Real-time hexose monophosphate shunt activity in light- and dark-adapted rabbit retinas.

abstract：:To evaluate the effect of single or repeated topical applications of prostaglandin E2 (PGE2) to the cornea on the blood-aqueous barrier, we have measured the extent of flare in the anterior chamber of rabbit eyes at various time intervals. PGE2 was applied to the cornea for 4 min with the use of a glass cylinder in pi...

journal_title：Ophthalmic research

authors： Numata-Watanabe K,Hirata H,Hiraki S,Hayasaka S

更新日期：1996-01-01 00:00:00

abstract：:Small RNA (microRNA or miRNA) is a kind of small noncoding single-stranded RNA that regulates complementary mRNA at the posttranscriptional level in eukaryotic organisms. As important regulatory factors, miRNAs play an important role in the occurrence and development of glaucoma and widely participate in regulating bi...

journal_title：Ophthalmic research

authors： Guo R,Shen W,Su C,Jiang S,Wang J

更新日期：2017-01-01 00:00:00

abstract：:To evaluate the possible role of nitric oxide in the pathogenesis of exogenous prostaglandin (PG) induced aqueous flare elevation, we examined the effect of NG-nitro-L-arginine methyl ester (L-NAME), an L-arginine analogue acting as a specific inhibitor of nitric oxide synthase, on the elevation of aqueous flare in pi...

journal_title：Ophthalmic research

authors： Hiraki S,Zhang XY,Hayasaka S

更新日期：1996-01-01 00:00:00

abstract：PURPOSE:To compare the effects between intravitreal and periocular injections of adenoviral vectored pigment epithelium-derived factor (AdPEDF) on suppressing established choroidal neovascularization (CNV) in rats. METHODS:Sixty-eight female BN rats (136 eyes) aged 6-8 weeks were involved in this study. The CNV animal...

journal_title：Ophthalmic research

authors： Yan H,Cui J,Wang Y,Yu Y

更新日期：2013-01-01 00:00:00

abstract：:The crystalline lens capsules of eye bank eyes, intraocular lens (IOL)-inserted eyes and those of monkey and rabbit eyes were observed in vivo and/or in vitro through a specular microscope or Scheimpflug slit images in combination with new image-processing techniques and scanning electron microscopy. Shagreen patterns...

journal_title：Ophthalmic research

authors： Sasaki K,Kojima M,Hara T

更新日期：1988-01-01 00:00:00

abstract：AIMS:Staphylococcus epidermidis is considered a commensal bacterium; however, it is frequently isolated from ocular infections showing a multidrug resistance. Ciprofloxacin-resistant strains have been isolated from ocular infections; however, resistance to quinolone, such as gatifloxacin and moxifloxacin, is not often ...

journal_title：Ophthalmic research

authors： Betanzos-Cabrera G,Juárez-Verdayes MA,González-González G,Cancino-Díaz ME,Cancino-Díaz JC

更新日期：2009-01-01 00:00:00

abstract：AIM:To develop a local approach to study rabbit lacrimal secretion in situ by administering specific secretagogues directly onto the lacrimal gland (LG). METHODS:After the rabbit has been anesthetized, the inferior bulbar conjunctiva and underlying connective tissue are blunt dissected. A polyethylene tube, for drug d...

journal_title：Ophthalmic research

authors： Ding C,Rife L,Nakamura T,Wang YW,Kopp K,Schechter JE

更新日期：2008-01-01 00:00:00

abstract：:Rat lenses with experimentally induced cataract (either by naphthalene or by streptozotocin) were analyzed biochemically. Both noxae had some effects in common. Water-soluble protein and aldose reductase activity decreased, and glucose-6-phosphate dehydrogenase, phosphofructokinase and glutathione reductase activity i...

journal_title：Ophthalmic research

authors： Korte I,Hockwin O,Bours J,Wegener A

更新日期：1988-01-01 00:00:00

abstract：PURPOSE:To compare tear film osmolarity (TFO) between patients with diabetes mellitus (DM) and normal healthy individuals. METHODS:In this prospective case-controlled study, the TFO in 46 normal subjects (control group) and 55 patients with DM (study group) was evaluated. TFO in milliosmole (mOsm) was measured by usin...

journal_title：Ophthalmic research

authors： Sağdık HM,Ugurbas SH,Can M,Tetikoğlu M,Ugurbas E,Uğurbaş SC,Alpay A,Uçar F

更新日期：2013-01-01 00:00:00

abstract：:Although it is essential that intraocular pressure (IOP) be reduced in glaucoma treatment, it is also vitally important to provide sufficient blood flow to eye tissues so that healthy visual field is maintained. It is possible for an agent to reduce IOP and blood supply to the eye. In that case, glaucoma appears to be...

journal_title：Ophthalmic research

authors： Chiou GC,Yan HY

更新日期：1986-01-01 00:00:00

abstract：:We measured prostaglandin E2 (PGE2) and prostacyclin levels in the vitreous bodies of 5 eyes of patients with diabetic retinopathy complicated by rhegmatogenous retinal detachment (RRD) and compared them with the corresponding levels in 9 nondiabetic eyes with the same condition as well as with 10 control eyes of dece...

journal_title：Ophthalmic research

authors： Naveh N,Belkin M,Ben-Chaim O,Weissman C,Treister G

更新日期：1990-01-01 00:00:00

abstract：AIM:The aim of the current study is to evaluate the role of povidone iodine (PVI) in the management of experimental bacterial endophthalmitis in young rabbits. METHOD:Twenty white rabbits were used. Colony-forming units (CFU) of Staphylococcus epidermidis were injected intravitreally into the right eye of each animal....

journal_title：Ophthalmic research

authors： Brozou CG,Karabatakis V,Giannousis M,Mandraveli K,Karkavelas G,Alexiou-Daniel S

更新日期：2009-01-01 00:00:00

abstract：PURPOSE:To analyze a multiflash multifocal electroretinogram in 20 patients with open-angle glaucoma (OAG). METHODS:The stimulation sequence consisted of a binary m-sequence (L(max) 200 cd/m(2), L(min) <1 cd/m(2)). Each m-sequence stimulus was followed by three global flashes (luminance: 400 cd/m(2)) at an interval of...

journal_title：Ophthalmic research

authors： Palmowski AM,Allgayer R,Heinemann-Vernaleken B,Ruprecht KW

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND:The aim of this study is to provide a quantitative evaluation of the blood-aqueous barrier (BAB) in patients with ocular blunt trauma and evaluate its association with intraocular pressure (IOP) elevation. METHODS:This is a prospective case-control study, and the following 3 groups were included: elevated I...

journal_title：Ophthalmic research

authors： Mao Z,Chen XB,Zhong YM,Guo XX,Liu X

更新日期：2016-07-01 00:00:00

abstract：:Autofluorescence and transmission values of the lens for blue-green light were determined at two locations with the use of identical fluorophotometers: in Coimbra, Portugal, in 44 healthy controls, 15 haemodialysis and 11 renal failure patients, and in Leiden, The Netherlands, in 57 healthy controls, 23 haemodialysis ...

journal_title：Ophthalmic research

authors： van Wirdum E,Mota MC,van Best JA,Leite E,Kappelhof JP,Faria de Abreu JR,Paul LC,Freitas Martins J,Oosterhuis JA,Marques A

更新日期：1988-01-01 00:00:00

abstract：PURPOSE:To investigate the effects, and their reversibility, of multiple oral voriconazole doses on a variety of visual tests in healthy male volunteers. METHODS:Single-center, double-blind, randomized, placebo-controlled, parallel-group study in 36 volunteers who received voriconazole (n=18, 400 mg every 12 h on day ...

journal_title：Ophthalmic research

authors： Zrenner E,Tomaszewski K,Hamlin J,Layton G,Wood N

更新日期：2014-01-01 00:00:00

abstract：PURPOSE:To investigate therapeutic ocular surface medium (TOSM), a potential physiological tear replacement therapy, for persistent epithelial defect (PED). METHODS:11 eyes of 10 patients with PED for ≥ 2 weeks without improvement despite conventional treatment were enrolled in a prospective pilot study of TOSM over 1...

journal_title：Ophthalmic research

authors： Watson SL,Geerling G,Dart JK

更新日期：2014-01-01 00:00:00

abstract：:A system for isolation of capillaries from the retina has been adapted to biochemical studies in vitro. Insulin receptors were identified in human and calf retinal blood vessels. Binding of 125I insulin by calf retinal blood vessels takes place through high affinity (low capacity) and low affinity (high capacity) rece...

journal_title：Ophthalmic research

authors： Cotlier E,Davidson C

更新日期：1983-01-01 00:00:00

abstract：INTRODUCTION:Diabetic Retinopathy (DR) is one of the major vision-threatening causes worldwide. Searching for an individualized therapeutic strategy to prevent its progress is challenging. OBJECTIVE:This work aimed to investigate the association of angiogenesis-inducer vascular endothelial growth factor (VEGF) gene fa...

journal_title：Ophthalmic research

authors： Abdelghany AA,Toraih EA,Mohamed AA,Lashine RM,Saleh MH,Nafie MS,Fawzy MS

更新日期：2020-08-24 00:00:00

abstract：:Lenticular S-adenosylmethionine synthetase has been partially purified and characterized. Lower levels of S-adenosylmethionine synthetase were detected by a sensitive radioactive assay procedure in the lenticular extract obtained from the pooled lenses of alloxan-treated rats 96 days of age as compared to the nontreat...

journal_title：Ophthalmic research

authors： Ahmad SS,Ahmad SI,Rahman MA

更新日期：1982-01-01 00:00:00

abstract：:The effects of optical defocusing with convex lenses on the amplitudes of pattern reversal visual-evoked response (PVER) were investigated. With the large check size and high-contrast pattern, PVER amplitudes showed a linear decrease in response to initial defocusing up to +5 to +6 dptr. As the degree of defocus incre...

journal_title：Ophthalmic research

authors： Katsumi O,Hirose T,Sakaue H,Mehta M,Rosenstein RB

更新日期：1990-01-01 00:00:00

abstract：:Modulation sensitivity functions ( MSFs ) of retinal ganglion cells of the pigeon were determined by recording action potentials from their end branching in the optic tectum as response indicator. The inverse Fourier transformation of a MSF is taken to represent the receptive field sensitivity function approximating t...

journal_title：Ophthalmic research

authors： Pak MA

更新日期：1984-01-01 00:00:00

abstract：:Extracellular recordings were performed on electrophysiologically identified achromatic neurons of the photosensitive pineal organ of the frog. The effects of iontophoretically applied aspartate and glutamate as well as one aspartate antagonist (D-alpha-aminoadipate) were observed on spontaneous activity and light-evo...

journal_title：Ophthalmic research

authors： Meissl H,George SR

更新日期：1984-01-01 00:00:00

abstract：:Statistically significant differences were found to exist in the frequencies of abnormal cell types in cultured lenses depending on the composition of the nutrient media (Eagle's and Dulbecco's modified essential medium with fetal calf serum FCS) they were cultured on. Abnormal cell growth (epithelioid, fibroblast-lik...

journal_title：Ophthalmic research

authors： Veroman S,Viikmaa M

更新日期：1989-01-01 00:00:00

abstract：:This study examined and characterized the distribution and kinetics of the inflammatory cell response to pseudomonas ocular challenge in susceptible C57BL/6J and resistant DBA/2J mice. Initially, in the cornea, the number of neutrophilic leukocytes (PMNs), macrophages/monocytes or lymphocytes was 2-2.5 times greater i...

journal_title：Ophthalmic research

authors： Hazlett LD,Zucker M,Berk RS

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVE:Transient receptor potential canonical (TRPC) channels are involved in neovascularization repairing after vascular injury in many tissues. However, whether TRPCs play a regulatory role in the development of diabetic retinopathy (DR) has rarely been reported. In the present study, we selected TRPC1, 3, and 6 t...

journal_title：Ophthalmic research

authors： Lang HB,Xie RX,Huang ML,Fang LY,Tang YB,Zhang F

更新日期：2020-01-01 00:00:00

abstract：:The development and extension of fibrovascular or fibroglial membranes onto the retinal surface are a major cause of visual loss in diabetic patients with proliferative retinopathy and in patients suffering from retinal detachment with proliferative vitreoretinopathy. The pathogenesis of these proliferative diseases, ...

journal_title：Ophthalmic research

authors： Fredj-Reygrobellet D,Baudouin C,Nègre F,Caruelle JP,Gastaud P,Lapalus P

更新日期：1991-01-01 00:00:00

abstract：PURPOSE:To study the ability to appreciate qualitative features that indicate disease activity in patients with neovascular age-related macular degeneration (AMD) and to analyze the differences in automated retinal thickness measurement, using 1 time domain optical coherence tomography (TD-OCT) and 2 different spectral...

journal_title：Ophthalmic research

authors： Querques G,Forte R,Berboucha E,Martinelli D,Coscas G,Soubrane G,Souied EH

更新日期：2011-01-01 00:00:00

abstract：PURPOSE:To analyze chloroquine-induced morphological changes in the retinal pigment epithelium (RPE) and Bruch's membrane (BM). METHODS:Retina-choroid complexes of chloroquine-treated Long-Evans rats were analyzed by electron microscopy. RESULTS:Intercellular spaces between the RPE cells and BM were enlarged. Residua...

journal_title：Ophthalmic research

authors： Peters S,Reinthal E,Blitgen-Heinecke P,Bartz-Schmidt KU,Schraermeyer U

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:To evaluate a technique of autologous internal limiting membrane (ILM) fragment transplantation for the treatment of large, chronic, and/or refractory macular holes (MH). DESIGN:This was a 6-month prospective interventional case series. METHOD:Ten eyes of 10 patients with MH underwent pars plana vitretomy (...

journal_title：Ophthalmic research

authors： De Novelli FJ,Preti RC,Ribeiro Monteiro ML,Pelayes DE,Junqueira Nóbrega M,Takahashi WY

更新日期：2015-01-01 00:00:00