Effect of graded hypothermia (27 degrees to 34 degrees C) on behavioral function, histopathology, and spinal blood flow after spinal ischemia in rat.

abstract：:Background and Purpose- Acetylsalicylic acid and clopidogrel are the 2 main antithrombotic drugs for secondary prevention in patients with ischemic stroke (IS) without indication for anticoagulation. Because of their limited efficacy and potential side effects, novel antiplatelet agents are urgently needed. Cilostazol...

journal_title：Stroke

authors： Bieber M,Schuhmann MK,Volz J,Kumar GJ,Vaidya JR,Nieswandt B,Pham M,Stoll G,Kleinschnitz C,Kraft P

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Enhanced thromboxane (TX) biosynthesis has previously been reported in the acute phase after ischemic stroke. We investigated whether enhanced urinary excretion of 11-dehydro-TXB2, a noninvasive index of platelet activation, was present in the chronic phase after a transient ischemic attack (TIA)...

journal_title：Stroke

authors： van Kooten F,Ciabattoni G,Koudstaal PJ,Dippel DW,Patrono C

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Fruits and vegetables are known for their beneficial effects on chronic diseases. The purpose of the present study was to investigate the protective effect of a diet rich in fruits and vegetables on total stroke mortality and its 2 main subtypes in men and women separately. METHODS:A prospective...

journal_title：Stroke

authors： Sauvaget C,Nagano J,Allen N,Kodama K

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The modified Rankin Scale (mRS) is the recommended functional outcome assessment in stroke trials. Utility of mRS may be limited by interobserver variability. prestroke function, described using mRS, is often used as trial entry criterion. We assessed the reliability and validity of prestroke mRS...

journal_title：Stroke

authors： Fearon P,McArthur KS,Garrity K,Graham LJ,McGroarty G,Vincent S,Quinn TJ

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Earlier tissue-type plasminogen activator (tPA) treatment for acute ischemic stroke increases efficacy, prompting national efforts to reduce door-to-needle times. We used lean process improvement methodology to develop a streamlined intravenous tPA protocol. METHODS:In early 2011, a multidiscipl...

journal_title：Stroke

authors： Ford AL,Williams JA,Spencer M,McCammon C,Khoury N,Sampson TR,Panagos P,Lee JM

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The results of previous studies suggest that early goal-directed fluid therapy (EGDT) reduces delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage, but the effects of EGDT on clinical outcomes are still unclear. This study aimed to determine whether EGDT improves outcomes comp...

journal_title：Stroke

authors： Mutoh T,Kazumata K,Terasaka S,Taki Y,Suzuki A,Ishikawa T

更新日期：2014-05-01 00:00:00

abstract：:To determine the incidence of perioperative silent cerebral infarction, 97 patients who underwent carotid endarterectomy were prospectively studied with preoperative and postoperative computed tomograms. Thirty-one of 96 patients (32%) had findings of cerebral infarction on preoperative computed tomograms. Silent cere...

journal_title：Stroke

authors： Sise MJ,Sedwitz MM,Rowley WR,Shackford SR

更新日期：1989-03-01 00:00:00

abstract：:We evaluated the effects of aging and hypertension on endothelium-dependent relaxation of rat common carotid arteries using 14-week-old (young) and 11-month-old (old) Wistar-Kyoto rats (WKY) and age-matched spontaneously hypertensive rats (SHR). Isometric tension of common carotid artery ring segments was measured. Wi...

journal_title：Stroke

authors： Hongo K,Nakagomi T,Kassell NF,Sasaki T,Lehman M,Vollmer DG,Tsukahara T,Ogawa H,Torner J

更新日期：1988-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The role of genetics in cerebrovascular disease remains controversial. The purpose of this study was to assess the influence of family history on atherothrombotic infarction or transient ischemic attack. METHODS:Ninety patients with stroke or transient ischemic attack and 90 age- and sex-matched...

journal_title：Stroke

authors： Graffagnino C,Gasecki AP,Doig GS,Hachinski VC

更新日期：1994-08-01 00:00:00

abstract：:The relationship between central conduction time (CCT) and levels of regional blood flow were studied in 9 primates. Flows were recorded in both hemispheres using the method of hydrogen (2 min) clearance. The somatosensory evoked potentials were recorded over the contralateral cortex and the dorsal columns, following ...

journal_title：Stroke

authors： Hargadine JR,Branston NM,Symon L

更新日期：1980-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Perihematomal edema (PHE) is associated with poor outcomes after intracerebral hemorrhage (ICH). PHE evolves in the early period after ICH, providing a therapeutic target and window for intervention. We studied the effect of PHE volume expansion in the first 72 hours (iPHE) and its relationship w...

journal_title：Stroke

authors： Murthy SB,Moradiya Y,Dawson J,Lees KR,Hanley DF,Ziai WC,VISTA-ICH Collaborators.

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Epidemiological studies have shown mixed findings on the association between hypertension and stroke in the oldest old. Heterogeneity of the populations under study may underlie variation in outcomes. We examined whether the level of physical and cognitive function moderates the association betwe...

journal_title：Stroke

authors： Sabayan B,van Vliet P,de Ruijter W,Gussekloo J,de Craen AJ,Westendorp RG

更新日期：2013-01-01 00:00:00

abstract：:We examined the 21-aminosteroid U74006F, a potent inhibitor of lipid peroxidation, for potential neuroprotective effects in a canine model of complete cerebral ischemia. Two 1.5-mg/kg boluses were administered to six dogs, the first bolus 15 minutes prior to a 12-minute episode of complete cerebral ischemia and the se...

journal_title：Stroke

authors： Perkins WJ,Milde LN,Milde JH,Michenfelder JD

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We sought to determine the recovery of cortical auditory discrimination in aphasic, left-hemisphere-stroke patients by using an electrophysiological response called mismatch negativity (MMN) and speech-comprehension tests. METHODS:MMN in 8 left-hemisphere stroke patients was recorded in response...

journal_title：Stroke

authors： Ilvonen TM,Kujala T,Kiesiläinen A,Salonen O,Kozou H,Pekkonen E,Roine RO,Kaste M,Näätänen R

更新日期：2003-07-01 00:00:00

abstract：:The effect of respiration on the cerebrovascular response to elevated intracranial pressure (ICP) was studied in anesthetized dogs. Total and regional cerebral blood flows were measured using labelled microspheres. In spontaneously breathing dogs total and regional cerebral blood flows increased when cerebral perfusio...

journal_title：Stroke

authors： Malik AB,Krasney JA,Royce GJ

更新日期：1977-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Exogenously administered fructose-1,6-bisphosphate reduces neuronal injury from hypoxic or ischemic brain insults. To test the hypothesis that fructose-1,6-bisphosphate prevents changes in intracellular calcium ([Ca2+]i) and high-energy phosphate levels, we measured [Ca2+]i, intracellular pH (pHi...

journal_title：Stroke

authors： Bickler PE,Kelleher JA

更新日期：1992-11-01 00:00:00

abstract：:Endothelium dysfunction may result from increased production of reactive oxygen species and decreased availability of nitric oxide. Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (ie, statins) exert cholesterol-independent vasoprotective effects that are mediated, in part, through the inhibiti...

journal_title：Stroke

authors： Endres M,Laufs U

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The impact of asymptomatic coronary artery disease on the risk of major vascular events in patients with cerebral infarction is unknown. METHODS:Four hundred five patients with acute cerebral infarction underwent carotid, femoral artery, thoracic, and abdominal aorta ultrasound examination. Of 3...

journal_title：Stroke

authors： Amarenco P,Lavallée PC,Labreuche J,Ducrocq G,Juliard JM,Feldman L,Cabrejo L,Meseguer E,Guidoux C,Adraï V,Ratani S,Kusmierek J,Lapergue B,Klein IF,Gongora-Rivera F,Jaramillo A,Abboud H,Olivot JM,Mazighi M,Touboul PJ

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Watershed ischemia is a significant cause of stroke in severe carotid disease, but its pathophysiology is unsettled. Although hemodynamic compromise has long been regarded as the main mechanism-particularly with deep watershed infarction-there is some contradictory evidence from clinical and path...

journal_title：Stroke

authors： Moustafa RR,Izquierdo-Garcia D,Jones PS,Graves MJ,Fryer TD,Gillard JH,Warburton EA,Baron JC

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Stroke is the leading cause of disability in the Western world; however, few therapies are at hand to decrease this burden. SUMMARY OF REVIEW:Endothelial progenitor cells (EPCs) have been introduced in cardiovascular medicine as factotums. EPCs can repair damaged endothelium and attenuate the de...

journal_title：Stroke

authors： Rouhl RP,van Oostenbrugge RJ,Damoiseaux J,Tervaert JW,Lodder J

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We have developed a minimally invasive model of photothrombotic occlusion of the distal middle cerebral artery in rats and have evaluated the patterns and features of the resulting histopathologic injury in two normotensive strains. METHODS:Food-deprived male Sprague-Dawley (n = 14) and Wistar (...

journal_title：Stroke

authors： Markgraf CG,Kraydieh S,Prado R,Watson BD,Dietrich WD,Ginsberg MD

更新日期：1993-02-01 00:00:00

abstract：:A patient with diffuse and focal cerebral dysfunction was found to have absent peripheral pulses. Cerbral angiography revealed evidence of an arteritis with bilateral high grade carotid stenosis. When there was no laboratory confirmation of the arteritis, an iatrogenic etiology (ergotism) was suspected. This was later...

journal_title：Stroke

authors： Senter HJ,Lieverman AN,Pinto R

更新日期：1976-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The purpose of these experiments was to examine mechanisms by which hypercapnia produces vasodilatation in brain. We examined the hypothesis that dilatation of cerebral arterioles during hypercapnia is dependent on activation of ATP-sensitive potassium channels and formation of nitric oxide. MET...

journal_title：Stroke

authors： Faraci FM,Breese KR,Heistad DD

更新日期：1994-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Electrocardiographic abnormalities are common after subarachnoid hemorrhage, but their significance remains uncertain. The aim of this study was to determine whether any specific electrocardiographic abnormalities are independently associated with adverse neurological outcomes. METHODS:This was ...

journal_title：Stroke

authors： Coghlan LA,Hindman BJ,Bayman EO,Banki NM,Gelb AW,Todd MM,Zaroff JG,IHAST Investigators.

更新日期：2009-02-01 00:00:00

abstract：:Correlations between changes in regional, cortical, cerebral blood flow (rCBF) and histological changes in the corresponding brain regions were examined following middle cerebral arterial occlusion in 24 cats. In all animals, the duration of arterial occlusion was 2 hours followed by 2 hours of recirculation. The anim...

journal_title：Stroke

authors： Tamura A,Asano T,Sano K

更新日期：1980-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Redundant internal carotid arteries have been considered a risk factor in tonsillectomy, adenoidectomy, and surgical treatment of peritonsillar abscess and also a potentially treatable cause of stroke. However, an association between internal carotid artery redundancy and spontaneous dissection h...

journal_title：Stroke

authors： Barbour PJ,Castaldo JE,Rae-Grant AD,Gee W,Reed JF 3rd,Jenny D,Longennecker J

更新日期：1994-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We used Riks-Stroke, the Swedish Stroke Register, to explore how thrombolysis has been disseminated in Swedish hospitals since it was approved in 2003. METHODS:All 78 hospitals in Sweden admitting patients with acute stroke participate in Riks-Stroke. Between 2003 and 2008, 72 033 adult patients...

journal_title：Stroke

authors： Eriksson M,Jonsson F,Appelros P,Asberg KH,Norrving B,Stegmayr B,Terént A,Asplund K,Riks-Stroke Collaboration.

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The influence of a nocturnal blood pressure dip on stroke recurrence has not yet been clarified. In this pilot study, we attempted to establish a correlation of the nocturnal blood pressure dip with stroke recurrence and development of new silent ischemic lesions in patients with chronic ischemic...

journal_title：Stroke

authors： Nakamura K,Oita J,Yamaguchi T

更新日期：1995-08-01 00:00:00

abstract：BACKGROUND:Urinary incontinence in the acute stage of stroke is seen as a predictor of death, severe disability, and an important factor on hospital discharge destination. Therefore, it is an important measure of stroke severity that not only affects the lives of stroke survivors but also those of caregivers. SUMMARY ...

journal_title：Stroke

authors： Brittain KR,Peet SM,Castleden CM

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:There have not been any new epidemiological studies related to stroke in Tibet for 20 years. This study aimed to collect stroke data from The City Staff Medical Insurance Registry in Lhasa, Tibet, to describe the incidence, clinical subtypes, and associated risk factors of stroke. METHODS:We use...

journal_title：Stroke

authors： Zhao Y,Yao Z,D'Souza W,Zhu C,Chun H,Zhuoga C,Zhang Q,Hu X,Zhou D

更新日期：2010-12-01 00:00:00