Abstract:
:A method for microscopical observation and quantification of corneal neovascularization in the living mouse is described. Measurements of the corneal vasculature were made on still-mode video-pictures of the cornea. The validity of the method was shown by the high correlation between the morphometric measurements and computerized values on the same vessel structures. The method was applied to describe the neovascular response of heat-killed tumour fragments implanted into corneal pockets. The neovascular response that was observed in some corneas was dependent on the distance from the edge of the pocket with heat-killed material to the nearest vessel loop. The pocket area was vascularized only if this distance (measured the 3rd day after implantation) was less than 0.70 mm. Resorption of heat-killed tissue occurred in corneas without any neovascular response and it was not altered by penetration of vessel into the cornea. The described method proved to be suitable for studying the neovascularization induced by corneal pocket implants.
journal_name
Ophthalmic Resjournal_title
Ophthalmic researchauthors
Falkvoll KHdoi
10.1159/000267097subject
Has Abstractpub_date
1991-01-01 00:00:00pages
104-14issue
2eissn
0030-3747issn
1423-0259journal_volume
23pub_type
杂志文章abstract:PURPOSE:To investigate the effects, and their reversibility, of multiple oral voriconazole doses on a variety of visual tests in healthy male volunteers. METHODS:Single-center, double-blind, randomized, placebo-controlled, parallel-group study in 36 volunteers who received voriconazole (n=18, 400 mg every 12 h on day ...
journal_title:Ophthalmic research
pub_type: 杂志文章,随机对照试验
doi:10.1159/000359952
更新日期:2014-01-01 00:00:00
abstract:PURPOSE:To evaluate the role of initial visual acuity (VA) as a potential prognostic factor for final VA in patients with branch retinal vein occlusion (BRVO). METHODS:A retrospective data analysis involving 163 patients with macular edema secondary to BRVO treated according to the recommendations of the Branch Vein O...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000321701
更新日期:2011-01-01 00:00:00
abstract::Modulation sensitivity functions ( MSFs ) of retinal ganglion cells of the pigeon were determined by recording action potentials from their end branching in the optic tectum as response indicator. The inverse Fourier transformation of a MSF is taken to represent the receptive field sensitivity function approximating t...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265299
更新日期:1984-01-01 00:00:00
abstract:PURPOSE:To establish a retinal blood flow database in normal human eyes using the Canon Laser Blood Flowmeter (CLBF). METHOD:Fourteen healthy subjects (7 males, 7 females) between the ages of 24 and 33 underwent birectional laser Doppler velocimetry (BLDV) in one eye using the CLBF. Measurements consisting of blood ve...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000065600
更新日期:2002-09-01 00:00:00
abstract::Ibudilast selectively vasodilates cerebral vessels without reducing blood pressure. We investigated the effect of the drug on retinal circulation in 8 patients with diabetes mellitus, using the video-densitometric image analysis of fluorescein angiography. We compared the build up time, the time constant of washout ra...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267168
更新日期:1992-01-01 00:00:00
abstract::VEGF is considered as an important factor in the pathogenesis of macular edema. VEGF induces the rupture of the blood retinal barrier and may also influence the retinal pigment epithelial (RPE) outer retinal barrier. The aim of this work was to analyze the influence of the VEGF receptor pathways in the modulation of t...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000119877
更新日期:2008-01-01 00:00:00
abstract::Two out of three normal eyes tested with frequent instillation of 30 microliters of drops of 0.5% bupranolol, a beta 1 + beta 2 blocking drug with some intrinsic sympathomimetic and local anesthetic activity, showed a miotic effect of the order of a 25% reduction of pupil area, as estimated by an open-loop iris-videor...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265407
更新日期:1986-01-01 00:00:00
abstract::Statistically significant differences were found to exist in the frequencies of abnormal cell types in cultured lenses depending on the composition of the nutrient media (Eagle's and Dulbecco's modified essential medium with fetal calf serum FCS) they were cultured on. Abnormal cell growth (epithelioid, fibroblast-lik...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000266786
更新日期:1989-01-01 00:00:00
abstract:PURPOSE:To investigate therapeutic ocular surface medium (TOSM), a potential physiological tear replacement therapy, for persistent epithelial defect (PED). METHODS:11 eyes of 10 patients with PED for ≥ 2 weeks without improvement despite conventional treatment were enrolled in a prospective pilot study of TOSM over 1...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000355065
更新日期:2014-01-01 00:00:00
abstract::In order to investigate the combined influence of age and light, the b-wave and oscillatory potentials (OPs) of the electroretinogram (ERG) were recorded in 1.5-, 7- and 12-month-old WAG/Rij rats, reared under homogenous low-intensity cyclic light exposure. Wistar albino rats of the same ages, reared under the same co...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267282
更新日期:1993-01-01 00:00:00
abstract::The development and extension of fibrovascular or fibroglial membranes onto the retinal surface are a major cause of visual loss in diabetic patients with proliferative retinopathy and in patients suffering from retinal detachment with proliferative vitreoretinopathy. The pathogenesis of these proliferative diseases, ...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267115
更新日期:1991-01-01 00:00:00
abstract::The vibrating probe detects and measures currents around cells and organs. With its use, it is possible to demonstrate strong outward potassium currents at the equator of the lens and strong inward sodium currents at the optical poles. The addition of microelectrodes to the system permits one to define the nature of t...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000266570
更新日期:1988-01-01 00:00:00
abstract:PURPOSE:The aim of the present study was to characterize the development of after-cataract in the rabbit by measuring its wet weight, protein, DNA and glycosaminoglycan (GAG) contents and using Scheimpflug and slitlamp analysis. Further, aqueous humor (AqH) leukocytes, protein and lens epithelial cell proliferation act...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000048320
更新日期:2002-01-01 00:00:00
abstract::This study is a first approach to identify UVA-related alterations in situ of bovine eye lens proteins from the water-soluble and urea-soluble fractions upon aging. The fractions were obtained from irradiated long-term organ culture lenses and analyzed by mini two-dimensional gel electrophoresis. This micropreparative...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000055613
更新日期:2000-09-01 00:00:00
abstract::The tear levels of cholesterol of 17 patients with chronic blepharitis and 17 healthy subjects were determined by the photometric method. The mean cholesterol level of the patients was determined to be 56.1 +/- 8.9 (SEM) mg/dl. No statistically significant difference between the tear cholesterol levels of the two grou...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267034
更新日期:1990-01-01 00:00:00
abstract:PURPOSE:Extensive clinical investigations of the biocompatibility of different intraocular lenses (IOLs) have been made in an effort to optimize the outcome of modern cataract surgery. The aim of this study was to add animal eye experimental implantation data regarding cellular reaction on the anterior surface of IOLs....
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000087100
更新日期:2005-09-01 00:00:00
abstract:PURPOSE:The aim of this study was to evaluate the characteristics of corneal endothelial cells and central corneal thickness (CCT) in patients with diabetes mellitus (DM), comparing them with those of healthy subjects (controls) and to determine potential factors affecting the corneal parameters in patients with DM. M...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000507197
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND/AIM:Corneal epithelial defects may heal slowly in patients with diabetes, limbal stem cell deficiency, extensive chemical burns or anesthetized corneas. Studies have shown that erythropoietin, a glycoprotein hormone that promotes red blood cell proliferation and inhibits apoptosis of erythroid progenitors, m...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000351627
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:In this study, we used a rat model of retinal detachment (RD) to investigate the effects of transient receptor potential mucolipin 1 (TRPML1) on photoreceptor cells and the underlying mechanism. METHODS:An RD model was established by subretinal injection of sodium hyaluronate, and mucolipin synthetic agonist...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000512104
更新日期:2020-10-07 00:00:00
abstract::Local pO2 was measured close to the ciliary process of the rabbit eye using polarographic microelectrodes under microendoscopic observation. The experiments were performed in 5 anaesthetized New Zealand rabbits. Changes in local pO2, intraocular pressure (IOP) and blood flow velocity (BFV) were investigated after intr...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267324
更新日期:1993-01-01 00:00:00
abstract::We investigated the effects of hyperthermia on the healing process of experimental Pseudomonas corneal ulceration (PCU). Hartley guinea pigs were used to develop animal models of PCU. As a heat source, disposable chemical pocket warmers were applied. The healing process of PCU was compared between the heat-treated cor...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000078780
更新日期:2004-07-01 00:00:00
abstract::Age-related lens opacity is the major cause of loss of vision affecting more than half of the world's blind. The development of cataract is associated with changes in the structure of the lens. The lens consists largely of closely packed fibre cells forming a transparent syncytium. The main intrinsic polypeptide (MIP)...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267974
更新日期:1996-01-01 00:00:00
abstract::Extracellular recordings were performed on electrophysiologically identified achromatic neurons of the photosensitive pineal organ of the frog. The effects of iontophoretically applied aspartate and glutamate as well as one aspartate antagonist (D-alpha-aminoadipate) were observed on spontaneous activity and light-evo...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265304
更新日期:1984-01-01 00:00:00
abstract:PURPOSE:Retinal gene therapy trials are currently ongoing in a small number of inherited retinal disorders and this number is expected to rise significantly. The aim of this study was to analyze the psychological aspects of patients with RPE65 deficiency awaiting potential enrollment in gene therapy trials. METHODS:Fi...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000435887
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:To evaluate the effect of transpupillary thermotherapy (TTT) on foveal thickness and macular function in eyes with choroidal neovascularization (CNV) associated with age-related macular degeneration. METHODS:Sixteen eyes with occult CNV and 6 eyes with classic CNV were treated with TTT. Optical coherence tomog...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000083020
更新日期:2005-01-01 00:00:00
abstract::The binding of fluorescein and 6-carboxyfluorescein by normal, diabetic and in vitro glycosylated human serum proteins was analyzed by absorption and fluorescence spectroscopy, gel filtration and equilibrium dialysis. The absorption spectra of bound fluorochromes showed red shifts and hypochromic changes, and fluoroch...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265219
更新日期:1982-01-01 00:00:00
abstract::The gut microbiome has important physiological functions and plays an indispensable role in the human body. Currently, there are an increasing number of studies revealing the close correlation between dysbiosis of the gut microbiome and a variety of autoimmune diseases, including autoimmune uveitis. This brief review ...
journal_title:Ophthalmic research
pub_type: 杂志文章,评审
doi:10.1159/000510212
更新日期:2020-07-16 00:00:00
abstract::Metabolic changes in the rabbit lens have been studied by means of nuclear magnetic resonance spectroscopy. These changes have been induced by prolonged topical treatment with dexamethasone. Our results demonstrate an increase in sorbitol, sorbitol-3-phosphate, fructose-3-phosphate, glycerol-3-phosphate and glucose-6-...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000055646
更新日期:2001-03-01 00:00:00
abstract::Calf water-soluble (WS) crystallins consist of high-molecular weight (HM), alpha-, beta H-, beta L-, beta s- and gamma-crystallins. alpha-Crystallin as a molecular chaperone forms a structure with a central hole, known as Carver's model. The only crystallins fitting into this central cavity are beta s- and gamma-cryst...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267939
更新日期:1996-01-01 00:00:00
abstract::The pineal organ of the pike is a functional photoreceptive organ in which a multiplicity of the cells of the receptor line (CRL i.e. typical and modified photoreceptors) was demonstrated. The CRL appeared to be (i) regionally distributed, (ii) photosensitive, and (iii) responsible for the storage of various indoles (...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265306
更新日期:1984-01-01 00:00:00