Postischemic application of lipid peroxidation inhibitor U-101033E reduces neuronal damage after global cerebral ischemia in rats.

abstract：BACKGROUND AND PURPOSE:The effect of tissue-type plasminogen activator on functional outcome decreases progressively over time. However, given the differential pattern of arterial occlusion, stroke severity, and speed of ischemic lesion growth among candidates for reperfusion, the time window should be adjusted accordi...

journal_title：Stroke

authors： Muchada M,Rubiera M,Rodriguez-Luna D,Pagola J,Flores A,Kallas J,Sanjuan E,Meler P,Alvarez-Sabin J,Ribo M,Molina CA

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Although corticosteroid use in acute hemorrhagic stroke is not widely adopted, management with intravenous dexamethasone has been standard of care at the University Hospital of Heraklion, Crete with observed outcomes superior to those reported in the literature. To explore this further, we conduc...

journal_title：Stroke

authors： Zaganas I,Halpin AP,Oleinik A,Alegakis A,Kotzamani D,Zafiris S,Chlapoutaki C,Tsimoulis D,Giannakoudakis E,Chochlidakis N,Ntailiani A,Valatsou C,Papadaki E,Vakis A,Furie KL,Greenberg SM,Plaitakis A

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:It is not known what fraction of patients with symptomatic cerebral aneurysms are misdiagnosed at initial medical presentation. It is also not clear whether misdiagnosed patients more frequently deteriorate before definitive aneurysm diagnosis and therapy or achieve a poorer outcome than correctl...

journal_title：Stroke

authors： Mayer PL,Awad IA,Todor R,Harbaugh K,Varnavas G,Lansen TA,Dickey P,Harbaugh R,Hopkins LN

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Many foods have been suggested to influence the risk of stroke. However, no previous studies have examined the relationship between overall dietary patterns and risk of stroke. METHODS:Using dietary information collected in 1984 from 71,768 women aged 38 to 63 years without a history of cardiova...

journal_title：Stroke

authors： Fung TT,Stampfer MJ,Manson JE,Rexrode KM,Willett WC,Hu FB

更新日期：2004-09-01 00:00:00

abstract：:We describe a patient with transient ischemic attacks secondary to a giant aneurysm who showed increased activity on platelet scintigrams at the origin of the left vertebral artery. This is assumed to be the first report of a presumed embolizing aneurysm with positive activity of labeled platelets. Platelet scintigrap...

journal_title：Stroke

authors： Maruyama M,Asai T,Kuriyama Y,Sawada T,Ogata J,Nishimura T,Omae T

更新日期：1989-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Intravenous tissue plasminogen activator (tPA) is an economically worthwhile but underused treatment option for acute ischemic stroke. We sought to identify the extent of tPA use in Canadian medical centers and the potential savings associated with increased use nationally and by province. METHO...

journal_title：Stroke

authors： Yip TR,Demaerschalk BM

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:It is unclear whether anxiety is a risk factor for stroke. We assessed the association between anxiety and the risk of incident stroke. METHODS:This population-based cohort study was based on 2 rounds of the Rotterdam Study. Each round was taken separately as baseline. In 1993 to 1995, anxiety s...

journal_title：Stroke

authors： Portegies ML,Bos MJ,Koudstaal PJ,Hofman A,Tiemeier HW,Ikram MA

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Wall shear stress (WSS) is one of the main pathogenic factors in the development of saccular cerebral aneurysms. The magnitude and distribution of the WSS in and around human middle cerebral artery (MCA) aneurysms were analyzed using the method of computed fluid dynamics (CFD). METHODS:Twenty ma...

journal_title：Stroke

authors： Shojima M,Oshima M,Takagi K,Torii R,Hayakawa M,Katada K,Morita A,Kirino T

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Symptomatic intracranial hemorrhage (SICH) is the most feared complication after tissue plasminogen activator (tPA) stroke treatment. Endogenous fibrinolysis inhibitors play an essential role in the coagulation/fibrinolysis balance and may be involved in the bleeding process. We aim to determine ...

journal_title：Stroke

authors： Ribo M,Montaner J,Molina CA,Arenillas JF,Santamarina E,Quintana M,Alvarez-Sabín J

更新日期：2004-09-01 00:00:00

abstract：:We have evaluated carotid gamma imaging using 111Indium-labelled platelets in the diagnosis of carotid artery disease and measured the accumulation of labelled platelets on endarterectomy specimens. Autologous 111In labelled platelets were injected in 25 patients with TIA. Gamma images were then taken daily and indepe...

journal_title：Stroke

authors： Goldman M,Leung JO,Aukland A,Hawker RJ,Drolc Z,McCollum CN

更新日期：1983-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Multiple brain infarcts are often seen on diffusion-weighted images in cardioembolic stroke patients. Recently, mobile aortic plaques (MAPs) have been proposed as embolic sources. However, the clinical characteristics of patients with MAPs are unclear. METHODS:We prospectively studied patients w...

journal_title：Stroke

authors： Ueno Y,Kimura K,Iguchi Y,Shibazaki K,Inoue T,Hattori N,Urabe T

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The purposes of this study were to assess the relationships between anatomic and technical factors and the 30-day risk of stroke or death after carotid angioplasty and stenting in the Endarterectomy versus Stenting in Patients with Symptomatic Severe Carotid Stenosis (EVA-3S) trial and to perform...

journal_title：Stroke

authors： Naggara O,Touzé E,Beyssen B,Trinquart L,Chatellier G,Meder JF,Mas JL,EVA-3S Investigators.

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:To test the role of fibrinolysis in stroke, we used a mouse model in which preformed 2.5- to 3-microm-diameter fibrin microemboli are injected into the cerebral circulation. The microemboli lodge in the downstream precapillary vasculature and are susceptible to fibrinolysis. METHODS:We injected ...

journal_title：Stroke

authors： Atochin DN,Murciano JC,Gürsoy-Ozdemir Y,Krasik T,Noda F,Ayata C,Dunn AK,Moskowitz MA,Huang PL,Muzykantov VR

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Our aim was to estimate the cost-effectiveness of transferring patients with intracerebral hemorrhage from centers without specialized neurological intensive care units (neuro-ICUs) to centers with neuro-ICUs. METHODS:Decision analytic models were developed for the lifetime horizons. Model input...

journal_title：Stroke

authors： Fletcher JJ,Kotagal V,Mammoser A,Peterson M,Morgenstern LB,Burke JF

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Prevalence of cerebral microbleeds (CMB) in white and Asian populations range from 4% to 15%. However, there is no information from indigenous Latin American people. We aimed to assess prevalence and cerebrovascular correlates of CMB in stroke-free older adults living in rural Ecuador. METHODS:O...

journal_title：Stroke

authors： Del Brutto VJ,Zambrano M,Mera RM,Del Brutto OH

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Prominent posterior cerebral artery (PCA) laterality upon 3-dimensional time-of-flight magnetic resonance angiography is often encountered in patients with middle cerebral artery occlusion. We hypothesized that this sign is correlated with improved functional outcome in patients with middle cereb...

journal_title：Stroke

authors： Ichijo M,Miki K,Ishibashi S,Tomita M,Kamata T,Fujigasaki H,Mizusawa H

更新日期：2013-02-01 00:00:00

abstract：:The etiology of cerebrovascular disease (CDV) in young patients is difficult to establish if the common causes of a focal neurological deficit are excluded by appropriate investigations. Since in some observations prolapse of the mitral-valve (MVP), alterations of platelet function, or both have been linked with cereb...

journal_title：Stroke

authors： Scharf RE,Hennerici M,Bluschke V,Lueck J,Kladetzky RG

更新日期：1982-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:[18F]fluoromisonidazole (FMISO) positron emission tomography has been used to image hypoxia early after human stroke. To further study the role of hypoxia in stroke and the binding characteristics of FMISO, we aimed to develop [3H]FMISO autoradiography in an animal stroke model. We hypothesized t...

journal_title：Stroke

authors： Spratt NJ,Ackerman U,Tochon-Danguy HJ,Donnan GA,Howells DW

更新日期：2006-07-01 00:00:00

abstract：:It has been recognized that small intracerebral hemorrhage not uncommonly produced lacunar syndromes. In this study, we examined cases of intracerebral hemorrhage presenting as lacunar syndromes. Of 174 cases with recent intracerebral hemorrhage, 19 presented with a lacunar syndrome: 4 presented with pure motor hemipa...

journal_title：Stroke

authors： Mori E,Tabuchi M,Yamadori A

更新日期：1985-05-01 00:00:00

abstract：:The external diameters of rat and rabbit basilar arteries were determined before and after formaldehyde fixation in relaxed and drug constricted vessels. Fixation usually resulted in an immediate vessel constriction followed by partial relaxation after several hours. However, the results were inconstant from vessel to...

journal_title：Stroke

authors： Hart MN,O'Donnell SL

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The relation between symptomatic lacunar infarction, silent stroke, and arterial hypertension is controversial. METHODS:From 500 patients with ischemic or hemorrhagic stroke admitted to the Downtown Barcelona Stroke Registry between July 1992 and December 1994, we evaluated prospectively the pre...

journal_title：Stroke

authors： Chamorro A,Saiz A,Vila N,Ascaso C,Blanc R,Alday M,Pujol J

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Adequate control of blood pressure (BP) is a cornerstone in stroke prevention. This study explored the risk of stroke in relation to the quality of BP control in a population-based cohort and whether control of hypertension was related to background characteristics of patients. METHODS:A total o...

journal_title：Stroke

authors： Li C,Engström G,Hedblad B,Berglund G,Janzon L

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Impaired rheological properties of as well as cytotoxic substances produced by granulocytes may contribute to tissue damage in acute ischemic stroke. To assess changes in the properties of circulating granulocytes, we measured their adhesion, deformability, and superoxide generation in the first ...

journal_title：Stroke

authors： Grau AJ,Berger E,Sung KL,Schmid-Schönbein GW

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The American Heart Association/American Stroke Association and Department of Health Stroke Coverdell Program convened a stakeholder meeting in upstate NY to develop recommendations to enhance stroke systems for acute large vessel occlusion. METHODS:Prehospital, hospital, and Department of Health...

journal_title：Stroke

authors： Magdon-Ismail Z,Benesch C,Cushman JT,Brissette I,Southerland AM,Brandler ES,Sozener CB,Flor S,Hemmitt R,Wales K,Parrigan K,Levine SR,Upstate New York Stroke Work Groups.

更新日期：2017-07-01 00:00:00

abstract：:Visually apparent EEG changes associated with clamping the internal carotid artery appeared in 55 of 176 consecutive patients (31%) undergoing carotid endarterectomy without shunt. Attenuation of higher frequency activity was the most common change. Changes were moderate in 33 patients (19%) and major in 22 (12.5%). M...

journal_title：Stroke

authors： Blume WT,Ferguson GG,McNeill DK

更新日期：1986-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Vorapaxar is an antiplatelet agent that antagonizes thrombin-mediated activation of the protease-activated receptor-1 on platelets. We tested the efficacy and safety of vorapaxar in a prespecified analysis in the stroke subcohort from a multinational, randomized, placebo-controlled trial. METHOD...

journal_title：Stroke

authors： Morrow DA,Alberts MJ,Mohr JP,Ameriso SF,Bonaca MP,Goto S,Hankey GJ,Murphy SA,Scirica BM,Braunwald E,Thrombin Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events–TIMI 50 Steering Committee and Investigators

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We have investigated the pathophysiological mechanisms of dysphagia in Wallenberg's syndrome (WS) that are due to lateral medullary infarction (LMI). METHODS:Twenty patients with WS were evaluated by means of clinical and electrophysiological methods that measured the oropharyngeal phase of volu...

journal_title：Stroke

authors： Aydogdu I,Ertekin C,Tarlaci S,Turman B,Kiylioglu N,Secil Y

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Warfarin reduces stroke risk in studies of predominantly white patients with atrial fibrillation (AF). Whether nonwhites also have lower rates of stroke while treated with warfarin is unclear. METHODS:A multiethnic stroke-free cohort hospitalized with nonrheumatic AF was identified in a large he...

journal_title：Stroke

authors： Shen AY,Yao JF,Brar SS,Jorgensen MB,Wang X,Chen W

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We sought to assess the reproducibility, interobserver variability, and application to clinical studies of a new method for the quantitative assessment of carotid plaque echogenicity. METHODS:Carotid plaques were scanned with the use of ultrasound, and their images were stored in a computer. The...

journal_title：Stroke

authors： Sabetai MM,Tegos TJ,Nicolaides AN,Dhanjil S,Pare GJ,Stevens JM

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:This study was conducted to analyze the association between reported risk factors for Alzheimer's disease, apolipoprotein E epsilon4 allele, and cardiovascular disease and neuropathological changes essential for the diagnosis of Alzheimer's disease. METHODS:Our data are based on clinical and pos...

journal_title：Stroke

authors： Irina A,Seppo H,Arto M,Paavo R Sr,Hilkka S

更新日期：1999-03-01 00:00:00