Abstract:
BACKGROUND AND PURPOSE:The Heart of Glass (HEG) receptor binds KRIT1 and functions with KRIT1, CCM2, and PDCD10 in a common signaling pathway required for heart and vascular development. Mutations in KRIT1, CCM2, and PDCD10 also underlie human cerebral cavernous malformation (CCM) and postnatal loss of these genes in the mouse endothelium results in rapid CCM formation. Here, we test the role of HEG in CCM formation in mice and in humans. METHODS:We constitutively or conditionally deleted Heg and Ccm2 genes in genetically modified mice. Mouse embryos, brain, and retina tissues were analyzed to assess CCM lesion formation. RESULTS:In postnatal mice, CCMs form with Ccm2-/- but not with Heg-/- or Heg-/-;Ccm2+/- endothelial cells. Consistent with these findings, human patients with CCM who lack exonic mutations in KRIT1, CCM2, or PDCD10 do not have mutations in HEG. CONCLUSIONS:These findings suggest that the HEG-CCM signaling functions during cardiovascular development and growth, whereas CCMs arise because of loss of HEG-independent CCM signaling in the endothelium of the central nervous system after birth.
journal_name
Strokejournal_title
Strokeauthors
Zheng X,Riant F,Bergametti F,Myers CD,Tang AT,Kleaveland B,Pan W,Yang J,Tournier-Lasserve E,Kahn MLdoi
10.1161/STROKEAHA.114.004809subject
Has Abstractpub_date
2014-05-01 00:00:00pages
1505-1509issue
5eissn
0039-2499issn
1524-4628journal_volume
45pub_type
杂志文章相关文献
STROKE文献大全abstract::Among 21 patients with angiographically demonstrated stenosis of the middle cerebral artery (MCA) 14 presented with a stroke and 7 with transient ischaemic attacks (TIAs). Of the former 4 had further strokes (3 fatal); of the latter one had a fatal stroke. Only 2 of the 21 patients had TIAs during the follow-up period...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.15.2.237
更新日期:1984-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Using the dexamethasone suppression test, we studied the suppressibility of the cortisol axis and its clinical determinants at various time points after stroke. A major aim was to examine the dexamethasone test as a diagnostic tool for the diagnosis of major depression in stroke patients. METHOD...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.24.1.52
更新日期:1993-01-01 00:00:00
abstract::A 55-year-old woman with an aortic arch syndrome of acute onset and dysphasia, resulting from the excessive administration of ergotamine tartrate suppositories, is described. Complete resolution of symptoms and return of upper limb and carotid artery pulses to normal occurred within four days of cessation of the ergot...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.14.5.811
更新日期:1983-09-01 00:00:00
abstract::Nonvalvular atrial fibrillation (NVAF) can be a source of cardiogenic brain embolism. We retrospectively reviewed the clinical features of 56 patients with acute brain infarction and NVAF. Based on clinical criteria, 35 infarcts (63%) were classified as probably embolic, 13 infarcts (23%) as probably nonembolic and 8 ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.14.5.688
更新日期:1983-09-01 00:00:00
abstract::Platelet-activating factor is a potent mediator of inflammation, which has untoward effects on cerebrovascular and neural elements. While several investigators have reported attenuation of ischemic damage after treatment with antagonists of platelet-activating factor, no study has proved endogenous production of plate...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.21.10.1452
更新日期:1990-10-01 00:00:00
abstract::Background and Purpose- Information on what effect disability before stroke can have on stroke outcome is lacking. We assessed prestroke disability in relation to poststroke hospital outcome. Methods- Analysis of prospectively collected data from the Sentinel Stroke National Audit Programme. A total of 1656 men (mean ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.119.027740
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The aim of this study was to assess the prevalence of extracranial carotid artery atherosclerosis and its relation to principal cardiovascular risk factors at different ages in a sample of the general population. METHODS:B-mode ultrasonography was used to investigate the carotid district in 457 ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.25.6.1133
更新日期:1994-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:This work was undertaken to determine to what degree long-term neurofunctional outcome of neonatal hypoxic-ischemic (HI) brain injury in mice correlates with anatomical extent of cerebral damage assessed by magnetic resonance imaging (MRI) and histopathology. METHODS:On postnatal day 7, mice wer...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000137768.25203.df
更新日期:2004-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Earlier tissue-type plasminogen activator (tPA) treatment for acute ischemic stroke increases efficacy, prompting national efforts to reduce door-to-needle times. We used lean process improvement methodology to develop a streamlined intravenous tPA protocol. METHODS:In early 2011, a multidiscipl...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.112.670687
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The purpose of this study was to assess individual differences in the pharmacological effects of acetylsalicylic acid (ASA) on bleeding time as measured by in vitro platelet aggregation and to examine the consistency of responses over time. METHODS:We measured template IIR bleeding time and plat...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.31.3.591
更新日期:2000-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Carotid angioplasty and stenting (CAS) has a higher incidence of periprocedural stroke compared with endarterectomy. Identifying CAS steps with the highest likelihood of embolization may have important implications. We evaluated CAS safety by correlating the findings of procedural transcranial Do...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.111.000659
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Cerebral infarction in sickle cell disease is associated with arterial narrowing or occlusions of intracranial arteries. Primary stroke prevention would be feasible if a noninvasive screening test could be developed to detect intracranial disease in patients before symptoms develop. METHODS:To d...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.23.8.1073
更新日期:1992-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Elevated low density lipoprotein and reduced high density lipoprotein cholesterol may increase the risk of atherothrombotic brain infarction, but the metabolic mechanisms accounting for this relation are poorly understood. METHODS:The kinetic parameters of low density and high density lipoprotei...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.23.9.1265
更新日期:1992-09-01 00:00:00
abstract::We studied 1,273 patients with ischemic cerebral infarction who were entered into the Stroke Data Bank, a prospective, observational study involving four university hospitals and the Biometry and Field Studies Branch of the National Institute of Neurological Disorders and Stroke. Forty patients had noniatrogenic recur...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.20.8.983
更新日期:1989-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Stroke has global importance and it causes an increasing amount of human suffering and economic burden, but its management is far from optimal. The unsuccessful outcome of several research programs highlights the need for reliable data on which to plan future clinical trials. The Virtual Internat...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.106.473579
更新日期:2007-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The Alberta Stroke program early CT score (ASPECTS) is a semiquantative scale for estimating extent and distribution of early ischemic changes within the MCA territory in the acute stroke setting. Good interobserver agreement of total ASPECTS is demonstrated for noncontrast CT (NCCT) and other im...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.112.665208
更新日期:2013-01-01 00:00:00
abstract::An ocular pneumoplethysmograph was devised to measure the systolic pressure in the ophthalmic artery and to obtain calibrated pulse volume changes from the ocular globe, with simultaneous recording from both eyes. The instrument is self-contained and portable. It can be applied by paramedical personnel, and the graphi...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.7.1.18
更新日期:1976-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Transcranial direct current stimulation is emerging as a promising tool for the treatment of several neurological conditions, including cerebral ischemia. The therapeutic role of this noninvasive treatment is, however, limited to chronic phases of stroke. We thus ought to investigate whether diff...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.113.001687
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:Urinary incontinence in the acute stage of stroke is seen as a predictor of death, severe disability, and an important factor on hospital discharge destination. Therefore, it is an important measure of stroke severity that not only affects the lives of stroke survivors but also those of caregivers. SUMMARY ...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/01.str.29.2.524
更新日期:1998-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The watershed cortical areas are the first to be deprived of sufficient blood flow in the event of cerebral hypoperfusion and will be the sites of watershed microinfarcts. Cerebral hypoperfusion is associated with Alzheimer disease (AD), but information regarding the occurrence of watershed corti...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.0000024523.82311.77
更新日期:2002-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Evidence indicates that center volume of cases affects outcomes for both carotid endarterectomy and stenting. We evaluated the effect of enrollment volume by site on complication rates in the Carotid Revascularization Endarterectomy Versus Stenting Trial (CREST). METHODS:The primary composite en...
journal_title:Stroke
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1161/STROKEAHA.114.006228
更新日期:2014-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Pathogenetic classification of intracerebral hemorrhage (ICH), using systems such as SMASH-U (structural vascular lesions, medication, cerebral amyloid angiopathy [CAA], systemic disease, hypertension, or undetermined), is important in predicting functional outcomes and mortality in patients with...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.114.005598
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Pneumonia has been estimated to occur in about one third of patients after acute stroke. Only limited data are available on stroke-associated pneumonia (SAP) in specialized neurological intensive care units (NICUs). METHODS:We enrolled 124 patients with acute stroke who were treated at our unive...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000063373.70993.CD
更新日期:2003-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Few studies currently assess the health-related quality of life of individuals following a stroke. One of the major challenges of assessing quality of life is the high likelihood that after a stroke a patient will not be able to complete such an assessment. One practical solution is to have a fam...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.28.10.1888
更新日期:1997-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We tested the hypothesis that fibrin structure/function is unfavorably altered in patients with cryptogenic ischemic stroke. METHODS:Ex vivo plasma fibrin clot permeability, turbidimetry, and efficiency of fibrinolysis were determined in 89 patients with patent foramen ovale (PFO) and a history ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.108.532812
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Patients with atrial fibrillation have a high risk of stroke and other vascular events even if anticoagulated. The primary objective here is to determine whether routine blood pressure-lowering provides additional protection for this high-risk patient group. METHODS:This study was a subsidiary a...
journal_title:Stroke
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1161/01.STR.0000181115.59173.42
更新日期:2005-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Elevated leukocyte count has been associated with cardiovascular and cerebrovascular disease in several epidemiological studies. We sought to determine whether white blood cell count (WBC) is associated with carotid plaque thickness in a stroke-free, multiethnic cohort. METHODS:For this cross-se...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.32.4.842
更新日期:2001-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The purpose of the present study is to determine the effect of mild hypothermia on the synthesis of ubiquitin, an important protein for maintenance of cell viability, in the hippocampal neurons following transient cerebral ischemia. METHODS:Transient ischemia was induced by occluding both common...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.22.12.1574
更新日期:1991-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Growth of an intracranial aneurysm occurs in around 10% of patients at 2-year follow-up imaging and may be associated with aneurysm rupture. We investigated whether PHASES, a score providing absolute risks of aneurysm rupture based on 6 easily retrievable risk factors, also predicts aneurysm grow...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/STROKEAHA.114.008198
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Analysis of quality of care for in-hospital stroke has not been previously performed at the national level. This study compares patient characteristics, process measures of quality, and outcomes for in-hospital strokes with those for community-onset strokes in a national cohort. METHODS:We perfo...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.113.003617
更新日期:2014-01-01 00:00:00