Abstract:
BACKGROUND:We studied 60 patients longitudinally to examine relations between regional cerebral blood flow and depressive states after stroke. METHODS:Poststroke depressive states were assessed by the Zung Self-Rating Depression Scale (SDS). Regional cerebral blood flow was measured using the 133xenon inhalation method with patients in the resting state on the same day as the SDS assessment. All patients were followed for an average of 14 months after the initial assessment. RESULTS:Severity of depression was inversely correlated with regional cerebral blood flow values in the parieto-occipital regions of the right hemisphere and in the anterior temporal region of the left hemisphere at the initial evaluation. Patients with lesions in left frontal or right parieto-occipital regions were more depressive in comparison with those with other brain lesions. Follow-up study showed significant inverse correlations between changes in SDS score and changes in regional cerebral blood flow at all scalp sites. Furthermore, higher inverse correlations were observed at specific brain regions in each hemisphere, including the parietal and parieto-occipital regions of the right hemisphere and the anterior temporal and inferior frontal regions of the left hemisphere. This relation was independent of recovery from neurological deficits. CONCLUSIONS:These results suggest that dysfunction of specific cortical and subcortical regions in both hemispheres asymmetrically contributes to depressive state after stroke.
journal_name
Strokejournal_title
Strokeauthors
Yamaguchi S,Kobayashi S,Koide H,Tsunematsu Tdoi
10.1161/01.str.23.12.1716subject
Has Abstractpub_date
1992-12-01 00:00:00pages
1716-22issue
12eissn
0039-2499issn
1524-4628journal_volume
23pub_type
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