Multiple Soluble Components of the Glycocalyx Are Increased in Patient Plasma After Ischemic Stroke.

Abstract:

:Background and Purpose- The GLX (glycocalyx) is a protein/polysaccharide meshwork at the cellular surface. Consisting largely of glycosaminoglycans and proteoglycans, the GLX can shed in response to stress. In this study, we assay 11 components of the GLX in plasma from patients with ischemic stroke from a longitudinal cohort. Methods- Plasma samples from healthy individuals (N=8), and patients with ischemic stroke day ≥3, day 7, and day 90 (N=9-14) were immunoassayed for diverse components of the GLX. Results- Median stroke severity was mild (National Institutes of Health Stroke Scale 2.0 (range, 0-6) at day ≤3). Three (keratan-chondroitin-heparan-sulfate) of 4 glycosaminoglycans and CD44 (proteoglycan) were increased at day 7 and returned to baseline at day 90. Proteoglycan syndecan (Syn)-3 increased and Syn-2 levels decreased, significantly. Conclusions- Individual GLX components are often assayed as stand-alone biomarkers for endothelial health. This study suggests a full assessment of GLX components is more indicative of the endothelial health of an individual and represents a complex GLX signature that may be valuable as a composite biomarker of disease.

journal_name

Stroke

journal_title

Stroke

authors

DellaValle B,Hasseldam H,Johansen FF,Iversen HK,Rungby J,Hempel C

doi

10.1161/STROKEAHA.119.025953

subject

Has Abstract

pub_date

2019-10-01 00:00:00

pages

2948-2951

issue

10

eissn

0039-2499

issn

1524-4628

journal_volume

50

pub_type

杂志文章

相关文献

STROKE文献大全
  • Positive scans in angiographically proved cases of recanalized cerebral infarction.

    abstract::In 20 patients with acute major cerebral arterial occlusion, follow-up angiograms were obtained to inspect the occluded artery. These angiograms were compared with brain scans in the fourth week after the stroke. The angiograms revealed that frequent recanalization of the occluded arteries occurred within a week after...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.6.2.132

    authors: Irino T,Taneda M,Minami T

    更新日期:1975-03-01 00:00:00

  • Blend Sign on Computed Tomography: Novel and Reliable Predictor for Early Hematoma Growth in Patients With Intracerebral Hemorrhage.

    abstract:BACKGROUND AND PURPOSE:Early hematoma growth is not uncommon in patients with intracerebral hemorrhage and is an independent predictor of poor functional outcome. The purpose of our study was to report and validate the use of our newly identified computed tomographic (CT) blend sign in predicting early hematoma growth....

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.115.009185

    authors: Li Q,Zhang G,Huang YJ,Dong MX,Lv FJ,Wei X,Chen JJ,Zhang LJ,Qin XY,Xie P

    更新日期:2015-08-01 00:00:00

  • An in vitro study of prolonged vasospasm of a rabbit cerebral artery.

    abstract::Longitudinal stretch of the rabbit basilar artery produces local injury followed by prolonged circular constriction. After stretching and rapid release in vitro localized constrictions promptly occurred. This could be prevented by prior treatment with cyanide or calcium-free solution. Once produced, constrictions pers...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.7.2.174

    authors: Duckles SP,Bevan RD,Bevan JA

    更新日期:1976-03-01 00:00:00

  • Alberta Stroke Program Early CT Scale evaluation of multimodal computed tomography in predicting clinical outcomes of stroke patients treated with aspiration thrombectomy.

    abstract:BACKGROUND AND PURPOSE:Patient selection is crucial in the endovascular treatment of acute ischemic stroke patients. Baseline computed tomographic (CT) images, evaluated with the Alberta Stroke Program Early CT Scale (ASPECTS), are considered significant predictors of outcome. In this study, we evaluated CT images and ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.113.001068

    authors: Psychogios MN,Schramm P,Frölich AM,Kallenberg K,Wasser K,Reinhardt L,Kreusch AS,Jung K,Knauth M

    更新日期:2013-08-01 00:00:00

  • Impact of admission hyperglycemia on stroke outcome after thrombolysis: risk stratification in relation to time to reperfusion.

    abstract:BACKGROUND AND PURPOSE:We evaluated the impact of admission hyperglycemia (HG) on stroke outcome in relation to the timing of reperfusion in patients treated with tissue plasminogen activator (tPA). METHODS:We studied 138 consecutive stroke patients with a documented middle cerebral artery (MCA) occlusion treated with...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000143728.45516.c6

    authors: Alvarez-Sabín J,Molina CA,Ribó M,Arenillas JF,Montaner J,Huertas R,Santamarina E,Rubiera M

    更新日期:2004-11-01 00:00:00

  • Early diagnosis of cerebral fat embolism syndrome by diffusion-weighted MRI (starfield pattern).

    abstract:BACKGROUND:Cerebral fat embolism syndrome is a rare, but potentially lethal, complication of long bone fractures. Neurological symptoms are variable, and the clinical diagnosis is difficult. The purpose of this case study is to demonstrate the value of diffusion-weighted MRI of the brain for early diagnosis of fat embo...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:

    authors: Parizel PM,Demey HE,Veeckmans G,Verstreken F,Cras P,Jorens PG,De Schepper AM

    更新日期:2001-12-01 00:00:00

  • Predictors of Early Neurologic Deterioration in Acute Pontine Infarction.

    abstract::Background and Purpose- The relationship between infarct dimensions and neurological progression in patients with acute pontine infarctions remains unclear. This study aimed to investigate the morphometric predictive value of magnetic resonance imaging for early neurological deterioration (END) in acute pontine infarc...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.119.027239

    authors: Li H,Dai Y,Wu H,Luo L,Wei L,Zhou L,Lin Y,Wang Q,Lu Z

    更新日期:2020-02-01 00:00:00

  • Effects of a selective CD11b/CD18 antagonist and recombinant human tissue plasminogen activator treatment alone and in combination in a rat embolic model of stroke.

    abstract:BACKGROUND AND PURPOSE:We evaluated the neuroprotective effect of UK-279,276 (also referred to as recombinant neutrophil inhibitory factor), a selective CD11b/CD18 antagonist, in combination with thrombolytic therapy on focal cerebral ischemia. METHODS:Male Wistar rats (n=88) were subjected to embolic middle cerebral ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000077016.55891.2E

    authors: Zhang L,Zhang ZG,Zhang RL,Lu M,Krams M,Chopp M

    更新日期:2003-07-01 00:00:00

  • Retreatment of ruptured cerebral aneurysms in patients randomized by coiling or clipping in the International Subarachnoid Aneurysm Trial (ISAT).

    abstract:BACKGROUND AND PURPOSE:Because the long-term security of endovascular treatments remains uncertain, a follow-up study of the patients treated in the International Subarachnoid Aneurysm Trial was performed to compare the frequency, timing, and consequences of aneurysm recurrence. METHODS:Patient data were reclassified ...

    journal_title:Stroke

    pub_type: 杂志文章,随机对照试验

    doi:10.1161/STROKEAHA.106.466987

    authors: Campi A,Ramzi N,Molyneux AJ,Summers PE,Kerr RS,Sneade M,Yarnold JA,Rischmiller J,Byrne JV

    更新日期:2007-05-01 00:00:00

  • Outcome of patients with negative CT angiography results for arterial occlusion treated with intravenous thrombolysis.

    abstract:BACKGROUND AND PURPOSE:Stroke patients without evidence of arterial occlusion may not be suitable candidates for thrombolytic therapy. In our study, we investigated the outcomes of patients with negative CT angiography results for arterial occlusion. METHODS:The study included patients treated within 3 hours after sym...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.108.532572

    authors: Mikulik R,Goldemund D,Reif M,Aulicky P,Krupa P

    更新日期:2009-03-01 00:00:00

  • Sonographic monitoring of midline shift in space-occupying stroke: an early outcome predictor.

    abstract:BACKGROUND AND PURPOSE:Transcranial color-coded duplex sonography (TCCS) allows bedside imaging of intracranial hemodynamics and parenchymal structures. It provides reliable information regarding midline shift (MLS) in space-occupying hemispheric stroke. We studied the value of MLS measurement to predict fatal outcome ...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章

    doi:10.1161/01.str.32.2.442

    authors: Gerriets T,Stolz E,König S,Babacan S,Fiss I,Jauss M,Kaps M

    更新日期:2001-02-01 00:00:00

  • Embolic stroke after smoking "crack" cocaine.

    abstract::A 39-year-old woman had an embolic upper division middle cerebral artery branch occlusion 3 hours after smoking the free base of cocaine ("crack"). Radionuclide ventriculography demonstrated cardiomyopathy, and echocardiography documented a left atrial thrombus. This case demonstrates that embolism is one mechanism of...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.21.11.1632

    authors: Petty GW,Brust JC,Tatemichi TK,Barr ML

    更新日期:1990-11-01 00:00:00

  • Measurement variability in duplex scan assessment of carotid atherosclerosis.

    abstract:BACKGROUND AND PURPOSE:The reproducibility of duplex scan measures of carotid atherosclerosis was evaluated as part of a study assessing the prevalence of carotid disease in elderly adults. METHODS:Doppler measures of blood flow velocity were used to evaluate disease severity, and extent of carotid plaque was scored f...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.23.2.215

    authors: Sutton-Tyrrell K,Wolfson SK Jr,Thompson T,Kelsey SF

    更新日期:1992-02-01 00:00:00

  • Siblings with ischemic stroke study: results of a genome-wide scan for stroke loci.

    abstract:BACKGROUND AND PURPOSE:Ischemic stroke has a strong familial component to risk. The Siblings With Ischemic Stroke Study (SWISS) is a genome-wide, family-based analysis that included use of imputed genotypes. The Siblings With Ischemic Stroke Study was conducted to examine the associations between single-nucleotide poly...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.111.620484

    authors: Meschia JF,Nalls M,Matarin M,Brott TG,Brown RD Jr,Hardy J,Kissela B,Rich SS,Singleton A,Hernandez D,Ferrucci L,Pearce K,Keller M,Worrall BB,Siblings With Ischemic Stroke Study Investigators.

    更新日期:2011-10-01 00:00:00

  • Changes in locomotor activity and passive avoidance task performance induced by cerebral ischemia in Mongolian gerbils.

    abstract:BACKGROUND AND PURPOSE:We investigated changes in locomotor activity, passive avoidance task performance, and hippocampal CA1 neurons induced by cerebral ischemia in Mongolian gerbils to examine the relation between these behavioral changes and CA1 neuronal damage. METHODS:Spontaneous locomotor activity was measured u...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.25.3.645

    authors: Karasawa Y,Araki H,Otomo S

    更新日期:1994-03-01 00:00:00

  • Hypoglycemia presenting as basilar artery thrombosis.

    abstract:BACKGROUND AND PURPOSE:Following our treatment of a patient with hypoglycemia-induced brain stem symptoms, we examined the possible mechanisms for hypoglycemia presenting as basilar artery disease. CASE DESCRIPTION:We describe a patient who had progressive brain stem symptoms due to a diet-induced hypoglycemia initial...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.23.1.112

    authors: Röther J,Schreiner A,Wentz KU,Hennerici M

    更新日期:1992-01-01 00:00:00

  • Cardiac autonomic nervous system and risk of arrhythmias in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).

    abstract:BACKGROUND AND PURPOSE:Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited systemic microangiopathy with prevalently cerebral manifestations. Among the causes of death, sudden unexpected death seems to occur in a significant number of CADASIL patients. Be...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000254530.38417.07

    authors: Rufa A,Guideri F,Acampa M,Cevenini G,Bianchi S,De Stefano N,Stromillo ML,Federico A,Dotti MT

    更新日期:2007-02-01 00:00:00

  • Vasodilator proteins: role in delayed cerebral vasospasm.

    abstract::Blood proteins could play a critical role in the pathogenesis of cerebral vasospasm in subarachnoid hemorrhage (SAH) as agonists and as antagonists of vasoconstriction. The present study was designed primarily to quantify the inhibition produced by antithrombin III of the phasic responses elicited by cumulative doses ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.17.2.207

    authors: White RP

    更新日期:1986-03-01 00:00:00

  • Relation between serum albumin and carotid atherosclerosis: the NHLBI Family Heart Study.

    abstract:BACKGROUND AND PURPOSE:Lower concentrations of albumin have been positively related to coronary disease. The aim of this project was to assess the association between serum albumin and carotid atherosclerosis. METHODS:B-mode ultrasound was used to assess carotid plaques and intima-media thickness (IMT) among white sub...

    journal_title:Stroke

    pub_type: 杂志文章,多中心研究

    doi:10.1161/01.str.0000048675.97975.84

    authors: Djoussé L,Rothman KJ,Cupples LA,Arnett DK,Ellison RC,NHLBI Family Heart Study.

    更新日期:2003-01-01 00:00:00

  • Prestroke modified rankin stroke scale has moderate interobserver reliability and validity in an acute stroke setting.

    abstract:BACKGROUND AND PURPOSE:The modified Rankin Scale (mRS) is the recommended functional outcome assessment in stroke trials. Utility of mRS may be limited by interobserver variability. prestroke function, described using mRS, is often used as trial entry criterion. We assessed the reliability and validity of prestroke mRS...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.112.670422

    authors: Fearon P,McArthur KS,Garrity K,Graham LJ,McGroarty G,Vincent S,Quinn TJ

    更新日期:2012-12-01 00:00:00

  • Cerebrovascular CO2 reactivity: role of a cholinergic mechanism modulated by anesthesia.

    abstract::Cerebral cortical blood flow was measured in rabbits with the hydrogen clearance technique. The reactivity to CO2, tested by changing the end tidal CO2 (ETCO2) in steps from 2 to 6 volumes %, was highly dependent on the kind of anesthesia, being greatest under halothane and least under nitrous oxide. Reactivity to CO2...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.9.2.160

    authors: Scremin OU,Rubinstein EH,Sonnenschein RR

    更新日期:1978-03-01 00:00:00

  • Anticoagulant therapy in cerebrovascular disease: review and meta-analysis.

    abstract::Sixteen acceptably randomized studies of anticoagulant therapy after cerebral or retinal ischemia or infarction are reviewed and the results among 1,046 anticoagulated patients and 1,071 controls are analyzed. The following conclusions are derived. 1) Anticoagulant therapy has not been shown to be better than control ...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章,评审

    doi:10.1161/01.str.19.8.1043

    authors: Jonas S

    更新日期:1988-08-01 00:00:00

  • MRI identification of white matter reorganization enhanced by erythropoietin treatment in a rat model of focal ischemia.

    abstract:BACKGROUND AND PURPOSE:The objectives of the present study were to: (1) noninvasively identify white matter reorganization and monitor its progress within 6 weeks after the onset of stroke; and (2) quantitatively investigate the effect of recombinant human erythropoietin treatment on this structural change using in viv...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.108.527713

    authors: Li L,Jiang Q,Ding G,Zhang L,Zhang ZG,Li Q,Panda S,Kapke A,Lu M,Ewing JR,Chopp M

    更新日期:2009-03-01 00:00:00

  • Diabetes mellitus: a risk factor for ischemic stroke in a large biracial population.

    abstract:BACKGROUND AND PURPOSE:We previously reported increased incidence of ischemic stroke among both blacks and whites with diabetes mellitus, especially in those aged <55 years. With rising prevalence of diabetes mellitus in the past decade, we revisit the impact of diabetes mellitus on stroke incidence in the same populat...

    journal_title:Stroke

    pub_type: 杂志文章,多中心研究

    doi:10.1161/STROKEAHA.113.001318

    authors: Khoury JC,Kleindorfer D,Alwell K,Moomaw CJ,Woo D,Adeoye O,Flaherty ML,Khatri P,Ferioli S,Broderick JP,Kissela BM

    更新日期:2013-06-01 00:00:00

  • Mechanical Thrombectomy in Perioperative Strokes: A Case-Control Study.

    abstract:BACKGROUND AND PURPOSE:Perioperative strokes (POS) are rare but serious complications for which mechanical thrombectomy could be beneficial. We aimed to compare the technical results and patients outcomes in a population of POS versus non-POS (nPOS) treated by mechanical thrombectomy. METHODS:From 2010 to 2017, 25 pat...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.117.018033

    authors: Premat K,Clovet O,Frasca Polara G,Shotar E,Bartolini B,Yger M,Di Maria F,Baronnet F,Pistocchi S,Le Bouc R,Pires C,Sourour N,Alamowitch S,Samson Y,Degos V,Clarençon F

    更新日期:2017-11-01 00:00:00

  • Prospective analysis of carotid endarterectomy and silent cerebral infarction in 97 patients.

    abstract::To determine the incidence of perioperative silent cerebral infarction, 97 patients who underwent carotid endarterectomy were prospectively studied with preoperative and postoperative computed tomograms. Thirty-one of 96 patients (32%) had findings of cerebral infarction on preoperative computed tomograms. Silent cere...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.20.3.329

    authors: Sise MJ,Sedwitz MM,Rowley WR,Shackford SR

    更新日期:1989-03-01 00:00:00

  • Decreased glomerular filtration rate is a risk factor for hemorrhagic but not for ischemic stroke: the Rotterdam Study.

    abstract:BACKGROUND AND PURPOSE:Persons with early stages of chronic kidney disease, defined by a decreased glomerular filtration rate (GFR), have an increased risk of cardiovascular disease. It is unclear whether decreased GFR is a risk factor for stroke. We assessed the association between GFR and stroke in a prospective popu...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.107.489807

    authors: Bos MJ,Koudstaal PJ,Hofman A,Breteler MM

    更新日期:2007-12-01 00:00:00

  • Depression and antidepressant use after stroke and transient ischemic attack.

    abstract:BACKGROUND AND PURPOSE:Patients with stroke and transient ischemic attack (TIA) often have comparable comorbidities, but it is unclear whether they have similar rates of depression or antidepressant use. METHODS:This study was a secondary analysis of a prospective cohort registry that enrolled subjects from 2006 to 20...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1161/STROKEAHA.111.643130

    authors: El Husseini N,Goldstein LB,Peterson ED,Zhao X,Pan W,Olson DM,Zimmer LO,Williams JW Jr,Bushnell C,Laskowitz DT

    更新日期:2012-06-01 00:00:00

  • Photothrombotic middle cerebral artery occlusion and reperfusion laser system in spontaneously hypertensive rats.

    abstract:BACKGROUND AND PURPOSE:To establish a less invasive and reproducible focal ischemia model in the rat, we adopted a 2-laser system (ie, photothrombosis and YAG laser-induced reperfusion). METHODS:The distal middle cerebral artery (MCA) of spontaneously hypertensive rats was occluded by 568-nm krypton laser and intraven...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000094730.38343.73

    authors: Yao H,Sugimori H,Fukuda K,Takada J,Ooboshi H,Kitazono T,Ibayashi S,Iida M

    更新日期:2003-11-01 00:00:00

  • Effects of race and poverty on the process and outcome of inpatient rehabilitation services among stroke patients.

    abstract:BACKGROUND AND PURPOSE:The greater mortality and residual physical impairments among black stroke patients may be attributable to differential utilization of rehabilitation services. This report examines, within an equal-access healthcare system, racial differences in time to initiation of stroke rehabilitation service...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000060028.60365.5D

    authors: Horner RD,Swanson JW,Bosworth HB,Matchar DB,VA Acute Stroke (VAST) Study Team.

    更新日期:2003-04-01 00:00:00