Synergistic effects of citicoline and MK-801 in temporary experimental focal ischemia in rats.

abstract：BACKGROUND AND PURPOSE:Maternal cigarette smoking increases the risk of neonatal morbidity. We tested the hypothesis that perinatal nicotine exposure causes heightened brain vulnerability to hypoxic-ischemic (HI) injury in neonatal rats through aberrant expression patterns of angiotensin II type 1 (AT(1)R) and type 2 (...

journal_title：Stroke

authors： Li Y,Xiao D,Dasgupta C,Xiong F,Tong W,Yang S,Zhang L

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Hypoxic-ischemic (HI) brain injury in newborn infants represents a major cause of cerebral palsy, development delay, and epilepsy. Stem cell-based therapy has the potential to rescue and replace the ischemic tissue caused by HI and to restore function. However, the mechanisms by which stem cell t...

journal_title：Stroke

authors： Daadi MM,Davis AS,Arac A,Li Z,Maag AL,Bhatnagar R,Jiang K,Sun G,Wu JC,Steinberg GK

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The objectives of the present study were to: (1) noninvasively identify white matter reorganization and monitor its progress within 6 weeks after the onset of stroke; and (2) quantitatively investigate the effect of recombinant human erythropoietin treatment on this structural change using in viv...

journal_title：Stroke

authors： Li L,Jiang Q,Ding G,Zhang L,Zhang ZG,Li Q,Panda S,Kapke A,Lu M,Ewing JR,Chopp M

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:In animals, drugs that increase brain amine concentrations influence the rate and degree of recovery from cortical lesions. It is therefore conceivable that antidepressants may influence outcome after ischemic brain injury in humans. We evaluated the effects of the norepinephrine reuptake blocker...

journal_title：Stroke

authors： Dam M,Tonin P,De Boni A,Pizzolato G,Casson S,Ermani M,Freo U,Piron L,Battistin L

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Iron is an essential element for the human body. It has, however, been suggested that excessive iron stores may increase the risk of vascular disease. So far, epidemiologic studies on stroke are sparse. METHODS:We studied the association between iron status and stroke risk in a population-based ...

journal_title：Stroke

authors： van der A DL,Grobbee DE,Roest M,Marx JJ,Voorbij HA,van der Schouw YT

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Disruption of the endothelial layer is the first step in the atherogenic process. Experimental studies have shown that endothelial progenitor cells (EPCs) are involved in endothelial homeostasis and repair. Conversely, EPC depletion has been demonstrated in the setting of established atherosclero...

journal_title：Stroke

authors： Fadini GP,Coracina A,Baesso I,Agostini C,Tiengo A,Avogaro A,de Kreutzenberg SV

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:With the advent of time-dependent thrombolytic therapy for ischemic stroke, it has become increasingly important for stroke patients to arrive at the hospital quickly. This study investigates the association between the use of emergency medical services (EMS) and delay time among individuals with...

journal_title：Stroke

authors： Schroeder EB,Rosamond WD,Morris DL,Evenson KR,Hinn AR

更新日期：2000-11-01 00:00:00

abstract：:Blood proteins could play a critical role in the pathogenesis of cerebral vasospasm in subarachnoid hemorrhage (SAH) as agonists and as antagonists of vasoconstriction. The present study was designed primarily to quantify the inhibition produced by antithrombin III of the phasic responses elicited by cumulative doses ...

journal_title：Stroke

authors： White RP

更新日期：1986-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:To date, studies on neonatal stroke have mainly focused on cortical stroke. We have focused on perforator strokes, noncortical strokes in the arterial vascular perforator area. We sought to identify risk factors and evaluate clinical presentation and neuroimaging findings for neonatal perforator ...

journal_title：Stroke

authors： Ecury-Goossen GM,Raets MM,Lequin M,Feijen-Roon M,Govaert P,Dudink J

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:To evaluate the impact of proximal flow control on efficacy and safety of mechanical thrombectomy in an in vitro middle cerebral artery occlusion. METHODS:Three independent variables, including clot type, device (Merci Retriever, Solitaire FR, and Trevo devices), and use of a balloon guide cathe...

journal_title：Stroke

authors： Chueh JY,Kühn AL,Puri AS,Wilson SD,Wakhloo AK,Gounis MJ

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:High-intensity transient signals (HITS) detected by transcranial Doppler ultrasonography correspond to microemboli in intracranial arteries. The purpose of this study was to develop new diagnostic criteria for the differentiation of these microembolic signals from artifact, based on a high-resolu...

journal_title：Stroke

authors： Ries F,Tiemann K,Pohl C,Bauer C,Mundo M,Becher H

更新日期：1998-03-01 00:00:00

abstract：:We investigated the effects of phenytoin on the rate of enzymatic release of free fatty acids and on the levels of energy metabolites and nucleoside phosphates in ischemic brain. Phenytoin (10 mg/kg i.v.) was administered 30 minutes before the onset of ischemia induced in 30 male Wistar rats by occluding the basilar a...

journal_title：Stroke

authors： Kinouchi H,Imaizumi S,Yoshimoto T,Motomiya M

更新日期：1990-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The role of the cerebral microcirculation in delayed ischemia after subarachnoid hemorrhage remains obscure. To test the hypothesis that cerebral arterioles have a reduced capacity to dilate after subarachnoid hemorrhage, we studied the microvascular responses to papaverine (PPV) in patients unde...

journal_title：Stroke

authors： Pennings FA,Albrecht KW,Muizelaar JP,Schuurman PR,Bouma GJ

更新日期：2009-01-01 00:00:00

abstract：:Contrast-enhanced computed tomography of the neck permits low-risk evaluation of morphologic complications of carotid plaque, including (and foremost) calcification. To investigate the patterns and clinical significance of calcified deposits in the cervical carotid arteries using computed tomography we studied 40 pati...

journal_title：Stroke

authors： Culebras A,Otero C,Toledo JR,Rubin BS

更新日期：1989-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The effect of flow diverter (FD) on hemodynamic changes observed in aneurysms is inevitably affected by the actual structural configuration of deployed FD. We studied the resultant hemodynamic changes after implantation of FDs using computational fluid dynamic simulations based on micro-computed ...

journal_title：Stroke

authors： Huang Q,Xu J,Cheng J,Wang S,Wang K,Liu JM

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Because the blood circulation system of retina and brain are closely related to each other, we examined whether stroke is associated with localized retinal nerve fiber layer defects (RNFLDs). METHODS:Patients with acute ischemic stroke as part of a hospital-based study group were compared with t...

journal_title：Stroke

authors： Wang D,Li Y,Wang C,Xu L,You QS,Wang YX,Zhao L,Wei WB,Zhao X,Jonas JB

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The aim of this study is to report on the use of transcranial Doppler ultrasonography as a noninvasive diagnostic monitoring tool during local intra-arterial thrombolysis in a patient with acute embolic occlusion of the middle cerebral artery. CASE DESCRIPTION:We describe a 41-year-old woman wit...

journal_title：Stroke

authors： Karnik R,Stelzer P,Slany J

更新日期：1992-02-01 00:00:00

abstract：:A new micro T-tube, 0.6 mm in outer diameter, has been constructed. Use of this tube has allowed 1-mm common carotid artery (CCA) bypass ofr periods of time up to 22 minutes. After bypass, scanning electron microscopic observation of sutured CCA endothelium showed widespread destruction, scattered attached platelets a...

journal_title：Stroke

authors： Gregorius FK,Rand RW

更新日期：1976-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Although left atrial enlargement (LAE) increases incident stroke risk, the association with recurrent stroke is less clear. Our aim was to determine the association of LAE with recurrent stroke most likely related to embolism (cryptogenic and cardioembolic) and all ischemic stroke recurrences. M...

journal_title：Stroke

authors： Yaghi S,Moon YP,Mora-McLaughlin C,Willey JZ,Cheung K,Di Tullio MR,Homma S,Kamel H,Sacco RL,Elkind MS

更新日期：2015-06-01 00:00:00

abstract：:To study the effects of antithrombotic therapy in experimental stroke, we have characterized a baboon model of acute cerebrovascular thrombosis. In this model an inflatable silastic balloon cuff has been implanted by transorbital approach around the right middle cerebral artery (MCA), proximal to the take-off of the l...

journal_title：Stroke

authors： Del Zoppo GJ,Copeland BR,Harker LA,Waltz TA,Zyroff J,Hanson SR,Battenberg E

更新日期：1986-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The EuroQol and Medical Outcome Survey 36-item short-form health survey (SF-36) questionnaires have both been validated for the assessment of health-related quality of life after stroke. However, the relationship between these instruments has not been studied after stroke. We therefore sought to ...

journal_title：Stroke

authors： Dorman PJ,Dennis M,Sandercock P

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:There is currently no consensus on (1) the percentage of patients who develop spasticity after ischemic stroke, (2) the relation between spasticity and initial clinical findings after acute stroke, and (3) the impact of spasticity on activities of daily living and health-related quality of life. ...

journal_title：Stroke

authors： Urban PP,Wolf T,Uebele M,Marx JJ,Vogt T,Stoeter P,Bauermann T,Weibrich C,Vucurevic GD,Schneider A,Wissel J

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Although chemokines have been implicated in cardiovascular diseases, few studies have addressed the role of these inflammatory mediators in ischemic stroke. This study tested the hypothesis that RANTES (CCL5; regulated on activation, normal T-cell expressed and secreted) mediates the cerebral mic...

journal_title：Stroke

authors： Terao S,Yilmaz G,Stokes KY,Russell J,Ishikawa M,Kawase T,Granger DN

更新日期：2008-09-01 00:00:00

abstract：:We describe a patient with transient ischemic attacks secondary to a giant aneurysm who showed increased activity on platelet scintigrams at the origin of the left vertebral artery. This is assumed to be the first report of a presumed embolizing aneurysm with positive activity of labeled platelets. Platelet scintigrap...

journal_title：Stroke

authors： Maruyama M,Asai T,Kuriyama Y,Sawada T,Ogata J,Nishimura T,Omae T

更新日期：1989-05-01 00:00:00

abstract：:A standardized neurologic assessment scoring instrument was developed and tested for use in a multicenter trial of hypervolemic hemodilution in acute hemispheric stroke. Components of the neurologic examination pertinent to hemispheric stroke syndromes were emphasized. The scale was evaluated using 16 acute stroke pat...

journal_title：Stroke

authors： Adams RJ,Meador KJ,Sethi KD,Grotta JC,Thomson DS

更新日期：1987-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:A variety of primary end points have been used in acute stroke trials. We focus on the modified Rankin Scale, a reliable and valid ordinal outcome measure that assesses disability on a 7-point scale. METHODS:We provide an abbreviated discussion of analytical methods for ordinal scales, and relat...

journal_title：Stroke

authors： Koziol JA,Feng AC

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The use of lithium as a neuroprotective agent has been demonstrated using various models in which improvements in infarct size, DNA damage, and neurological function were reported. We further investigated neurohemodynamic aspects of the treatment-associated recovery by assessing the therapeutic e...

journal_title：Stroke

authors： Kim YR,van Meer MP,Tejima E,Murata Y,Mandeville JB,Dai G,Chuang DM,Rosen BR,Lo EH

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Occluding a large intracranial artery in rats produces a brain lesion that grows in terms of an increase in both surface area and number of necrotic neurons. The present study investigated whether reperfusing the ischemic territory 30 to 60 minutes after the arterial occlusion would have a benefi...

journal_title：Stroke

authors： Garcia JH,Wagner S,Liu KF,Hu XJ

更新日期：1995-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cerebral ischemia and stroke are leading causes of morbidity and mortality. An approach to protecting the brain during ischemia is to try to increase the delivery of oxygen via the residual blood flow through and around ischemic tissue. To test this hypothesis, we used a novel oxygen delivery age...

journal_title：Stroke

authors： Watson JC,Doppenberg EM,Bullock MR,Zauner A,Rice MR,Abraham D,Young HF

更新日期：1997-08-01 00:00:00

abstract：:Mild hypothermia is an established neuroprotectant in the laboratory, showing remarkable and consistent effects across multiple laboratories and models of brain injury. At the clinical level, mild hypothermia has shown benefits in patients who have experienced cardiac arrest and in some pediatric populations experienc...

journal_title：Stroke

authors： Yenari MA,Hemmen TM

更新日期：2010-10-01 00:00:00