Cerebral cavernous malformations arise independent of the heart of glass receptor.


BACKGROUND AND PURPOSE:The Heart of Glass (HEG) receptor binds KRIT1 and functions with KRIT1, CCM2, and PDCD10 in a common signaling pathway required for heart and vascular development. Mutations in KRIT1, CCM2, and PDCD10 also underlie human cerebral cavernous malformation (CCM) and postnatal loss of these genes in the mouse endothelium results in rapid CCM formation. Here, we test the role of HEG in CCM formation in mice and in humans. METHODS:We constitutively or conditionally deleted Heg and Ccm2 genes in genetically modified mice. Mouse embryos, brain, and retina tissues were analyzed to assess CCM lesion formation. RESULTS:In postnatal mice, CCMs form with Ccm2-/- but not with Heg-/- or Heg-/-;Ccm2+/- endothelial cells. Consistent with these findings, human patients with CCM who lack exonic mutations in KRIT1, CCM2, or PDCD10 do not have mutations in HEG. CONCLUSIONS:These findings suggest that the HEG-CCM signaling functions during cardiovascular development and growth, whereas CCMs arise because of loss of HEG-independent CCM signaling in the endothelium of the central nervous system after birth.






Zheng X,Riant F,Bergametti F,Myers CD,Tang AT,Kleaveland B,Pan W,Yang J,Tournier-Lasserve E,Kahn ML




Has Abstract


2014-05-01 00:00:00














  • Global Survey of the Frequency of Atrial Fibrillation-Associated Stroke: Embolic Stroke of Undetermined Source Global Registry.

    abstract:BACKGROUND AND PURPOSE:Atrial fibrillation (AF) is increasingly recognized as the single most important cause of disabling ischemic stroke in the elderly. We undertook an international survey to characterize the frequency of AF-associated stroke, methods of AF detection, and patient features. METHODS:Consecutive patie...


    pub_type: 杂志文章


    authors: Perera KS,Vanassche T,Bosch J,Swaminathan B,Mundl H,Giruparajah M,Barboza MA,O'Donnell MJ,Gomez-Schneider M,Hankey GJ,Yoon BW,Roxas A Jr,Lavallee P,Sargento-Freitas J,Shamalov N,Brouns R,Gagliardi RJ,Kasner SE,Pieroni

    更新日期:2016-09-01 00:00:00

  • Effect of atherosclerosis on cerebral vascular responses to activation of leukocytes and platelets in monkeys.

    abstract::The goal of this study was to test the hypothesis that atherosclerosis alters responses of cerebral arteries and the ocular circulation to the activation in vivo of leukocytes and platelets. We measured blood flow to the brain and eye using microspheres and pressure in the cerebral microvessels of normal and atheroscl...


    pub_type: 杂志文章


    authors: Faraci FM,Lopez AG,Breese K,Armstrong ML,Heistad DD

    更新日期:1991-06-01 00:00:00

  • Predictors of Early Neurologic Deterioration in Acute Pontine Infarction.

    abstract::Background and Purpose- The relationship between infarct dimensions and neurological progression in patients with acute pontine infarctions remains unclear. This study aimed to investigate the morphometric predictive value of magnetic resonance imaging for early neurological deterioration (END) in acute pontine infarc...


    pub_type: 杂志文章


    authors: Li H,Dai Y,Wu H,Luo L,Wei L,Zhou L,Lin Y,Wang Q,Lu Z

    更新日期:2020-02-01 00:00:00

  • Changes in locomotor activity and passive avoidance task performance induced by cerebral ischemia in Mongolian gerbils.

    abstract:BACKGROUND AND PURPOSE:We investigated changes in locomotor activity, passive avoidance task performance, and hippocampal CA1 neurons induced by cerebral ischemia in Mongolian gerbils to examine the relation between these behavioral changes and CA1 neuronal damage. METHODS:Spontaneous locomotor activity was measured u...


    pub_type: 杂志文章


    authors: Karasawa Y,Araki H,Otomo S

    更新日期:1994-03-01 00:00:00

  • Increasing stroke incidence in Sweden between 1989 and 2000 among persons aged 30 to 65 years: evidence from the Swedish Hospital Discharge Register.

    abstract:BACKGROUND AND PURPOSE:Stroke mortality is decreasing in Sweden, as is the case in other Western European countries. However, both decreases and increases have been reported in Sweden for persons younger than age 65 years. The aim of this study was to compare the incidence of stroke in Sweden between the periods 1989 a...


    pub_type: 杂志文章


    authors: Medin J,Nordlund A,Ekberg K,Swedish Hospital Discharge Register.

    更新日期:2004-05-01 00:00:00

  • Mechanism of ATP-induced [Ca(2+)](i) mobilization in rat basilar smooth muscle cells.

    abstract:BACKGROUND AND PURPOSE:We have previously reported that extracellular ATP activates P(2u) receptors and increases intracellular free Ca(2+) ([Ca(2+)](i)) by G protein/phospholipase C/inositol 1,4,5-triphosphate pathways in cerebral artery smooth muscle cells. However, the possible contribution of other signaling pathwa...


    pub_type: 杂志文章


    authors: Aoki K,Zubkov AY,Parent AD,Zhang JH

    更新日期:2000-06-01 00:00:00

  • Increased circulating immune complexes in acute stroke: the triggering role of Chlamydia pneumoniae and cytomegalovirus.

    abstract:BACKGROUND AND PURPOSE:The mechanisms of immune reaction involved in the pathogenesis and clinical course of acute vascular incidents are still not completely understood. The aim of this study was to examine the presence of immune complexes (IC) in the acute stroke setting and the first month thereafter and to characte...


    pub_type: 临床试验,杂志文章


    authors: Tarnacka B,Gromadzka G,Członkowska A

    更新日期:2002-04-01 00:00:00

  • Mouse model of microembolic stroke and reperfusion.

    abstract:BACKGROUND AND PURPOSE:To test the role of fibrinolysis in stroke, we used a mouse model in which preformed 2.5- to 3-microm-diameter fibrin microemboli are injected into the cerebral circulation. The microemboli lodge in the downstream precapillary vasculature and are susceptible to fibrinolysis. METHODS:We injected ...


    pub_type: 杂志文章


    authors: Atochin DN,Murciano JC,Gürsoy-Ozdemir Y,Krasik T,Noda F,Ayata C,Dunn AK,Moskowitz MA,Huang PL,Muzykantov VR

    更新日期:2004-09-01 00:00:00

  • Altered Fibrin Clot Properties in Patients With Cerebral Venous Sinus Thrombosis: Association With the Risk of Recurrence.

    abstract:BACKGROUND AND PURPOSE:Venous thromboembolism and ischemic stroke are associated with unfavorable fibrin clot structure and function. We hypothesized that denser fibrin networks displaying impaired lysability characterize patients with cerebral venous sinus thrombosis (CVST). METHODS:We assessed plasma fibrin clot pro...


    pub_type: 杂志文章


    authors: Siudut J,Świat M,Undas A

    更新日期:2015-09-01 00:00:00

  • Association Between Unruptured Intracranial Aneurysms and Downstream Stroke.

    abstract::Background and Purpose- Case reports suggest that unruptured intracranial aneurysms may serve as a nidus for thrombus formation and downstream embolic stroke. However, few data exist to support an association between unruptured aneurysms and ischemic stroke. Methods- We conducted a within-subjects case-control study o...


    pub_type: 杂志文章


    authors: Chen ML,Gupta A,Chatterjee A,Khazanova D,Dou E,Patel H,Gialdini G,Merkler AE,Navi BB,Kamel H

    更新日期:2018-09-01 00:00:00

  • Beyond conventional stroke guidelines: setting priorities.

    abstract:BACKGROUND AND PURPOSE:Priorities in the care of stroke patients are often intuitive. An open and translucent priority-setting procedure would benefit patients, professionals, and decision-makers. Prioritization is an innovative part of the new Swedish national stroke guidelines. METHODS:Working groups identified diag...


    pub_type: 杂志文章


    authors: Norrving B,Wester P,Sunnerhagen KS,Terént A,Sohlberg A,Berggren F,Wester PO,Asplund K,Stroke Guidelines Working Group, National Board of Health and Welfare, Stockholm, Sweden.

    更新日期:2007-07-01 00:00:00

  • Detection of intracranial atherosclerosis: which imaging techniques are available in European hospitals?

    abstract:BACKGROUND AND PURPOSE:The diagnosis of intracranial atherosclerosis requires availability of appropriate imaging techniques. The objective was to evaluate the proportion of European hospitals where imaging techniques necessary to detect intracranial atherosclerosis are available. Method- We randomly selected 886 hospi...


    pub_type: 杂志文章


    authors: Balucani C,Leys D,Ringelstein EB,Kaste M,Hacke W,Executive Committee of the European Stroke Initiative.

    更新日期:2009-03-01 00:00:00

  • Endothelial progenitor cell research in stroke: a potential shift in pathophysiological and therapeutical concepts.

    abstract:BACKGROUND AND PURPOSE:Stroke is the leading cause of disability in the Western world; however, few therapies are at hand to decrease this burden. SUMMARY OF REVIEW:Endothelial progenitor cells (EPCs) have been introduced in cardiovascular medicine as factotums. EPCs can repair damaged endothelium and attenuate the de...


    pub_type: 杂志文章


    authors: Rouhl RP,van Oostenbrugge RJ,Damoiseaux J,Tervaert JW,Lodder J

    更新日期:2008-07-01 00:00:00

  • Early intensive versus minimally invasive approach to postoperative hemodynamic management after subarachnoid hemorrhage.

    abstract:BACKGROUND AND PURPOSE:The results of previous studies suggest that early goal-directed fluid therapy (EGDT) reduces delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage, but the effects of EGDT on clinical outcomes are still unclear. This study aimed to determine whether EGDT improves outcomes comp...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Mutoh T,Kazumata K,Terasaka S,Taki Y,Suzuki A,Ishikawa T

    更新日期:2014-05-01 00:00:00

  • Spinal cord infarction: a highly reproducible stroke model.

    abstract::The study of focal central nervous system ischemia has been impeded by the lack of animal models that are both reproducible and simulate human ischemic strokes. To circumvent these problems, we have developed a rabbit spinal cord infarction model. Infarction of the caudal lumbar cord is produced by temporary occlusion...


    pub_type: 杂志文章


    authors: Zivin JA,DeGirolami U

    更新日期:1980-03-01 00:00:00

  • The prognostic value of capillary glucose levels in acute stroke: the GLycemia in Acute Stroke (GLIAS) study.

    abstract:BACKGROUND AND PURPOSE:Evidence is accumulating regarding the prognostic influence of hyperglycemia in patients with acute ischemic stroke. However, the level associated with poor outcome is unknown. Our objectives were to establish the capillary glucose threshold with the highest predictive accuracy of poor outcome an...


    pub_type: 杂志文章,多中心研究


    authors: Fuentes B,Castillo J,San José B,Leira R,Serena J,Vivancos J,Dávalos A,Nuñez AG,Egido J,Díez-Tejedor E,Stroke Project of the Cerebrovascular Diseases Study Group, Spanish Society of Neurology.

    更新日期:2009-02-01 00:00:00

  • Association Between Thrombus Perviousness Assessed on Computed Tomography and Stroke Cause.

    abstract:BACKGROUND AND PURPOSE:A recent study proposed that thrombus perviousness (TP)-the degree to which contrast agents penetrate the thrombus in an occluded vessel measured on noncontrast computed tomography (NCCT) and CT angiography-may be associated with cardioembolic stroke cause with high specificity. Our aim was to in...


    pub_type: 杂志文章


    authors: Kufner A,Erdur H,Endres M,Nolte CH,Scheel M,Schlemm L

    更新日期:2020-12-01 00:00:00

  • Minocycline-induced attenuation of iron overload and brain injury after experimental intracerebral hemorrhage.

    abstract:BACKGROUND AND PURPOSE:Brain iron overload plays a detrimental role in brain injury after intracerebral hemorrhage (ICH). A recent study found that minocycline acts as an iron chelator and reduces iron-induced neuronal death in vitro. The present study investigated if minocycline reduces iron overload after ICH and iro...


    pub_type: 杂志文章


    authors: Zhao F,Hua Y,He Y,Keep RF,Xi G

    更新日期:2011-12-01 00:00:00

  • Color duplex measurement of cerebral blood flow volume in healthy adults.

    abstract:BACKGROUND AND PURPOSE:Global cerebral blood flow (CBF) is an important yet largely unknown quantity in the treatment of neurological intensive care patients. Color duplex sonography of the extracranial cerebral arteries can be used to measure global CBF volume directly at the bedside. To establish reference data on gl...


    pub_type: 杂志文章


    authors: Scheel P,Ruge C,Petruch UR,Schöning M

    更新日期:2000-01-01 00:00:00

  • Bridging therapy in acute ischemic stroke: a systematic review and meta-analysis.

    abstract:BACKGROUND AND PURPOSE:Pending the results of randomized controlled trials, the benefit and safety of bridging therapy (combined intravenous and intra-arterial thrombolysis) remain to be determined. The aim of this analysis was to give reliable estimates of efficacy and safety outcomes of bridging therapy. METHODS:We ...


    pub_type: 杂志文章,meta分析,评审


    authors: Mazighi M,Meseguer E,Labreuche J,Amarenco P

    更新日期:2012-05-01 00:00:00

  • Effect of Fluosol on oxygen availability, regional cerebral blood flow, and infarct size in a model of temporary focal cerebral ischemia.

    abstract::Twenty-four cats had an intravenous infusion of either Fluosol or saline and then were subjected to 2 hours of middle cerebral artery occlusion. All the animals infused with Fluosol and one-half the animals infused with saline were ventilated with 100% O2. Tissue oxygen availability and regional cerebral blood flow we...


    pub_type: 杂志文章


    authors: Kolluri S,Heros RC,Hedley-Whyte ET,Vonsattel JP,Miller D,Zervas NT

    更新日期:1986-09-01 00:00:00

  • Longitudinal study of regional cerebral blood flow changes in depression after stroke.

    abstract:BACKGROUND:We studied 60 patients longitudinally to examine relations between regional cerebral blood flow and depressive states after stroke. METHODS:Poststroke depressive states were assessed by the Zung Self-Rating Depression Scale (SDS). Regional cerebral blood flow was measured using the 133xenon inhalation metho...


    pub_type: 杂志文章


    authors: Yamaguchi S,Kobayashi S,Koide H,Tsunematsu T

    更新日期:1992-12-01 00:00:00

  • Tuberculosis and the risk of ischemic stroke: a 3-year follow-up study.

    abstract:BACKGROUND AND PURPOSE:The aim of this study is to estimate the risk of ischemic stroke during a 3-year follow-up period after a tuberculosis diagnosis using a nationwide, population-based study and a retrospective cohort design. METHOD:The study cohort comprised 2283 patients who had received treatment for tuberculos...


    pub_type: 杂志文章


    authors: Sheu JJ,Chiou HY,Kang JH,Chen YH,Lin HC

    更新日期:2010-02-01 00:00:00

  • Increasing rates of dementia at time of declining mortality from stroke.

    abstract:BACKGROUND AND PURPOSE:Stroke is associated with increased risk of dementia. There has been a decline in mortality from stroke among persons 65 and over in recent decades in the US. It is not clear, however, how this process has affected incidence of various dementias. METHODS:We evaluated over time changes in stroke ...


    pub_type: 杂志文章


    authors: Ukraintseva S,Sloan F,Arbeev K,Yashin A

    更新日期:2006-05-01 00:00:00

  • White Matter Hyperintensities Are Under Strong Genetic Influence.

    abstract:BACKGROUND AND PURPOSE:The genetic basis of white matter hyperintensities (WMH) is still unknown. This study examines the heritability of WMH in both sexes and in different brain regions, and the influence of age. METHODS:Participants from the Older Australian Twins Study were recruited (n=320; 92 monozygotic and 68 d...


    pub_type: 杂志文章


    authors: Sachdev PS,Thalamuthu A,Mather KA,Ames D,Wright MJ,Wen W,OATS Collaborative Research Team.

    更新日期:2016-06-01 00:00:00

  • Occurrence and mechanisms of occlusion of the anterior cerebral artery.

    abstract::Occlusion of the anterior cerebral artery is a rare condition. A review of CT scans from 413 patients with ischemic infarction confirmed this low relative incidence: only 3% of CT scans evidencing infarction involved the territory of the anterior cerebral artery. Four major mechanisms of anterior cerebral artery occlu...


    pub_type: 杂志文章


    authors: Gacs G,Fox AJ,Barnett HJ,Vinuela F

    更新日期:1983-11-01 00:00:00

  • Genetic heritability of ischemic stroke and the contribution of previously reported candidate gene and genomewide associations.

    abstract:BACKGROUND AND PURPOSE:The contribution of genetics to stroke risk, and whether this differs for different stroke subtypes, remainsuncertain. Genomewide complex trait analysis allows heritability to be assessed from genomewide association study (GWAS) data. Previous candidate gene studies have identified many associati...


    pub_type: 杂志文章


    authors: Bevan S,Traylor M,Adib-Samii P,Malik R,Paul NL,Jackson C,Farrall M,Rothwell PM,Sudlow C,Dichgans M,Markus HS

    更新日期:2012-12-01 00:00:00

  • Treatment of constipation and fecal incontinence in stroke patients: randomized controlled trial.

    abstract:BACKGROUND AND PURPOSE:Despite its high prevalence in stroke survivors, there is little clinical research on bowel dysfunction in this population. This is the first randomized controlled trial to evaluate treatment of constipation and fecal incontinence in stroke survivors. METHODS:Stroke patients with constipation or...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Harari D,Norton C,Lockwood L,Swift C

    更新日期:2004-11-01 00:00:00

  • Risk factors, clinical presentation, and neuroimaging findings of neonatal perforator stroke.

    abstract:BACKGROUND AND PURPOSE:To date, studies on neonatal stroke have mainly focused on cortical stroke. We have focused on perforator strokes, noncortical strokes in the arterial vascular perforator area. We sought to identify risk factors and evaluate clinical presentation and neuroimaging findings for neonatal perforator ...


    pub_type: 杂志文章


    authors: Ecury-Goossen GM,Raets MM,Lequin M,Feijen-Roon M,Govaert P,Dudink J

    更新日期:2013-08-01 00:00:00

  • Anesthetic modulation of cerebral hemodynamic and evoked responses to transient middle cerebral artery occlusion in cats.

    abstract::We measured cerebral blood flow and somatosensory evoked potentials during transient focal cerebral ischemia in cats to compare the effects of four commonly used anesthetic regimens: ketamine/fentanyl/N2O (fentanyl), pentobarbital, ketamine/alpha-chloralose (alpha-chloralose), and ketamine/halothane/N2O (halothane). S...


    pub_type: 杂志文章


    authors: Helfaer MA,Kirsch JR,Traystman RJ

    更新日期:1990-05-01 00:00:00