Phenytoin affects metabolism of free fatty acids and nucleotides in rat cerebral ischemia.

abstract：BACKGROUND AND PURPOSE:Functional stimulation is accompanied by increases in regional cerebral blood flow which exceed metabolic demands under normal circumstances, but it is unknown whether functional stimulation is beneficial or detrimental in the setting of acute ischemia. The aim of this study was to determine the ...

journal_title：Stroke

authors： Burnett MG,Shimazu T,Szabados T,Muramatsu H,Detre JA,Greenberg JH

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We sought to identify the most powerful binary measures of the treatment effect of tissue plasminogen activator (tPA) in the National Institute of Neurological Disorders and Stroke (NINDS) rTPA Stroke Trial. METHODS:Using the Classification and Regression Tree (CART) algorithm, we evaluated bina...

journal_title：Stroke

authors： Broderick JP,Lu M,Kothari R,Levine SR,Lyden PD,Haley EC,Brott TG,Grotta J,Tilley BC,Marler JR,Frankel M

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:In Rivaroxaban Once Daily Oral Direct Factor Xa Inhibitor Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF) trial, rivaroxaban was noninferior to dose-adjusted warfarin in preventing stroke or systemic embolism among patients with no...

journal_title：Stroke

authors： Wong KS,Hu DY,Oomman A,Tan RS,Patel MR,Singer DE,Breithardt G,Mahaffey KW,Becker RC,Califf R,Fox KA,Berkowitz SD,Hacke W,Hankey GJ,Executive Steering Committee and the ROCKET AF Study Investigators.

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Limited systemic fibrinolysis and reduced dosage are features of intra-arterial thrombolyis (IAT) that may be advantageous in the treatment of postoperative strokes. However, IAT may increase the risk of surgical bleeding. We sought to determine the safety of postoperative IAT. METHODS:This was ...

journal_title：Stroke

authors： Chalela JA,Katzan I,Liebeskind DS,Rasmussen P,Zaidat O,Suarez JI,Chiu D,Klucznick RP,Jauch E,Cucchiara BL,Saver J,Kasner SE

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Hypertension control is a cornerstone of preventive treatment in patients at risk for cerebral attack. The aim of this study was to analyze hypertension management in secondary prevention of stroke as compared with patients in secondary prevention of myocardial infarction (MI). METHODS:The ECLAT...

journal_title：Stroke

authors： Amar J,Cambou JP,Touzé E,Bongard V,Jullien G,Vahanian A,Coppé G,Mas JL,ECLAT1 Study Investigators.

更新日期：2004-07-01 00:00:00

abstract：:It has been recognized that small intracerebral hemorrhage not uncommonly produced lacunar syndromes. In this study, we examined cases of intracerebral hemorrhage presenting as lacunar syndromes. Of 174 cases with recent intracerebral hemorrhage, 19 presented with a lacunar syndrome: 4 presented with pure motor hemipa...

journal_title：Stroke

authors： Mori E,Tabuchi M,Yamadori A

更新日期：1985-05-01 00:00:00

abstract：BACKGROUND:We studied 60 patients longitudinally to examine relations between regional cerebral blood flow and depressive states after stroke. METHODS:Poststroke depressive states were assessed by the Zung Self-Rating Depression Scale (SDS). Regional cerebral blood flow was measured using the 133xenon inhalation metho...

journal_title：Stroke

authors： Yamaguchi S,Kobayashi S,Koide H,Tsunematsu T

更新日期：1992-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The objective of this study was to determine the clinical features, angiographic findings, and response to treatment with thrombolytic therapy in patients with ischemic stroke caused by acute occlusion of the distal internal carotid artery. METHODS:This is a retrospective case series from a pros...

journal_title：Stroke

authors： Zaidat OO,Suarez JI,Santillan C,Sunshine JL,Tarr RW,Paras VH,Selman WR,Landis DM

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:"Incidental" MRI white matter (WM) lesions, comprising periventricular lesions (PVLs) and deep subcortical lesions (DSCLs), are common in the aging brain. Direct evidence of ischemia associated with incidental WM lesions (WMLs) has been lacking, and their pathogenesis is unresolved. METHODS:A po...

journal_title：Stroke

authors： Fernando MS,Simpson JE,Matthews F,Brayne C,Lewis CE,Barber R,Kalaria RN,Forster G,Esteves F,Wharton SB,Shaw PJ,O'Brien JT,Ince PG,MRC Cognitive Function and Ageing Neuropathology Study Group.

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The vitamin K-dependent protein Z (PZ) has been shown to possess anticoagulant as well as procoagulant properties. Plasma levels of PZ show a broad interindividual variation, but it is unknown to which extent this variation is under genetic control. Recent clinical studies revealed contradictory ...

journal_title：Stroke

authors： Lichy C,Kropp S,Dong-Si T,Genius J,Dolan T,Hampe T,Stoll F,Reuner K,Grond-Ginsbach C,Grau A

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Despite its low efficacy, aspirin is the most widely used drug for secondary stroke prevention. The reasons why stroke recurs while patients are on aspirin are unknown. We have analyzed a series of patients who had recurrent strokes while on aspirin. METHODS:Out of 2231 consecutive patients who ...

journal_title：Stroke

authors： Bornstein NM,Karepov VG,Aronovich BD,Gorbulev AY,Treves TA,Korczyn AD

更新日期：1994-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Inflammatory cytokines are involved in the pathogenesis of cerebral vasospasm after subarachnoid hemorrhage (SAH). This study was conducted to examine the role of p38 mitogen-activated protein kinase (MAPK) in the development of vasospasm and cytokine production. METHODS:We measured the expressi...

journal_title：Stroke

authors： Sasaki T,Kasuya H,Onda H,Sasahara A,Goto S,Hori T,Inoue I

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Acute cerebral ischemia is frequently associated with headache. It is unknown whether concomitant headache reflects a partly different pathogenesis, and thus, may influence long-term prognosis after stroke. Here, we compared the long-term risk of recurrent vascular events in patients in whom a tr...

journal_title：Stroke

authors： Maino A,Algra A,Koudstaal PJ,van Zwet EW,Ferrari MD,Wermer MJ,LiLAC Study Group.

更新日期：2013-09-01 00:00:00

abstract：:We reviewed demographic data on patients having 2,256 carotid endarterectomies in eight large hospitals in North Carolina to determine the frequency of blacks among these patients. Blacks comprised only 4.6% of the patients having carotid endarterectomy even though they comprised 26% of all patients discharged and 22%...

journal_title：Stroke

authors： Maxwell JG,Rutherford EJ,Covington D,Clancy TV,Tackett AD,Robinson N,Johnson G Jr

更新日期：1989-01-01 00:00:00

abstract：:In the rat an intracisternal injection of blood induces an angiographically demonstrable biphasic cerebral arterial vasospasm. Chemical destruction of the central serotoninergic and dopaminergic pathways prior to the cisternal blood injection does not affect the spasm pattern after the subarachnoid haemorrhage. It is ...

journal_title：Stroke

authors： Svendgaard NA,Brismar J,Delgado TJ,Rosengren E,Stenevi U

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Ischemic stroke accounts for 70% to 80% of all strokes, but intracerebral and subarachnoid hemorrhagic strokes have greater fatality. Age-standardized death rates from overall stroke are higher among men than women, but little is known about sex differences in stroke subtype mortality by race/eth...

journal_title：Stroke

authors： Ayala C,Croft JB,Greenlund KJ,Keenan NL,Donehoo RS,Malarcher AM,Mensah GA

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We aimed to determine if ischemia involving Broca area predicts Broca aphasia more reliably in acute or chronic stroke. METHODS:We included consecutive right-hand-dominant patients with left hemisphere ischemic stroke (<48 hours from onset for acute stroke or >6 months after stroke for chronic s...

journal_title：Stroke

authors： Ochfeld E,Newhart M,Molitoris J,Leigh R,Cloutman L,Davis C,Crinion J,Hillis AE

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Patients with acute ischemic stroke and intracranial arterial obstructions have a poor prognosis and a high probability of deteriorating at 24 hours. We aimed to evaluate the diagnostic accuracy of power motion mode Doppler (PMD-TCD) compared with CT angiography as standard in diagnosing intracra...

journal_title：Stroke

authors： Brunser AM,Lavados PM,Hoppe A,Lopez J,Valenzuela M,Rivas R

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Growth of an intracranial aneurysm occurs in around 10% of patients at 2-year follow-up imaging and may be associated with aneurysm rupture. We investigated whether PHASES, a score providing absolute risks of aneurysm rupture based on 6 easily retrievable risk factors, also predicts aneurysm grow...

journal_title：Stroke

authors： Backes D,Vergouwen MD,Tiel Groenestege AT,Bor AS,Velthuis BK,Greving JP,Algra A,Wermer MJ,van Walderveen MA,terBrugge KG,Agid R,Rinkel GJ

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We assessed whether the load of cerebral small vessel disease (cSVD) and its individual markers, including lacunes, white matter hyperintensities, microbleeds, and enlarged perivascular spaces (EPVS), are associated with arterial stiffness. METHODS:We evaluated cSVD markers in a cohort of 782 hy...

journal_title：Stroke

authors： Riba-Llena I,Jiménez-Balado J,Castañé X,Girona A,López-Rueda A,Mundet X,Jarca CI,Álvarez-Sabin J,Montaner J,Delgado P

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:In a previous study from our laboratory, ritanserin, a specific 5-HT2 serotonin receptor antagonist, reduced ischemic damage in the setting of transient global ischemia. In this study, we examined the effect of ritanserin on ischemic cerebral blood flow, systemic blood pressure, and infarct volum...

journal_title：Stroke

authors： Takagi K,Ginsberg MD,Globus MY,Busto R,Dietrich WD

更新日期：1994-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Perihematomal edema formation and consequent cell death contribute to the delayed brain injury evoked by intracerebral hemorrhage (ICH). We aimed to evaluate the effect of α7 nicotinic acetylcholine receptor (α7nAChR) stimulation on behavior, brain edema, and neuronal apoptosis. Furthermore, we a...

journal_title：Stroke

authors： Krafft PR,Altay O,Rolland WB,Duris K,Lekic T,Tang J,Zhang JH

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Brain injury caused by stroke is a frequent cause of perinatal morbidity and mortality with limited therapeutic options. Mesenchymal stem cells (MSC) have been shown to improve outcome after neonatal hypoxic-ischemic brain injury mainly by secretion of growth factors stimulating repair processes....

journal_title：Stroke

authors： van Velthoven CT,Sheldon RA,Kavelaars A,Derugin N,Vexler ZS,Willemen HL,Maas M,Heijnen CJ,Ferriero DM

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Perfusion-weighted magnetic resonance imaging (PWI) is a reliable and semiquantitative method for estimating cerebral hemodynamics. We sought to evaluate the potential of PWI for assessing cerebral blood flow (CBF) and metabolism compared with positron emission tomography (PET) in patients with c...

journal_title：Stroke

authors： Kajimoto K,Moriwaki H,Yamada N,Hayashida K,Kobayashi J,Miyashita K,Naritomi H

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Improvements in cardiac surgery mortality and morbidity have focused interest on the neurological injury such as stroke and cognitive decline that may accompany an otherwise successful operation. We aimed to investigate (1) the rate of stroke, new ischemic change on MRI, and cognitive impairment ...

journal_title：Stroke

authors： Barber PA,Hach S,Tippett LJ,Ross L,Merry AF,Milsom P

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Carotid plaque composition is a major determinant of cerebrovascular events. In the present analysis, we evaluated the relationship between intraplaque hemorrhage (IPH) and a thin/ruptured fibrous cap (TRFC) in moderately stenosed carotid arteries and cerebral infarcts on MRI in the ipsilateral h...

journal_title：Stroke

authors： de Rotte AA,Truijman MT,van Dijk AC,Liem MI,Schreuder FH,van der Kolk AG,de Kruijk JR,Daemen MJ,van der Steen AF,de Borst GJ,Luijten PR,Nederkoorn PJ,Kooi ME,van der Lugt A,Hendrikse J

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The aim of the present study was to investigate cerebral hemodynamics in patients requiring surgical treatment for lobar intracerebral hemorrhage. METHODS:Twenty patients who underwent surgery to remove a lobar spontaneous intracerebral hemorrhage were scanned before and after surgery using perf...

journal_title：Stroke

authors： Etminan N,Beseoglu K,Turowski B,Steiger HJ,Hänggi D

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Some strokes of unknown etiology may be the result of a paradoxical embolism traversing through a nonfused foramen ovale (patent foramen ovale [PFO]). The utility of percutaneously placed devices for treatment of patients with cryptogenic stroke or transient ischemic attack (TIA) and PFO is unkno...

journal_title：Stroke

authors： Furlan AJ,Reisman M,Massaro J,Mauri L,Adams H,Albers GW,Felberg R,Herrmann H,Kar S,Landzberg M,Raizner A,Wechsler L,CLOSURE I Investigators.

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cerebral white matter hyperintensities (WMHs) are believed to be the consequence of small vessel disease, and it is uncertain whether their extent predicts the risk of dementia in patients with vascular disease history. Method- Brain MRI was performed in 226 participants of the PROGRESS study. WM...

journal_title：Stroke

authors： Dufouil C,Godin O,Chalmers J,Coskun O,MacMahon S,Tzourio-Mazoyer N,Bousser MG,Anderson C,Mazoyer B,Tzourio C,PROGRESS MRI Substudy Investigators.

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The most powerful predictors of functional recovery and eventual home discharge among stroke survivors are the initial severity of the stroke and the patient's age. We analyzed a large population of stroke rehabilitation admissions by stratifying subgroups with coherent outcomes in an attempt to ...

journal_title：Stroke

authors： Alexander MP

更新日期：1994-01-01 00:00:00