Animal Models of Proliferative Vitreoretinopathy and Their Use in Pharmaceutical Investigations.

abstract：OBJECTIVE:The pathogenesis of Behçet's disease (BD) may be related to excessive production of reactive oxygen species, activated neutrophils, and T lymphocytes. The goal of this prospective study was to investigate whether there is any relationship among the oxidant/antioxidant system and nitric oxide (NO) and malondia...

journal_title：Ophthalmic research

authors： Aydin E,Sögüt S,Ozyurt H,Ozugurlu F,Akyol O

更新日期：2004-05-01 00:00:00

abstract：PURPOSE:To investigate the role of integrin-linked kinase (ILK) in endothelial cell migration, proliferation and tube formation in vitro. MATERIALS AND METHODS:Cultured RF/6A cells were knocked down for ILK using small interfering RNA (siRNA). Cellular ILK expression was quantified by real-time quantitative PCR and We...

journal_title：Ophthalmic research

authors： Guo L,Yu W,Li X,Zhao G,He P

更新日期：2009-01-01 00:00:00

abstract：:We investigated the effects of hyperthermia on the healing process of experimental Pseudomonas corneal ulceration (PCU). Hartley guinea pigs were used to develop animal models of PCU. As a heat source, disposable chemical pocket warmers were applied. The healing process of PCU was compared between the heat-treated cor...

journal_title：Ophthalmic research

authors： Nanbu PN,Wakabayashi T,Yamashita R,Hayashi H,Hisano S,Oshika T

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND:To compare intraocular pressure (IOP) measurements obtained with the digital tonometer TGDc-01 'PRA' with those from a Goldmann applanation tonometer (GAT). METHODS:The IOP in 176 eyes of 88 healthy volunteers was measured prospectively in a sitting position. One single measurement, generated by the TGDc-01...

journal_title：Ophthalmic research

authors： Meyer MW,Gockeln R,Hoy L,Meyer A,Erb C

更新日期：2004-09-01 00:00:00

abstract：:L-Timolol (0.4 mg/kg) reduced significantly retinal blood flow (17%), systemic blood pressure (18-20%) and heart rate (28%) in the rabbit. D-Timolol (4.0 mg/kg) increased retinal blood flow slightly (9%) and did not significantly affect systemic blood pressure or heart rate. Since D-timolol is effective in reducing in...

journal_title：Ophthalmic research

authors： Yan HY,Chiou GC

更新日期：1987-01-01 00:00:00

abstract：:To ascertain the effectiveness of topical antioxidant therapy on acute corneal inflammation, we have studied the effectiveness of topical treatment with a saline solution and with antioxidants such as 0.2% superoxide dismutase and 0.5% dimethylthiourea (DMTU) in a controlled experimental study. The evolution of the in...

journal_title：Ophthalmic research

authors： Alio JL,Ayala MJ,Mulet ME,Artola A,Ruiz JM,Bellot J

更新日期：1995-01-01 00:00:00

abstract：:Cholinergic agents used to lower intraocular pressure in the medical management of glaucoma act on muscarinic receptors in the eye. Recently, subtypes of muscarinic receptors have been recognized in many tissues including the eye. To localize the M3 muscarinic receptor subtype and m3 messenger RNA (mRNA) in the human ...

journal_title：Ophthalmic research

authors： Gupta N,Drance SM,McAllister R,Prasad S,Rootman J,Cynader MS

更新日期：1994-01-01 00:00:00

abstract：:Substance P (SP) immunoreactivity was demonstrated using the indirect immunofluorescence technique in one normal and one retinoblastomatous human retina. In the normal retina SP immunoreaction was located in nerve fibres but not in the neurons in the inner plexiform layer. A similar location was observed in the histol...

journal_title：Ophthalmic research

authors： Tarkkanen A,Tervo T,Tervo K,Eränkö L,Eränkö O,Cuello AC

更新日期：1983-01-01 00:00:00

abstract：:Modulation sensitivity functions ( MSFs ) of retinal ganglion cells of the pigeon were determined by recording action potentials from their end branching in the optic tectum as response indicator. The inverse Fourier transformation of a MSF is taken to represent the receptive field sensitivity function approximating t...

journal_title：Ophthalmic research

authors： Pak MA

更新日期：1984-01-01 00:00:00

abstract：PURPOSE:The possibility of providing cultured corneal endothelial cells (CECs) for clinical transplantation has gained much attention. However, the worldwide need for human (h) donor corneas far exceeds supply. The pig (p) might provide an alternative source. The aim of this study was to compare the proliferative capac...

journal_title：Ophthalmic research

authors： Fujita M,Mehra R,Lee SE,Roh DS,Long C,Funderburgh JL,Ayares DL,Cooper DK,Hara H

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:Weak oxidants produced by activated human leukocytes are proven antimicrobial substances. We tested whether N-chlorotaurine (NCT, taurine chloramine), the chlorinated metabolite of the amino acid taurine, in addition to direct virucidal effects on viral suspensions, has the capability to prevent cell-to-cell ...

journal_title：Ophthalmic research

authors： Huemer HP,Nagl M,Irschick EU

更新日期：2010-01-01 00:00:00

abstract：:The purpose of this study was to determine the expression of metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in the aqueous humour of patients with exfoliation syndrome (XFS). XFS and control samples were analysed for their MMP content by zymography and for their tissue inhibitors by ELISA. In XFS eyes, ...

journal_title：Ophthalmic research

authors： Gartaganis SP,Georgakopoulos CD,Mela EK,Exarchou A,Ziouti N,Assouti M,Vynios DH

更新日期：2002-05-01 00:00:00

abstract：:We examined the density and morphology of lens epithelial cells (LECs) in vivo in a group of normal volunteers and cataract patients by using a newly developed noncontact specular microscope. There was a statistically significant decrease in the cell density of LECs in a group of cataract patients over the age of 80 y...

journal_title：Ophthalmic research

authors： Oharazawa H,Ibaraki N,Matsui H,Ohara K

更新日期：2001-11-01 00:00:00

abstract：:To study the mode of riboflavin metabolism in the lens in vivo, the uptake of 14C-labeled riboflavin and synthesis of ester forms from 14C-riboflavin were assayed in the single whole lens of the rats. 14C-riboflavin uptake increased in proportion to the substrate concentration in the incubation medium, reaching a plat...

journal_title：Ophthalmic research

authors： Ono S,Hirano H

更新日期：1983-01-01 00:00:00

abstract：:The use of corneal tissue for ex vivo therapeutic evaluations is limited due to its rapid loss of viability after excision. Optimization of storage conditions may allow prolonged retention of physical tissue properties. In this study, we evaluated how storage in optimized organ culture (OC) medium at 37°C or phosphate...

journal_title：Ophthalmic research

authors： Thakur SS,Shrestha D,Rupenthal ID

更新日期：2019-01-01 00:00:00

abstract：INTRODUCTION:Retinitis pigmentosa (RP) is an inherited retinal disorder, characterized by photoreceptor degeneration inducing progressive vision loss. This study evaluates its impact on quality of life (QOL) and emotional states of patients affected by RP. METHODS:A cross-sectional study was conducted on 60 RP patient...

journal_title：Ophthalmic research

authors： Azoulay L,Chaumet-Riffaud P,Jaron S,Roux C,Sancho S,Berdugo N,Audo I,Sahel JA,Mohand-Saïd S

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:To investigate the effect of propolis, a natural resin produced by honeybees, in the treatment of alkali-injured rabbit eyes. METHOD:A corneal alkali burn was induced by applying filter paper immersed in 1 N NaOH on the central axis of the right corneas of 24 rabbits for 30 s. The animals were divided into thr...

journal_title：Ophthalmic research

authors： Oztürk F,Kurt E,Cerçi M,Emiroglu L,Inan U,Türker M,Ilker S

更新日期：2000-01-01 00:00:00

abstract：:To evaluate the effect of single or repeated topical applications of prostaglandin E2 (PGE2) to the cornea on the blood-aqueous barrier, we have measured the extent of flare in the anterior chamber of rabbit eyes at various time intervals. PGE2 was applied to the cornea for 4 min with the use of a glass cylinder in pi...

journal_title：Ophthalmic research

authors： Numata-Watanabe K,Hirata H,Hiraki S,Hayasaka S

更新日期：1996-01-01 00:00:00

abstract：:VEGF is considered as an important factor in the pathogenesis of macular edema. VEGF induces the rupture of the blood retinal barrier and may also influence the retinal pigment epithelial (RPE) outer retinal barrier. The aim of this work was to analyze the influence of the VEGF receptor pathways in the modulation of t...

journal_title：Ophthalmic research

authors： Miyamoto N,de Kozak Y,Normand N,Courtois Y,Jeanny JC,Benezra D,Behar-Cohen F

更新日期：2008-01-01 00:00:00

abstract：PURPOSE:To investigate the antiangiogenic effect of itraconazole for the prevention of experimentally induced corneal neovascularization and whether the efficacy depends on the route of administration. MATERIALS AND METHODS:Thirty-six rats were randomly divided into 6 groups with 6 rats in each group. Chemical cauteri...

journal_title：Ophthalmic research

authors： Goktas S,Sakarya R,Erdogan E,Sakarya Y,Ozcimen M,Dursunoglu D,Kocacan M,Alpfidan I,Erdogan E,Bukus A,Ivacık IS

更新日期：2014-01-01 00:00:00

abstract：PURPOSE:To establish a retinal blood flow database in normal human eyes using the Canon Laser Blood Flowmeter (CLBF). METHOD:Fourteen healthy subjects (7 males, 7 females) between the ages of 24 and 33 underwent birectional laser Doppler velocimetry (BLDV) in one eye using the CLBF. Measurements consisting of blood ve...

journal_title：Ophthalmic research

authors： Garcia JP Jr,Garcia PT,Rosen RB

更新日期：2002-09-01 00:00:00

abstract：:Small RNA (microRNA or miRNA) is a kind of small noncoding single-stranded RNA that regulates complementary mRNA at the posttranscriptional level in eukaryotic organisms. As important regulatory factors, miRNAs play an important role in the occurrence and development of glaucoma and widely participate in regulating bi...

journal_title：Ophthalmic research

authors： Guo R,Shen W,Su C,Jiang S,Wang J

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Genipin (GP) is a safe method for corneal crosslinking, even for very thin corneas. However, there have been no reports on the optimal GP concentration range to use in vivo for corneal crosslinking. OBJECTIVES:To investigate the safety of corneal crosslinking after a 24-h incubation with different concentra...

journal_title：Ophthalmic research

authors： Song W,Tang Y,Qiao J,Li H,Rong B,Yang S,Wu Y,Yan X

更新日期：2019-01-01 00:00:00

abstract：:Local pO2 was measured close to the ciliary process of the rabbit eye using polarographic microelectrodes under microendoscopic observation. The experiments were performed in 5 anaesthetized New Zealand rabbits. Changes in local pO2, intraocular pressure (IOP) and blood flow velocity (BFV) were investigated after intr...

journal_title：Ophthalmic research

authors： Höper J,Funk RH

更新日期：1993-01-01 00:00:00

abstract：:Cellular immune responses in retinal autoimmunity have scarcely been studied in rabbits. An effective isolation of rabbit peripheral blood lymphocytes is difficult to achieve and requires specific conditions. This hampers especially the assay of antigen-induced lymphocyte transformation. We have improved the lymphocyt...

journal_title：Ophthalmic research

authors： Broekhuyse RM,Van Vugt AH

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the effect of C constant for ray tracing-assisted intraocular lens (IOL) power calculation in the patients with different refractive power, we compared the refractive outcome of ray-tracing method based on C constant and conventional IOL calculation formula. METHODS:215 eyes which underwent phaco...

journal_title：Ophthalmic research

authors： Chang P,Zhang F,Wang J,Zhao Y

更新日期：2020-04-20 00:00:00

abstract：:The influence of nonselective and selective alpha-adrenergic agonists on intraocular pressure (IOP) was studied in isolated arterially perfused rabbit eyes. Drugs were given intra-arterially or topically. With either route of administration, no initial hypertensive phase was observed after l-epinephrine, l-norepinephr...

journal_title：Ophthalmic research

authors： van Pinxteren PC

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Diabetic retinopathy (DR) is a severe ocular complication of diabetes. Kallistatin has multiple biological functions including anti-inflammation and antiangiogenesis. Our aim was to detect the level of kallistatin in the vitreous of proliferative DR (PDR) and its effect on proliferation, migration, and tube ...

journal_title：Ophthalmic research

authors： Xing Q,Zhang G,Kang L,Wu J,Chen H,Liu G,Zhu R,Guan H,Lu P

更新日期：2017-01-01 00:00:00

abstract：PURPOSE:To examine melanocortin receptor (from MC-1 to MC-5) mRNA and the effect of alpha-melanocyte-stimulating hormone (alpha-MSH) on interleukin 8 (IL-8) and monocyte chemotactic protein 1 (MCP-1) expression in a human retinal pigment epithelial cell line (ARPE-19) stimulated with IL-1beta or tumor necrosis factor a...

journal_title：Ophthalmic research

authors： Cui HS,Hayasaka S,Zhang XY,Chi ZL,Hayasaka Y

更新日期：2005-09-01 00:00:00

abstract：PURPOSE:To investigate the effect of vitreomacular adhesion (VMA) on the outcome of antiangiogenic treatment for neovascular age-related macular degeneration (AMD). METHODS:Ninety-nine eyes of 83 patients were used in our cohort study. We prospectively evaluated best corrected visual acuity (BCVA) and central retinal ...

journal_title：Ophthalmic research

authors： Kanadani TCM,Dos Reis Veloso CE,Dorairaj S,Nehemy MB

更新日期：2017-01-01 00:00:00