Abstract：
:The eyes of 200 rats (Mol:SPRD, Moellegaard Ltd., Skensvet, Denmark), 8 weeks of age and of both sexes, were examined routinely with a photo-slitlamp microscope (Zeiss) and opthalmoscope (Heine) 3-4 times in the course of four different 12-week toxicity studies. The animals were kept under constant lighting conditions at a room temperature of 20 +/- 2 degrees C and 55 +/- 5% humidity on a standard diet. More than 70% of the animals were found to have more or less prominent corneal opacities already at the beginning of the study. These were morphologically characterized as meshwork-like alterations of the deeper corneal epithelium, mostly located in the central and nasal region. The temporal, upper and lower periphery remained always unaffected. Male animals were more frequently and more intensively affected than the females. The occurrence of the opacity was totally independent of the treatment scheme (controls and drug dosages, respectively), showing a slight increase in density in some of the animals of all groups and remaining stable in others. Regression was rarely observed. Light and electron microscopical investigations demonstrated focal degenerations of the basal epithelial cell layer as well as alterations of its basement membrane. The lesion was not associated with inflammation or irritation. Therefore, we considered that a genetically determined metabolic disorder of the basal epithelial cells might have led to the impairment of basement membrane synthesis. Further screenings performed in conjunction with the breeder evidenced that these opacities are probably caused by a spontaneous mutation with a complex, not X-linked genetic background.
journal_name
Ophthalmic Resjournal_title
Ophthalmic researchauthors
Wegener A,Jochims Kdoi
10.1159/000267492subject
Has Abstractpub_date
1994-01-01 00:00:00pages
296-303issue
5eissn
0030-3747issn
1423-0259journal_volume
26pub_type
杂志文章abstract：OBJECTIVE:To evaluate a technique of autologous internal limiting membrane (ILM) fragment transplantation for the treatment of large, chronic, and/or refractory macular holes (MH). DESIGN:This was a 6-month prospective interventional case series. METHOD:Ten eyes of 10 patients with MH underwent pars plana vitretomy (...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000440767
更新日期：2015-01-01 00:00:00
abstract：:Ocular pneumoplethysmography was performed before and after 1,737 carotid endarterectomies, 82% of which were performed for carotid lesions of hemodynamic consequence. Preoperative ocular hypoperfusion without ischemia was associated with at least transient postoperative ocular hyperemia. A difference in ocular volume...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000055558
更新日期：1999-01-01 00:00:00
abstract：:To investigate the binding of peanut-agglutinin (PNA) on porcine corneal tissue, several methods of tissue processing were used. In cryostat sections of postmortem tissue, PNA labeling of epithelial cell membranes was detected. In the stroma, a fibrillar structure parallel to the corneal surface was found. The anterio...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000266748
更新日期：1988-01-01 00:00:00
abstract：:In an experimental study using freshly enucleated pig's eyes, we investigated the endothelial cell loss on the cut edge. Remote-control rotating trephine was found to be the least injuring when it was applied to fresh and preserved human corneas. Corneal culture does not seem to enhance endothelial cell damage due to ...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000265224
更新日期：1982-01-01 00:00:00
abstract：:Two out of three normal eyes tested with frequent instillation of 30 microliters of drops of 0.5% bupranolol, a beta 1 + beta 2 blocking drug with some intrinsic sympathomimetic and local anesthetic activity, showed a miotic effect of the order of a 25% reduction of pupil area, as estimated by an open-loop iris-videor...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000265407
更新日期：1986-01-01 00:00:00
abstract：PURPOSE:To compare the effects between intravitreal and periocular injections of adenoviral vectored pigment epithelium-derived factor (AdPEDF) on suppressing established choroidal neovascularization (CNV) in rats. METHODS:Sixty-eight female BN rats (136 eyes) aged 6-8 weeks were involved in this study. The CNV animal...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000342979
更新日期：2013-01-01 00:00:00
abstract：:The effect of topical neutral formaldehyde on the blood-aqueous barrier of the rat was studied. Thirty minutes after irritation, the protein concentration of the aqueous humour had increased from the control value of 1.95 +/- 0.25 to 2.95 +/- 0.45 mg/ml (p less than 0.05). Extravasation of Evans blue dye from the iris...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000265442
更新日期：1986-01-01 00:00:00
abstract：:Equine recurrent uveitis (ERU) is an autoimmune disease that occurs with a high prevalence (10%) in horses. ERU represents the only reliable spontaneous model for human autoimmune uveitis. We already identified and characterized novel autoantigens (malate dehydrogenase, recoverin, CRALBP) by analyzing the autoantibody...
journal_title：Ophthalmic research
pub_type： 杂志文章,评审
doi：10.1159/000119867
更新日期：2008-01-01 00:00:00
abstract：:This study was undertaken to characterize the mechanism of ocular irritation to YAG laser capsulotomy in rabbits. The blocking agents were administered intravitreally. (D-Arg1,D-Pro2,D-Trp7,9)-SP, a substance P antagonist, tended to reduce miosis but had no effect on intraocular pressure (IOP). It had less effect on m...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000266900
更新日期：1989-01-01 00:00:00
abstract：BACKGROUND/AIMS:It has been suggested that eye makeup could interact with human meibum causing a decrease in the stability of the tear film. The aim of this pilot study was to measure makeup-human meibum interactions in vitro. METHODS:Human meibum-makeup interactions were quantified by measuring order-to-disorder lipi...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000371852
更新日期：2015-01-01 00:00:00
abstract：:The main objective of this study was to determine the intraocular concentration of fluorescein after applying five eye drops with only 1-min intervals in human eyes. The concentration of fluorescein in corea and aqueous was studied with fluorophotometry in 11 healthy volunteers. Five 10-microliter drops of 2% fluoresc...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000267997
更新日期：1997-01-01 00:00:00
abstract：AIMS:The purpose of this paper was to determine the lacrimal concentration of IL-1α and MMP-9 in patients with active ocular rosacea before and after systemic treatment with azithromycin or doxycycline. METHODS:After 4 weeks of therapy with azithromycin (500 mg/day, 3 days a week PO) or doxycycline (200 mg/day PO), la...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000489092
更新日期：2018-01-01 00:00:00
abstract：AIMS:Mutations in the PAX6 are the major cause of congenital aniridia. The objective of this study was to analyze genetic mutations in PAX6 in Chinese patients with congenital aniridia. METHODS:Total genomic DNA was isolated from the peripheral blood of the aniridia patients, all healthy family members and 100 healthy...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000327593
更新日期：2012-01-01 00:00:00
abstract：:During the process of terminal differentiation, the fibre cells in the eye lens undergo many changes that are reminiscent of apoptotic/necrotic changes. Mitochondria, for instance, undergo permeability transition and nuclear degradation is accompanied by chromatin condensation, disintegration of the nucleolus, dissolu...
journal_title：Ophthalmic research
pub_type： 杂志文章,评审
doi：10.1159/000055530
更新日期：1999-01-01 00:00:00
abstract：:The influence of nonselective and selective alpha-adrenergic agonists on intraocular pressure (IOP) was studied in isolated arterially perfused rabbit eyes. Drugs were given intra-arterially or topically. With either route of administration, no initial hypertensive phase was observed after l-epinephrine, l-norepinephr...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000265400
更新日期：1985-01-01 00:00:00
abstract：PURPOSE:To evaluate diabetic retinopathy (DR) progression in patients with diabetes mellitus type 2 in 2 populations of different ethnicity. METHODS:A prospective observational study was designed to follow eyes/patients with mild nonproliferative DR, for 2 years or until the development of central-involved macular ede...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000484666
更新日期：2018-01-01 00:00:00
abstract：:Cholinergic agents used to lower intraocular pressure in the medical management of glaucoma act on muscarinic receptors in the eye. Recently, subtypes of muscarinic receptors have been recognized in many tissues including the eye. To localize the M3 muscarinic receptor subtype and m3 messenger RNA (mRNA) in the human ...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000267472
更新日期：1994-01-01 00:00:00
abstract：PURPOSE:To propose a new noncontact tonometer based on corneal photoelasticity. METHOD:In this study, we experimented with 18 enucleated porcine eyes. The anterior chamber was infused with a physiological solution. A circular polarizing filter was attached to an ophthalmic surgical microscope. Color fringe changes at ...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000320600
更新日期：2011-01-01 00:00:00
abstract：:To ascertain the effectiveness of topical antioxidant therapy on acute corneal inflammation, we have studied the effectiveness of topical treatment with a saline solution and with antioxidants such as 0.2% superoxide dismutase and 0.5% dimethylthiourea (DMTU) in a controlled experimental study. The evolution of the in...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000267648
更新日期：1995-01-01 00:00:00
abstract：OBJECTIVE:To evaluate the sensitivity and specificity of pseudoexfoliation syndrome diagnosis in pseudophakic patients and potential means of improving it. METHODS:This prospective, nonrandomized study comprised 41 consecutive patients (41 eyes) scheduled for cataract surgery at a tertiary medical center during 2016-2...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000508336
更新日期：2020-04-30 00:00:00
abstract：:Using cuprolinic blue staining, we histochemically examined the ultrastructural localization of proteoglycans in the fibrous-type human posterior capsule opacification. This capsule opacification contained proteoglycans that showed positive staining with cuprolinic blue. Many cuprolinic-blue-positive filaments were pr...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000267707
更新日期：1995-01-01 00:00:00
abstract：:The effects of optical defocusing with convex lenses on the amplitudes of pattern reversal visual-evoked response (PVER) were investigated. With the large check size and high-contrast pattern, PVER amplitudes showed a linear decrease in response to initial defocusing up to +5 to +6 dptr. As the degree of defocus incre...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000267051
更新日期：1990-01-01 00:00:00
abstract：INTRODUCTION:This study aimed to evaluate the longitudinal changes in retinal layers thickness in patients treated with hydroxychloroquine and no signs of retinal toxicity. METHODS:Longitudinal retrospective study of patients taking hydroxychloroquine followed in a hydroxychloroquine retinal toxicity screening program...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000511592
更新日期：2020-09-15 00:00:00
abstract：PURPOSE:Primary open-angle glaucoma (POAG) is a chronic progressive optic neuropathy, leading to degeneration of retinal ganglion cells and characteristic morphological changes at the optic disc. In advanced stages of the disease, functional tests, such as standard automated perimetry (SAP), are the main diagnostic too...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000501693
更新日期：2020-01-01 00:00:00
abstract：:The effect of large intake of dietary ascorbic acid on heat-induced eye lens protein damage has been studied. Male guinea pigs of the Hartley strain were used. Ascorbic acid was administered to the experimental animals in the drinking water. The mean daily ascorbic acid intakes for the control and experimental animals...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000267008
更新日期：1990-01-01 00:00:00
abstract：:The binding of fluorescein and 6-carboxyfluorescein by normal, diabetic and in vitro glycosylated human serum proteins was analyzed by absorption and fluorescence spectroscopy, gel filtration and equilibrium dialysis. The absorption spectra of bound fluorochromes showed red shifts and hypochromic changes, and fluoroch...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000265219
更新日期：1982-01-01 00:00:00
abstract：PURPOSE:To demonstrate the value of the laser-scanning optical-resolution (LSOR)-photoacoustic (PA) microscopy (PAM) system and the conventional multimodal imaging techniques in the evaluation of laser-induced retinal injury and choroidal neovascularization (CNV) in rats. METHODS:Different degrees of retinal injury we...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000502800
更新日期：2020-01-01 00:00:00
abstract：:The refractive indices in various rat retinal layers, based on the total dry mass concentration, ranged from 1.369 to 1.385. The ratios of the refractive indices of neighboring retinal layers were near unity. This finding suggests that light passes through the rat retina without much refraction. ...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000267223
更新日期：1993-01-01 00:00:00
abstract：:Epinephrine (1, 3 and 10 micrograms/kg) was found to increase retinal and choroidal blood flow (22, 49 and 67%) when it was administered intravenously. The increase in retinal and choroidal blood flow coincided well with the increase in systemic blood pressure (44, 65 and 96%, respectively). When epinephrine (2%) was ...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000266728
更新日期：1988-01-01 00:00:00
abstract：PURPOSE:To investigate the antiangiogenic effect of itraconazole for the prevention of experimentally induced corneal neovascularization and whether the efficacy depends on the route of administration. MATERIALS AND METHODS:Thirty-six rats were randomly divided into 6 groups with 6 rats in each group. Chemical cauteri...
journal_title：Ophthalmic research
pub_type： 杂志文章
doi：10.1159/000366283
更新日期：2014-01-01 00:00:00
