Hemostatic therapy in experimental intracerebral hemorrhage associated with the direct thrombin inhibitor dabigatran.

abstract：BACKGROUND AND PURPOSE:Osteogenic protein-1 (OP1) not only possesses trophic activity on bone tissue but also influences neuronal survival and differentiation in vitro. Specific receptors for OP1 are present in brain and spinal cord and can be upregulated during cerebral contusion. OP1 is a member of the transforming g...

journal_title：Stroke

authors： Lin SZ,Hoffer BJ,Kaplan P,Wang Y

更新日期：1999-01-01 00:00:00

abstract：:Adenylate cyclase activity was investigated in either homogenate or particulate fractions from the frontal cerebral cortex of the gerbil following five experimental conditions of bilateral ischemia. After periods of 15 min ischemia, 15 min ischemia plus 15 min of recirculation or 60 min ischemia the enzyme generally d...

journal_title：Stroke

authors： Taylor MD,Palmer GC,Callahan AS 3rd

更新日期：1984-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:A previous systematic review of randomized trials suggested a positive effect of antiplatelet therapy in patients with aneurysmal subarachnoid hemorrhage (SAH). We performed a randomized controlled trial to assess whether acetylsalicylic acid (ASA) reduces the risk of delayed ischemic neurologica...

journal_title：Stroke

authors： van den Bergh WM,MASH Study Group.,Algra A,Dorhout Mees SM,van Kooten F,Dirven CM,van Gijn J,Vermeulen M,Rinkel GJ

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We sought to identify variables associated with intracerebral hemorrhage in patients with acute ischemic stroke who receive tissue plasminogen activator (t-PA). METHODS:We performed subgroup analyses of data from a randomized, double-blind, placebo-controlled trial of intravenous t-PA administer...

journal_title：Stroke

authors：

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Thick cisternal clot on CT is a well-recognized risk factor for delayed cerebral ischemia (DCI) after subarachnoid hemorrhage (SAH). Whether intraventricular hemorrhage (IVH) or intracerebral hemorrhage (ICH) predisposes to DCI is unclear. The Fisher CT grading scale identifies thick SAH but does...

journal_title：Stroke

authors： Claassen J,Bernardini GL,Kreiter K,Bates J,Du YE,Copeland D,Connolly ES,Mayer SA

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The reliability of the EuroQol and SF-36 questionnaires after stroke is not known. We therefore aimed to assess and compare the test-retest reliability of both instruments in a group of stroke patients. METHODS:A total of 2253 patients with stroke entered by United Kingdom hospitals in the Inter...

journal_title：Stroke

authors： Dorman P,Slattery J,Farrell B,Dennis M,Sandercock P

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Stroke-induced neuroinflammation and white matter damage are associated with neurological deficits. Whether D-4F, an apolipoprotein A-I mimetic peptide, treatment of stroke decreases neuroinflammation and white matter damage and improves functional outcome has not been investigated. METHODS:Adul...

journal_title：Stroke

authors： Cui X,Chopp M,Zacharek A,Cui C,Yan T,Ning R,Chen J

更新日期：2016-01-01 00:00:00

abstract：:Background and Purpose- Preterm neonates with intraventricular hemorrhage (IVH) are at risk for posthemorrhagic hydrocephalus and poor neurological outcomes. Iron has been implicated in ventriculomegaly, hippocampal injury, and poor outcomes following IVH. We hypothesized that levels of cerebrospinal fluid blood break...

journal_title：Stroke

authors： Mahaney KB,Buddhala C,Paturu M,Morales D,Limbrick DD Jr,Strahle JM

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Citicoline, a naturally occurring precursor of phosphatidylcholine, is neuroprotective and is currently being assessed in clinical trials. To evaluate potential synergistic neuroprotective effects of prolonged citicoline treatment and early N-methyl-D-aspartate (NMDA) antagonist therapy, suboptim...

journal_title：Stroke

authors： Onal MZ,Li F,Tatlisumak T,Locke KW,Sandage BW Jr,Fisher M

更新日期：1997-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Transcranial Doppler ultrasound can detect circulating cerebral emboli. Monitoring of patients with potential embolic sources may allow identification of high-risk patients who can then be selected for prophylactic treatment. However, practical patient monitoring will require automated programs t...

journal_title：Stroke

authors： Markus H,Loh A,Brown MM

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Enlarged perivascular spaces in the brain are common but generally overlooked and of uncertain pathophysiology. They may reflect underlying cerebral small vessel disease. We determined whether enlarged perivascular spaces were associated with lacunar stroke subtype and white matter hyperintensiti...

journal_title：Stroke

authors： Doubal FN,MacLullich AM,Ferguson KJ,Dennis MS,Wardlaw JM

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Randomized clinical trials testing aspirin in relatively low-risk, middle-aged people have consistently shown small increases in stroke associated with aspirin use. We analyzed the relationship between the regular use of aspirin and incident ischemic and hemorrhagic stroke among people aged 65 ye...

journal_title：Stroke

authors： Kronmal RA,Hart RG,Manolio TA,Talbert RL,Beauchamp NJ,Newman A

更新日期：1998-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Nimodipine, a calcium antagonist, has been reported to have beneficial effects in acute ischemic infarction. Some calcium channel antagonists have antiplatelet effects. We investigated the effect of oral nimodipine on platelet function in healthy volunteers. METHODS:Twelve healthy volunteers (6 ...

journal_title：Stroke

authors： Feinberg WM,Bruck DC

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Neuroradiological characteristics and functional outcomes of patients with intracerebral hemorrhage (ICH) during novel oral anticoagulant treatment were not well defined. We examined these in comparison with those during warfarin treatment. METHODS:The consecutive 585 patients with ICH admitted ...

journal_title：Stroke

authors： Hagii J,Tomita H,Metoki N,Saito S,Shiroto H,Hitomi H,Kamada T,Seino S,Takahashi K,Baba Y,Sasaki S,Uchizawa T,Iwata M,Matsumoto S,Osanai T,Yasujima M,Okumura K

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The CHADS(2) score is used for risk stratification of ischemic stroke in patients with nonvalvular atrial fibrillation and high CHADS(2) scores are associated with increased risk of stroke. Most components of the CHADS(2) score are also risk factors for atherosclerosis. Therefore, high CHADS(2) s...

journal_title：Stroke

authors： Kim YD,Cha MJ,Kim J,Lee DH,Lee HS,Nam CM,Nam HS,Heo JH

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Most patients have elevated blood pressure (BP) in the early phase after an acute ischemic stroke. Mechanism and effects of this BP elevation are not well understood. The benefits of intervention by lowering the initial BP or waiting for spontaneous return to normal values remain debated. We stud...

journal_title：Stroke

authors： Yong M,Diener HC,Kaste M,Mau J

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cerebral autoregulation may be impaired in the early days after subarachnoid hemorrhage (SAH). The purpose of this study was to examine the relationship between cerebral autoregulation and angiographic vasospasm (aVSP) and radiographic delayed cerebral ischemia (DCI) in patients with SAH. METHOD...

journal_title：Stroke

authors： Otite F,Mink S,Tan CO,Puri A,Zamani AA,Mehregan A,Chou S,Orzell S,Purkayastha S,Du R,Sorond FA

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The risk of stroke and death in patients with atrial fibrillation is strongly associated with age and concomitant comorbidities. The aim of this study was to examine the age dependence of risk factors for stroke and mortality in young patients with atrial fibrillation. METHODS:This study is a po...

journal_title：Stroke

authors： Melgaard L,Rasmussen LH,Skjøth F,Lip GY,Larsen TB

更新日期：2014-05-01 00:00:00

abstract：:Background and Purpose- Intracerebral hemorrhage (ICH) has a poorer prognosis than acute ischemic stroke (AIS). However, clinician perception of prognosis may influence treatment decisions and adversely affect outcome. On acute CT, the conspicuity of ICH compared with AIS may lead clinicians to overestimate severity a...

journal_title：Stroke

authors： Tilling EJ,El Tawil S,Muir KW

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Hyperglycemia may worsen brain injury during acute cerebral infarction. We tested the feasibility and tolerability of aggressive hyperglycemia correction with intravenous insulin compared with usual care during acute cerebral infarction. METHODS:We conducted a randomized, multicenter, blinded pi...

journal_title：Stroke

authors： Bruno A,Kent TA,Coull BM,Shankar RR,Saha C,Becker KJ,Kissela BM,Williams LS

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We used a rat model of reversible spinal ischemia to assess the effect of spinal cord temperature on the development of neurological and histopathologic changes after 20 minutes of reversible aortic occlusion. Spinal cord blood flow and CO2 reactivity was tested by using laser Doppler before and ...

journal_title：Stroke

authors： Marsala M,Vanicky I,Yaksh TL

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Exogenously administered fructose-1,6-bisphosphate reduces neuronal injury from hypoxic or ischemic brain insults. To test the hypothesis that fructose-1,6-bisphosphate prevents changes in intracellular calcium ([Ca2+]i) and high-energy phosphate levels, we measured [Ca2+]i, intracellular pH (pHi...

journal_title：Stroke

authors： Bickler PE,Kelleher JA

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Mechanical thrombectomy (MT) is the recommended treatment for acute ischemic stroke caused by anterior circulation large vessel occlusion. However, despite a high rate of reperfusion, the clinical response to successful MT remains highly variable in the early time window where optimal imaging sel...

journal_title：Stroke

authors： Olivot JM,Albucher JF,Guenego A,Thalamas C,Mlynash M,Rousseau V,Drif A,Christensen S,Sommet A,Viguier A,Darcourt J,Calvière L,Menegon P,Raposo N,Januel AC,Bonneville F,Tourdias T,Mazighi M,Sibon I,Albers GW,Cognar

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:It was found that glutamate, a major neurotransmitter, is vasoactive in the cerebral circulation. However, the mechanism is unclear. This study was designed to investigate the role of nitric oxide (NO) and N-methyl-D-aspartate (NMDA) receptors in cerebral arteriolar dilation to glutamate. METHOD...

journal_title：Stroke

authors： Meng W,Tobin JR,Busija DW

更新日期：1995-05-01 00:00:00

abstract：:We studied the pattern and outcome of strokes in 200 Saudi patients. Cerebral infarction constituted 87% of strokes, subarachnoid hemorrhage 4.5%, cerebral hemorrhage 6.5%, and venous infarction 2%. The vessel most commonly involved was part or all of the middle cerebral artery, constituting 52% (90) of the 174 arteri...

journal_title：Stroke

authors： Yaqub BA,Shamena AR,Kolawole TM,Patel PJ

更新日期：1991-09-01 00:00:00

abstract：:In a postasphyxia neonatal lamb model, the responses of the cerebral circulation to hypoxic hypoxia and changes in systemic arterial blood pressure were examined. Ventilated newborn lambs (n = 14) were subjected to a gradual asphyxial insult, resuscitated, and returned to control ventilator settings. During the time 2...

journal_title：Stroke

authors： Rosenberg AA

更新日期：1988-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Interhospital transfer is a critical component in the treatment of acute anterior circulation large vessel occlusive stroke transferred for mechanical thrombectomy. Real-world data for benchmarking and theoretical modeling are limited. We sought to characterize transfer workflow from primary stro...

journal_title：Stroke

authors： Ng FC,Low E,Andrew E,Smith K,Campbell BCV,Hand PJ,Crompton DE,Wijeratne T,Dewey HM,Choi PM

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:A number of clinical syndromes describing the presentation of deep brain infarcts are called lacunar syndromes resulting from small vessel occlusion (SVO). To verify the reliability of the clinical diagnosis "lacunar syndrome," the value was investigated with diffusion-weighted MRI (DWI). METHODS AND RESULT...

journal_title：Stroke

authors： Wessels T,Röttger C,Jauss M,Kaps M,Traupe H,Stolz E

更新日期：2005-04-01 00:00:00

abstract：:Using the dexamethasone suppression test, we studied the activity of the hypothalamic-pituitary-adrenal axis within the first week after onset in 62 patients with acute ischemic stroke. Compared with two control groups (one comprising 25 elderly patients with various acute medical disorders and the other comprising 33...

journal_title：Stroke

authors： Olsson T,Aström M,Eriksson S,Forssell A

更新日期：1989-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Epidemiological data about stroke are scarce in low- and middle-income Latin-American countries. We investigated annual incidence of first-ever stroke and transient ischemic attack (TIA) and 30-day case-fatality rates in a population-based setting in Tandil, Argentina. METHODS:We prospectively i...

journal_title：Stroke

authors： Bahit MC,Coppola ML,Riccio PM,Cipriano LE,Roth GA,Lopes RD,Feigin VL,Borrego Guerrero B,De Martino M,Díaz A,Ferrante D,Funaro F,Lavados P,Lewin ML,López DH,Macarrone P,Marciello R,Marino D,Martens C,Martínez P,Odr

更新日期：2016-06-01 00:00:00