Phenytoin affects metabolism of free fatty acids and nucleotides in rat cerebral ischemia.


:We investigated the effects of phenytoin on the rate of enzymatic release of free fatty acids and on the levels of energy metabolites and nucleoside phosphates in ischemic brain. Phenytoin (10 mg/kg i.v.) was administered 30 minutes before the onset of ischemia induced in 30 male Wistar rats by occluding the basilar and both common carotid arteries. The rats' brains were frozen in situ after 0, 5, or 30 minutes of ischemia or 10, 30, or 60 minutes of recirculation following 30 minutes of ischemia (n = 5 at each time). Nucleoside triphosphate levels were higher in the phenytoin-treated rats than in corresponding untreated rats at each time during and after ischemia. Phenytoin significantly attenuated the accumulation of lactate and free fatty acids (arachidonic acid and stearic acid) during ischemia and accelerated their recovery during recirculation. These results suggest that phenytoin has favorable protective effects on ischemic brain and that phenytoin may inhibit calcium-mediated phenomena, especially the inositol cycle, in cerebral ischemia.






Kinouchi H,Imaizumi S,Yoshimoto T,Motomiya M




Has Abstract


1990-09-01 00:00:00














  • Early intravenous infusion of sodium nitrite protects brain against in vivo ischemia-reperfusion injury.

    abstract:BACKGROUND AND PURPOSE:The rate of nitric oxide (NO) generation from nitrite is linearly dependent on reductions in oxygen and pH levels. Recently, nitrite-derived NO has been reported to exert a profound protection against liver and heart ischemia-reperfusion injury. In this study, we hypothesized that nitrite would b...


    pub_type: 杂志文章


    authors: Jung KH,Chu K,Ko SY,Lee ST,Sinn DI,Park DK,Kim JM,Song EC,Kim M,Roh JK

    更新日期:2006-11-01 00:00:00

  • Leukocyte accumulation and hemodynamic changes in the cerebral microcirculation during early reperfusion after stroke.

    abstract:BACKGROUND AND PURPOSE:Leukocytes contribute to cerebral ischemia-reperfusion injury. However, few experimental models examine both in vivo behavior of leukocytes and microvascular rheology after stroke. The purpose of the present study was to characterize patterns of leukocyte accumulation in the cerebral microcircula...


    pub_type: 杂志文章


    authors: Ritter LS,Orozco JA,Coull BM,McDonagh PF,Rosenblum WI

    更新日期:2000-05-01 00:00:00

  • Stroke and Embolic Events in Hypertrophic Cardiomyopathy: Risk Stratification in Patients Without Atrial Fibrillation.

    abstract:BACKGROUND AND PURPOSE:Stroke and systemic embolic events are known to occur as complications of hypertrophic cardiomyopathy (HCM), and these complications are more common in patients with accompanying atrial fibrillation (AF). The diagnosis of AF is sometimes difficult, however, and it is possible that subclinical asy...


    pub_type: 杂志文章


    authors: Haruki S,Minami Y,Hagiwara N

    更新日期:2016-04-01 00:00:00

  • Toll-like receptor 7 preconditioning induces robust neuroprotection against stroke by a novel type I interferon-mediated mechanism.

    abstract:BACKGROUND AND PURPOSE:Systemic administration of Toll-like receptor (TLR) 4 and TLR9 agonists before cerebral ischemia have been shown to reduce ischemic injury by reprogramming the response of the brain to stroke. Our goal was to explore the mechanism of TLR-induced neuroprotection by determining whether a TLR7 agoni...


    pub_type: 杂志文章


    authors: Leung PY,Stevens SL,Packard AE,Lessov NS,Yang T,Conrad VK,van den Dungen NN,Simon RP,Stenzel-Poore MP

    更新日期:2012-05-01 00:00:00

  • Cerebral mast cells mediate blood-brain barrier disruption in acute experimental ischemic stroke through perivascular gelatinase activation.

    abstract:BACKGROUND AND PURPOSE:Perivascularly positioned cerebral mast cells (MC) have been shown to participate in acute blood-brain barrier disruption and expansive brain edema following experimental transient cerebral ischemia. However, the underlying molecular mechanisms remain unknown. Because proteolytic gelatinase enzym...


    pub_type: 杂志文章


    authors: Mattila OS,Strbian D,Saksi J,Pikkarainen TO,Rantanen V,Tatlisumak T,Lindsberg PJ

    更新日期:2011-12-01 00:00:00

  • Carotid arterial remodeling: a maladaptive phenomenon in type 2 diabetes but not in impaired glucose metabolism: the Hoorn study.

    abstract:BACKGROUND AND PURPOSE:Deteriorating glucose tolerance is associated with an increased cardiovascular disease (CVD) risk. The underlying mechanisms remain unclear. Arterial remodeling is the change in structural properties through time in response to atherogenic and/or hemodynamic alterations and aims to maintain circu...


    pub_type: 杂志文章


    authors: Henry RM,Kostense PJ,Dekker JM,Nijpels G,Heine RJ,Kamp O,Bouter LM,Stehouwer CD

    更新日期:2004-03-01 00:00:00

  • Magnetic resonance imaging and dynamic CT scan in cervical artery dissections.

    abstract:BACKGROUND AND PURPOSE:The typical magnetic resonance imaging picture of arterial dissection, namely, a narrowed eccentric signal void surrounded by a semilunar signal hyper-intensity (corresponding to the mural hematoma) on T1- and T2-weighted images, has been repeatedly reported, but the sensitivity of magnetic reson...


    pub_type: 杂志文章


    authors: Zuber M,Meary E,Meder JF,Mas JL

    更新日期:1994-03-01 00:00:00

  • Selective effects of subarachnoid hemorrhage on cerebral vascular responses to 4-aminopyridine in rats.

    abstract:BACKGROUND AND PURPOSE:We postulated that some abnormalities in cerebrovascular function after subarachnoid hemorrhage (SAH) may involve underlying alterations in K(+) channel function. Thus, using pharmacological inhibitors, we assessed the influence of SAH on function of 2 types of K(+) channel in regulation of basil...


    pub_type: 杂志文章


    authors: Quan L,Sobey CG

    更新日期:2000-10-01 00:00:00

  • The importance of size: successful recanalization by intravenous thrombolysis in acute anterior stroke depends on thrombus length.

    abstract:BACKGROUND AND PURPOSE:We hypothesize that in acute middle cerebral artery stroke, thrombus lengths measured in thin-slice nonenhanced CT images define a limit beyond which systemic thrombolysis will fail to recanalize occluded arteries. METHODS:In 138 patients who presented with acute middle cerebral artery stroke an...


    pub_type: 杂志文章


    authors: Riedel CH,Zimmermann P,Jensen-Kondering U,Stingele R,Deuschl G,Jansen O

    更新日期:2011-06-01 00:00:00

  • Reporting standards for angioplasty and stent-assisted angioplasty for intracranial atherosclerosis.

    abstract:BACKGROUND AND PURPOSE:Intracranial cerebral atherosclerosis causes ischemic stroke in a significant number of patients. Technological advances over the past 10 years have enabled endovascular treatment of intracranial atherosclerotic stenosis. The number of patients treated with angioplasty or stent-assisted angioplas...


    pub_type: 杂志文章,评审


    authors: Schumacher HC,Meyers PM,Higashida RT,Derdeyn CP,Lavine SD,Nesbit GM,Sacks D,Rasmussen P,Wechsler LR

    更新日期:2009-05-01 00:00:00

  • Early intravenous thrombolysis for acute ischemic stroke in a community-based approach.

    abstract:BACKGROUND AND PURPOSE:Controlled multicenter studies have demonstrated the efficacy of systemic recombinant tissue-type plasminogen activator (rtPA) treatment in selected cases of acute ischemic stroke. The feasibility of this therapeutic option in clinical practice was assessed in a community-based approach. METHODS...


    pub_type: 临床试验,杂志文章,多中心研究


    authors: Grond M,Stenzel C,Schmülling S,Rudolf J,Neveling M,Lechleuthner A,Schneweis S,Heiss WD

    更新日期:1998-08-01 00:00:00

  • Absolute quantitation of diffusion constants in human stroke.

    abstract:BACKGROUND AND PURPOSE:Animal studies have shown that MR diffusion imaging can outline acute ischemic regions before irreversible damage (infarction) occurs. To study evolution of ischemic lesions in humans, it is therefore important to quantify absolute diffusion constants (D values), but quantitation has not been rep...


    pub_type: 杂志文章


    authors: Uluğ AM,Beauchamp N Jr,Bryan RN,van Zijl PC

    更新日期:1997-03-01 00:00:00

  • Pseudocontinuous arterial spin labeling quantifies relative cerebral blood flow in acute stroke.

    abstract:BACKGROUND AND PURPOSE:The aim of this study was to test whether arterial spin labeling (ASL) can detect significant differences in relative cerebral blood flow (rCBF) in the core, mismatch, and reverse-mismatch regions, and whether rCBF values measured by ASL in those areas differ from values obtained using dynamic su...


    pub_type: 杂志文章


    authors: Hernandez DA,Bokkers RP,Mirasol RV,Luby M,Henning EC,Merino JG,Warach S,Latour LL

    更新日期:2012-03-01 00:00:00

  • Functional reorganization of motor cortex increases with greater axonal injury from CADASIL.

    abstract:BACKGROUND AND PURPOSE:Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited small-artery disease that clinically involves only the brain. Particularly early in the disease, patients can show substantial or complete recovery after individual strokes. Cortic...


    pub_type: 临床试验,杂志文章


    authors: Reddy H,De Stefano N,Mortilla M,Federico A,Matthews PM

    更新日期:2002-02-01 00:00:00

  • Incomplete infarct and delayed neuronal death after transient middle cerebral artery occlusion in rats.

    abstract:BACKGROUND AND PURPOSE:The clinical syndrome of transient ischemic attacks is accompanied in a significant percentage of patients by brain lesions or neuroimaging abnormalities whose structural counterparts have not been defined. The objective of this study was to analyze, in an experimental model of short-term (< 25 m...


    pub_type: 杂志文章


    authors: Garcia JH,Liu KF,Ye ZR,Gutierrez JA

    更新日期:1997-11-01 00:00:00

  • Graded neurologic scale for use in acute hemispheric stroke treatment protocols.

    abstract::A standardized neurologic assessment scoring instrument was developed and tested for use in a multicenter trial of hypervolemic hemodilution in acute hemispheric stroke. Components of the neurologic examination pertinent to hemispheric stroke syndromes were emphasized. The scale was evaluated using 16 acute stroke pat...


    pub_type: 杂志文章


    authors: Adams RJ,Meador KJ,Sethi KD,Grotta JC,Thomson DS

    更新日期:1987-05-01 00:00:00

  • Left ventricular mass indexed to height and prevalent MRI cerebrovascular disease in an African American cohort: the Atherosclerotic Risk in Communities study.

    abstract:BACKGROUND AND PURPOSE:Previous studies have demonstrated that echocardiographic left ventricular mass (LVM) is an independent risk factor for stroke in whites. Despite the greater burden of stroke, the echocardiographic predictors of stroke in African Americans remain poorly understood. METHODS:This investigation is ...


    pub_type: 杂志文章


    authors: Fox ER,Taylor HA Jr,Benjamin EJ,Ding J,Liebson PR,Arnett D,Quin EM,Skelton TN

    更新日期:2005-03-01 00:00:00

  • Rapid decline of cerebral microemboli of arterial origin after intravenous acetylsalicylic acid.

    abstract:BACKGROUND AND PURPOSE:The present study investigated the influence of the antiplatelet agent acetylsalicylic acid (ASA) on cerebral microembolism as detected by transcranial Doppler sonography (TCD). METHODS:Nine patients with recent transient ischemic attack or minor stroke of arterial origin were investigated. Eigh...


    pub_type: 临床试验,杂志文章


    authors: Goertler M,Baeumer M,Kross R,Blaser T,Lutze G,Jost S,Wallesch CW

    更新日期:1999-01-01 00:00:00

  • Cardiac cycle-dependent alternating flow in vertebral arteries with subclavian artery stenoses.

    abstract::Continuous-wave Doppler sonography is a reliable method for detecting severe subclavian stenosis and occlusion as well as subclavian steal. Intermediate stages leading to subclavian steal can also be detected. These are characterized by a cardiac-phase-dependent alternating flow direction in the vertebral artery. Some...


    pub_type: 杂志文章


    authors: von Reutern GM,Pourcelot L

    更新日期:1978-05-01 00:00:00

  • Results in 95 hemorrhagic stroke patients included in CLASS, a controlled trial of clomethiazole versus placebo in acute stroke patients.

    abstract:BACKGROUND AND PURPOSE:Clomethiazole is a neuroprotective drug that enhances gamma-aminobutyrate type A (GABA(A)) receptor activity. Its efficacy and safety were tested in the CLomethiazole Acute Stroke Study (CLASS). The protocol allowed a CT scan to be done after randomization but within 7 days of stroke onset to min...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Wahlgren NG,Díez-Tejedor E,Teitelbaum J,Arboix A,Leys D,Ashwood T,Grossman E

    更新日期:2000-01-01 00:00:00

  • Risk Profile of Symptomatic Lacunar Stroke Versus Nonlobar Intracerebral Hemorrhage.

    abstract:BACKGROUND AND PURPOSE:Although lacunar stroke (LS) and deep intracerebral hemorrhage (dICH) represent acute manifestations of the same pathological process involving cerebral small vessels (small vessel disease), it remains unclear what factors predispose to one phenotype rather than the other at individual level. ME...


    pub_type: 杂志文章


    authors: Morotti A,Paciaroni M,Zini A,Silvestrelli G,Del Zotto E,Caso V,Dell'Acqua ML,Simone AM,Lanari A,Costa P,Poli L,De Giuli V,Gamba M,Ciccone A,Ritelli M,Di Castelnuovo A,Iacoviello L,Colombi M,Agnelli G,Grassi M,de G

    更新日期:2016-08-01 00:00:00

  • Racial disparities in stroke risk factors: the impact of socioeconomic status.

    abstract:BACKGROUND AND PURPOSE:In the US, blacks have a higher incidence of stroke and more severe strokes than whites. Our objective was to determine if differences in income, education, and insurance, as well as differences in the prevalence of stroke risk factors, accounted for the association between ethnicity and stroke. ...


    pub_type: 杂志文章


    authors: Bravata DM,Wells CK,Gulanski B,Kernan WN,Brass LM,Long J,Concato J

    更新日期:2005-07-01 00:00:00

  • Retrospective Methods Analysis of Semiautomated Intracerebral Hemorrhage Volume Quantification From a Selection of the STICH II Cohort (Early Surgery Versus Initial Conservative Treatment in Patients With Spontaneous Supratentorial Lobar Intracerebral Hae

    abstract:BACKGROUND AND PURPOSE:The ABC/2 method for calculating intracerebral hemorrhage (ICH) volume has been well validated. However, the formula, derived from the volume of an ellipse, assumes the shape of ICH is elliptical. We sought to compare the agreement of the ABC/2 formula with other methods through retrospective ana...


    pub_type: 杂志文章


    authors: Haley MD,Gregson BA,Mould WA,Hanley DF,Mendelow AD

    更新日期:2018-02-01 00:00:00

  • Chlamydia pneumoniae antibodies and high lipoprotein(a) levels do not predict ischemic cerebral infarctions. Results from a nested case-control study in Northern Sweden.

    abstract:BACKGROUND AND PURPOSE:An association between high lipoprotein(a) [Lp(a)] levels and positive Chlamydia pneumoniae IgG titers in coronary artery disease has been described. The possibility of predicting ischemic stroke by measurements of plasma Lp(a) and C pneumoniae antibodies was investigated. METHODS:This incident ...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Glader CA,Stegmayr B,Boman J,Stenlund H,Weinehall L,Hallmans G,Dahlén GH

    更新日期:1999-10-01 00:00:00

  • Stroke rehabilitation outcome: impact of coronary artery disease.

    abstract::The frequency of clinically significant coronary artery disease (CAD) among stroke patients and the impact of CAD on stroke rehabilitation were studied in 132 patients with first thrombotic or embolic stroke who participated in comprehensive rehabilitation. Sixty-one patients (46%) had a history of CAD, and 16 of the ...


    pub_type: 杂志文章


    authors: Roth EJ,Mueller K,Green D

    更新日期:1988-01-01 00:00:00

  • Mild hypothermia ameliorates ubiquitin synthesis and prevents delayed neuronal death in the gerbil hippocampus.

    abstract:BACKGROUND AND PURPOSE:The purpose of the present study is to determine the effect of mild hypothermia on the synthesis of ubiquitin, an important protein for maintenance of cell viability, in the hippocampal neurons following transient cerebral ischemia. METHODS:Transient ischemia was induced by occluding both common...


    pub_type: 杂志文章


    authors: Yamashita K,Eguchi Y,Kajiwara K,Ito H

    更新日期:1991-12-01 00:00:00

  • Outcome in patients with acute basilar artery occlusion requiring mechanical ventilation.

    abstract:BACKGROUND AND PURPOSE:Many patients with acute basilar artery occlusion may require endotracheal intubation and mechanical ventilation. The circumstances and predictive value for outcome in these patients are not well documented. METHODS:We reviewed the medical records of 25 patients admitted into the intensive care ...


    pub_type: 杂志文章


    authors: Wijdicks EF,Scott JP

    更新日期:1996-08-01 00:00:00

  • Cigarette smoking and risk of stroke in the chinese adult population.

    abstract:BACKGROUND AND PURPOSE:We studied the relationship between cigarette smoking and stroke incidence and mortality in the Chinese adult population. METHODS:We conducted a prospective cohort study in a nationally representative sample of 169 871 Chinese men and women aged 40 years and older. Data on cigarette smoking and ...


    pub_type: 杂志文章


    authors: Kelly TN,Gu D,Chen J,Huang JF,Chen JC,Duan X,Wu X,Chen CS,He J

    更新日期:2008-06-01 00:00:00

  • Arterial Spin Labeling Magnetic Resonance Imaging Estimation of Antegrade and Collateral Flow in Unilateral Middle Cerebral Artery Stenosis.

    abstract:BACKGROUND AND PURPOSE:Three-dimensional pseudocontinuous arterial spin labeling with multiple postlabeling delays has been used to assess cerebral blood flow (CBF). We used this modality to estimate antegrade and collateral flow in patients with unilateral middle cerebral artery stenosis. METHODS:Consecutive patients...


    pub_type: 杂志文章


    authors: Lyu J,Ma N,Liebeskind DS,Wang DJ,Ma L,Xu Y,Wang T,Miao Z,Lou X

    更新日期:2016-02-01 00:00:00

  • Transcranial color-coded sonography of the basal cerebral circulation. Reference data from 115 volunteers.

    abstract:BACKGROUND AND PURPOSE:Transcranial color-coded sonography is a new development in noninvasive cerebral vascular imaging. Reference data using this technique are described. METHODS:Blood velocities and pulsatility and resistance indices were determined in the anterior cerebral, middle cerebral, posterior cerebral, ver...


    pub_type: 杂志文章


    authors: Martin PJ,Evans DH,Naylor AR

    更新日期:1994-02-01 00:00:00