Insulin receptors in calf and human retinal blood vessels.

abstract：:To evaluate the possible role of nitric oxide in the pathogenesis of exogenous prostaglandin (PG) induced aqueous flare elevation, we examined the effect of NG-nitro-L-arginine methyl ester (L-NAME), an L-arginine analogue acting as a specific inhibitor of nitric oxide synthase, on the elevation of aqueous flare in pi...

journal_title：Ophthalmic research

authors： Hiraki S,Zhang XY,Hayasaka S

更新日期：1996-01-01 00:00:00

abstract：:Tear hyperosmolarity is known to cause ocular surface inflammation in dry eye syndrome. Benzalkonium chloride (BAK), an eyedrop preservative, is known to induce dry eye in long-term-treated patients. Analyzing the modulation of the proinflammatory potential of hyperosmolarity in the presence of BAK on the conjunctiva ...

journal_title：Ophthalmic research

authors： Warcoin E,Clouzeau C,Roubeix C,Raveu AL,Godefroy D,Riancho L,Baudouin C,Brignole-Baudouin F

更新日期：2017-01-01 00:00:00

abstract：PURPOSE:To demonstrate the value of the laser-scanning optical-resolution (LSOR)-photoacoustic (PA) microscopy (PAM) system and the conventional multimodal imaging techniques in the evaluation of laser-induced retinal injury and choroidal neovascularization (CNV) in rats. METHODS:Different degrees of retinal injury we...

journal_title：Ophthalmic research

authors： Xiao M,Dai C,Li L,Zhou C,Wang F

更新日期：2020-01-01 00:00:00

abstract：AIM:This study was done to evaluate the role of pentosidine in predicting the progression of diabetic retinopathy. PATIENTS AND METHODS:We included 30 subjects with insulin-dependent diabetes mellitus (type 1) and 10 healthy control individuals. A case control study was done. Full ophthalmological examination together...

journal_title：Ophthalmic research

authors： Salman AG,Mansour DE,Swelem AH,Al-Zawahary WM,Radwan AA

更新日期：2009-01-01 00:00:00

abstract：:The use of corneal tissue for ex vivo therapeutic evaluations is limited due to its rapid loss of viability after excision. Optimization of storage conditions may allow prolonged retention of physical tissue properties. In this study, we evaluated how storage in optimized organ culture (OC) medium at 37°C or phosphate...

journal_title：Ophthalmic research

authors： Thakur SS,Shrestha D,Rupenthal ID

更新日期：2019-01-01 00:00:00

abstract：:Low intensity diffuse white fluorescent light (1,000 lx for 2 h) exclusively induced photoreceptor damage in the inferior retina of albino rats; the temporal retina showed extensive damage, whereas the nasal retina revealed threshold lesions prior to recovery. To expand our morphological data, further experiments were...

journal_title：Ophthalmic research

authors： de Raad S,Szczesny PJ,Munz K,Remé CE

更新日期：1996-01-01 00:00:00

abstract：:The gut microbiome has important physiological functions and plays an indispensable role in the human body. Currently, there are an increasing number of studies revealing the close correlation between dysbiosis of the gut microbiome and a variety of autoimmune diseases, including autoimmune uveitis. This brief review ...

journal_title：Ophthalmic research

authors： Fu X,Chen Y,Chen D

更新日期：2020-07-16 00:00:00

abstract：:Adult human lenses with focal opacities were processed for normal as well as freeze fracture electron microscopy. Cholesterol was demonstrated using filipin cytochemistry. Filipin cytochemistry in combination with freeze fracture revealed that the amount of cholesterol in the normal fibre membranes was fully comparabl...

journal_title：Ophthalmic research

authors： VanMarle J,Vrensen GF

更新日期：2000-11-01 00:00:00

abstract：:This study was undertaken to characterize the mechanism of ocular irritation to YAG laser capsulotomy in rabbits. The blocking agents were administered intravitreally. (D-Arg1,D-Pro2,D-Trp7,9)-SP, a substance P antagonist, tended to reduce miosis but had no effect on intraocular pressure (IOP). It had less effect on m...

journal_title：Ophthalmic research

authors： Oksala O,Stjernschantz J,von Dickhoff K

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVE:Transient receptor potential canonical (TRPC) channels are involved in neovascularization repairing after vascular injury in many tissues. However, whether TRPCs play a regulatory role in the development of diabetic retinopathy (DR) has rarely been reported. In the present study, we selected TRPC1, 3, and 6 t...

journal_title：Ophthalmic research

authors： Lang HB,Xie RX,Huang ML,Fang LY,Tang YB,Zhang F

更新日期：2020-01-01 00:00:00

abstract：AIM/BACKGROUND:A 1-bp deletion (1147delA) in the SAG (also known as arrestin or S-antigen) gene is the most frequently seen mutation in Japanese patients suffering from Oguchi disease, a recessively inherited stationary night blindness. We investigated macular function in a patient with Oguchi disease with the 1147delA...

journal_title：Ophthalmic research

authors： Hayashi T,Tsuzuranuki S,Kozaki K,Urashima M,Tsuneoka H

更新日期：2011-10-01 00:00:00

abstract：:Substance P (SP) immunoreactivity was demonstrated using the indirect immunofluorescence technique in one normal and one retinoblastomatous human retina. In the normal retina SP immunoreaction was located in nerve fibres but not in the neurons in the inner plexiform layer. A similar location was observed in the histol...

journal_title：Ophthalmic research

authors： Tarkkanen A,Tervo T,Tervo K,Eränkö L,Eränkö O,Cuello AC

更新日期：1983-01-01 00:00:00

abstract：:To determine the conditions under which anesthetized pigs can be used in acute noninvasive investigations of ocular hydro- and hemodynamics, the intraocular pressure (IOP) of adult pigs was recorded under the following conditions: (1) after intravenous injection of propofol plus ketamine; (2) during inhalation of isof...

journal_title：Ophthalmic research

authors： Buehner E,Pietsch UC,Bringmann A,Foja C,Wiedemann P,Uhlmann S

更新日期：2011-01-01 00:00:00

abstract：:Equine recurrent uveitis (ERU) is an autoimmune disease that occurs with a high prevalence (10%) in horses. ERU represents the only reliable spontaneous model for human autoimmune uveitis. We already identified and characterized novel autoantigens (malate dehydrogenase, recoverin, CRALBP) by analyzing the autoantibody...

journal_title：Ophthalmic research

authors： Deeg CA,Hauck SM,Amann B,Pompetzki D,Altmann F,Raith A,Schmalzl T,Stangassinger M,Ueffing M

更新日期：2008-01-01 00:00:00

abstract：:Energy-dispersive X-ray analysis was used to obtain distribution profiles of Na, K, Cl, P and S in rapidly frozen-dried bulk specimens, and in cryosections of the normal rat lens. Na and Cl are highly concentrated in the capsule, and K and P, in the epithelial cells. Profiles of the entire radius of a lens show relati...

journal_title：Ophthalmic research

authors： Harding CV,Susan S,Bobrowski W

更新日期：1984-01-01 00:00:00

abstract：:To determine the effect of interleukin-10 (IL-10) and transforming growth factor-beta (TGF-beta) on the down-regulation of MHC class II antigens, bovine retinal pigment epithelial (RPE) cells were incubated with interferon-gamma (IFN-gamma) in different concentrations. Subsequently, the IFN-gamma pretreated RPE cells ...

journal_title：Ophthalmic research

authors： Enzmann V,Stadler M,Wiedemann P,Kohen L

更新日期：1999-01-01 00:00:00

abstract：:Using cuprolinic blue staining, we histochemically examined the ultrastructural localization of proteoglycans in the fibrous-type human posterior capsule opacification. This capsule opacification contained proteoglycans that showed positive staining with cuprolinic blue. Many cuprolinic-blue-positive filaments were pr...

journal_title：Ophthalmic research

authors： Ishibashi T,Araki H,Sugai S,Tawara A,Inomata H

更新日期：1995-01-01 00:00:00

abstract：AIMS:To evaluate the biologic effects of fluoroquinolone eye solutions without preservatives on cultured human corneal epithelial cells in vitro. METHODS:We studied the effect of diverse generations of topical fluoroquinolones such as ofloxacin 0.3%, levofloxacin 0.5%, tosufloxacin 0.3%, moxifloxacin 0.5% and gatiflox...

journal_title：Ophthalmic research

authors： Oum BS,Kim NM,Lee JS,Park YM

更新日期：2014-01-01 00:00:00

abstract：INTRODUCTION:Retinitis pigmentosa (RP) is an inherited retinal disorder, characterized by photoreceptor degeneration inducing progressive vision loss. This study evaluates its impact on quality of life (QOL) and emotional states of patients affected by RP. METHODS:A cross-sectional study was conducted on 60 RP patient...

journal_title：Ophthalmic research

authors： Azoulay L,Chaumet-Riffaud P,Jaron S,Roux C,Sancho S,Berdugo N,Audo I,Sahel JA,Mohand-Saïd S

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:To evaluate a technique of autologous internal limiting membrane (ILM) fragment transplantation for the treatment of large, chronic, and/or refractory macular holes (MH). DESIGN:This was a 6-month prospective interventional case series. METHOD:Ten eyes of 10 patients with MH underwent pars plana vitretomy (...

journal_title：Ophthalmic research

authors： De Novelli FJ,Preti RC,Ribeiro Monteiro ML,Pelayes DE,Junqueira Nóbrega M,Takahashi WY

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:To evaluate the corneal button of primary penetrating keratoplasty of patients diagnosed with congenital aniridia. The study took place at the Instituto Universitario Barraquer and the Centro de Oftalmología Barraquer. METHODS:A retrospective analysis of cases diagnosed with congenital aniridia was carried out...

journal_title：Ophthalmic research

authors： Bausili MM,Alvarez de Toledo J,Barraquer RI,Michael R,Tresserra F,de la Paz MF

更新日期：2016-01-01 00:00:00

abstract：PURPOSE:In this investigation the authors studied the effect of dapiprazole, an alpha-adrenergic blocking agent, on aqueous humor dynamics in patients affected with pigmentary glaucoma. METHODS:Dapiprazole 0.5% eye drops were administered 3 times daily as adjunctive therapy to 16 pigmentary glaucoma patients in additi...

journal_title：Ophthalmic research

authors： Mastropasqua L,Carpineto P,Ciancaglini M,Lobefalo L,Costagliola C,Gallenga PE

更新日期：1996-01-01 00:00:00

abstract：PURPOSE:Abnormalities in electroretinograms (ERG), such as reduced amplitudes and delayed implicit times of a- and b-wave and oscillatory potentials (OPs), are one of the earliest features of diabetic retinopathy prior to obvious vascular changes in diabetic retinas. We have previously shown that serum levels of advanc...

journal_title：Ophthalmic research

authors： Maeda S,Matsui T,Ojima A,Suematsu M,Kaseda K,Higashimoto Y,Yamakawa R,Yamagishi S

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:To compare tear film osmolarity (TFO) between patients with diabetes mellitus (DM) and normal healthy individuals. METHODS:In this prospective case-controlled study, the TFO in 46 normal subjects (control group) and 55 patients with DM (study group) was evaluated. TFO in milliosmole (mOsm) was measured by usin...

journal_title：Ophthalmic research

authors： Sağdık HM,Ugurbas SH,Can M,Tetikoğlu M,Ugurbas E,Uğurbaş SC,Alpay A,Uçar F

更新日期：2013-01-01 00:00:00

abstract：:Conventional Scheimpflug photography uses slits with a constant width of 80 microns. This parameter limits the resolution as sharp contours are imaged with a basic uncertainty. In order to reduce this basic uncertainty we developed an illumination slit with a width of 20 microns and less, using a green helium-neon las...

journal_title：Ophthalmic research

authors： Huebscher HJ,Möller DE,Seiler T

更新日期：1996-01-01 00:00:00

abstract：:We hypothesize that the differential susceptibility to photic injury among different strains of rat retinas may depend on the levels of phospholipid hydroperoxide glutathione peroxidase (PHGPX) activity, one of the endogenous antioxidant enzymes in the retina. The retinas of four inbred strains of albino rat (Fischer,...

journal_title：Ophthalmic research

authors： Wang L,Lam TT,Lam KW,Tso MO

更新日期：1994-01-01 00:00:00

abstract：:The eyes of 200 rats (Mol:SPRD, Moellegaard Ltd., Skensvet, Denmark), 8 weeks of age and of both sexes, were examined routinely with a photo-slitlamp microscope (Zeiss) and opthalmoscope (Heine) 3-4 times in the course of four different 12-week toxicity studies. The animals were kept under constant lighting conditions...

journal_title：Ophthalmic research

authors： Wegener A,Jochims K

更新日期：1994-01-01 00:00:00

abstract：:Oxidative stress plays a role in the pathogenesis of neurodegeneration in diabetic retinopathy (DR). However, whether an excellent reactive oxygen species scavenger, U83836E, inhibits the neurodegeneration in DR remains uncertain. This study is aimed at clarifying the effects of U83836E on DR. Two weeks after streptoz...

journal_title：Ophthalmic research

authors： Wang H,Zheng Z,Gong Y,Zhu B,Xu X

更新日期：2011-01-01 00:00:00

abstract：PURPOSE:Osthole is an agent isolated from Cnidium monnieri (L.) Cusson and has been used to treat several disorders. Corneal neovascularization is a sight-threatening condition associated with several inflammatory or infectious ocular disorders. In this study, we investigated the anti-angiogenic effects of osthole on c...

journal_title：Ophthalmic research

authors： Zhang QY,Tao SY,Lu C,Li JJ,Li XM,Jiang Q,Yan B

更新日期：2020-01-01 00:00:00

abstract：:Dry eye is the most prominent pathology among those involving the ocular surface: a decrease of the aqueous (less frequent) or the lipid (more frequent) component of the tear film is the cause of the diminished stability of tears that is observed in this pathology. Dry eye shows a clear distribution linked to both sex...

journal_title：Ophthalmic research

authors： Rusciano D,Pezzino S,Olivieri M,Cristaldi M,Gagliano C,Lupo G,Anfuso CD

更新日期：2018-01-01 00:00:00