Abstract:
:This study was undertaken to characterize the mechanism of ocular irritation to YAG laser capsulotomy in rabbits. The blocking agents were administered intravitreally. (D-Arg1,D-Pro2,D-Trp7,9)-SP, a substance P antagonist, tended to reduce miosis but had no effect on intraocular pressure (IOP). It had less effect on miosis than (D-Arg1,D-Pro2,D-Trp7,9,Leu11)-SP another SP antagonist. Met-enkephalin and tetracaine had no effect on miosis or the increase in IOP after YAG laser capsulotomy, whereas tetrodotoxin reduced miosis, but had no clear-cut effect on IOP, or the increase in aqueous humor protein concentration. This indicates an involvement of sensory neurons with release of SP or a closely related peptide in the miotic component part while the increase in IOP and the barrier breakdown probably are dependent mainly on a release of prostaglandins.
journal_name
Ophthalmic Resjournal_title
Ophthalmic researchauthors
Oksala O,Stjernschantz J,von Dickhoff Kdoi
10.1159/000266900subject
Has Abstractpub_date
1989-01-01 00:00:00pages
360-8issue
5eissn
0030-3747issn
1423-0259journal_volume
21pub_type
杂志文章abstract::A technique for chronic implantation of a device for long-term continuous, quantitative monitoring of intraocular pressure (IOP) in experimental animals is presented. The methodology employed is straight forward and should be easily duplicated for experimental investigations where such monitoring might be useful. Cont...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265179
更新日期:1982-01-01 00:00:00
abstract::Oxidative stress plays a role in the pathogenesis of neurodegeneration in diabetic retinopathy (DR). However, whether an excellent reactive oxygen species scavenger, U83836E, inhibits the neurodegeneration in DR remains uncertain. This study is aimed at clarifying the effects of U83836E on DR. Two weeks after streptoz...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000321952
更新日期:2011-01-01 00:00:00
abstract::To evaluate the effect of single or repeated topical applications of prostaglandin E2 (PGE2) to the cornea on the blood-aqueous barrier, we have measured the extent of flare in the anterior chamber of rabbit eyes at various time intervals. PGE2 was applied to the cornea for 4 min with the use of a glass cylinder in pi...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267895
更新日期:1996-01-01 00:00:00
abstract::Lenticular S-adenosylmethionine synthetase has been partially purified and characterized. Lower levels of S-adenosylmethionine synthetase were detected by a sensitive radioactive assay procedure in the lenticular extract obtained from the pooled lenses of alloxan-treated rats 96 days of age as compared to the nontreat...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265169
更新日期:1982-01-01 00:00:00
abstract:PURPOSE:To describe the characteristics of macular lesions after eye trauma using spectral-domain optical coherence tomography (OCT). METHODS:We retrospectively reviewed and described 2-dimensional (2D) and 3-dimensional (3D) spectral-domain OCT characteristics of 24 consecutive eyes of 24 cases that were identified w...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000325732
更新日期:2012-01-01 00:00:00
abstract:PURPOSE:To study the ability to appreciate qualitative features that indicate disease activity in patients with neovascular age-related macular degeneration (AMD) and to analyze the differences in automated retinal thickness measurement, using 1 time domain optical coherence tomography (TD-OCT) and 2 different spectral...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000325027
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND/AIMS:By the release of antiangiogenic factors, Müller glial cells provide an angiostatic environment in the normal and ischemic retina. We determined whether Müller cells produce thrombospondin-1 (TSP-1), a known inhibitor of angiogenesis. METHODS:Secretion of TSP-1 by cultured Müller cells was determined w...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000362371
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:To compare intraocular pressure (IOP) measurements obtained with the digital tonometer TGDc-01 'PRA' with those from a Goldmann applanation tonometer (GAT). METHODS:The IOP in 176 eyes of 88 healthy volunteers was measured prospectively in a sitting position. One single measurement, generated by the TGDc-01...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000081204
更新日期:2004-09-01 00:00:00
abstract:BACKGROUND:Diabetic retinopathy (DR) is a severe ocular complication of diabetes. Kallistatin has multiple biological functions including anti-inflammation and antiangiogenesis. Our aim was to detect the level of kallistatin in the vitreous of proliferative DR (PDR) and its effect on proliferation, migration, and tube ...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000447776
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:The lens is the ocular structure most susceptible to oxidative damage. Antioxidants, micronutrients and phytochemicals have been extensively studied for their possible effects to prevent or delay the progression of various eye diseases. OBJECTIVES:A brief overview of the updated literature on the role of an...
journal_title:Ophthalmic research
pub_type: 杂志文章,评审
doi:10.1159/000316477
更新日期:2010-01-01 00:00:00
abstract::We examined 304 conjunctiva in 152 subjects by clinical, cytologic, and bacteriologic methods. Bacteriologic samples were evaluated after a 48-hour incubation. Bacterial growth was found in 8 (20.5%) of 39 patients with clinically normal conjunctiva and no polymorphonuclear leukocytes (PMNs), and in 8 (61.5%) of 13 su...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267086
更新日期:1991-01-01 00:00:00
abstract::Ocular pneumoplethysmography was performed before and after 1,737 carotid endarterectomies, 82% of which were performed for carotid lesions of hemodynamic consequence. Preoperative ocular hypoperfusion without ischemia was associated with at least transient postoperative ocular hyperemia. A difference in ocular volume...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000055558
更新日期:1999-01-01 00:00:00
abstract::Equine recurrent uveitis (ERU) is an autoimmune disease that occurs with a high prevalence (10%) in horses. ERU represents the only reliable spontaneous model for human autoimmune uveitis. We already identified and characterized novel autoantigens (malate dehydrogenase, recoverin, CRALBP) by analyzing the autoantibody...
journal_title:Ophthalmic research
pub_type: 杂志文章,评审
doi:10.1159/000119867
更新日期:2008-01-01 00:00:00
abstract::In an experimental study using freshly enucleated pig's eyes, we investigated the endothelial cell loss on the cut edge. Remote-control rotating trephine was found to be the least injuring when it was applied to fresh and preserved human corneas. Corneal culture does not seem to enhance endothelial cell damage due to ...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265224
更新日期:1982-01-01 00:00:00
abstract::In a search for a pharmacologic adjuvant in the management of posttraumatic proliferative vitreoretinopathy (PVR), we investigated the effect of intravitreal injection of prinomastat (AG3340) on an experimental model. Posterior penetrating eye trauma was created in one eye each of 24 New Zealand white rabbits. One wee...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000055636
更新日期:2001-01-01 00:00:00
abstract::The pathology of rainbow trout lenses incubated in various media and at various temperatures was examined by electron microscopy. After incubation at 0 degrees C for 5 h, no changes were observed in transparency and cytology. Irreversible warm cataract occurred at 37 degrees C, which corresponds to the body temperatur...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265427
更新日期:1986-01-01 00:00:00
abstract::The influence of nonselective and selective alpha-adrenergic agonists on intraocular pressure (IOP) was studied in isolated arterially perfused rabbit eyes. Drugs were given intra-arterially or topically. With either route of administration, no initial hypertensive phase was observed after l-epinephrine, l-norepinephr...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265400
更新日期:1985-01-01 00:00:00
abstract::Dragomirescu et al. [1983] described a 2-chamber flow system for the incubation of lenses with an inserted photometer to measure changes in lens transparency. Mester et al. [1984] applied the method to simulate conditions occurring during vitrectomy, which occasionally leads to reversible lens opacification. Using Sch...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265357
更新日期:1985-01-01 00:00:00
abstract::Vitamin E (d-alpha-tocopherol) and aspirin were evaluated for their effects on the phase separation temperature, Tc, of calf lens cytoplasm. Vitamin E and aspirin were added to nuclear homogenate and the change in Tc was measured. Aspirin had no measurable effect on Tc. Vitamin E lowered Tc at a rate of -22 degrees C ...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265475
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND:The aim of this work was to compare the efficacy of intravitreal dexamethasone implant (Ozurdex) and intravitreal ranibizumab (Lucentis) in the treatment of macular edema (ME) caused by retinal vein occlusion (RVO). METHODS:Thirty-two ME cases treated with Ozurdex and 32 ME cases treated with ranibizumab we...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000458534
更新日期:2017-01-01 00:00:00
abstract::Diabetic macular edema is considered the most important factor related to visual impairment in patients with diabetic retinopathy. Together with the use of grid and focal laser photocoagulation, today the intravitreal administration of pharmacotherapies represents the standard of care for the treatment of this complic...
journal_title:Ophthalmic research
pub_type: 杂志文章,评审
doi:10.1159/000362764
更新日期:2014-01-01 00:00:00
abstract::The aim of the study was to examine the effects of nonsteroidal anti-inflammatory drugs (NSAIDs)/acetylsalicylic acid (ASA) on human lens epithelial cells (HLECs) during oxidative stress. HLECs were exposed to H2O2 in the absence or presence of indomethacin, diclofenac, celecoxib (NSAIDs) or ASA for 24 h. HLECs were a...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000113885
更新日期:2008-01-01 00:00:00
abstract::The effects of inhibition of both glutathione synthesis and of glutathione reductase and catalase activities have been determined in the regulation of hydrogen peroxide (H2O2) in the anterior chamber of pigmented rabbits. Glutathione reductase inhibition using intravitreal 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) ...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267124
更新日期:1991-01-01 00:00:00
abstract::The antioxidants sodium benzoate and 2,3-dihydroxybenzoic acid reduced the inflammatory response in experimental phacoanaphylactic endophthalmitis. The 2,3-dihydroxybenzoic acid was by far the more effective antiphlogistic agent. The molecular mechanisms that may have contributed to the observed difference in antiphlo...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265483
更新日期:1987-01-01 00:00:00
abstract:PURPOSE:To demonstrate the value of the laser-scanning optical-resolution (LSOR)-photoacoustic (PA) microscopy (PAM) system and the conventional multimodal imaging techniques in the evaluation of laser-induced retinal injury and choroidal neovascularization (CNV) in rats. METHODS:Different degrees of retinal injury we...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000502800
更新日期:2020-01-01 00:00:00
abstract::Inflammation is substantially contributing to the development and worsening of diabetic retinopathy in general and diabetic macular edema (DME) in particular, which provides the rationale to treat DME with corticosteroids. While anti-vascular endothelial growth factor (VEGF) agents are mostly chosen as a first-line tr...
journal_title:Ophthalmic research
pub_type: 杂志文章,评审
doi:10.1159/000499540
更新日期:2019-01-01 00:00:00
abstract::In order to investigate the combined influence of age and light, the b-wave and oscillatory potentials (OPs) of the electroretinogram (ERG) were recorded in 1.5-, 7- and 12-month-old WAG/Rij rats, reared under homogenous low-intensity cyclic light exposure. Wistar albino rats of the same ages, reared under the same co...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267282
更新日期:1993-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect of C constant for ray tracing-assisted intraocular lens (IOL) power calculation in the patients with different refractive power, we compared the refractive outcome of ray-tracing method based on C constant and conventional IOL calculation formula. METHODS:215 eyes which underwent phaco...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000507963
更新日期:2020-04-20 00:00:00
abstract:OBJECTIVE:To evaluate the feasibility of a new technique for the implantation of ultrathin substrates containing stem cell-derived retinal pigment epithelium (RPE) cells into the subretinal space of retina-degenerate Royal College of Surgeon (RCS) rats. METHODS:A platform device was used for the implantation of 4-µm-t...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000338749
更新日期:2012-01-01 00:00:00
abstract::Autofluorescence and transmission values of the lens for blue-green light were determined at two locations with the use of identical fluorophotometers: in Coimbra, Portugal, in 44 healthy controls, 15 haemodialysis and 11 renal failure patients, and in Leiden, The Netherlands, in 57 healthy controls, 23 haemodialysis ...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000266736
更新日期:1988-01-01 00:00:00