Abstract:
:Photodocumented measurements of the lens thickness using an EAS-1000 Scheimpflug camera were performed in 261 cataract eyes (162 pure type) compared with 52 control eyes. The lens thickness in normal eyes usually increased with age by 0.015 mm annually. The cataractous lens, especially in the anterior subcapsular type combined with the superficial cortical and posterior subcapsular types of opacity, showed statistically significant lens thinning. The photodocumented values of lens thickness were higher in 7.9%, and those of the anterior chamber depth were lower in 5% compared with A scan ultrasonographic measurements.
journal_name
Ophthalmic Resjournal_title
Ophthalmic researchauthors
Shyn KH,Kim HC,Kim JCdoi
10.1159/000267205subject
Has Abstractpub_date
1992-01-01 00:00:00pages
32-5eissn
0030-3747issn
1423-0259journal_volume
24 Suppl 1pub_type
杂志文章abstract:OBJECTIVE:Acute corneal permeability change after instillation of benzalkonium chloride (BAC) was evaluated using a newly developed in vivo corneal transepithelial electric resistance (TER) measurement method. METHOD:Corneal TER was measured by Ag/AgCl electrodes placed in the anterior aqueous chamber and on the corne...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000109986
更新日期:2007-01-01 00:00:00
abstract:AIMS:Mutations in the PAX6 are the major cause of congenital aniridia. The objective of this study was to analyze genetic mutations in PAX6 in Chinese patients with congenital aniridia. METHODS:Total genomic DNA was isolated from the peripheral blood of the aniridia patients, all healthy family members and 100 healthy...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000327593
更新日期:2012-01-01 00:00:00
abstract::The effect of large intake of dietary ascorbic acid on heat-induced eye lens protein damage has been studied. Male guinea pigs of the Hartley strain were used. Ascorbic acid was administered to the experimental animals in the drinking water. The mean daily ascorbic acid intakes for the control and experimental animals...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267008
更新日期:1990-01-01 00:00:00
abstract::The aim of the present study was to investigate biochemical and morphological changes in rat lenses following long-term UV B irradiation. After an irradiation period of 156 days with follow-up documentation by means of Scheimpflug photography, section-related biochemical analyses of the lenses as well as histological ...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267187
更新日期:1992-01-01 00:00:00
abstract:PURPOSE:The aim of the present study was to characterize the development of after-cataract in the rabbit by measuring its wet weight, protein, DNA and glycosaminoglycan (GAG) contents and using Scheimpflug and slitlamp analysis. Further, aqueous humor (AqH) leukocytes, protein and lens epithelial cell proliferation act...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000048320
更新日期:2002-01-01 00:00:00
abstract:AIMS:Biomaterials are widely used in ophthalmology, and biodegradable polymers have been evaluated for use in surgery, tissue engineering and targeted drug delivery. We examined the tissue reactions attributable to 3 biodegradable polymers in the rat eye. METHODS:Inion GTR™ membrane [a blend of 85:15 poly(L-lactide-co...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000322996
更新日期:2011-01-01 00:00:00
abstract:PURPOSE:The purpose of our study was to investigate the profiles of inflammatory cytokines and the macrophage polarization gene in a choroidal neovascularization (CNV) mouse model before and after intravitreal aflibercept treatment. METHODS:The CNV mouse model was conducted by laser photocoagulation. A total of 58 cyt...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000513588
更新日期:2020-12-04 00:00:00
abstract::Dry eye is the most prominent pathology among those involving the ocular surface: a decrease of the aqueous (less frequent) or the lipid (more frequent) component of the tear film is the cause of the diminished stability of tears that is observed in this pathology. Dry eye shows a clear distribution linked to both sex...
journal_title:Ophthalmic research
pub_type: 杂志文章,评审
doi:10.1159/000489093
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:Primary open-angle glaucoma (POAG) is a chronic progressive optic neuropathy, leading to degeneration of retinal ganglion cells and characteristic morphological changes at the optic disc. In advanced stages of the disease, functional tests, such as standard automated perimetry (SAP), are the main diagnostic too...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000501693
更新日期:2020-01-01 00:00:00
abstract::Calf water-soluble (WS) crystallins consist of high-molecular weight (HM), alpha-, beta H-, beta L-, beta s- and gamma-crystallins. alpha-Crystallin as a molecular chaperone forms a structure with a central hole, known as Carver's model. The only crystallins fitting into this central cavity are beta s- and gamma-cryst...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267939
更新日期:1996-01-01 00:00:00
abstract::L-Timolol (0.4 mg/kg) reduced significantly retinal blood flow (17%), systemic blood pressure (18-20%) and heart rate (28%) in the rabbit. D-Timolol (4.0 mg/kg) increased retinal blood flow slightly (9%) and did not significantly affect systemic blood pressure or heart rate. Since D-timolol is effective in reducing in...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265470
更新日期:1987-01-01 00:00:00
abstract::The binding of fluorescein and 6-carboxyfluorescein by normal, diabetic and in vitro glycosylated human serum proteins was analyzed by absorption and fluorescence spectroscopy, gel filtration and equilibrium dialysis. The absorption spectra of bound fluorochromes showed red shifts and hypochromic changes, and fluoroch...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265219
更新日期:1982-01-01 00:00:00
abstract:AIM:To investigate the diagnostic efficacy and clinical application value of plasma endothelin-1 for diabetic retinopathy using receiver operating characteristic (ROC) curve analysis. METHODS:This was a prospective investigational study. Funduscopy and fundus fluorescein angiography were used as gold standards for the...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000108123
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:The aim of this study is to provide a quantitative evaluation of the blood-aqueous barrier (BAB) in patients with ocular blunt trauma and evaluate its association with intraocular pressure (IOP) elevation. METHODS:This is a prospective case-control study, and the following 3 groups were included: elevated I...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000445352
更新日期:2016-07-01 00:00:00
abstract:PURPOSE:The aim of this study was to evaluate the choroidal thickness (CT) and its determinants in primary angle closure glaucoma (PACG) eyes with and without malignant glaucoma (MG). METHODS:In this cross-sectional study, we enrolled 25 patients with bilateral primary angle closure (PAC) diseases; 1 eye of each patie...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000490914
更新日期:2018-01-01 00:00:00
abstract::We investigated the effects of hyperthermia on the healing process of experimental Pseudomonas corneal ulceration (PCU). Hartley guinea pigs were used to develop animal models of PCU. As a heat source, disposable chemical pocket warmers were applied. The healing process of PCU was compared between the heat-treated cor...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000078780
更新日期:2004-07-01 00:00:00
abstract:PURPOSE:In this investigation the authors studied the effect of dapiprazole, an alpha-adrenergic blocking agent, on aqueous humor dynamics in patients affected with pigmentary glaucoma. METHODS:Dapiprazole 0.5% eye drops were administered 3 times daily as adjunctive therapy to 16 pigmentary glaucoma patients in additi...
journal_title:Ophthalmic research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000267920
更新日期:1996-01-01 00:00:00
abstract:OBJECTIVE:The pathogenesis of Behçet's disease (BD) may be related to excessive production of reactive oxygen species, activated neutrophils, and T lymphocytes. The goal of this prospective study was to investigate whether there is any relationship among the oxidant/antioxidant system and nitric oxide (NO) and malondia...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000077332
更新日期:2004-05-01 00:00:00
abstract::Lipid peroxidation was induced with porcine retinal homogenates using ferric iron or UV light. A number of lipid and aqueous-soluble antioxidants were tested and their protective effects measured after 60 min of exposure. The iron system produced up to 5 times more lipid hydroperoxides as quantified by the fluorescenc...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267103
更新日期:1991-01-01 00:00:00
abstract::To investigate the binding of peanut-agglutinin (PNA) on porcine corneal tissue, several methods of tissue processing were used. In cryostat sections of postmortem tissue, PNA labeling of epithelial cell membranes was detected. In the stroma, a fibrillar structure parallel to the corneal surface was found. The anterio...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000266748
更新日期:1988-01-01 00:00:00
abstract::Chloroquine retinopathy was produced experimentally in the eye of the albino corydoras (one of the tropical fish) by daily administration of chloroquine (0.1 mg per os). The enucleated eyes were examined from the 14th day to 3 months after the beginning of drug administration under light and electron microscopy. The f...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265429
更新日期:1986-01-01 00:00:00
abstract::We measured prostaglandin E2 (PGE2) and prostacyclin levels in the vitreous bodies of 5 eyes of patients with diabetic retinopathy complicated by rhegmatogenous retinal detachment (RRD) and compared them with the corresponding levels in 9 nondiabetic eyes with the same condition as well as with 10 control eyes of dece...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000266995
更新日期:1990-01-01 00:00:00
abstract::Conventional Scheimpflug photography uses slits with a constant width of 80 microns. This parameter limits the resolution as sharp contours are imaged with a basic uncertainty. In order to reduce this basic uncertainty we developed an illumination slit with a width of 20 microns and less, using a green helium-neon las...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267967
更新日期:1996-01-01 00:00:00
abstract::The presence of chondroitin- and heparan sulfate-containing proteoglycans and type IV collagen was searched for in human cameral mucous gel (CMG). Monoclonal antibodies specific for human heparan sulfate, chondroitin sulfate and collagen IV were used in ultrathin sections of Lowicryl-embedded human CMG. Only chondroit...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267569
更新日期:1995-01-01 00:00:00
abstract::The purpose of this study was to compare the variability of the amplitude ratios and latencies of the electro-oculogram (EOG) light peak (LP) in three different recording conditions: Arden ratio (dark trough (DT): 12 min), modified Arden ratio (DT: 15 min) and light peak/dark baseline ratio (LP/BL: 35 min of dark adap...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267320
更新日期:1993-01-01 00:00:00
abstract::Net changes in the levels of lens calcium, magnesium, sodium, potassium, and water content were determined following exposure in vitro to iodoacetate, ouabain, lanthanum, cyanide, quercetin and cold temperature. The lens calcium content rose following inhibition of lens metabolism but did not change following specific...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265197
更新日期:1982-01-01 00:00:00
abstract::Previous research from this laboratory showed that human lacrimal fluid peroxidase has cyclic variations during the menstrual cycle, correlated with plasma levels of 17beta-oestradiol. In the present investigation, variations of enzyme activity and total protein content during the oestrous cycle of young adult female ...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000055666
更新日期:2001-05-01 00:00:00
abstract::The polyamines putrescine, spermidine and spermine have been proposed to be a part of the acute phase inflammatory response. They have been shown to be useful markers for cellular kinetics and change with various pathological conditions. The hypothesis that aqueous humor polyamines could be used to follow the time cou...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267165
更新日期:1992-01-01 00:00:00
abstract::The use of corneal tissue for ex vivo therapeutic evaluations is limited due to its rapid loss of viability after excision. Optimization of storage conditions may allow prolonged retention of physical tissue properties. In this study, we evaluated how storage in optimized organ culture (OC) medium at 37°C or phosphate...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000493488
更新日期:2019-01-01 00:00:00
abstract::Animal models are indispensable for pharmaceutical investigations. However, investigators often have difficulty choosing the appropriate modal for their research. To provide a comprehensive and convenient source of information about animal models of proliferative vitreoretinopathy (PVR), the current review sorted and ...
journal_title:Ophthalmic research
pub_type: 杂志文章,评审
doi:10.1159/000488492
更新日期:2018-01-01 00:00:00