 00:00:00
abstract:PURPOSE:To investigate the role of integrin-linked kinase (ILK) in endothelial cell migration, proliferation and tube formation in vitro. MATERIALS AND METHODS:Cultured RF/6A cells were knocked down for ILK using small interfering RNA (siRNA). Cellular ILK expression was quantified by real-time quantitative PCR and We...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000232971
更新日期:2009-01-01 00:00:00
abstract:PURPOSE:To investigate the effects, and their reversibility, of multiple oral voriconazole doses on a variety of visual tests in healthy male volunteers. METHODS:Single-center, double-blind, randomized, placebo-controlled, parallel-group study in 36 volunteers who received voriconazole (n=18, 400 mg every 12 h on day ...
journal_title:Ophthalmic research
pub_type: 杂志文章,随机对照试验
doi:10.1159/000359952
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Genipin (GP) is a safe method for corneal crosslinking, even for very thin corneas. However, there have been no reports on the optimal GP concentration range to use in vivo for corneal crosslinking. OBJECTIVES:To investigate the safety of corneal crosslinking after a 24-h incubation with different concentra...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000499571
更新日期:2019-01-01 00:00:00
abstract:AIM:The aim of the current study is to evaluate the role of povidone iodine (PVI) in the management of experimental bacterial endophthalmitis in young rabbits. METHOD:Twenty white rabbits were used. Colony-forming units (CFU) of Staphylococcus epidermidis were injected intravitreally into the right eye of each animal....
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000217721
更新日期:2009-01-01 00:00:00
abstract:PURPOSE:In this investigation the authors studied the effect of dapiprazole, an alpha-adrenergic blocking agent, on aqueous humor dynamics in patients affected with pigmentary glaucoma. METHODS:Dapiprazole 0.5% eye drops were administered 3 times daily as adjunctive therapy to 16 pigmentary glaucoma patients in additi...
journal_title:Ophthalmic research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000267920
更新日期:1996-01-01 00:00:00
abstract:PURPOSE:Retinal gene therapy trials are currently ongoing in a small number of inherited retinal disorders and this number is expected to rise significantly. The aim of this study was to analyze the psychological aspects of patients with RPE65 deficiency awaiting potential enrollment in gene therapy trials. METHODS:Fi...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000435887
更新日期:2015-01-01 00:00:00
abstract::The antioxidants sodium benzoate and 2,3-dihydroxybenzoic acid reduced the inflammatory response in experimental phacoanaphylactic endophthalmitis. The 2,3-dihydroxybenzoic acid was by far the more effective antiphlogistic agent. The molecular mechanisms that may have contributed to the observed difference in antiphlo...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265483
更新日期:1987-01-01 00:00:00
abstract:PURPOSE:Single-field non-mydriatic fundus photography (NMFP) has been used to detect diabetic retinopathy (DR) in many studies; however, its value in a general clinical setting has not been established. Here we performed a meta-analysis to evaluate its diagnostic effectiveness. METHOD:We systematically searched PubMed...
journal_title:Ophthalmic research
pub_type: meta分析
doi:10.1159/000499106
更新日期:2019-01-01 00:00:00
abstract::Ocular pneumoplethysmography was performed before and after 1,737 carotid endarterectomies, 82% of which were performed for carotid lesions of hemodynamic consequence. Preoperative ocular hypoperfusion without ischemia was associated with at least transient postoperative ocular hyperemia. A difference in ocular volume...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000055558
更新日期:1999-01-01 00:00:00
abstract::The pineal organ of the pike is a functional photoreceptive organ in which a multiplicity of the cells of the receptor line (CRL i.e. typical and modified photoreceptors) was demonstrated. The CRL appeared to be (i) regionally distributed, (ii) photosensitive, and (iii) responsible for the storage of various indoles (...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265306
更新日期:1984-01-01 00:00:00
abstract::Cataractous lens images taken with different camera types for retroillumination photography were compared. Images taken by conventional photo slitlamp and fundus cameras were not suitable for image analysis. Retroillumination photography with a conventional fundus camera with additional polarizing filters seemed to be...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267063
更新日期:1990-01-01 00:00:00
abstract:AIM/BACKGROUND:A 1-bp deletion (1147delA) in the SAG (also known as arrestin or S-antigen) gene is the most frequently seen mutation in Japanese patients suffering from Oguchi disease, a recessively inherited stationary night blindness. We investigated macular function in a patient with Oguchi disease with the 1147delA...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000325024
更新日期:2011-10-01 00:00:00
abstract:INTRODUCTION:Diabetic Retinopathy (DR) is one of the major vision-threatening causes worldwide. Searching for an individualized therapeutic strategy to prevent its progress is challenging. OBJECTIVE:This work aimed to investigate the association of angiogenesis-inducer vascular endothelial growth factor (VEGF) gene fa...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000511087
更新日期:2020-08-24 00:00:00
abstract::A system for isolation of capillaries from the retina has been adapted to biochemical studies in vitro. Insulin receptors were identified in human and calf retinal blood vessels. Binding of 125I insulin by calf retinal blood vessels takes place through high affinity (low capacity) and low affinity (high capacity) rece...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265234
更新日期:1983-01-01 00:00:00
abstract:AIMS:The purpose of this paper was to determine the lacrimal concentration of IL-1α and MMP-9 in patients with active ocular rosacea before and after systemic treatment with azithromycin or doxycycline. METHODS:After 4 weeks of therapy with azithromycin (500 mg/day, 3 days a week PO) or doxycycline (200 mg/day PO), la...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000489092
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:To characterize the 1-year progression of retinal thickness (RT) increase occurring in eyes with subclinical macular edema in type 2 diabetes. METHODS:Forty-eight type 2 diabetic eyes/patients with mild nonproliferative diabetic retinopathy (NPDR; levels 20 and 35 in the Early Treatment Diabetic Retinopathy St...
journal_title:Ophthalmic research
pub_type: 杂志文章,多中心研究
doi:10.1159/000438793
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:To evaluate the role of initial visual acuity (VA) as a potential prognostic factor for final VA in patients with branch retinal vein occlusion (BRVO). METHODS:A retrospective data analysis involving 163 patients with macular edema secondary to BRVO treated according to the recommendations of the Branch Vein O...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000321701
更新日期:2011-01-01 00:00:00
abstract::Vitamin E (d-alpha-tocopherol) and aspirin were evaluated for their effects on the phase separation temperature, Tc, of calf lens cytoplasm. Vitamin E and aspirin were added to nuclear homogenate and the change in Tc was measured. Aspirin had no measurable effect on Tc. Vitamin E lowered Tc at a rate of -22 degrees C ...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265475
更新日期:1987-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the sensitivity and specificity of pseudoexfoliation syndrome diagnosis in pseudophakic patients and potential means of improving it. METHODS:This prospective, nonrandomized study comprised 41 consecutive patients (41 eyes) scheduled for cataract surgery at a tertiary medical center during 2016-2...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000508336
更新日期:2020-04-30 00:00:00
abstract::The aim of the present study was to investigate biochemical and morphological changes in rat lenses following long-term UV B irradiation. After an irradiation period of 156 days with follow-up documentation by means of Scheimpflug photography, section-related biochemical analyses of the lenses as well as histological ...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267187
更新日期:1992-01-01 00:00:00
abstract::Indirect measurement in vivo of nuclear color of 64 cataractous eyes was made using a method of image analysis of photographed lenses developed by the authors. The grade of yellow of lens color was characterized by its dominant wavelength and excitation purity in the CIE chromaticity diagram. The differences were smal...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265345
更新日期:1985-01-01 00:00:00
abstract::The purpose of this study was to compare the variability of the amplitude ratios and latencies of the electro-oculogram (EOG) light peak (LP) in three different recording conditions: Arden ratio (dark trough (DT): 12 min), modified Arden ratio (DT: 15 min) and light peak/dark baseline ratio (LP/BL: 35 min of dark adap...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267320
更新日期:1993-01-01 00:00:00