Abstract:
BACKGROUND:The lens is the ocular structure most susceptible to oxidative damage. Antioxidants, micronutrients and phytochemicals have been extensively studied for their possible effects to prevent or delay the progression of various eye diseases. OBJECTIVES:A brief overview of the updated literature on the role of antioxidants and micronutrients in the prevention and treatment of ocular diseases is to be presented with an emphasis on cataract. DATA SOURCES:PubMed search and individual papers from journals. DATA SYNTHESIS:The review discusses linkages of various micronutrients and antioxidants as well as oxidative stress with cataract. Dietary interventions as strategy for prevention of cataract and other ocular disorders are also reviewed. CONCLUSIONS:Consumption of food-based antioxidants like β-carotene lutein and zeaxanthin seem to be useful for the treatment of macular degeneration and cataracts. Supplements of vitamin A, vitamin C, vitamin E and zinc may prevent advanced age-related macular degeneration only in high-risk individuals.
journal_name
Ophthalmic Resjournal_title
Ophthalmic researchauthors
Agte V,Tarwadi Kdoi
10.1159/000316477subject
Has Abstractpub_date
2010-01-01 00:00:00pages
166-72issue
3eissn
0030-3747issn
1423-0259pii
000316477journal_volume
44pub_type
杂志文章,评审abstract::The refractive indices in various rat retinal layers, based on the total dry mass concentration, ranged from 1.369 to 1.385. The ratios of the refractive indices of neighboring retinal layers were near unity. This finding suggests that light passes through the rat retina without much refraction. ...
journal_title:Ophthalmic research
pub_type: 杂志文章
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journal_title:Ophthalmic research
pub_type: 杂志文章
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更新日期:2001-03-01 00:00:00
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journal_title:Ophthalmic research
pub_type: 杂志文章
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更新日期:1982-01-01 00:00:00
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journal_title:Ophthalmic research
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doi:10.1159/000267404
更新日期:1994-01-01 00:00:00
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更新日期:2015-01-01 00:00:00
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journal_title:Ophthalmic research
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doi:10.1159/000365487
更新日期:2015-01-01 00:00:00
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journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000063879
更新日期:2002-07-01 00:00:00
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journal_title:Ophthalmic research
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更新日期:2011-01-01 00:00:00
abstract::A method for microscopical observation and quantification of corneal neovascularization in the living mouse is described. Measurements of the corneal vasculature were made on still-mode video-pictures of the cornea. The validity of the method was shown by the high correlation between the morphometric measurements and ...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267097
更新日期:1991-01-01 00:00:00
abstract::Energy-dispersive X-ray analysis was used to obtain distribution profiles of Na, K, Cl, P and S in rapidly frozen-dried bulk specimens, and in cryosections of the normal rat lens. Na and Cl are highly concentrated in the capsule, and K and P, in the epithelial cells. Profiles of the entire radius of a lens show relati...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265328
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journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000048320
更新日期:2002-01-01 00:00:00
abstract::The binding of fluorescein and 6-carboxyfluorescein by normal, diabetic and in vitro glycosylated human serum proteins was analyzed by absorption and fluorescence spectroscopy, gel filtration and equilibrium dialysis. The absorption spectra of bound fluorochromes showed red shifts and hypochromic changes, and fluoroch...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265219
更新日期:1982-01-01 00:00:00
abstract::The high-voltage electron microscope (HVEM) permits examination of sections much thicker (up to 1 micron) than those usually used in transmission electron microscopy, which are approximately 70 nm in thickness. Two examples of the utility of the HVEM in research on the ultrastructure of the retinal pigment epithelium ...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265457
更新日期:1986-01-01 00:00:00
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journal_title:Ophthalmic research
pub_type: 杂志文章,评审
doi:10.1159/000488492
更新日期:2018-01-01 00:00:00
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journal_title:Ophthalmic research
pub_type: meta分析
doi:10.1159/000499106
更新日期:2019-01-01 00:00:00
abstract::During the process of terminal differentiation, the fibre cells in the eye lens undergo many changes that are reminiscent of apoptotic/necrotic changes. Mitochondria, for instance, undergo permeability transition and nuclear degradation is accompanied by chromatin condensation, disintegration of the nucleolus, dissolu...
journal_title:Ophthalmic research
pub_type: 杂志文章,评审
doi:10.1159/000055530
更新日期:1999-01-01 00:00:00
abstract:PURPOSE:To assess the natural variability in the diameter of small collagen fibrils in the lamellae of corneal stroma of healthy young rabbits. MATERIALS AND METHODS:The corneas of 6 young adult female New Zealand White rabbits (2.1 kg) were prepared for transmission electron microscopy (TEM) by fixation with a cacody...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000096228
更新日期:2006-01-01 00:00:00
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journal_title:Ophthalmic research
pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00
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journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000083020
更新日期:2005-01-01 00:00:00
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journal_title:Ophthalmic research
pub_type: 杂志文章,多中心研究
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journal_title:Ophthalmic research
pub_type: 杂志文章
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更新日期:2017-01-01 00:00:00
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journal_title:Ophthalmic research
pub_type: 杂志文章
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更新日期:2016-07-01 00:00:00
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journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000266934
更新日期:1989-01-01 00:00:00
abstract::The eyes of 200 rats (Mol:SPRD, Moellegaard Ltd., Skensvet, Denmark), 8 weeks of age and of both sexes, were examined routinely with a photo-slitlamp microscope (Zeiss) and opthalmoscope (Heine) 3-4 times in the course of four different 12-week toxicity studies. The animals were kept under constant lighting conditions...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267492
更新日期:1994-01-01 00:00:00
abstract::In a search for a pharmacologic adjuvant in the management of posttraumatic proliferative vitreoretinopathy (PVR), we investigated the effect of intravitreal injection of prinomastat (AG3340) on an experimental model. Posterior penetrating eye trauma was created in one eye each of 24 New Zealand white rabbits. One wee...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000055636
更新日期:2001-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1986-01-01 00:00:00
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journal_title:Ophthalmic research
pub_type: 杂志文章
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更新日期:2005-09-01 00:00:00
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journal_title:Ophthalmic research
pub_type: 杂志文章
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更新日期:2017-01-01 00:00:00