Effect of DPPD (diphenyl-para-phenylenediamine) on stroke and cerebral edema in gerbils.

Abstract:

:Diphenyl-para-phenylenediamine (DPPD) is an antioxidant that has been shown to decrease liver damage due to the peroxidative process of carbon tetrachloride in rats and to ameliorate cold-induced cerebral edema in cats. Because lipid peroxidation disrupts the integrity of the plasma membrane, a process believed to occur in cerebral infraction, which is a major cause of cerebral edema. DPPD was tested for its protective effect against cerebral infarction. When given intraperitoneally in gerbils with unilateral ligation of the common carotid artery, DPPD had no effect on resultant incidence, morbidity, or mortality of cerebral infarction. Despite these findings, the authors believe, on the basis of what is known about free radical pathology, that DPPD and other antioxidants deserve further laboratory trials as possible drugs in the treatment of brain trauma and cerebral edema.

journal_name

Stroke

journal_title

Stroke

authors

Butterfield JD,McGraw CP

doi

10.1161/01.str.9.5.480

subject

Has Abstract

pub_date

1978-09-01 00:00:00

pages

480-3

issue

5

eissn

0039-2499

issn

1524-4628

journal_volume

9

pub_type

杂志文章

相关文献

STROKE文献大全
  • Emergency physician and stroke specialist beliefs and expectations regarding telestroke.

    abstract:BACKGROUND AND PURPOSE:Telestroke has been effective in the management of acute ischemic stroke. This study characterizes and compares stroke specialist (SS) and emergency physician (EP) perceptions of telestroke and identifies barriers preventing increased implementation. METHODS:A survey was developed and distribute...

    journal_title:Stroke

    pub_type: 信件

    doi:10.1161/STROKEAHA.109.574137

    authors: Moskowitz A,Chan YF,Bruns J,Levine SR

    更新日期:2010-04-01 00:00:00

  • Independent associations between electrocardiographic abnormalities and outcomes in patients with aneurysmal subarachnoid hemorrhage: findings from the intraoperative hypothermia aneurysm surgery trial.

    abstract:BACKGROUND AND PURPOSE:Electrocardiographic abnormalities are common after subarachnoid hemorrhage, but their significance remains uncertain. The aim of this study was to determine whether any specific electrocardiographic abnormalities are independently associated with adverse neurological outcomes. METHODS:This was ...

    journal_title:Stroke

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1161/STROKEAHA.108.528778

    authors: Coghlan LA,Hindman BJ,Bayman EO,Banki NM,Gelb AW,Todd MM,Zaroff JG,IHAST Investigators.

    更新日期:2009-02-01 00:00:00

  • Incidental magnetic resonance diffusion-weighted imaging-positive lesions are rare in neurologically asymptomatic community-dwelling adults.

    abstract:BACKGROUND AND PURPOSE:Incidental magnetic resonance diffusion-weighted imaging (DWI)-positive lesions, considered to represent small acute infarcts, have been detected in patients with cerebral small vessel diseases or cognitive impairment, but the prevalence in the community population is unknown. METHODS:DWI sequen...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.114.005782

    authors: Batool S,O'Donnell M,Sharma M,Islam S,Dagenais GR,Poirier P,Lear SA,Wielgosz A,Teo K,Stotts G,McCreary CR,Frayne R,DeJesus J,Rangarajan S,Yusuf S,Smith EE,PURE Study Investigators.

    更新日期:2014-07-01 00:00:00

  • Thromboxane synthesis inhibitor in a beagle pup model of perinatal asphyxia.

    abstract::During perinatal asphyxia, cerebral blood flow is markedly reduced in the gray and white matter of the telencephalon. Since previous work has implicated prostaglandins in the control of blood flow, we tested the hypothesis that a thromboxane synthesis inhibitor would improve cerebral blood flow and blunt the metabolic...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.20.6.809

    authors: Ment LR,Stewart WB,Petroff OA,Duncan CC

    更新日期:1989-06-01 00:00:00

  • Association between interleukin-1A polymorphism and cerebral amyloid angiopathy-related hemorrhage.

    abstract:BACKGROUND AND PURPOSE:It has been suggested that the interleukin-1A (IL-1A) allele 2 is a risk factor for Alzheimer's disease (AD). Because cerebral amyloid angiopathy-related hemorrhage (CAAH) often coexists with AD, we examined the IL-1A polymorphism in CAAH. METHODS:In a case-control study, patients with pathologi...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000089294.85447.1E

    authors: McCarron MO,Stewart J,McCarron P,Love S,Vinters HV,Ironside JW,Mann DM,Graham DI,Nicoll JA

    更新日期:2003-10-01 00:00:00

  • Hypercortisolism revealed by the dexamethasone suppression test in patients [corrected] with acute ischemic stroke.

    abstract::Using the dexamethasone suppression test, we studied the activity of the hypothalamic-pituitary-adrenal axis within the first week after onset in 62 patients with acute ischemic stroke. Compared with two control groups (one comprising 25 elderly patients with various acute medical disorders and the other comprising 33...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.20.12.1685

    authors: Olsson T,Aström M,Eriksson S,Forssell A

    更新日期:1989-12-01 00:00:00

  • High-resolution emboli detection and differentiation by characteristic postembolic spectral patterns.

    abstract:BACKGROUND AND PURPOSE:High-intensity transient signals (HITS) detected by transcranial Doppler ultrasonography correspond to microemboli in intracranial arteries. The purpose of this study was to develop new diagnostic criteria for the differentiation of these microembolic signals from artifact, based on a high-resolu...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.29.3.668

    authors: Ries F,Tiemann K,Pohl C,Bauer C,Mundo M,Becher H

    更新日期:1998-03-01 00:00:00

  • The concept of patient motivation: a qualitative analysis of stroke professionals' attitudes.

    abstract:BACKGROUND AND PURPOSE:The purpose of this work was to investigate how stroke rehabilitation professionals understand the concept of motivation and the ways that they use this concept in their clinical practice. METHODS:This qualitative study used semistructured, in-depth interviews with the professionals working in t...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/hs0202.102367

    authors: Maclean N,Pound P,Wolfe C,Rudd A

    更新日期:2002-02-01 00:00:00

  • Mevastatin, an HMG-CoA reductase inhibitor, reduces stroke damage and upregulates endothelial nitric oxide synthase in mice.

    abstract:BACKGROUND AND PURPOSE:The 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) lower serum cholesterol and decrease the incidence of stroke and cardiovascular disease. There is growing evidence that statins exert some of their beneficial effects independent of cholesterol lowering. Indeed, we...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.32.4.980

    authors: Amin-Hanjani S,Stagliano NE,Yamada M,Huang PL,Liao JK,Moskowitz MA

    更新日期:2001-04-01 00:00:00

  • Dietary flavonoids and risk of stroke in women.

    abstract:BACKGROUND AND PURPOSE:To date, few studies have examined associations between the wide range of flavonoid subclasses and risk of ischemic, hemorrhagic, and total stroke. METHODS:We conducted a prospective study among 69 622 women from the Nurses' Health Study. Total flavonoid and subclass intakes were calculated from...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章

    doi:10.1161/STROKEAHA.111.637835

    authors: Cassidy A,Rimm EB,O'Reilly EJ,Logroscino G,Kay C,Chiuve SE,Rexrode KM

    更新日期:2012-04-01 00:00:00

  • Neuroprotective effects of leptin against ischemic injury induced by oxygen-glucose deprivation and transient cerebral ischemia.

    abstract:BACKGROUND AND PURPOSE:Leptin is the major adipose hormone that regulates body weight and energy expenditure by activating leptin receptors in the hypothalamus. Leptin receptors are also present in other cell types, and a potent antiapoptotic effect for leptin has recently been reported. We investigated whether leptin ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.107.482786

    authors: Zhang F,Wang S,Signore AP,Chen J

    更新日期:2007-08-01 00:00:00

  • Thrombotic risk factors in primary antiphospholipid syndrome: a 5-year prospective study.

    abstract:BACKGROUND AND PURPOSE:Because thromboembolic events are frequently observed in primary antiphospholipid syndrome (PAPS), we assessed the risk factors for new thrombotic episodes. METHODS:Fifty-six PAPS patients (mean age, 37+/-10 years) were prospectively studied for 5 years. The preliminary Sapporo classification cr...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000170645.40562.09

    authors: Turiel M,Sarzi-Puttini P,Peretti R,Rossi E,Atzeni F,Parsons W,Doria A

    更新日期:2005-07-01 00:00:00

  • IMPS (intact months of patient survival): an analysis of the results of carotid endarterectomy.

    abstract::The literature on carotid surgery for lesions appropriate to prior episodes of ischemia has been reviewed. Only one randomized study and six non-controlled reports give useful data (this despite more than thirty years of surgical activity in this field). When analyzed by the IMPS (intact months of patient survival) cr...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章

    doi:10.1161/01.str.17.6.1329

    authors: Jonas S

    更新日期:1986-11-01 00:00:00

  • Dabigatran or Aspirin After Embolic Stroke of Undetermined Source in Patients With Patent Foramen Ovale: Results From RE-SPECT ESUS.

    abstract:BACKGROUND AND PURPOSE:Patent foramen ovale (PFO) may increase the risk of embolic stroke of undetermined source (ESUS). Guidelines suggest anticoagulation may be more effective than antiplatelets in preventing stroke in patients with ESUS and PFO when interventional closure is not performed. METHODS:Patients with ESU...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.120.031237

    authors: Diener HC,Chutinet A,Easton JD,Granger CB,Kleine E,Marquardt L,Meyerhoff J,Zini A,Sacco RL

    更新日期:2021-01-28 00:00:00

  • Ejection fraction response of the left ventricle of the heart to acute cerebrovascular accident in patients with coronary artery disease.

    abstract::The ejection fraction (EF) of the left ventricle was measured by radionuclide ventriculography in 64 patients during an acute cerebrovascular accident. Sixteen patients (12 with coronary artery disease) died within two weeks of the onset of symptoms and had only one EF measurement. In the remaining 48 patients, the EF...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.17.4.613

    authors: Front D,Frankel A,Israel O,Aharon Y,Satinger A,Linn S

    更新日期:1986-07-01 00:00:00

  • Hemodynamic changes by flow diverters in rabbit aneurysm models: a computational fluid dynamic study based on micro-computed tomography reconstruction.

    abstract:BACKGROUND AND PURPOSE:The effect of flow diverter (FD) on hemodynamic changes observed in aneurysms is inevitably affected by the actual structural configuration of deployed FD. We studied the resultant hemodynamic changes after implantation of FDs using computational fluid dynamic simulations based on micro-computed ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.113.001202

    authors: Huang Q,Xu J,Cheng J,Wang S,Wang K,Liu JM

    更新日期:2013-07-01 00:00:00

  • Transcranial Doppler correlation with cerebral angiography in sickle cell disease.

    abstract:BACKGROUND AND PURPOSE:Cerebral infarction in sickle cell disease is associated with arterial narrowing or occlusions of intracranial arteries. Primary stroke prevention would be feasible if a noninvasive screening test could be developed to detect intracranial disease in patients before symptoms develop. METHODS:To d...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.23.8.1073

    authors: Adams RJ,Nichols FT,Figueroa R,McKie V,Lott T

    更新日期:1992-08-01 00:00:00

  • Beneficial effects of hematopoietic growth factor therapy in chronic ischemic stroke in rats.

    abstract:BACKGROUND AND PURPOSE:Stroke is the leading cause of adult disability worldwide. Currently, there is no effective treatment for stroke survivors. Stem cell factor (SCF) and granulocyte-colony stimulating factor (G-CSF) are the growth factors regulating hematopoiesis. We have previously observed that SCF and G-CSF have...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.107.486217

    authors: Zhao LR,Berra HH,Duan WM,Singhal S,Mehta J,Apkarian AV,Kessler JA

    更新日期:2007-10-01 00:00:00

  • On the analysis and interpretation of outcome measures in stroke clinical trials: lessons from the SAINT I study of NXY-059 for acute ischemic stroke.

    abstract:BACKGROUND AND PURPOSE:A variety of primary end points have been used in acute stroke trials. We focus on the modified Rankin Scale, a reliable and valid ordinal outcome measure that assesses disability on a 7-point scale. METHODS:We provide an abbreviated discussion of analytical methods for ordinal scales, and relat...

    journal_title:Stroke

    pub_type: 杂志文章,评审

    doi:10.1161/01.STR.0000241106.81293.2b

    authors: Koziol JA,Feng AC

    更新日期:2006-10-01 00:00:00

  • Does Contralesional Hand Function After Neonatal Stroke Only Depend on Lesion Characteristics?

    abstract:BACKGROUND AND PURPOSE:In children having suffered from neonatal arterial ischemic stroke, the relationship between contralesional hand performance and structural changes in brain areas remote from the infarct site was examined. METHODS:Using voxel-based morphometry, we correlated contralesional gross manual dexterity...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.116.013545

    authors: Dinomais M,Hertz-Pannier L,Groeschel S,Delion M,Husson B,Kossorotoff M,Renaud C,Chabrier S,The Tich SN,AVCnn Study Group.

    更新日期:2016-06-01 00:00:00

  • Cochrane report: A systematic review of mannitol therapy for acute ischemic stroke and cerebral parenchymal hemorrhage.

    abstract:BACKGROUND:Mannitol was reported to decrease cerebral edema associated with tissue damage and is used to treat acute stroke in many countries. SUMMARY OF REVIEW:We tested whether there is any evidence from unconfounded randomized clinical trials that treatment with mannitol reduces short- and long-term case fatality a...

    journal_title:Stroke

    pub_type: 杂志文章,评审

    doi:10.1161/01.str.31.11.2719

    authors: Bereczki D,Liu M,Prado GF,Fekete I

    更新日期:2000-11-01 00:00:00

  • The pilot Stroke Data Bank: definition, design, and data.

    abstract::Four university centers collaborated to contribute 1158 patients with acute episodes of cerebrovascular disease to the pilot Stroke Data Bank, initiated by NINCDS in 1978. During the pilot project a standard set of data collection forms were developed and used at each of the collaborating centers. Data on clinical cou...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.15.4.740

    authors: Kunitz SC,Gross CR,Heyman A,Kase CS,Mohr JP,Price TR,Wolf PA

    更新日期:1984-07-01 00:00:00

  • Combining theta burst stimulation with training after subcortical stroke.

    abstract:BACKGROUND AND PURPOSE:Repetitive transcranial magnetic stimulation of the primary motor cortex (M1) may improve outcomes after stroke. The aim of this study was to determine the effects of M1 theta burst stimulation (TBS) and standardized motor training on upper-limb function of patients with chronic stroke. METHODS:...

    journal_title:Stroke

    pub_type: 信件

    doi:10.1161/STROKEAHA.110.583278

    authors: Ackerley SJ,Stinear CM,Barber PA,Byblow WD

    更新日期:2010-07-01 00:00:00

  • Low-grade inflammation is a risk factor for clinical stroke events in addition to silent cerebral infarcts in Japanese older hypertensives: the Jichi Medical School ABPM Study, wave 1.

    abstract:BACKGROUND AND PURPOSE:High-sensitivity C-reactive protein (hsCRP), a marker of inflammation, is associated with atherosclerosis, hypertensive target organ damage, and cardiovascular events. In the general Japanese population, the level of hsCRP is reported to be lower than that in Western countries, and the relationsh...

    journal_title:Stroke

    pub_type: 杂志文章,随机对照试验

    doi:10.1161/01.STR.0000258115.46765.f1

    authors: Ishikawa J,Tamura Y,Hoshide S,Eguchi K,Ishikawa S,Shimada K,Kario K

    更新日期:2007-03-01 00:00:00

  • Significance of EEG changes at carotid endarterectomy.

    abstract::Visually apparent EEG changes associated with clamping the internal carotid artery appeared in 55 of 176 consecutive patients (31%) undergoing carotid endarterectomy without shunt. Attenuation of higher frequency activity was the most common change. Changes were moderate in 33 patients (19%) and major in 22 (12.5%). M...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.17.5.891

    authors: Blume WT,Ferguson GG,McNeill DK

    更新日期:1986-09-01 00:00:00

  • Is there a future for endovascular treatment of intracranial atherosclerotic disease after Stenting and Aggressive Medical Management for Preventing Recurrent Stroke and Intracranial Stenosis (SAMMPRIS)?

    abstract::The Stenting and Aggressive Medical Management for Preventing Recurrent Stroke and Intracranial Stenosis (SAMMPRIS) trial, a randomized clinical trial comparing aggressive medical management to stenting with aggressive medical management for symptomatic intracranial stenosis, was prematurely halted when a high rate of...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.111.645507

    authors: Marks MP

    更新日期:2012-02-01 00:00:00

  • Cortical photothrombotic infarcts impair the recall of previously acquired memories but spare the formation of new ones.

    abstract:BACKGROUND AND PURPOSE:Despite a high incidence of poststroke dementia, there is no specific treatment for this condition. Because the evaluation of poststroke cognitive deficits in animal models of stroke is exceedingly challenging, the preclinical evaluation of candidate drugs is limited. We aimed to explore the impa...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.113.001907

    authors: Diederich K,Schmidt A,Strecker JK,Schäbitz WR,Schilling M,Minnerup J

    更新日期:2014-02-01 00:00:00

  • Tumor necrosis factor-alpha-238G>A promoter polymorphism is associated with increased risk of new hemorrhage in the natural course of patients with brain arteriovenous malformations.

    abstract:BACKGROUND AND PURPOSE:Identification of single-nucleotide polymorphisms (SNPs) associated with increased risk of new intracranial hemorrhage (ICH) after brain arteriovenous malformation (BAVM) diagnosis would facilitate risk stratification and identify potential targets for therapeutic intervention. METHODS:Patients ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000195133.98378.4b

    authors: Achrol AS,Pawlikowska L,McCulloch CE,Poon KY,Ha C,Zaroff JG,Johnston SC,Lee C,Lawton MT,Sidney S,Marchuk DA,Kwok PY,Young WL,UCSF BAVM Study Project.

    更新日期:2006-01-01 00:00:00

  • Intracranial Arterial Dolichoectasia and Stenosis: Risk Factors and Relation to Cerebral Small Vessel Disease.

    abstract:BACKGROUND AND PURPOSE:Intracranial arterial dolichoectasia (IADE) is a poorly understood arteriopathy compared with intracranial atherosclerotic stenosis (ICAS). We aimed to investigate the risk factors of IADE and ICAS and their relationship with neuroimaging markers of cerebral small vessel disease in a population-b...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.117.020130

    authors: Zhai FF,Yan S,Li ML,Han F,Wang Q,Zhou LX,Ni J,Yao M,Zhang SY,Cui LY,Jin ZY,Zhu YC

    更新日期:2018-05-01 00:00:00

  • Cardiac sources of embolism in patients with pial artery infarcts and lacunar lesions.

    abstract:BACKGROUND AND PURPOSE:On the assumption that the majority of lacunes are caused by small-vessel diseases and that pial artery infarcts arise from cardio-embolic or large-vessel diseases, 194 patients from the Berlin Cerebral Ischemia Data Bank with either lacunar or pial artery infarcts were analyzed for the frequency...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.25.4.776

    authors: Mast H,Thompson JL,Völler H,Mohr JP,Marx P

    更新日期:1994-04-01 00:00:00