Lens transmission and autofluorescence in renal disease.


:Autofluorescence and transmission values of the lens for blue-green light were determined at two locations with the use of identical fluorophotometers: in Coimbra, Portugal, in 44 healthy controls, 15 haemodialysis and 11 renal failure patients, and in Leiden, The Netherlands, in 57 healthy controls, 23 haemodialysis and 47 renal transplant patients. The increase in lens autofluorescence as a function of age was 42% higher in the Portuguese controls than that in the Dutch controls (p less than 0.001), but the lens transmission did not differ significantly (p = 0.21). Significant differences were found between the autofluorescence values of the Portuguese haemodialysis and renal failure patients and those of age-matched local controls (+18%, p = 0.009, and +26%, p = 0.03, respectively), as well as between the lens transmission values of the Portuguese renal failure patients and those of age-matched local controls (-2%, p = 0.03). In the renal transplant patients the average autofluorescence and lens transmission values were equal to those of the local controls (within 3%) and independent of the number of anti-rejection treatments administered.


Ophthalmic Res


Ophthalmic research


van Wirdum E,Mota MC,van Best JA,Leite E,Kappelhof JP,Faria de Abreu JR,Paul LC,Freitas Martins J,Oosterhuis JA,Marques A




Has Abstract


1988-01-01 00:00:00












  • Changes in foveal thickness and macular function after transpupillary thermotherapy for age-related macular degeneration.

    abstract:PURPOSE:To evaluate the effect of transpupillary thermotherapy (TTT) on foveal thickness and macular function in eyes with choroidal neovascularization (CNV) associated with age-related macular degeneration. METHODS:Sixteen eyes with occult CNV and 6 eyes with classic CNV were treated with TTT. Optical coherence tomog...

    journal_title:Ophthalmic research

    pub_type: 杂志文章


    authors: Ishikawa K,Terasaki H,Kobayashi C,Niwa Y,Piao CH,Ito Y,Kondo M,Miyake Y

    更新日期:2005-01-01 00:00:00

  • The Effect and Mechanism of TRPC1, 3, and 6 on the Proliferation, Migration, and Lumen Formation of Retinal Vascular Endothelial Cells Induced by High Glucose.

    abstract:OBJECTIVE:Transient receptor potential canonical (TRPC) channels are involved in neovascularization repairing after vascular injury in many tissues. However, whether TRPCs play a regulatory role in the development of diabetic retinopathy (DR) has rarely been reported. In the present study, we selected TRPC1, 3, and 6 t...

    journal_title:Ophthalmic research

    pub_type: 杂志文章


    authors: Lang HB,Xie RX,Huang ML,Fang LY,Tang YB,Zhang F

    更新日期:2020-01-01 00:00:00

  • Binding of fluorescein and carboxyfluorescein by normal and glycosylated human serum proteins.

    abstract::The binding of fluorescein and 6-carboxyfluorescein by normal, diabetic and in vitro glycosylated human serum proteins was analyzed by absorption and fluorescence spectroscopy, gel filtration and equilibrium dialysis. The absorption spectra of bound fluorochromes showed red shifts and hypochromic changes, and fluoroch...

    journal_title:Ophthalmic research

    pub_type: 杂志文章


    authors: Rockey JH,Li W

    更新日期:1982-01-01 00:00:00

  • Optical Coherence Tomography Angiography in Children with Leber-Coats Disease.

    abstract:INTRODUCTION:The aim of this work was to describe the optical coherence tomography (OCT) angiography (OCTA) features in paediatric Leber-Coats disease. METHODS:Three children presenting with unilateral, clinically active Leber-Coats disease were evaluated using spectral domain OCT and OCTA. OCT angiograms were analyse...

    journal_title:Ophthalmic research

    pub_type: 杂志文章


    authors: Fortunato M,Turtoro A,Cennamo G

    更新日期:2017-01-01 00:00:00

  • Polymorphonuclear leukocytes and bacterial growth of the normal and mildly inflamed conjunctiva.

    abstract::We examined 304 conjunctiva in 152 subjects by clinical, cytologic, and bacteriologic methods. Bacteriologic samples were evaluated after a 48-hour incubation. Bacterial growth was found in 8 (20.5%) of 39 patients with clinically normal conjunctiva and no polymorphonuclear leukocytes (PMNs), and in 8 (61.5%) of 13 su...

    journal_title:Ophthalmic research

    pub_type: 杂志文章


    authors: Ugomori S,Hayasaka S,Setogawa T

    更新日期:1991-01-01 00:00:00

  • Direct in vivo measurement of corneal epithelial metabolic activity using a polarographic oxygen sensor.

    abstract::The component oxygen fluxes that constitute a single recording of corneal oxygen uptake when a polarographic oxygen sensor (POS) is placed in contact with the cornea were determined in the in vivo rabbit eye by removing the epithelium and injecting an air bubble into the anterior chamber. The relative contribution of ...

    journal_title:Ophthalmic research

    pub_type: 杂志文章


    authors: Holden BA,Sulonen J,Vannas A,Sweeney DF,Efron N

    更新日期:1985-01-01 00:00:00

  • Comparison of intraocular pressure measurements with the digital tonometer TGDc-01 'PRA' and the Goldmann applanation tonometer.

    abstract:BACKGROUND:To compare intraocular pressure (IOP) measurements obtained with the digital tonometer TGDc-01 'PRA' with those from a Goldmann applanation tonometer (GAT). METHODS:The IOP in 176 eyes of 88 healthy volunteers was measured prospectively in a sitting position. One single measurement, generated by the TGDc-01...

    journal_title:Ophthalmic research

    pub_type: 杂志文章


    authors: Meyer MW,Gockeln R,Hoy L,Meyer A,Erb C

    更新日期:2004-09-01 00:00:00

  • Ultrastructural study of rainbow trout lenses incubated under various conditions.

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    journal_title:Ophthalmic research

    pub_type: 杂志文章


    authors: Uga S,Ishikawa S,Hikida M,Iwata S

    更新日期:1986-01-01 00:00:00

  • Modulation sensitivity and functional organization of the receptive field of ganglion cells in the pigeon (Columba livia).

    abstract::Modulation sensitivity functions ( MSFs ) of retinal ganglion cells of the pigeon were determined by recording action potentials from their end branching in the optic tectum as response indicator. The inverse Fourier transformation of a MSF is taken to represent the receptive field sensitivity function approximating t...

    journal_title:Ophthalmic research

    pub_type: 杂志文章


    authors: Pak MA

    更新日期:1984-01-01 00:00:00

  • Influence of Vitreomacular Adhesion on Anti-Vascular Endothelial Growth Factor Treatment for Neovascular Age-Related Macular Degeneration.

    abstract:PURPOSE:To investigate the effect of vitreomacular adhesion (VMA) on the outcome of antiangiogenic treatment for neovascular age-related macular degeneration (AMD). METHODS:Ninety-nine eyes of 83 patients were used in our cohort study. We prospectively evaluated best corrected visual acuity (BCVA) and central retinal ...

    journal_title:Ophthalmic research

    pub_type: 杂志文章


    authors: Kanadani TCM,Dos Reis Veloso CE,Dorairaj S,Nehemy MB

    更新日期:2017-01-01 00:00:00

  • Bilateral Lateral Rectus Recession for the Treatment of Recurrent Exotropia after Bilateral Medial Rectus Resection.

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    journal_title:Ophthalmic research

    pub_type: 杂志文章


    authors: Wang X,Chen X,Liu L

    更新日期:2019-01-01 00:00:00

  • Light damage in the rat retina: glial fibrillary acidic protein accumulates in Müller cells in correlation with photoreceptor damage.

    abstract::Low intensity diffuse white fluorescent light (1,000 lx for 2 h) exclusively induced photoreceptor damage in the inferior retina of albino rats; the temporal retina showed extensive damage, whereas the nasal retina revealed threshold lesions prior to recovery. To expand our morphological data, further experiments were...

    journal_title:Ophthalmic research

    pub_type: 杂志文章


    authors: de Raad S,Szczesny PJ,Munz K,Remé CE

    更新日期:1996-01-01 00:00:00

  • Monitoring lens transparency during in vitro incubation by Scheimpflug photography and densitometric image analysis.

    abstract::Dragomirescu et al. [1983] described a 2-chamber flow system for the incubation of lenses with an inserted photometer to measure changes in lens transparency. Mester et al. [1984] applied the method to simulate conditions occurring during vitrectomy, which occasionally leads to reversible lens opacification. Using Sch...

    journal_title:Ophthalmic research

    pub_type: 杂志文章


    authors: Hockwin O,Dragomirescu V,Schwarz B

    更新日期:1985-01-01 00:00:00

  • Quercetin inhibits vascular endothelial growth factor-induced choroidal and retinal angiogenesis in vitro.

    abstract:PURPOSE:The aim of this study was to investigate the effects of quercetin on vascular endothelial growth factor (VEGF)-induced choroidal and retinal angiogenesis in vitro using a rhesus macaque choroid-retinal endothelial (RF/6A) cell line. METHODS:RF/6A cells were cultured in Dulbecco's modified Eagle's medium contai...

    journal_title:Ophthalmic research

    pub_type: 杂志文章


    authors: Li F,Bai Y,Zhao M,Huang L,Li S,Li X,Chen Y

    更新日期:2015-01-01 00:00:00

  • Green tea (Camellia sinensis) protects against selenite-induced oxidative stress in experimental cataractogenesis.

    abstract::Cataract is the leading cause of blindness worldwide. It is a multifactorial disease primarily associated with oxidative stress produced by free radicals. The protection offered by various antioxidants in cataract development is well established. Polyphenolic compounds present in green tea (Camellia sinensis) are repo...

    journal_title:Ophthalmic research

    pub_type: 杂志文章


    authors: Gupta SK,Halder N,Srivastava S,Trivedi D,Joshi S,Varma SD

    更新日期:2002-07-01 00:00:00

  • Comparison of the effects between intravitreal and periocular injections of adenoviral vectored pigment epithelium-derived factor on suppressing choroidal neovascularization in rats.

    abstract:PURPOSE:To compare the effects between intravitreal and periocular injections of adenoviral vectored pigment epithelium-derived factor (AdPEDF) on suppressing established choroidal neovascularization (CNV) in rats. METHODS:Sixty-eight female BN rats (136 eyes) aged 6-8 weeks were involved in this study. The CNV animal...

    journal_title:Ophthalmic research

    pub_type: 杂志文章


    authors: Yan H,Cui J,Wang Y,Yu Y

    更新日期:2013-01-01 00:00:00

  • A mild progression type of naphthalene-induced cataract in brown-Norway rats.

    abstract::Naphthalene-induced rat cataract is a useful experimental cataract--however, because of its short survival period, studies using this model have been for limited purposes. Based on the consideration that the short survival might be caused by systemic toxicity of an overdose of naphthalene administration (1 g/kg body w...

    journal_title:Ophthalmic research

    pub_type: 杂志文章


    authors: Nagata M,Murano H,Kojima M,Sasaki K

    更新日期:1995-01-01 00:00:00

  • In vitro prevention of vaccinia and herpesvirus infection spread in explanted human corneas by N-chlorotaurine.

    abstract:OBJECTIVE:Weak oxidants produced by activated human leukocytes are proven antimicrobial substances. We tested whether N-chlorotaurine (NCT, taurine chloramine), the chlorinated metabolite of the amino acid taurine, in addition to direct virucidal effects on viral suspensions, has the capability to prevent cell-to-cell ...

    journal_title:Ophthalmic research

    pub_type: 杂志文章


    authors: Huemer HP,Nagl M,Irschick EU

    更新日期:2010-01-01 00:00:00

  • Insulin receptors in calf and human retinal blood vessels.

    abstract::A system for isolation of capillaries from the retina has been adapted to biochemical studies in vitro. Insulin receptors were identified in human and calf retinal blood vessels. Binding of 125I insulin by calf retinal blood vessels takes place through high affinity (low capacity) and low affinity (high capacity) rece...

    journal_title:Ophthalmic research

    pub_type: 杂志文章


    authors: Cotlier E,Davidson C

    更新日期:1983-01-01 00:00:00


    abstract:INTRODUCTION:This study aimed to evaluate the longitudinal changes in retinal layers thickness in patients treated with hydroxychloroquine and no signs of retinal toxicity. METHODS:Longitudinal retrospective study of patients taking hydroxychloroquine followed in a hydroxychloroquine retinal toxicity screening program...

    journal_title:Ophthalmic research

    pub_type: 杂志文章


    authors: Godinho G,Madeira C,Falcão M,Penas S,Dinah-Bragança T,Brandão E,Carneiro Â,Santos-Silva R,Falcão-Reis F,Beato J

    更新日期:2020-09-15 00:00:00

  • A novel, local technique for studying rabbit lacrimal gland secretion in situ.

    abstract:AIM:To develop a local approach to study rabbit lacrimal secretion in situ by administering specific secretagogues directly onto the lacrimal gland (LG). METHODS:After the rabbit has been anesthetized, the inferior bulbar conjunctiva and underlying connective tissue are blunt dissected. A polyethylene tube, for drug d...

    journal_title:Ophthalmic research

    pub_type: 杂志文章


    authors: Ding C,Rife L,Nakamura T,Wang YW,Kopp K,Schechter JE

    更新日期:2008-01-01 00:00:00

  • DNA Aptamer Raised against Advanced Glycation End Products Prevents Abnormalities in Electroretinograms of Experimental Diabetic Retinopathy.

    abstract:PURPOSE:Abnormalities in electroretinograms (ERG), such as reduced amplitudes and delayed implicit times of a- and b-wave and oscillatory potentials (OPs), are one of the earliest features of diabetic retinopathy prior to obvious vascular changes in diabetic retinas. We have previously shown that serum levels of advanc...

    journal_title:Ophthalmic research

    pub_type: 杂志文章


    authors: Maeda S,Matsui T,Ojima A,Suematsu M,Kaseda K,Higashimoto Y,Yamakawa R,Yamagishi S

    更新日期:2015-01-01 00:00:00

  • A method to quantify neovascularization in the mouse cornea.

    abstract::A method for microscopical observation and quantification of corneal neovascularization in the living mouse is described. Measurements of the corneal vasculature were made on still-mode video-pictures of the cornea. The validity of the method was shown by the high correlation between the morphometric measurements and ...

    journal_title:Ophthalmic research

    pub_type: 杂志文章


    authors: Falkvoll KH

    更新日期:1991-01-01 00:00:00

  • Acute corneal epithelial change after instillation of benzalkonium chloride evaluated using a newly developed in vivo corneal transepithelial electric resistance measurement method.

    abstract:OBJECTIVE:Acute corneal permeability change after instillation of benzalkonium chloride (BAC) was evaluated using a newly developed in vivo corneal transepithelial electric resistance (TER) measurement method. METHOD:Corneal TER was measured by Ag/AgCl electrodes placed in the anterior aqueous chamber and on the corne...

    journal_title:Ophthalmic research

    pub_type: 杂志文章


    authors: Uematsu M,Kumagami T,Kusano M,Yamada K,Mishima K,Fujimura K,Sasaki H,Kitaoka T

    更新日期:2007-01-01 00:00:00

  • Management of Diabetic Macular Edema.

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    journal_title:Ophthalmic research

    pub_type: 杂志文章,评审


    authors: Moisseiev E,Loewenstein A

    更新日期:2017-01-01 00:00:00

  • IL-1α and MMP-9 Tear Levels of Patients with Active Ocular Rosacea before and after Treatment with Systemic Azithromycin or Doxycycline.

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    journal_title:Ophthalmic research

    pub_type: 杂志文章


    authors: Lam-Franco L,Perfecto-Avalos Y,Patiño-Ramírez BE,Rodríguez García A

    更新日期:2018-01-01 00:00:00

  • Characteristics of the cellular response of the rat conjunctiva to topically applied leukotriene B4.

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    journal_title:Ophthalmic research

    pub_type: 杂志文章


    authors: Trocmé SD,Gilbert CM,Allansmith MR,Bloch KJ,Abelson MB

    更新日期:1989-01-01 00:00:00

  • Effect of pneumatic suction ring placement on intraocular pressure in cats.

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    journal_title:Ophthalmic research

    pub_type: 杂志文章


    authors: Li B

    更新日期:2001-09-01 00:00:00

  • Lens fibre cell differentiation - A link with apoptosis?

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    journal_title:Ophthalmic research

    pub_type: 杂志文章,评审


    authors: Dahm R

    更新日期:1999-01-01 00:00:00

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    journal_title:Ophthalmic research

    pub_type: 杂志文章


    authors: Hwang H,Kim M,Park C

    更新日期:2011-01-01 00:00:00