Transcranial Doppler correlation with cerebral angiography in sickle cell disease.

Abstract:

BACKGROUND AND PURPOSE:Cerebral infarction in sickle cell disease is associated with arterial narrowing or occlusions of intracranial arteries. Primary stroke prevention would be feasible if a noninvasive screening test could be developed to detect intracranial disease in patients before symptoms develop. METHODS:To determine the sensitivity and specificity of transcranial Doppler in detecting significant (greater than or equal to 50% lumen diameter reduction) intracranial arterial lesions, we compared transcranial Doppler and cerebral angiography in a primarily young, symptomatic group of 33 patients (18 males and 15 females) with sickle cell disease. RESULTS:From a total of 34 examinations, transcranial Doppler detected significant abnormalities in 26 of 29 (sensitivity 90%, specificity 100%). Five were normal by both techniques. The transorbital examination detected abnormalities in two patients whose studies were otherwise unremarkable. CONCLUSIONS:Transcranial Doppler is sensitive and specific for the detection of arterial vasculopathy of sickle cell disease. Screening should include a transorbital examination of the distal internal carotid artery as well as examination using the transtemporal approach.

journal_name

Stroke

journal_title

Stroke

authors

Adams RJ,Nichols FT,Figueroa R,McKie V,Lott T

doi

10.1161/01.str.23.8.1073

subject

Has Abstract

pub_date

1992-08-01 00:00:00

pages

1073-7

issue

8

eissn

0039-2499

issn

1524-4628

journal_volume

23

pub_type

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