Abstract:
BACKGROUND/AIMS:To evaluate the safety of suramin compared with mitomycin-C (MMC) as an adjunctive agent in trabeculectomy by determining its ciliary body toxicity at predetermined effective dosages in rabbit eyes. METHODS:Thirty-two New Zealand albino rabbits received either suramin (200, 300, 400, or 800 mg/ml) or MMC (0.2, 0.3, 0.4, or 0.8 mg/ml) injections subconjunctivally in the right eye. Enucleations were performed on the 1st, 3rd, 7th and 28th day. Untreated left eyes were injected with balanced salt solution and served as controls. The injection-exposed ciliary body specimens were processed to be investigated under the light microscope and transmission electron microscope. RESULTS:There was no pathologic abnormality in specimens under light microscopy. The morphologic evaluation with transmission electron microscopy showed severe changes in structure, except for eyes treated with 200 mg/ml suramin and 0.2 mg/ml of MMC. These changes were more prominent in eyes exposed to MMC, and appeared earlier compared to suramin-treated eyes. CONCLUSIONS:Suramin 200 mg/ml and MMC 0.2 mg/ml seem to be comparatively nontoxic to the ciliary body of the rabbit eye. Concentrations higher than these values caused severe damage.
journal_name
Ophthalmic Resjournal_title
Ophthalmic researchauthors
Cetinkaya A,Akman A,Take G,Bilezikci B,Akova YAdoi
10.1159/000187625subject
Has Abstractpub_date
2009-01-01 00:00:00pages
91-7issue
2eissn
0030-3747issn
1423-0259pii
000187625journal_volume
41pub_type
杂志文章abstract::Vitamin E (d-alpha-tocopherol) and aspirin were evaluated for their effects on the phase separation temperature, Tc, of calf lens cytoplasm. Vitamin E and aspirin were added to nuclear homogenate and the change in Tc was measured. Aspirin had no measurable effect on Tc. Vitamin E lowered Tc at a rate of -22 degrees C ...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265475
更新日期:1987-01-01 00:00:00
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journal_title:Ophthalmic research
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更新日期:2005-09-01 00:00:00
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journal_title:Ophthalmic research
pub_type: 杂志文章
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更新日期:1982-01-01 00:00:00
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journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267858
更新日期:1995-01-01 00:00:00
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journal_title:Ophthalmic research
pub_type: 杂志文章
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更新日期:1985-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1159/000342979
更新日期:2013-01-01 00:00:00
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journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265483
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pub_type: 杂志文章
doi:10.1159/000448117
更新日期:2017-01-01 00:00:00
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journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000078780
更新日期:2004-07-01 00:00:00
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journal_title:Ophthalmic research
pub_type: 杂志文章
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更新日期:1988-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1996-01-01 00:00:00
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journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265345
更新日期:1985-01-01 00:00:00
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journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267045
更新日期:1990-01-01 00:00:00
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journal_title:Ophthalmic research
pub_type: 杂志文章,评审
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更新日期:2010-01-01 00:00:00
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journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265357
更新日期:1985-01-01 00:00:00
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journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265179
更新日期:1982-01-01 00:00:00
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journal_title:Ophthalmic research
pub_type: 杂志文章
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更新日期:1991-01-01 00:00:00
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journal_title:Ophthalmic research
pub_type: 杂志文章
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更新日期:1987-01-01 00:00:00
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journal_title:Ophthalmic research
pub_type: 杂志文章
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更新日期:1986-01-01 00:00:00