Nocturnal blood pressure dip in stroke survivors. A pilot study.


BACKGROUND AND PURPOSE:The influence of a nocturnal blood pressure dip on stroke recurrence has not yet been clarified. In this pilot study, we attempted to establish a correlation of the nocturnal blood pressure dip with stroke recurrence and development of new silent ischemic lesions in patients with chronic ischemic cerebrovascular disease. METHODS:We monitored circadian blood pressure patterns by use of a portable blood pressure monitoring device in 81 patients with chronic ischemic cerebrovascular disease and divided them into two subgroups according to levels of diurnal and nocturnal blood pressure (nocturnal blood pressure dippers and nondippers). The subgroups were prospectively followed up and compared for stroke recurrence and new silent ischemic lesions on magnetic resonance imaging. RESULTS:The average follow-up period was 27.2 +/- 11.3 months (mean +/- SD). Seventy-six patients completed the study; 43 (36 men and 7 women, aged 63.0 +/- 6.3 years) were being treated with antihypertensive agents and 33 (25 men and 8 women, aged 64.7 +/- 9.2 years) were not receiving treatment. In the treated group, recurrence was more frequent among the nocturnal dippers (5 of 18 patients, 12.5% per patient-year) than among the nondippers (1 of 25 patients, 1.5% per patient-year) (P < .05). All subjects who developed a recurrent attack during sleep had had a nocturnal blood pressure dip pattern before the attack. Furthermore, the increase in symptomatic (recurrence) and/or asymptomatic (silent) brain lesions was more frequent in the nocturnal dippers than in the nondippers (9 of 14 versus 2 of 18, P < .01). In the nontreated group, no clear difference was found between the two subgroups. CONCLUSIONS:This study indicated that the nocturnal blood pressure dip in patients treated with antihypertensive agents may accelerate the increase in ischemic brain lesions.






Nakamura K,Oita J,Yamaguchi T




Has Abstract


1995-08-01 00:00:00














  • Infrequency of blacks among patients having carotid endarterectomy.

    abstract::We reviewed demographic data on patients having 2,256 carotid endarterectomies in eight large hospitals in North Carolina to determine the frequency of blacks among these patients. Blacks comprised only 4.6% of the patients having carotid endarterectomy even though they comprised 26% of all patients discharged and 22%...


    pub_type: 杂志文章


    authors: Maxwell JG,Rutherford EJ,Covington D,Clancy TV,Tackett AD,Robinson N,Johnson G Jr

    更新日期:1989-01-01 00:00:00

  • Distribution of Chlamydia pneumoniae infection in the athersclerotic carotid artery.

    abstract:BACKGROUND AND PURPOSE:Chlamydia pneumoniae infection has recently become noteworthy in relation to atherosclerosis. We investigated by immunohistochemistry the distribution of C pneumoniae infection in the atherosclerotic carotid artery. METHODS:Twenty carotid atherosclerotic lesions that were resected during carotid...


    pub_type: 临床试验,杂志文章


    authors: Yamashita K,Ouchi K,Shirai M,Gondo T,Nakazawa T,Ito H

    更新日期:1998-04-01 00:00:00

  • An in vitro study of prolonged vasospasm of a rabbit cerebral artery.

    abstract::Longitudinal stretch of the rabbit basilar artery produces local injury followed by prolonged circular constriction. After stretching and rapid release in vitro localized constrictions promptly occurred. This could be prevented by prior treatment with cyanide or calcium-free solution. Once produced, constrictions pers...


    pub_type: 杂志文章


    authors: Duckles SP,Bevan RD,Bevan JA

    更新日期:1976-03-01 00:00:00

  • Increasing stroke incidence in Sweden between 1989 and 2000 among persons aged 30 to 65 years: evidence from the Swedish Hospital Discharge Register.

    abstract:BACKGROUND AND PURPOSE:Stroke mortality is decreasing in Sweden, as is the case in other Western European countries. However, both decreases and increases have been reported in Sweden for persons younger than age 65 years. The aim of this study was to compare the incidence of stroke in Sweden between the periods 1989 a...


    pub_type: 杂志文章


    authors: Medin J,Nordlund A,Ekberg K,Swedish Hospital Discharge Register.

    更新日期:2004-05-01 00:00:00

  • Effects of global cerebral ischemia in the pregnant rat.

    abstract:BACKGROUND AND PURPOSE:Stroke during pregnancy is an emerging concern. Although females undergo many physiological, endocrine, and neurological alterations during pregnancy, the consequences of such changes on outcome after stroke are unclear. It is predicted that increases in steroid hormones observed during pregnancy...


    pub_type: 杂志文章


    authors: Spencer SJ,Galic MA,Tsutsui M,Pittman QJ,Mouihate A

    更新日期:2008-03-01 00:00:00

  • Daily functioning and quality of life in a randomized controlled trial of therapeutic exercise for subacute stroke survivors.

    abstract:BACKGROUND AND PURPOSE:The ability of therapeutic exercise after stroke to improve daily functioning and quality of life (QOL) remains controversial. We examined treatment effects on these outcomes in a randomized controlled trial (RCT) of exercise in subacute stroke survivors. METHODS:This is a secondary analysis of ...


    pub_type: 杂志文章,随机对照试验


    authors: Studenski S,Duncan PW,Perera S,Reker D,Lai SM,Richards L

    更新日期:2005-08-01 00:00:00

  • Prestroke Disability Predicts Adverse Poststroke Outcome: A Registry-Based Prospective Cohort Study of Acute Stroke.

    abstract::Background and Purpose- Information on what effect disability before stroke can have on stroke outcome is lacking. We assessed prestroke disability in relation to poststroke hospital outcome. Methods- Analysis of prospectively collected data from the Sentinel Stroke National Audit Programme. A total of 1656 men (mean ...


    pub_type: 杂志文章


    authors: Han TS,Fry CH,Gulli G,Affley B,Robin J,Irvin-Sellers M,Fluck D,Kakar P,Sharma S,Sharma P

    更新日期:2020-02-01 00:00:00

  • Positive platelet scintigram of a vertebral aneurysm presenting thromboembolic transient ischemic attacks.

    abstract::We describe a patient with transient ischemic attacks secondary to a giant aneurysm who showed increased activity on platelet scintigrams at the origin of the left vertebral artery. This is assumed to be the first report of a presumed embolizing aneurysm with positive activity of labeled platelets. Platelet scintigrap...


    pub_type: 杂志文章


    authors: Maruyama M,Asai T,Kuriyama Y,Sawada T,Ogata J,Nishimura T,Omae T

    更新日期:1989-05-01 00:00:00

  • Problems and benefits reported by stroke family caregivers: results from a prospective epidemiological study.

    abstract:BACKGROUND AND PURPOSE:Stroke symptoms can be very stressful for family caregivers, but most knowledge about the prevalence and stressfulness of stroke-related patient problems is derived from convenience samples. In addition, little is known about perceived benefits of the stroke caregiving experience. The purpose of ...


    pub_type: 杂志文章


    authors: Haley WE,Allen JY,Grant JS,Clay OJ,Perkins M,Roth DL

    更新日期:2009-06-01 00:00:00

  • Bexarotene Enhances Macrophage Erythrophagocytosis and Hematoma Clearance in Experimental Intracerebral Hemorrhage.

    abstract::Background and Purpose- Enhancement of erythrophagocytosis by macrophages in a timely manner can limit the toxic effects of erythrocyte metabolites and promote brain recovery after intracerebral hemorrhage (ICH). In the current study, we investigated the therapeutic effect of retinoid X receptor agonist, bexarotene, i...


    pub_type: 杂志文章


    authors: Chang CF,Massey J,Osherov A,Angenendt da Costa LH,Sansing LH

    更新日期:2020-02-01 00:00:00

  • Differential changes in alpha- and beta-adrenoceptors in the cerebral cortex and hippocampus of the Mongolian gerbil after unilateral brain ischemia.

    abstract:BACKGROUND AND PURPOSE:Changes in adrenoceptors in the cerebral cortex and hippocampus of Mongolian gerbils after brain ischemia were investigated. METHODS:Twenty-four hours after unilateral occlusion of the common carotid artery, alpha 1-, alpha 2-, and beta-receptors of the membrane fraction of the cerebral cortex o...


    pub_type: 杂志文章


    authors: Mizuki T,Kobayashi H,Ueno S,Nakashima Y,Kuroiwa A,Izumi F

    更新日期:1995-12-01 00:00:00

  • Angiographic reconstructions from whole-brain perfusion CT for the detection of large vessel occlusion in acute stroke.

    abstract:BACKGROUND AND PURPOSE:Multimodal CT imaging consisting of nonenhanced CT, CT angiography (CTA), and whole-brain volume perfusion CT is increasingly used for acute stroke imaging. In these patients, presence of vessel occlusion is an important factor governing treatment decisions and possible endovascular therapy. The ...


    pub_type: 杂志文章


    authors: Frölich AM,Psychogios MN,Klotz E,Schramm R,Knauth M,Schramm P

    更新日期:2012-01-01 00:00:00

  • Detection of mitral valve abnormalities by carotid Doppler flow study: implications for the management of patients with cerebrovascular disease.

    abstract::Patients with symptoms of cerebral ischemia are often evaluated with non-invasive carotid artery testing. An abnormal carotid Doppler ultrasound frequency shift pattern of early systolic flutter (ESF) was demonstrated by auscultation and velocity wave form analysis in patients with normal carotid bifurcations. Ten of ...


    pub_type: 杂志文章


    authors: Weinberger J,Goldman M

    更新日期:1985-11-01 00:00:00

  • Results in 95 hemorrhagic stroke patients included in CLASS, a controlled trial of clomethiazole versus placebo in acute stroke patients.

    abstract:BACKGROUND AND PURPOSE:Clomethiazole is a neuroprotective drug that enhances gamma-aminobutyrate type A (GABA(A)) receptor activity. Its efficacy and safety were tested in the CLomethiazole Acute Stroke Study (CLASS). The protocol allowed a CT scan to be done after randomization but within 7 days of stroke onset to min...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Wahlgren NG,Díez-Tejedor E,Teitelbaum J,Arboix A,Leys D,Ashwood T,Grossman E

    更新日期:2000-01-01 00:00:00

  • Importance of intracranial atherosclerotic disease in patients with symptomatic stenosis of the internal carotid artery. The North American Symptomatic Carotid Endarterectomy Trail.

    abstract:BACKGROUND AND PURPOSE:The estimated prevalence of intracranial atherosclerotic disease (IAD) in patients with stenosis of the extracranial internal carotid artery (ICA) varies between 20% and 50%. The benefits of carotid endarterectomy (CE) in patients with both IAD and symptomatic extracranial ICA stenosis are uncert...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Kappelle LJ,Eliasziw M,Fox AJ,Sharpe BL,Barnett HJ

    更新日期:1999-02-01 00:00:00

  • Venous sinus thrombosis associated with androgens in a healthy young man.

    abstract:BACKGROUND:Cerebral venous sinus thrombosis is rare and can be promoted by various conditions. We report the case of cerebral venous thrombosis in a patient using androgens. CASE DESCRIPTION:A 31-year-old man using androgens for bodybuilding was admitted for headache and vomiting. He had cerebral venous sinus thrombos...


    pub_type: 杂志文章


    authors: Jaillard AS,Hommel M,Mallaret M

    更新日期:1994-01-01 00:00:00

  • One-year outcome after cerebral infarction in whites, blacks, and Hispanics.

    abstract::Little is known about outcome after cerebral infarction for different ethnic groups. Of 590 stroke patients hospitalized from 1983 to 1986 at the Neurological Institute, cerebral infarction over age 39 years occurred in 135 whites, 177 blacks, and 82 Hispanics. Outcome after cerebral infarction differed by ethnicity. ...


    pub_type: 杂志文章


    authors: Sacco RL,Hauser WA,Mohr JP,Foulkes MA

    更新日期:1991-03-01 00:00:00

  • Younger Age and Depressive Symptoms Predict High Risk of Generalized Anxiety After Stroke and Transient Ischemic Attack.

    abstract::Background and Purpose- Depression and anxiety are common after stroke/transient ischemic attack (TIA). These conditions are associated with poor functional outcome and worse quality of life. However, few studies have explored predictors of poststroke risk of generalized anxiety, especially in patients without comorbi...


    pub_type: 杂志文章


    authors: Kapoor A,Si K,Yu AYX,Lanctot KL,Herrmann N,Murray BJ,Swartz RH

    更新日期:2019-09-01 00:00:00

  • Distinct Short-Term Outcomes in Patients With Mild Versus Rapidly Improving Stroke Not Treated With Thrombolytics.

    abstract:BACKGROUND AND PURPOSE:Mild stroke (MS) and rapidly improving stroke (RIS) symptoms are common stroke presentations. Our objective is to describe the short-term outcomes in this population. METHODS:A retrospective analysis of patients with ischemic stroke in the Get With The Guidelines-Stroke registry who arrived ≤4.5...


    pub_type: 杂志文章


    authors: Romano JG,Smith EE,Liang L,Gardener H,Campo-Bustillo I,Khatri P,Bhatt DL,Fonarow GC,Sacco RL,Schwamm LH

    更新日期:2016-05-01 00:00:00

  • Autonomic Dysfunction Predicts Clinical Outcomes After Acute Ischemic Stroke: A Prospective Observational Study.

    abstract:BACKGROUND AND PURPOSE:Central autonomic dysfunction increases stroke morbidity and mortality. We aimed to investigate whether poststroke autonomic dysfunction graded by Ewing battery can predict clinical outcome. METHODS:In this prospective observational study, we assessed autonomic function of ischemic stroke patien...


    pub_type: 临床试验,杂志文章


    authors: Xiong L,Tian G,Leung H,Soo YOY,Chen X,Ip VHL,Mok VCT,Chu WCW,Wong KS,Leung TWH

    更新日期:2018-01-01 00:00:00

  • Nosocomial pneumonia after acute stroke: implications for neurological intensive care medicine.

    abstract:BACKGROUND AND PURPOSE:Pneumonia has been estimated to occur in about one third of patients after acute stroke. Only limited data are available on stroke-associated pneumonia (SAP) in specialized neurological intensive care units (NICUs). METHODS:We enrolled 124 patients with acute stroke who were treated at our unive...


    pub_type: 杂志文章


    authors: Hilker R,Poetter C,Findeisen N,Sobesky J,Jacobs A,Neveling M,Heiss WD

    更新日期:2003-04-01 00:00:00

  • Detection of arterial emboli using Doppler ultrasound in rabbits.

    abstract::The purpose of this study was to develop an animal model that could be used to test the ability of Doppler ultrasound to detect arterial emboli composed of materials that are often involved in cerebral emboli. Emboli introduced into the rabbit aorta via the left renal artery consisted of clotted whole blood, platelets...


    pub_type: 杂志文章


    authors: Russell D,Madden KP,Clark WM,Sandset PM,Zivin JA

    更新日期:1991-02-01 00:00:00

  • Shunt-associated migraine responds favorably to atrial septal repair: a case-control study.

    abstract:BACKGROUND AND PURPOSE:Transcatheter closure of patent foramen ovale (PFO) has been reported to improve migraine in patients with cerebrovascular disorders in noncontrolled studies. The aim of the study was to compare the course of migraine assessed prospectively over a 12-month period in symptomatic (for cerebrovascul...


    pub_type: 杂志文章


    authors: Anzola GP,Frisoni GB,Morandi E,Casilli F,Onorato E

    更新日期:2006-02-01 00:00:00

  • Relationship between white-matter hyperintensities and hematoma volume and growth in patients with intracerebral hemorrhage.

    abstract:BACKGROUND AND PURPOSE:The presence of white-matter hyperintensities (WMHs) has been linked to intracerebral hemorrhage (ICH). We sought to determine whether the severity of WMHs influences hematoma growth and ICH volume. METHODS:We retrospectively reviewed prospectively collected clinical, laboratory, and radiologic ...


    pub_type: 杂志文章


    authors: Lou M,Al-Hazzani A,Goddeau RP Jr,Novak V,Selim M

    更新日期:2010-01-01 00:00:00

  • 4G/4G genotype of PAI-1 gene is associated with reduced risk of stroke in elderly.

    abstract:BACKGROUND AND PURPOSE:Plasminogen activator inhibitor type 1 (PAI-1) is the main inhibitor of fibrinolysis, and high levels may increase the risk of cardiovascular disease. The 4G/5G polymorphism affects PAI-1 gene transcription with lower levels of plasma PAI-1 in the presence of the 5G allele. We investigated whethe...


    pub_type: 杂志文章


    authors: Hoekstra T,Geleijnse JM,Kluft C,Giltay EJ,Kok FJ,Schouten EG

    更新日期:2003-12-01 00:00:00

  • Common carotid artery intima-media thickness progression as a predictor of stroke in multi-ethnic study of atherosclerosis.

    abstract:BACKGROUND AND PURPOSE:Carotid artery intima-media thickness (IMT) is a marker of cardiovascular disease associated with incident stroke. We studied whether IMT rate of change is associated with stroke. METHODS:We studied 5028 participants of the Multi-Ethnic Study of Atherosclerosis (MESA) comprising white, Chinese, ...


    pub_type: 杂志文章


    authors: Polak JF,Pencina MJ,O'Leary DH,D'Agostino RB

    更新日期:2011-11-01 00:00:00

  • Acute stroke teams: results of a national survey. National Acute Stroke Team Group.

    abstract:BACKGROUND AND PURPOSE:The sensitivity of the brain to brief periods of profound ischemia or prolonged periods of modest ischemia mandates an aggressive approach to acute stroke care. Past studies have shown that many stroke patients do not receive acute care in an urgent and timely fashion. The formation of acute stro...


    pub_type: 杂志文章


    authors: Alberts MJ,Chaturvedi S,Graham G,Hughes RL,Jamieson DG,Krakowski F,Raps E,Scott P

    更新日期:1998-11-01 00:00:00

  • Role of the interleukin-6 -174 G>C gene polymorphism in retinal artery occlusion.

    abstract:BACKGROUND AND PURPOSE:Proinflammatory cytokines including interleukin-6 (IL-6) are supposed to play a pivotal role in the development of atherosclerosis. A common polymorphism in the promoter of the IL-6 gene (IL-6 -174G>C) affects plasma IL-6 concentrations and has been suggested as a risk factor for cardiovascular d...


    pub_type: 杂志文章


    authors: Weger M,Steinbrugger I,Haas A,März W,El-Shabrawi Y,Weger W,Schmut O,Renner W

    更新日期:2005-02-01 00:00:00

  • Safety of thrombolysis in stroke mimics: results from a multicenter cohort study.

    abstract:BACKGROUND AND PURPOSE:Intravenous thrombolysis for acute ischemic stroke is beneficial within 4.5 hours of symptom onset, but the effect rapidly decreases over time, necessitating quick diagnostic in-hospital work-up. Initial time strain occasionally results in treatment of patients with an alternate diagnosis (stroke...


    pub_type: 杂志文章,多中心研究


    authors: Zinkstok SM,Engelter ST,Gensicke H,Lyrer PA,Ringleb PA,Artto V,Putaala J,Haapaniemi E,Tatlisumak T,Chen Y,Leys D,Sarikaya H,Michel P,Odier C,Berrouschot J,Arnold M,Heldner MR,Zini A,Fioravanti V,Padjen V,Beslac-Bu

    更新日期:2013-04-01 00:00:00

  • The California, ABCD, and unified ABCD2 risk scores and the presence of acute ischemic lesions on diffusion-weighted imaging in TIA patients.

    abstract:BACKGROUND AND PURPOSE:Some clinical models, like California ABCD and unified ABCD2 scores, are now available to predict the early risk of stroke after a TIA. Despite the transitivity of symptoms, DWI identified an area of acute brain ischemia in almost half of patients. It would be interesting to know how the presence...


    pub_type: 信件


    authors: Purroy F,Begué R,Quílez A,Piñol-Ripoll G,Sanahuja J,Brieva L,Setó E,Gil MI

    更新日期:2009-06-01 00:00:00