Description of a Novel Phosphodiesterase (PDE)-3 Inhibitor Protecting Mice From Ischemic Stroke Independent From Platelet Function.

abstract：:Platelet-activating factor is a potent mediator of inflammation, which has untoward effects on cerebrovascular and neural elements. While several investigators have reported attenuation of ischemic damage after treatment with antagonists of platelet-activating factor, no study has proved endogenous production of plate...

journal_title：Stroke

authors： Lindsberg PJ,Yue TL,Frerichs KU,Hallenbeck JM,Feuerstein G

更新日期：1990-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:the association of autosomal-dominant polycystic kidney disease (ADPKD) with intracranial aneurysm (ICAN) is well known but little is known about the characteristics of ICAN in ADPKD. The purpose of this study was to investigate the prevalence and characteristics of ICAN in ADPKD. METHODS:we scr...

journal_title：Stroke

authors： Xu HW,Yu SQ,Mei CL,Li MH

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Preceding infection as an important risk factor for ischemic stroke has been reported but neglected for hemorrhagic stroke, especially in young and middle-aged patients. This study investigates whether newly diagnosed leptospirosis is associated with an increased risk of stroke. METHODS:We ident...

journal_title：Stroke

authors： Li KY,Chou MC,Wei JC,Lin MC,Hung YM,Chang R

更新日期：2021-01-26 00:00:00

abstract：:Many patients suffer a stroke early after a transient ischemic attack, but the reason why is often unclear. We studied 12 patients with less than 75% stenosis of the internal carotid artery and a single hemispheric transient ischemic attack lasting less than 1 hour who had a normal neurologic examination 3-13 hours la...

journal_title：Stroke

authors： Bogousslavsky J,Delaloye-Bischof A,Regli F,Delaloye B

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Despite its high prevalence in stroke survivors, there is little clinical research on bowel dysfunction in this population. This is the first randomized controlled trial to evaluate treatment of constipation and fecal incontinence in stroke survivors. METHODS:Stroke patients with constipation or...

journal_title：Stroke

authors： Harari D,Norton C,Lockwood L,Swift C

更新日期：2004-11-01 00:00:00

abstract：:Background and Purpose- The purpose of this study was to assess recent trends in the admission and mortality rates for subarachnoid hemorrhage in Canada. Methods- This retrospective cross-sectional study was based on data retrieved from the Canadian Institute for Health Information for all patients diagnosed with suba...

journal_title：Stroke

authors： Chan V,Lindsay P,McQuiggan J,Zagorski B,Hill MD,O'Kelly C

更新日期：2018-11-21 00:00:00

abstract：BACKGROUND AND PURPOSE:The joint effect of risk factors on the risk of aneurysmal SAH (aSAH) has been studied sparsely. METHODS:We examined the potential synergism between cigarette smoking, hypertension, and regular alcohol consumption and the risk of aSAH in a prospective, population-based cohort of participants fro...

journal_title：Stroke

authors： Lindekleiv H,Sandvei MS,Romundstad PR,Wilsgaard T,Njølstad I,Ingebrigtsen T,Vik A,Mathiesen EB

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Brain atrophy, cortical infarction, and subcortical ischemic vasculopathy have all been associated with cognitive dysfunction. The interrelationships between these pathologies and their independent contributions to cognitive function remain unclear. Despite the high frequency of Alzheimer disease...

journal_title：Stroke

authors： Swartz RH,Stuss DT,Gao F,Black SE

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Ischemic stroke patients often have intracranial atherosclerosis (ICAS), despite heterogeneity in the cause of stroke. We tested the hypothesis that ICAS burden can independently reflect the risk of long-term vascular outcome. METHODS:This was a retrospective cohort study analyzing data from a p...

journal_title：Stroke

authors： Kim BS,Chung PW,Park KY,Won HH,Bang OY,Chung CS,Lee KH,Kim GM

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:To prevent new cardiovascular events after stroke, prescribed preventive drugs should be used continuously. This study measures persistent use of preventive drugs after stroke and identifies factors associated with persistence. METHODS:A 1-year cohort (21,077 survivors) from Riks-Stroke, the Swe...

journal_title：Stroke

authors： Glader EL,Sjölander M,Eriksson M,Lundberg M

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Abnormalities of dermal connective tissue have been detected in patients with spontaneous cervical artery dissections (sCAD), suggesting an underlying structural defect of the arterial wall. Alpha1-antitrypsin (A1-AT) is a circulating serine proteinase inhibitor of proteolytic enzymes that helps ...

journal_title：Stroke

authors： Vila N,Millán M,Ferrer X,Riutort N,Escudero D

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Some strokes of unknown etiology may be the result of a paradoxical embolism traversing through a nonfused foramen ovale (patent foramen ovale [PFO]). The utility of percutaneously placed devices for treatment of patients with cryptogenic stroke or transient ischemic attack (TIA) and PFO is unkno...

journal_title：Stroke

authors： Furlan AJ,Reisman M,Massaro J,Mauri L,Adams H,Albers GW,Felberg R,Herrmann H,Kar S,Landzberg M,Raizner A,Wechsler L,CLOSURE I Investigators.

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The remaining limitations of ultrasonographic imaging in accurately quantifying internal carotid stenosis or diagnosing internal carotid occlusion may be overcome by enhancing the echogenicity of flowing arterial blood with contrast agents. This study assessed the usefulness of the intravenous (t...

journal_title：Stroke

authors： Sitzer M,Fürst G,Siebler M,Steinmetz H

更新日期：1994-02-01 00:00:00

abstract：:The influence of chronic arterial hypertension upon the permeability to albumin of the cerebral capillaries, i.e. the blood-brain barrier, was studied in normotensive Wistar and spontaneously hypertensive Wistar rats with experimental subarachnoid hemorrhage. The blood-brain barrier permeability to albumin was assesse...

journal_title：Stroke

authors： Dóczi T,Joó F,Sonkodi S,Adám G

更新日期：1986-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Thromboxane prostaglandin receptors have been implicated to be involved in the atherosclerotic process. We assessed whether Terutroban, a thromboxane prostaglandin receptor antagonist, affects the progression of atherosclerosis, as measured by common carotid intima-media thickness and carotid pla...

journal_title：Stroke

authors： Bots ML,Ford I,Lloyd SM,Laurent S,Touboul PJ,Hennerici MG,Prevention of Cerebrovascular and Cardiovascular Events of Ischemic Origin With Terutroban in Patients With a History of Ischemic Stroke or Transient Ischemic Attack Vascular Ultrasou

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The ankle-brachial index (ABI) is a fast, cheap, noninvasive indicator of atherosclerotic burden that may also be a predictor of stroke recurrence. In this systematic review and meta-analysis, we sought to explore ABI's merit as a marker for stroke recurrence and vascular risk by synthesizing the...

journal_title：Stroke

authors： Hong JB,Leonards CO,Endres M,Siegerink B,Liman TG

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited systemic microangiopathy with prevalently cerebral manifestations. Among the causes of death, sudden unexpected death seems to occur in a significant number of CADASIL patients. Be...

journal_title：Stroke

authors： Rufa A,Guideri F,Acampa M,Cevenini G,Bianchi S,De Stefano N,Stromillo ML,Federico A,Dotti MT

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The reliability of the National Institutes of Health Stroke Scale (NIHSS) has been established through testing its use in live and videotaped patients. This reliability testing has primarily focused on the use of the scale by neurologists. We sought to determine the reliability of the NIHSS as us...

journal_title：Stroke

authors： Goldstein LB,Samsa GP

更新日期：1997-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Evidence is accumulating regarding the prognostic influence of hyperglycemia in patients with acute ischemic stroke. However, the level associated with poor outcome is unknown. Our objectives were to establish the capillary glucose threshold with the highest predictive accuracy of poor outcome an...

journal_title：Stroke

authors： Fuentes B,Castillo J,San José B,Leira R,Serena J,Vivancos J,Dávalos A,Nuñez AG,Egido J,Díez-Tejedor E,Stroke Project of the Cerebrovascular Diseases Study Group, Spanish Society of Neurology.

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Victims of air embolism often recover rapidly on hyperbaric treatment then deteriorate again, even if hyperbaric treatment is continued. In previous animal experiments, lidocaine has been shown to improve recovery of somatosensory evoked response amplitude after air embolism. However, animals in ...

journal_title：Stroke

authors： Dutka AJ,Mink R,McDermott J,Clark JB,Hallenbeck JM

更新日期：1992-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Little is known about how regions vary in their use of thrombolysis (intravenous tissue-type plasminogen activator and intra-arterial treatment) for acute stroke. We sought to determine regional variation in thrombolysis treatment and investigate the extent to which regional variation is accounte...

journal_title：Stroke

authors： Skolarus LE,Meurer WJ,Shanmugasundaram K,Adelman EE,Scott PA,Burke JF

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The *2 allele of the aldehyde dehydrogenase 2 gene (ALDH2) is the most common variant in Asian populations. The variant resulting in enzyme dysfunction was highly related to coronary artery disease. Recently, genome-wide association studies also discovered that the 12q24 locus near ALDH2 gene was...

journal_title：Stroke

authors： Sung YF,Lu CC,Lee JT,Hung YJ,Hu CJ,Jeng JS,Chiou HY,Peng GS

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We have investigated the pathophysiological mechanisms of dysphagia in Wallenberg's syndrome (WS) that are due to lateral medullary infarction (LMI). METHODS:Twenty patients with WS were evaluated by means of clinical and electrophysiological methods that measured the oropharyngeal phase of volu...

journal_title：Stroke

authors： Aydogdu I,Ertekin C,Tarlaci S,Turman B,Kiylioglu N,Secil Y

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:There is little reported of the safety and efficacy of high-dose intravenous recombinant tissue plasminogen activator (alteplase) in combination with heparin anticoagulation in patients presenting with acute ischemic stroke. METHODS:Thirty-two patients with severe hemispheric stroke syndrome cau...

journal_title：Stroke

authors： von Kummer R,Hacke W

更新日期：1992-05-01 00:00:00

abstract：:Blood proteins could play a critical role in the pathogenesis of cerebral vasospasm in subarachnoid hemorrhage (SAH) as agonists and as antagonists of vasoconstriction. The present study was designed primarily to quantify the inhibition produced by antithrombin III of the phasic responses elicited by cumulative doses ...

journal_title：Stroke

authors： White RP

更新日期：1986-03-01 00:00:00

abstract：:Cerebral blood flow and clinical parameters were studied in 30 stroke patients at 15th, 30th, 60th, 90th days after the cerebral insult (Xenon 133 inhalation method). The clinical improvement was not accompanied by a progressive normalization of the CBF at rest. No relationship was found between the clinical data and ...

journal_title：Stroke

authors： Demeurisse G,Verhas M,Capon A,Paternot J

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The trends in stroke incidence reported so far have not been entirely consistent, although declining trends in mortality from stroke have been reported from a number of studies around the world. This study aims to evaluate the 10-year trends (from 1983 through 1992) in incidence, attack rate, and...

journal_title：Stroke

authors： Tuomilehto J,Rastenyte D,Sivenius J,Sarti C,Immonen-Räihä P,Kaarsalo E,Kuulasmaa K,Narva EV,Salomaa V,Salmi K,Torppa J

更新日期：1996-05-01 00:00:00

abstract：BACKGROUND:In the United States, stroke mortality is higher in the south than in other regions. Hypertension is the main risk factor for stroke among older adults; however, few studies have examined group-specific regional and urbanization differences in hypertension prevalence. METHODS:Data from the Third National He...

journal_title：Stroke

authors： Obisesan TO,Vargas CM,Gillum RF

更新日期：2000-01-01 00:00:00

abstract：:The etiology of cerebrovascular disease (CDV) in young patients is difficult to establish if the common causes of a focal neurological deficit are excluded by appropriate investigations. Since in some observations prolapse of the mitral-valve (MVP), alterations of platelet function, or both have been linked with cereb...

journal_title：Stroke

authors： Scharf RE,Hennerici M,Bluschke V,Lueck J,Kladetzky RG

更新日期：1982-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We sought to identify variables associated with intracerebral hemorrhage in patients with acute ischemic stroke who receive tissue plasminogen activator (t-PA). METHODS:We performed subgroup analyses of data from a randomized, double-blind, placebo-controlled trial of intravenous t-PA administer...

journal_title：Stroke

authors：

更新日期：1997-11-01 00:00:00