Phenytoin affects metabolism of free fatty acids and nucleotides in rat cerebral ischemia.

Abstract:

:We investigated the effects of phenytoin on the rate of enzymatic release of free fatty acids and on the levels of energy metabolites and nucleoside phosphates in ischemic brain. Phenytoin (10 mg/kg i.v.) was administered 30 minutes before the onset of ischemia induced in 30 male Wistar rats by occluding the basilar and both common carotid arteries. The rats' brains were frozen in situ after 0, 5, or 30 minutes of ischemia or 10, 30, or 60 minutes of recirculation following 30 minutes of ischemia (n = 5 at each time). Nucleoside triphosphate levels were higher in the phenytoin-treated rats than in corresponding untreated rats at each time during and after ischemia. Phenytoin significantly attenuated the accumulation of lactate and free fatty acids (arachidonic acid and stearic acid) during ischemia and accelerated their recovery during recirculation. These results suggest that phenytoin has favorable protective effects on ischemic brain and that phenytoin may inhibit calcium-mediated phenomena, especially the inositol cycle, in cerebral ischemia.

journal_name

Stroke

journal_title

Stroke

authors

Kinouchi H,Imaizumi S,Yoshimoto T,Motomiya M

doi

10.1161/01.str.21.9.1326

subject

Has Abstract

pub_date

1990-09-01 00:00:00

pages

1326-32

issue

9

eissn

0039-2499

issn

1524-4628

journal_volume

21

pub_type

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