Single-Field Non-Mydriatic Fundus Photography for Diabetic Retinopathy Screening: A Systematic Review and Meta-Analysis.

Abstract:

PURPOSE:Single-field non-mydriatic fundus photography (NMFP) has been used to detect diabetic retinopathy (DR) in many studies; however, its value in a general clinical setting has not been established. Here we performed a meta-analysis to evaluate its diagnostic effectiveness. METHOD:We systematically searched PubMed, EMBASE, and Cochrane databases for candidate studies published through May 19, 2018. A random-effect model was used to calculate the diagnostic indicators including the sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), area under the curve (AUC), and 95% confidence intervals. RESULTS:Ten prospective studies were ultimately included. The pooled sensitivity, specificity, PLR, NLR, and DOR were 0.68, 0.94, 11.2, 0.34 and 33, respectively. The AUC was 0.88. Subgroup analysis showed that single-field NMFP had a respective sensitivity and specificity of 0.73 and 0.91 when compared to standard 7-field mydriatic stereoscopic photography (7SF), and 0.54 and 0.98 when compared to slit-lamp biomicroscopy as reference standard. CONCLUSIONS:Single-field NMFP is inadequate to detect DR. Additionally, it showed higher sensitivity and lower specificity when 7SF was used as reference standard, as compared to slit-lamp biomicroscopy, suggesting that different reference standards used in DR screening might have affected the diagnostic results.

journal_name

Ophthalmic Res

journal_title

Ophthalmic research

authors

Hu J,Chen R,Lu Y,Dou X,Ye B,Cai Z,Pu Z,Mou L

doi

10.1159/000499106

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

61-67

issue

2

eissn

0030-3747

issn

1423-0259

pii

000499106

journal_volume

62

pub_type

meta分析
  • Green tea (Camellia sinensis) protects against selenite-induced oxidative stress in experimental cataractogenesis.

    abstract::Cataract is the leading cause of blindness worldwide. It is a multifactorial disease primarily associated with oxidative stress produced by free radicals. The protection offered by various antioxidants in cataract development is well established. Polyphenolic compounds present in green tea (Camellia sinensis) are repo...

    journal_title:Ophthalmic research

    pub_type: 杂志文章

    doi:10.1159/000063881

    authors: Gupta SK,Halder N,Srivastava S,Trivedi D,Joshi S,Varma SD

    更新日期:2002-07-01 00:00:00

  • Calf lens alpha-crystallin, a molecular chaperone, builds stable complexes with beta s- and gamma-crystallins.

    abstract::Calf water-soluble (WS) crystallins consist of high-molecular weight (HM), alpha-, beta H-, beta L-, beta s- and gamma-crystallins. alpha-Crystallin as a molecular chaperone forms a structure with a central hole, known as Carver's model. The only crystallins fitting into this central cavity are beta s- and gamma-cryst...

    journal_title:Ophthalmic research

    pub_type: 杂志文章

    doi:10.1159/000267939

    authors: Bours J

    更新日期:1996-01-01 00:00:00

  • Effects of fluoroquinolone eye solutions without preservatives on human corneal epithelial cells in vitro.

    abstract:AIMS:To evaluate the biologic effects of fluoroquinolone eye solutions without preservatives on cultured human corneal epithelial cells in vitro. METHODS:We studied the effect of diverse generations of topical fluoroquinolones such as ofloxacin 0.3%, levofloxacin 0.5%, tosufloxacin 0.3%, moxifloxacin 0.5% and gatiflox...

    journal_title:Ophthalmic research

    pub_type: 杂志文章

    doi:10.1159/000357976

    authors: Oum BS,Kim NM,Lee JS,Park YM

    更新日期:2014-01-01 00:00:00

  • Distribution of glycosyltransferase in bovine eyes.

    abstract::The activities of sialyl-, fucosyl- and galactosyltransferase were measured in membrane preparations from bovine eyes. Radioactive sugars from CMP-N-neuraminic acid, GDP-fucose and UDP-galactose were incorporated into the endogenous and exogenous acceptors. The enzymatic activities of all three glycosyltransferases we...

    journal_title:Ophthalmic research

    pub_type: 杂志文章

    doi:10.1159/000267045

    authors: Unoki K,Uehara F,Muramatsu T

    更新日期:1990-01-01 00:00:00

  • Effect of optical defocus on the steady state pattern reversal visual-evoked response.

    abstract::The effects of optical defocusing with convex lenses on the amplitudes of pattern reversal visual-evoked response (PVER) were investigated. With the large check size and high-contrast pattern, PVER amplitudes showed a linear decrease in response to initial defocusing up to +5 to +6 dptr. As the degree of defocus incre...

    journal_title:Ophthalmic research

    pub_type: 杂志文章

    doi:10.1159/000267051

    authors: Katsumi O,Hirose T,Sakaue H,Mehta M,Rosenstein RB

    更新日期:1990-01-01 00:00:00

  • Acute corneal epithelial change after instillation of benzalkonium chloride evaluated using a newly developed in vivo corneal transepithelial electric resistance measurement method.

    abstract:OBJECTIVE:Acute corneal permeability change after instillation of benzalkonium chloride (BAC) was evaluated using a newly developed in vivo corneal transepithelial electric resistance (TER) measurement method. METHOD:Corneal TER was measured by Ag/AgCl electrodes placed in the anterior aqueous chamber and on the corne...

    journal_title:Ophthalmic research

    pub_type: 杂志文章

    doi:10.1159/000109986

    authors: Uematsu M,Kumagami T,Kusano M,Yamada K,Mishima K,Fujimura K,Sasaki H,Kitaoka T

    更新日期:2007-01-01 00:00:00

  • Postmortem evaluation of rabbit aqueous humor partial pressure of carbon dioxide, total carbon dioxide, bicarbonate, partial pressure of oxygen and ionized calcium levels.

    abstract::The aqueous humors of 100 freshly enucleated rabbit eyes were assessed within 10 min postmortem by taking samples in the last stage of corneal dissection following the Dikstein-Maurice procedure. Aqueous levels of partial pressure of carbon dioxide (pCO2) averaged 58.2 +/- 8.5 mm Hg to give calculated tCO2 and bicarbo...

    journal_title:Ophthalmic research

    pub_type: 杂志文章

    doi:10.1159/000267269

    authors: Doughty MJ

    更新日期:1993-01-01 00:00:00

  • Is the insertional anatomy of rectus extraocular muscles binocularly symmetrical?

    abstract:PURPOSE:This study was performed to examine the location, width, and insertional shape of rectus extraocular muscles (EOMs), and to elucidate the symmetry of the insertional anatomy of rectus EOMs in the left and right eyes. METHODS:EOMs were dissected from their origin to the insertion point in 100 intact orbits of 5...

    journal_title:Ophthalmic research

    pub_type: 杂志文章

    doi:10.1159/000272021

    authors: Cho HK,Shin SY

    更新日期:2010-01-01 00:00:00

  • Animal Models of Proliferative Vitreoretinopathy and Their Use in Pharmaceutical Investigations.

    abstract::Animal models are indispensable for pharmaceutical investigations. However, investigators often have difficulty choosing the appropriate modal for their research. To provide a comprehensive and convenient source of information about animal models of proliferative vitreoretinopathy (PVR), the current review sorted and ...

    journal_title:Ophthalmic research

    pub_type: 杂志文章,评审

    doi:10.1159/000488492

    authors: Hou H,Nudleman E,Weinreb RN

    更新日期:2018-01-01 00:00:00

  • Effect of dapiprazole, an alpha-adrenergic blocking agent, on aqueous humor dynamics in pigmentary glaucoma.

    abstract:PURPOSE:In this investigation the authors studied the effect of dapiprazole, an alpha-adrenergic blocking agent, on aqueous humor dynamics in patients affected with pigmentary glaucoma. METHODS:Dapiprazole 0.5% eye drops were administered 3 times daily as adjunctive therapy to 16 pigmentary glaucoma patients in additi...

    journal_title:Ophthalmic research

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000267920

    authors: Mastropasqua L,Carpineto P,Ciancaglini M,Lobefalo L,Costagliola C,Gallenga PE

    更新日期:1996-01-01 00:00:00

  • CMDBS, functional analogue of heparin sulfate as a new class of corneal ulcer healing agents.

    abstract::Soluble dextran polymer derivatives (CMDBSs) are originally synthesized as heparin-like plasma substitutes. Some of them mimic heparin in its interactions and stabilize, protect and facilitate actions of heparin binding growth factors. The wound healing activity of one specific CMDBS was studied in a model of corneal ...

    journal_title:Ophthalmic research

    pub_type: 杂志文章

    doi:10.1159/000267497

    authors: Fredj-Reygrobellet D,Hristova DL,Ettaiche M,Meddahi A,Jozefonwicz J,Barritault D

    更新日期:1994-01-01 00:00:00

  • Autologous Internal Limiting Membrane Fragment Transplantation for Large, Chronic, and Refractory Macular Holes.

    abstract:OBJECTIVE:To evaluate a technique of autologous internal limiting membrane (ILM) fragment transplantation for the treatment of large, chronic, and/or refractory macular holes (MH). DESIGN:This was a 6-month prospective interventional case series. METHOD:Ten eyes of 10 patients with MH underwent pars plana vitretomy (...

    journal_title:Ophthalmic research

    pub_type: 杂志文章

    doi:10.1159/000440767

    authors: De Novelli FJ,Preti RC,Ribeiro Monteiro ML,Pelayes DE,Junqueira Nóbrega M,Takahashi WY

    更新日期:2015-01-01 00:00:00

  • Decreased aqueous-flare reaction to repeated applications of prostaglandin E2 to the cornea in pigmented rabbits.

    abstract::To evaluate the effect of single or repeated topical applications of prostaglandin E2 (PGE2) to the cornea on the blood-aqueous barrier, we have measured the extent of flare in the anterior chamber of rabbit eyes at various time intervals. PGE2 was applied to the cornea for 4 min with the use of a glass cylinder in pi...

    journal_title:Ophthalmic research

    pub_type: 杂志文章

    doi:10.1159/000267895

    authors: Numata-Watanabe K,Hirata H,Hiraki S,Hayasaka S

    更新日期:1996-01-01 00:00:00

  • Spectral-domain versus time domain optical coherence tomography before and after ranibizumab for age-related macular degeneration.

    abstract:PURPOSE:To study the ability to appreciate qualitative features that indicate disease activity in patients with neovascular age-related macular degeneration (AMD) and to analyze the differences in automated retinal thickness measurement, using 1 time domain optical coherence tomography (TD-OCT) and 2 different spectral...

    journal_title:Ophthalmic research

    pub_type: 杂志文章

    doi:10.1159/000325027

    authors: Querques G,Forte R,Berboucha E,Martinelli D,Coscas G,Soubrane G,Souied EH

    更新日期:2011-01-01 00:00:00

  • Effect of acetylcysteine (Mucomyst) on epithelial wound healing.

    abstract::The rate of reepithelialization of the rabbit cornea, receiving isotonic NaCl solution and acetylcysteine (Mucomyst) solution at 10 and 20% concentrations, following a superficial epithelial ulcer was studied by fluorescein staining, photography and light microscopy. Acetylcysteine solution does not seem to retard nor...

    journal_title:Ophthalmic research

    pub_type: 杂志文章

    doi:10.1159/000265198

    authors: Petroutsos G,Guimaraes R,Giraud JP,Renard G,Pouliquen Y

    更新日期:1982-01-01 00:00:00

  • Expression of CREB in primary pterygium and correlation with cyclin D1, ki-67, MMP7, p53, p63, Survivin and Vimentin.

    abstract:AIM:Ultraviolet (UV) B irradiation induces gene expression that leads to skin cancer. Among the transcription factors induced by UVB radiation exposure, the cyclic AMP response element-binding protein (CREB) is significant. Since several factors downstream of CREB signaling are known to be involved in pterygium pathoge...

    journal_title:Ophthalmic research

    pub_type: 杂志文章

    doi:10.1159/000347124

    authors: Nubile M,Curcio C,Lanzini M,Calienno R,Iezzi M,Mastropasqua A,Di Nicola M,Mastropasqua L

    更新日期:2013-01-01 00:00:00

  • Hyperosmolarity and Benzalkonium Chloride Differently Stimulate Inflammatory Markers in Conjunctiva-Derived Epithelial Cells in vitro.

    abstract::Tear hyperosmolarity is known to cause ocular surface inflammation in dry eye syndrome. Benzalkonium chloride (BAK), an eyedrop preservative, is known to induce dry eye in long-term-treated patients. Analyzing the modulation of the proinflammatory potential of hyperosmolarity in the presence of BAK on the conjunctiva ...

    journal_title:Ophthalmic research

    pub_type: 杂志文章

    doi:10.1159/000448117

    authors: Warcoin E,Clouzeau C,Roubeix C,Raveu AL,Godefroy D,Riancho L,Baudouin C,Brignole-Baudouin F

    更新日期:2017-01-01 00:00:00

  • Experimental chloroquine retinopathy.

    abstract::Chloroquine retinopathy was produced experimentally in the eye of the albino corydoras (one of the tropical fish) by daily administration of chloroquine (0.1 mg per os). The enucleated eyes were examined from the 14th day to 3 months after the beginning of drug administration under light and electron microscopy. The f...

    journal_title:Ophthalmic research

    pub_type: 杂志文章

    doi:10.1159/000265429

    authors: Matsumura M,Ohkuma M,Tsukahara I

    更新日期:1986-01-01 00:00:00

  • Effect of the cutting procedure on the vitality of corneal endothelium in donor material.

    abstract::In an experimental study using freshly enucleated pig's eyes, we investigated the endothelial cell loss on the cut edge. Remote-control rotating trephine was found to be the least injuring when it was applied to fresh and preserved human corneas. Corneal culture does not seem to enhance endothelial cell damage due to ...

    journal_title:Ophthalmic research

    pub_type: 杂志文章

    doi:10.1159/000265224

    authors: Böhnke M,Draeger J,Niesmann U

    更新日期:1982-01-01 00:00:00

  • Age-related changes of human lens epithelial cells in vivo.

    abstract::We examined the density and morphology of lens epithelial cells (LECs) in vivo in a group of normal volunteers and cataract patients by using a newly developed noncontact specular microscope. There was a statistically significant decrease in the cell density of LECs in a group of cataract patients over the age of 80 y...

    journal_title:Ophthalmic research

    pub_type: 杂志文章

    doi:10.1159/000055694

    authors: Oharazawa H,Ibaraki N,Matsui H,Ohara K

    更新日期:2001-11-01 00:00:00

  • Quercetin inhibits vascular endothelial growth factor-induced choroidal and retinal angiogenesis in vitro.

    abstract:PURPOSE:The aim of this study was to investigate the effects of quercetin on vascular endothelial growth factor (VEGF)-induced choroidal and retinal angiogenesis in vitro using a rhesus macaque choroid-retinal endothelial (RF/6A) cell line. METHODS:RF/6A cells were cultured in Dulbecco's modified Eagle's medium contai...

    journal_title:Ophthalmic research

    pub_type: 杂志文章

    doi:10.1159/000369824

    authors: Li F,Bai Y,Zhao M,Huang L,Li S,Li X,Chen Y

    更新日期:2015-01-01 00:00:00

  • Lens transmission and autofluorescence in renal disease.

    abstract::Autofluorescence and transmission values of the lens for blue-green light were determined at two locations with the use of identical fluorophotometers: in Coimbra, Portugal, in 44 healthy controls, 15 haemodialysis and 11 renal failure patients, and in Leiden, The Netherlands, in 57 healthy controls, 23 haemodialysis ...

    journal_title:Ophthalmic research

    pub_type: 杂志文章

    doi:10.1159/000266736

    authors: van Wirdum E,Mota MC,van Best JA,Leite E,Kappelhof JP,Faria de Abreu JR,Paul LC,Freitas Martins J,Oosterhuis JA,Marques A

    更新日期:1988-01-01 00:00:00

  • A photodocumented study on lens thickness and densitometric value according to the type of cataract.

    abstract::Photodocumented measurements of the lens thickness using an EAS-1000 Scheimpflug camera were performed in 261 cataract eyes (162 pure type) compared with 52 control eyes. The lens thickness in normal eyes usually increased with age by 0.015 mm annually. The cataractous lens, especially in the anterior subcapsular type...

    journal_title:Ophthalmic research

    pub_type: 杂志文章

    doi:10.1159/000267205

    authors: Shyn KH,Kim HC,Kim JC

    更新日期:1992-01-01 00:00:00

  • Effects of L-timolol, D-timolol, haloperidol and domperidone on rabbit retinal blood flow measured with laser Doppler method.

    abstract::L-Timolol (0.4 mg/kg) reduced significantly retinal blood flow (17%), systemic blood pressure (18-20%) and heart rate (28%) in the rabbit. D-Timolol (4.0 mg/kg) increased retinal blood flow slightly (9%) and did not significantly affect systemic blood pressure or heart rate. Since D-timolol is effective in reducing in...

    journal_title:Ophthalmic research

    pub_type: 杂志文章

    doi:10.1159/000265470

    authors: Yan HY,Chiou GC

    更新日期:1987-01-01 00:00:00

  • Macular Dysfunction in Oguchi Disease with the Frequent Mutation 1147delA in the SAG Gene.

    abstract:AIM/BACKGROUND:A 1-bp deletion (1147delA) in the SAG (also known as arrestin or S-antigen) gene is the most frequently seen mutation in Japanese patients suffering from Oguchi disease, a recessively inherited stationary night blindness. We investigated macular function in a patient with Oguchi disease with the 1147delA...

    journal_title:Ophthalmic research

    pub_type: 杂志文章

    doi:10.1159/000325024

    authors: Hayashi T,Tsuzuranuki S,Kozaki K,Urashima M,Tsuneoka H

    更新日期:2011-10-01 00:00:00

  • Acidic FGF and other growth factors in preretinal membranes from patients with diabetic retinopathy and proliferative vitreoretinopathy.

    abstract::The development and extension of fibrovascular or fibroglial membranes onto the retinal surface are a major cause of visual loss in diabetic patients with proliferative retinopathy and in patients suffering from retinal detachment with proliferative vitreoretinopathy. The pathogenesis of these proliferative diseases, ...

    journal_title:Ophthalmic research

    pub_type: 杂志文章

    doi:10.1159/000267115

    authors: Fredj-Reygrobellet D,Baudouin C,Nègre F,Caruelle JP,Gastaud P,Lapalus P

    更新日期:1991-01-01 00:00:00

  • A mild progression type of naphthalene-induced cataract in brown-Norway rats.

    abstract::Naphthalene-induced rat cataract is a useful experimental cataract--however, because of its short survival period, studies using this model have been for limited purposes. Based on the consideration that the short survival might be caused by systemic toxicity of an overdose of naphthalene administration (1 g/kg body w...

    journal_title:Ophthalmic research

    pub_type: 杂志文章

    doi:10.1159/000267836

    authors: Nagata M,Murano H,Kojima M,Sasaki K

    更新日期:1995-01-01 00:00:00

  • Ocular volume change per minute with ocular pneumoplethysmography.

    abstract::Ocular pneumoplethysmography was performed before and after 1,737 carotid endarterectomies, 82% of which were performed for carotid lesions of hemodynamic consequence. Preoperative ocular hypoperfusion without ischemia was associated with at least transient postoperative ocular hyperemia. A difference in ocular volume...

    journal_title:Ophthalmic research

    pub_type: 杂志文章

    doi:10.1159/000055558

    authors: Gee W,Reed JF 3rd

    更新日期:1999-01-01 00:00:00

  • A novel approach for subretinal implantation of ultrathin substrates containing stem cell-derived retinal pigment epithelium monolayer.

    abstract:OBJECTIVE:To evaluate the feasibility of a new technique for the implantation of ultrathin substrates containing stem cell-derived retinal pigment epithelium (RPE) cells into the subretinal space of retina-degenerate Royal College of Surgeon (RCS) rats. METHODS:A platform device was used for the implantation of 4-µm-t...

    journal_title:Ophthalmic research

    pub_type: 杂志文章

    doi:10.1159/000338749

    authors: Hu Y,Liu L,Lu B,Zhu D,Ribeiro R,Diniz B,Thomas PB,Ahuja AK,Hinton DR,Tai YC,Hikita ST,Johnson LV,Clegg DO,Thomas BB,Humayun MS

    更新日期:2012-01-01 00:00:00

  • Aqueous humor polyamines and alkaline phosphatase activity in endotoxin-induced uveitis: correlations to diverse leukocyte subsets.

    abstract::The polyamines putrescine, spermidine and spermine have been proposed to be a part of the acute phase inflammatory response. They have been shown to be useful markers for cellular kinetics and change with various pathological conditions. The hypothesis that aqueous humor polyamines could be used to follow the time cou...

    journal_title:Ophthalmic research

    pub_type: 杂志文章

    doi:10.1159/000267165

    authors: Wickström K,Lundgren B,Törngren L,Ostberg C

    更新日期:1992-01-01 00:00:00