Abstract:
:Naphthalene-induced rat cataract is a useful experimental cataract--however, because of its short survival period, studies using this model have been for limited purposes. Based on the consideration that the short survival might be caused by systemic toxicity of an overdose of naphthalene administration (1 g/kg body weight every other day), the authors successfully established a naphthalene-induced cataract with mild progression in Brown-Norway rats. The naphthalene administration proposed is to initially administer 0.5 g/kg and after a 1-week interval 1 g/kg of 10% naphthalene once or twice a week through a stomach tube. While the type of lens opacification induced in the two groups administered once and twice a week, respectively, was the same as that seen by the previous administration method, the progression of lens opacification seen in the groups showed a dose-dependent increase. The survival rate in the rats given naphthalene every other day according to the old method was 50% at the 6th week and 0% at the 9th week. Survival of the two new groups was 70 and 60% at the 30th week, respectively. This new type of naphthalene-induced rat cataract should be a suitable model for long-term observations.
journal_name
Ophthalmic Resjournal_title
Ophthalmic researchauthors
Nagata M,Murano H,Kojima M,Sasaki Kdoi
10.1159/000267836subject
Has Abstractpub_date
1995-01-01 00:00:00pages
34-8eissn
0030-3747issn
1423-0259journal_volume
27 Suppl 1pub_type
杂志文章abstract::In corneal organ culture, a contamination of sterile culture media with endotoxin is frequently found. Thus, we investigated if the presence of endotoxin affects the viability of cultured porcine corneal endothelial cells. Endotoxin in high concentrations caused morphological cell changes in porcine corneal endothelia...
journal_title:Ophthalmic research
pub_type: 杂志文章
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journal_title:Ophthalmic research
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journal_title:Ophthalmic research
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journal_title:Ophthalmic research
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更新日期:1984-01-01 00:00:00
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更新日期:2010-01-01 00:00:00
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更新日期:2005-09-01 00:00:00
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更新日期:2007-01-01 00:00:00