Brain imaging and cognitive predictors of stroke and Alzheimer disease in the Framingham Heart Study.


BACKGROUND AND PURPOSE:Exposure to vascular risk factors has a gradual deleterious effect on brain MRI and cognitive measures. We explored whether a pattern of these measures exists that predicts stroke and Alzheimer disease (AD) risk. METHODS:A cognitive battery was administered to 1679 dementia and stroke-free Framingham offspring (age, >55 years; mean, 65.7±7.0) between 1999 and 2004; participants were also free of other neurological conditions that could affect cognition and >90% also had brain MRI examination. We related cognitive and MRI measures to risks of incident stroke and AD ≤10 years of follow-up. As a secondary analysis, we explored these associations in The Framingham Heart Study original cohort (mean age, 67.5±7.3 and 84.8±3.3 years at the cognitive assessment and MRI examination, respectively). RESULTS:A total of 55 Offspring participants sustained strokes and 31 developed AD. Offspring who scored <1.5 SD below predicted mean scores, for age and education, on an executive function test, had a higher risk of future stroke (hazard ratio [HR], 2.27; 95% confidence interval [CI], 1.06-4.85) and AD (HR, 3.60; 95% CI, 1.52-8.52); additional cognitive tests also predicted AD. Participants with low (<20 percentile) total brain volume and high (>20 percentile) white matter hyperintensity volume had a higher risk of stroke (HR, 1.97; 95% CI, 1.03-3.77 and HR, 2.74; 95% CI, 1.51-5.00, respectively) but not AD. Hippocampal volume at the bottom quintile predicted AD in the offspring and original cohorts (HR, 4.41; 95% CI, 2.00-9.72 and HR, 2.37; 95% CI, 1.12-5.00, respectively). A stepwise increase in stroke risk was apparent with increasing numbers of these cognitive and imaging markers. CONCLUSIONS:Specific patterns of cognitive and brain structural measures observed even in early aging predict stroke risk and may serve as biomarkers for risk prediction.






Weinstein G,Beiser AS,Decarli C,Au R,Wolf PA,Seshadri S




Has Abstract


2013-10-01 00:00:00
















  • Cerebral venous thrombosis in the absence of headache.

    abstract:BACKGROUND AND PURPOSE:Although headache is the most common symptom in cerebral venous thrombosis, 5% to 30% of patients do not report headache at baseline. Characteristics of these patients have not been investigated. METHODS:In post hoc analysis of the International Study on Cerebral Vein and Dural Sinus Thrombosis ...


    pub_type: 杂志文章


    authors: Coutinho JM,Stam J,Canhão P,Barinagarrementeria F,Bousser MG,Ferro JM,ISCVT Investigators.

    更新日期:2015-01-01 00:00:00

  • Phenytoin affects metabolism of free fatty acids and nucleotides in rat cerebral ischemia.

    abstract::We investigated the effects of phenytoin on the rate of enzymatic release of free fatty acids and on the levels of energy metabolites and nucleoside phosphates in ischemic brain. Phenytoin (10 mg/kg i.v.) was administered 30 minutes before the onset of ischemia induced in 30 male Wistar rats by occluding the basilar a...


    pub_type: 杂志文章


    authors: Kinouchi H,Imaizumi S,Yoshimoto T,Motomiya M

    更新日期:1990-09-01 00:00:00

  • Occurrence and clinical impact of microembolic signals during or after cardiosurgical procedures.

    abstract:BACKGROUND AND PURPOSE:Microembolic signals (MESs) are detectable within the transcranial Doppler frequency spectrum downstream from vascular atherothrombotic or cardiothrombotic lesions. A frequent occurrence of MESs has also been shown during bypass surgery or after mechanical valve implantation. We sought to compile...


    pub_type: 杂志文章,评审


    authors: Dittrich R,Ringelstein EB

    更新日期:2008-02-01 00:00:00

  • Predictors of rehemorrhage after treatment of ruptured intracranial aneurysms: the Cerebral Aneurysm Rerupture After Treatment (CARAT) study.

    abstract:BACKGROUND AND PURPOSE:The primary purpose of intracranial aneurysm treatment is to prevent rupture. Risk factors for rupture after aneurysm treatment have not been clearly established, and the need to completely occlude aneurysms is debated. METHODS:The Cerebral Aneurysm Rerupture After Treatment (CARAT) study is an ...


    pub_type: 杂志文章,多中心研究


    authors: Johnston SC,Dowd CF,Higashida RT,Lawton MT,Duckwiler GR,Gress DR,CARAT Investigators.

    更新日期:2008-01-01 00:00:00

  • Homocyst(e)ine and risk of cerebral infarction in a biracial population : the stroke prevention in young women study.

    abstract:BACKGROUND AND PURPOSE:Genetic enzyme variation and vitamin intake are important determinants of blood homocyst(e)ine levels. The prevalence of common genetic polymorphisms influencing homocyst(e)ine levels varies by race, and vitamin intake varies by socioeconomic status. Therefore, we examined the effect of vitamin i...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Kittner SJ,Giles WH,Macko RF,Hebel JR,Wozniak MA,Wityk RJ,Stolley PD,Stern BJ,Sloan MA,Sherwin R,Price TR,McCarter RJ,Johnson CJ,Earley CJ,Buchholz DW,Malinow MR

    更新日期:1999-08-01 00:00:00

  • Level and value of circulating endothelial progenitor cells in patients after acute ischemic stroke.

    abstract:BACKGROUND AND PURPOSE:Endothelial progenitor cells (EPCs) migrate from bone marrow to systemic circulation in response to tissue ischemia where they differentiate into mature endothelial cells for angiogenesis in situ. This study tested the hypothesis that the level of circulating EPCs is substantially increased and p...


    pub_type: 杂志文章


    authors: Yip HK,Chang LT,Chang WN,Lu CH,Liou CW,Lan MY,Liu JS,Youssef AA,Chang HW

    更新日期:2008-01-01 00:00:00

  • Compliance with the stroke education performance measure in the Michigan Paul Coverdell National Acute Stroke Registry.

    abstract:BACKGROUND AND PURPOSE:Stroke education, 1 of 8 endorsed stroke performance measures, consists of 5 specific subcomponents: risk factors, stroke warning signs, emergency medical service activation, physician follow-up, and discharge medications. We identified predictors of stroke education performance measure complianc...


    pub_type: 杂志文章


    authors: Nickles A,Fiedler J,Roberts S,Lyon-Callo S,Hurst R,Reeves M

    更新日期:2013-05-01 00:00:00

  • Reporting standards for angioplasty and stent-assisted angioplasty for intracranial atherosclerosis.

    abstract:BACKGROUND AND PURPOSE:Intracranial cerebral atherosclerosis causes ischemic stroke in a significant number of patients. Technological advances over the past 10 years have enabled endovascular treatment of intracranial atherosclerotic stenosis. The number of patients treated with angioplasty or stent-assisted angioplas...


    pub_type: 杂志文章,评审


    authors: Schumacher HC,Meyers PM,Higashida RT,Derdeyn CP,Lavine SD,Nesbit GM,Sacks D,Rasmussen P,Wechsler LR

    更新日期:2009-05-01 00:00:00

  • PHASES Score for Prediction of Intracranial Aneurysm Growth.

    abstract:BACKGROUND AND PURPOSE:Growth of an intracranial aneurysm occurs in around 10% of patients at 2-year follow-up imaging and may be associated with aneurysm rupture. We investigated whether PHASES, a score providing absolute risks of aneurysm rupture based on 6 easily retrievable risk factors, also predicts aneurysm grow...


    pub_type: 杂志文章,多中心研究


    authors: Backes D,Vergouwen MD,Tiel Groenestege AT,Bor AS,Velthuis BK,Greving JP,Algra A,Wermer MJ,van Walderveen MA,terBrugge KG,Agid R,Rinkel GJ

    更新日期:2015-05-01 00:00:00

  • Isolated and borderline isolated systolic hypertension relative to long-term risk and type of stroke: a 20-year follow-up of the national health and nutrition survey.

    abstract:BACKGROUND AND PURPOSE:Although the short-term risks of stroke and types of stroke associated with isolated systolic hypertension (ISH) and borderline isolated systolic hypertension (BISH) have been described, the long-term effects of these hypertensive conditions, particularly in younger individuals, are unclear. We p...


    pub_type: 杂志文章


    authors: Qureshi AI,Suri MF,Mohammad Y,Guterman LR,Hopkins LN

    更新日期:2002-12-01 00:00:00

  • Increased cytochrome c-mediated DNA fragmentation and cell death in manganese-superoxide dismutase-deficient mice after exposure to subarachnoid hemolysate.

    abstract:BACKGROUND AND PURPOSE:We sought to investigate the mechanisms for oxidative injury caused by subarachnoid hemolysate, a pro-oxidant. METHODS:Injection of 50 microL of subarachnoid hemolysate or saline was performed in CD1 mice (n=75), mutant mice deficient in Mn-superoxide dismutase (Sod2+/-; n=23), and their wild-ty...


    pub_type: 杂志文章


    authors: Matz PG,Fujimura M,Lewen A,Morita-Fujimura Y,Chan PH

    更新日期:2001-02-01 00:00:00

  • Intakes of potassium, magnesium, and calcium and risk of stroke.

    abstract:BACKGROUND AND PURPOSE:We aimed to investigate the associations of dietary and total potassium, magnesium, and calcium intakes with stroke occurrence. METHODS:A prospective cohort study was conducted among 36 094 participants aged 21 to 70 years. Dietary intake was assessed with a food frequency questionnaire. RESULT...


    pub_type: 杂志文章


    authors: Sluijs I,Czernichow S,Beulens JW,Boer JM,van der Schouw YT,Verschuren WM,Grobbee DE

    更新日期:2014-04-01 00:00:00

  • MRI identification of white matter reorganization enhanced by erythropoietin treatment in a rat model of focal ischemia.

    abstract:BACKGROUND AND PURPOSE:The objectives of the present study were to: (1) noninvasively identify white matter reorganization and monitor its progress within 6 weeks after the onset of stroke; and (2) quantitatively investigate the effect of recombinant human erythropoietin treatment on this structural change using in viv...


    pub_type: 杂志文章


    authors: Li L,Jiang Q,Ding G,Zhang L,Zhang ZG,Li Q,Panda S,Kapke A,Lu M,Ewing JR,Chopp M

    更新日期:2009-03-01 00:00:00

  • Proportional Motor Recovery After Stroke: Implications for Trial Design.

    abstract:BACKGROUND AND PURPOSE:Recovery of upper-limb motor impairment after first-ever ischemic stroke is proportional to the degree of initial impairment in patients with a functional corticospinal tract (CST). This study aimed to investigate whether proportional recovery occurs in a more clinically relevant sample including...


    pub_type: 杂志文章


    authors: Stinear CM,Byblow WD,Ackerley SJ,Smith MC,Borges VM,Barber PA

    更新日期:2017-03-01 00:00:00

  • Renin-Angiotensin system modulators modestly reduce vascular risk in persons with prior stroke.

    abstract:BACKGROUND AND PURPOSE:Although the efficacy of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in reducing future vascular events for patients with coronary heart disease is established, less is known about the precise benefit of these agents among patients with stroke. We evaluated whether ...


    pub_type: 杂志文章,meta分析


    authors: Lee M,Saver JL,Hong KS,Hao Q,Chow J,Ovbiagele B

    更新日期:2012-01-01 00:00:00

  • Cathecholamine and 5-hydroxytryptamine levels in ischemic brain. Influence of p-chlorophenylalanine.

    abstract::The effect of ischemia on catecholamine and 5-hydroxytryptamine (5-HT) levels in brain cortex was examined in the gerbil stroke model. Unilateral common carotid artery occlusion produced bilateral decrease in cortical dopamine levels in gerbils both symptomatic and asymptomatic of cerbral ischemia. The 5-HT progressiv...


    pub_type: 杂志文章


    authors: Welch KM,Chabi E,Buckingham J,Bergin B,Achar VS,Meyer JS

    更新日期:1977-05-01 00:00:00

  • Polymorphisms of coagulation factor XIII subunit A and risk of nonfatal hemorrhagic stroke in young white women.

    abstract:BACKGROUND AND PURPOSE:Although family studies have suggested a genetic influence on hemorrhagic stroke, the underlying genetic risk factors remain poorly defined. Coagulation factor XIII, which is involved in hemostasis, fibrinolysis, vascular remodeling, and tissue repair, represents a candidate gene for hemorrhagic ...


    pub_type: 杂志文章


    authors: Reiner AP,Schwartz SM,Frank MB,Longstreth WT Jr,Hindorff LA,Teramura G,Rosendaal FR,Gaur LK,Psaty BM,Siscovick DS

    更新日期:2001-11-01 00:00:00

  • New insights into brain damage in stroke-prone rats: a nuclear magnetic imaging study.

    abstract:BACKGROUND AND PURPOSE:The spontaneously hypertensive stroke-prone rat (SHRSP) is an animal model for a complex form of cerebrovascular pathology. MRI provides an efficient and noninvasive tool for studying the time course of brain damage. The aim of this study was to gain new insights into the pathological phenomena r...


    pub_type: 杂志文章


    authors: Guerrini U,Sironi L,Tremoli E,Cimino M,Pollo B,Calvio AM,Paoletti R,Asdente M

    更新日期:2002-03-01 00:00:00

  • Reducing door-to-needle times using Toyota's lean manufacturing principles and value stream analysis.

    abstract:BACKGROUND AND PURPOSE:Earlier tissue-type plasminogen activator (tPA) treatment for acute ischemic stroke increases efficacy, prompting national efforts to reduce door-to-needle times. We used lean process improvement methodology to develop a streamlined intravenous tPA protocol. METHODS:In early 2011, a multidiscipl...


    pub_type: 杂志文章


    authors: Ford AL,Williams JA,Spencer M,McCammon C,Khoury N,Sampson TR,Panagos P,Lee JM

    更新日期:2012-12-01 00:00:00

  • Interobserver agreement of ASPECT score distribution for noncontrast CT, CT angiography, and CT perfusion in acute stroke.

    abstract:BACKGROUND AND PURPOSE:The Alberta Stroke program early CT score (ASPECTS) is a semiquantative scale for estimating extent and distribution of early ischemic changes within the MCA territory in the acute stroke setting. Good interobserver agreement of total ASPECTS is demonstrated for noncontrast CT (NCCT) and other im...


    pub_type: 杂志文章


    authors: Finlayson O,John V,Yeung R,Dowlatshahi D,Howard P,Zhang L,Swartz R,Aviv RI

    更新日期:2013-01-01 00:00:00

  • Decreased glomerular filtration rate is a risk factor for hemorrhagic but not for ischemic stroke: the Rotterdam Study.

    abstract:BACKGROUND AND PURPOSE:Persons with early stages of chronic kidney disease, defined by a decreased glomerular filtration rate (GFR), have an increased risk of cardiovascular disease. It is unclear whether decreased GFR is a risk factor for stroke. We assessed the association between GFR and stroke in a prospective popu...


    pub_type: 杂志文章


    authors: Bos MJ,Koudstaal PJ,Hofman A,Breteler MM

    更新日期:2007-12-01 00:00:00

  • Effect of graded hypothermia (27 degrees to 34 degrees C) on behavioral function, histopathology, and spinal blood flow after spinal ischemia in rat.

    abstract:BACKGROUND AND PURPOSE:We used a rat model of reversible spinal ischemia to assess the effect of spinal cord temperature on the development of neurological and histopathologic changes after 20 minutes of reversible aortic occlusion. Spinal cord blood flow and CO2 reactivity was tested by using laser Doppler before and ...


    pub_type: 杂志文章


    authors: Marsala M,Vanicky I,Yaksh TL

    更新日期:1994-10-01 00:00:00

  • PROACT: a phase II randomized trial of recombinant pro-urokinase by direct arterial delivery in acute middle cerebral artery stroke. PROACT Investigators. Prolyse in Acute Cerebral Thromboembolism.

    abstract:BACKGROUND AND PURPOSE:To test the safety and recanalization efficacy of intra-arterial local delivery of plasminogen activators in acute ischemic stroke, a randomized trial of recombinant pro-urokinase (rpro-UK) versus placebo was undertaken in patients with angiographically documented proximal middle cerebral artery ...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: del Zoppo GJ,Higashida RT,Furlan AJ,Pessin MS,Rowley HA,Gent M

    更新日期:1998-01-01 00:00:00

  • Elevated tissue plasminogen activator antigen and stroke risk: The Stroke Prevention In Young Women Study.

    abstract:BACKGROUND AND PURPOSE:Abnormalities in endogenous fibrinolysis are associated with an increased risk for stroke in men and older adults. We tested the hypothesis that elevated plasma tissue plasminogen activator (tPA) antigen, a marker for impaired endogenous fibrinolysis, is an independent risk factor for stroke in y...


    pub_type: 杂志文章


    authors: Macko RF,Kittner SJ,Epstein A,Cox DK,Wozniak MA,Wityk RJ,Stern BJ,Sloan MA,Sherwin R,Price TR,McCarter RJ,Johnson CJ,Earley CJ,Buchholz DW,Stolley PD

    更新日期:1999-01-01 00:00:00

  • Glutamate-induced cerebral vasodilation is mediated by nitric oxide through N-methyl-D-aspartate receptors.

    abstract:BACKGROUND AND PURPOSE:It was found that glutamate, a major neurotransmitter, is vasoactive in the cerebral circulation. However, the mechanism is unclear. This study was designed to investigate the role of nitric oxide (NO) and N-methyl-D-aspartate (NMDA) receptors in cerebral arteriolar dilation to glutamate. METHOD...


    pub_type: 杂志文章


    authors: Meng W,Tobin JR,Busija DW

    更新日期:1995-05-01 00:00:00

  • Clinical severity in CADASIL related to ultrastructural damage in white matter: in vivo study with diffusion tensor MRI.

    abstract:BACKGROUND AND PURPOSE:CADASIL is a newly recognized cause of subcortical ischemic strokes that progressively leads to dementia associated with pseudobulbar palsy and severe motor disability. This deleterious progression and the severity of clinical presentation are widely variable among affected subjects. The exact ro...


    pub_type: 杂志文章


    authors: Chabriat H,Pappata S,Poupon C,Clark CA,Vahedi K,Poupon F,Mangin JF,Pachot-Clouard M,Jobert A,Le Bihan D,Bousser MG

    更新日期:1999-12-01 00:00:00

  • Increased release of tumor necrosis factor-alpha into the cerebrospinal fluid and peripheral circulation of aged rats.

    abstract:BACKGROUND AND PURPOSE:We earlier reported that risk factors for stroke prepare brain stem tissue for a modified Shwartzman reaction, including the development of ischemia and hemorrhage and the production of tumor necrosis factor-alpha, after a provocative dose of lipopolysaccharide. In the present study, we sought to...


    pub_type: 杂志文章


    authors: Sirén AL,Liu Y,Feuerstein G,Hallenbeck JM

    更新日期:1993-06-01 00:00:00

  • Reversed intracranial blood flow in patients with an intra-aortic balloon pump.

    abstract::As a preliminary investigation into the cerebral effects of mechanical cardiac assist devices, using transcranial Doppler ultrasonography I examined the basal cerebral arteries in three patients placed on an intra-aortic balloon pump. Unassisted systoles had normal blood velocities and waveforms. When the pump was in ...


    pub_type: 杂志文章


    authors: Brass LM

    更新日期:1990-03-01 00:00:00

  • Potential of early [(18)F]-2-fluoro-2-deoxy-D-glucose positron emission tomography for identifying hypoperfusion and predicting fate of tissue in a rat embolic stroke model.

    abstract:BACKGROUND AND PURPOSE:Experimental stroke models are essential to study in vivo pathophysiological processes of focal cerebral ischemia. In this study, an embolic stroke model in rats was applied (1) to characterize early development of regional cerebral blood flow and metabolism with positron emission tomography (PET...


    pub_type: 杂志文章


    authors: Walberer M,Backes H,Rueger MA,Neumaier B,Endepols H,Hoehn M,Fink GR,Schroeter M,Graf R

    更新日期:2012-01-01 00:00:00

  • Leukocyte activation detected by increased plasma levels of inflammatory mediators in patients with ischemic cerebrovascular diseases.

    abstract:BACKGROUND AND PURPOSE:Leukocytes have been implicated in the development of ischemic atherosclerotic vascular diseases. In a prospective study we investigated whether the plasma concentrations of inflammatory mediators, ie, proteases and cytokines, as markers for systemic leukocyte activation, are increased in patient...


    pub_type: 杂志文章


    authors: Elneihoum AM,Falke P,Axelsson L,Lundberg E,Lindgärde F,Ohlsson K

    更新日期:1996-10-01 00:00:00