Abstract:
INTRODUCTION:This study aimed to evaluate the longitudinal changes in retinal layers thickness in patients treated with hydroxychloroquine and no signs of retinal toxicity. METHODS:Longitudinal retrospective study of patients taking hydroxychloroquine followed in a hydroxychloroquine retinal toxicity screening program of a tertiary hospital between January 2010 and April 2019. Patients who performed two OCT scans at least 1 year apart were included. All subjects with hydroxychloroquine suspected or confirmed retinal toxicity, glaucoma, retinal pathology, or poor segmented images were excluded. Spectral-domain optical coherence tomography (Spectralis HRA-OCT, Heidelberg) was used to evaluate the macular area. Automatically segmented ETDRS retinal thickness maps were compared between the first and the last OCT evaluation available. Full retina (FR), inner retina (IRL), ganglion cells (GCL), inner nuclear (INL) and outer retina (ORL) layers thicknesses were measured in the foveolar, paracentral and peripheral area. RESULTS:The population included 144 eyes of 144 patients. The mean interval between OCT scans was 38.1±18.4 months and the mean cumulative dose was 406.9 ± 223.9g. Foveolar (p=0.040, p=0.006 and p=0.001, respectively) and paracentral (p=0.006, p=0.001 and p=0.005, respectively) FR, IRL and GCL decreased overtime. No differences were found in INL or ORL. A very week correlation was found between age and foveal IRL change overtime (p=0.037; R=0.175), as well as, between the hydroxychloroquine time of use and foveal GCL variation (p=0.032; R=0.179). CONCLUSION:Hydroxychloroquine was found to cause progressive thinning of the inner retinal layers, specifically in the GCL of the foveolar and paracentral areas, but no changes were observed in the outer retina.
journal_name
Ophthalmic Resjournal_title
Ophthalmic researchauthors
Godinho G,Madeira C,Falcão M,Penas S,Dinah-Bragança T,Brandão E,Carneiro Â,Santos-Silva R,Falcão-Reis F,Beato Jdoi
10.1159/000511592subject
Has Abstractpub_date
2020-09-15 00:00:00eissn
0030-3747issn
1423-0259pii
000511592pub_type
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abstract::Naphthalene-induced rat cataract is a useful experimental cataract--however, because of its short survival period, studies using this model have been for limited purposes. Based on the consideration that the short survival might be caused by systemic toxicity of an overdose of naphthalene administration (1 g/kg body w...
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journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000119877
更新日期:2008-01-01 00:00:00
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更新日期:2013-01-01 00:00:00
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更新日期:2001-01-01 00:00:00
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doi:10.1159/000490914
更新日期:2018-01-01 00:00:00
abstract::The polyamines putrescine, spermidine and spermine have been proposed to be a part of the acute phase inflammatory response. They have been shown to be useful markers for cellular kinetics and change with various pathological conditions. The hypothesis that aqueous humor polyamines could be used to follow the time cou...
journal_title:Ophthalmic research
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journal_title:Ophthalmic research
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2014-01-01 00:00:00
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更新日期:2015-01-01 00:00:00
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更新日期:2005-09-01 00:00:00
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更新日期:2011-01-01 00:00:00
abstract::Cannabinoid receptor involvement in the intraocular-pressure (IOP)-lowering effect of the cannabinoids has not been determined. These receptors bind four structural classes of agonists: the classical and the nonclassical cannabinoids, the aminoalkylindoles and the arachidonylethanolamides (the endogenous ligands). We ...
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更新日期:1997-01-01 00:00:00
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更新日期:1991-01-01 00:00:00
abstract::In an experimental study using freshly enucleated pig's eyes, we investigated the endothelial cell loss on the cut edge. Remote-control rotating trephine was found to be the least injuring when it was applied to fresh and preserved human corneas. Corneal culture does not seem to enhance endothelial cell damage due to ...
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更新日期:1982-01-01 00:00:00
abstract::The component oxygen fluxes that constitute a single recording of corneal oxygen uptake when a polarographic oxygen sensor (POS) is placed in contact with the cornea were determined in the in vivo rabbit eye by removing the epithelium and injecting an air bubble into the anterior chamber. The relative contribution of ...
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更新日期:1985-01-01 00:00:00