Pharmacologic interventions for stroke: looking beyond the thrombolysis time window into the penumbra with biomarkers, not a stopwatch.

abstract：BACKGROUND AND PURPOSE:Efforts to reduce disparities in recurrent stroke among Black and Latino stroke survivors have met with limited success. We aimed to determine the effect of peer education on secondary stroke prevention among predominantly minority stroke survivors. METHODS:Between 2009 and 2012, we enrolled 600...

journal_title：Stroke

authors： Kronish IM,Goldfinger JZ,Negron R,Fei K,Tuhrim S,Arniella G,Horowitz CR

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Acupuncture may be a promising treatment for poststroke paralysis. We conducted a meta-analysis, assessing the efficacy of acupuncture with and without stroke rehabilitation. METHODS:We identified randomized trials comparing acupuncture with no acupuncture within 6 months of stroke by searching ...

journal_title：Stroke

authors： Sze FK,Wong E,Or KK,Lau J,Woo J

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Carotid artery stenosis causes up to 10% of all ischemic strokes. Carotid endarterectomy (CEA) was introduced as a treatment to prevent stroke in the early 1950s. Carotid stenting (CAS) was introduced as a treatment to prevent stroke in 1994. METHODS:The Carotid Revascularization Endarterectomy ...

journal_title：Stroke

authors： Mantese VA,Timaran CH,Chiu D,Begg RJ,Brott TG,CREST Investigators.

更新日期：2010-10-01 00:00:00

abstract：:Correlations between changes in regional, cortical, cerebral blood flow (rCBF) and histological changes in the corresponding brain regions were examined following middle cerebral arterial occlusion in 24 cats. In all animals, the duration of arterial occlusion was 2 hours followed by 2 hours of recirculation. The anim...

journal_title：Stroke

authors： Tamura A,Asano T,Sano K

更新日期：1980-09-01 00:00:00

abstract：:Background and Purpose- Ischemic stroke is one of the leading causes of morbidity and mortality worldwide and a major cause of long-term disability. Recently, long noncoding RNAs have been revealed, which are tightly associated with several human diseases. However, the functions of long noncoding RNAs in ischemic stro...

journal_title：Stroke

authors： Deng Y,Chen D,Wang L,Gao F,Jin B,Lv H,Zhang G,Sun X,Liu L,Mo D,Ma N,Song L,Huo X,Yan T,Miao Z

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Coronary artery bypass grafting (CABG) is a frequently performed surgical procedure that can be associated with neurological complications. Some studies have demonstrated that new focal brain lesions, detected by MRI, can develop after CABG. Furthermore, it has been suggested that the presence of...

journal_title：Stroke

authors： Restrepo L,Wityk RJ,Grega MA,Borowicz L Jr,Barker PB,Jacobs MA,Beauchamp NJ,Hillis AE,McKhann GM

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND:Diffusion-weighted MRI (DWI) and perfusion-weighted MRI (PWI) are new techniques that can be used for the evaluation of acute ischemic stroke. However, their potential role in the management of patients treated with recombinant tissue plasminogen activator (rtPA) has yet to be determined. CASE DESCRIPTION:T...

journal_title：Stroke

authors： Lansberg MG,Tong DC,Norbash AM,Yenari MA,Moseley ME

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Stroke education, 1 of 8 endorsed stroke performance measures, consists of 5 specific subcomponents: risk factors, stroke warning signs, emergency medical service activation, physician follow-up, and discharge medications. We identified predictors of stroke education performance measure complianc...

journal_title：Stroke

authors： Nickles A,Fiedler J,Roberts S,Lyon-Callo S,Hurst R,Reeves M

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The physiological function of cellular prion protein (PrPc) is not yet understood. Recent findings suggest that PrPc may have neuroprotective properties, and its absence increases susceptibility to neuronal injury. The purpose of this study was to elucidate the role of PrPc in ischemic brain inju...

journal_title：Stroke

authors： Weise J,Sandau R,Schwarting S,Crome O,Wrede A,Schulz-Schaeffer W,Zerr I,Bähr M

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Recovery from hemiparesis due to corticospinal tract infarction is well documented, but the mechanism of recovery is unknown. Functional MRI (fMRI) provides a means of identifying focal brain activity related to movement of a paretic hand. Although prior studies have suggested that supplementary ...

journal_title：Stroke

authors： Marshall RS,Perera GM,Lazar RM,Krakauer JW,Constantine RC,DeLaPaz RL

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:In intracerebral hemorrhage (ICH), preexisting cognitive impairment has been identified as a risk factor for increased mortality and morbidity. However, previous studies examined predominantly White populations; therefore, the prevalence and effect of preICH cognitive impairment has not been stud...

journal_title：Stroke

authors： Sawyer RP,Yim E,Coleman E,Demel SL,Sekar P,Woo D

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The estimated prevalence of intracranial atherosclerotic disease (IAD) in patients with stenosis of the extracranial internal carotid artery (ICA) varies between 20% and 50%. The benefits of carotid endarterectomy (CE) in patients with both IAD and symptomatic extracranial ICA stenosis are uncert...

journal_title：Stroke

authors： Kappelle LJ,Eliasziw M,Fox AJ,Sharpe BL,Barnett HJ

更新日期：1999-02-01 00:00:00

abstract：:We examined cerebral lipid peroxidation, estimated by a thiobarbituric acid test, in rat brain regions after 30 minutes of severe forebrain ischemia and at recirculation periods of up to 72 hours. The lipid peroxide levels remained unaltered in all brain regions during ischemia and during the first hour of recirculati...

journal_title：Stroke

authors： Bromont C,Marie C,Bralet J

更新日期：1989-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:In addition to low-density lipoprotein (LDL) cholesterol, small, dense LDL particles and oxidative modification of LDL have been linked to the pathogenesis of atherosclerosis. The present study was aimed at investigating the association between carotid artery intima-media thickness (IMT) and LDL ...

journal_title：Stroke

authors： Liu ML,Ylitalo K,Nuotio I,Salonen R,Salonen JT,Taskinen MR

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The aim of the present study was to investigate the effects of normobaric oxygen (NBO) therapy on T2*-weighted images of intracranial hemorrhages (ICHs). METHODS:Two common models of ICH were performed in mice, and longitudinal T2*-weighted images of the hematomas were acquired under normoxia or...

journal_title：Stroke

authors： Gaberel T,Gakuba C,Hebert M,Montagne A,Agin V,Rubio M,Emery E,Vivien D,Gauberti M

更新日期：2013-12-01 00:00:00

abstract：:We observed the effects of a new thyrotropin-releasing hormone derivative, YM-14673 (N alpha-[[(S)-4-oxo-2-azetidinyl]carbonyl]-L-histidyl-L-prolinamide dihydrate), on behavioral changes in rats for 3 weeks after focal cerebral ischemia. Under halothane anesthesia, the left middle cerebral artery was occluded via a tr...

journal_title：Stroke

authors： Yamamoto M,Tamura A,Kirino T,Shimizu M,Sano K

更新日期：1989-03-01 00:00:00

abstract：BACKGROUND:We sought to determine interrater agreement in evaluation of stroke patients with the Unified Form for Neurological Stroke Scales (UFNSS). SUMMARY OF REPORT:Fifty inpatients were independently examined by three neurologists. Kendall coefficients of concordance were computed for the different items of the UF...

journal_title：Stroke

authors： Treves TA,Karepov VG,Aronovich BD,Gorbulev AY,Bornstein NM,Korczyn AD

更新日期：1994-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Silent cerebrovascular disease (CVD) has been proposed as a predisposing condition for clinically overt stroke and vascular dementia. Recently, we found increased thrombin generation in silent CVD patients. Here, we report the effect of thrombin inhibition using a potent selective thrombin inhibi...

journal_title：Stroke

authors： Kario K,Matsuo T,Hoshide S,Umeda Y,Shimada K

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Depression after stroke is often described as underdiagnosed and undertreated. However, there are few data on self-reported depression and use of antidepressants in stroke patients at large. MATERIALS AND METHODS:In the Swedish national quality assessment register, Riks-Stroke, 15 747 stroke sur...

journal_title：Stroke

authors： Eriksson M,Asplund K,Glader EL,Norrving B,Stegmayr B,Terént A,Asberg KH,Wester PO,Riks-Stroke Collaboration.

更新日期：2004-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:In acute ischemic stroke patients, diffusion-weighted imaging (DWI)-Alberta Stroke Program Early Computed Tomography Score (ASPECTS) is correlated with infarct volume and is an independent factor of functional outcome. Patients with pretreatment DWI-ASPECTS ≤6 were excluded or under-represented i...

journal_title：Stroke

authors： Desilles JP,Consoli A,Redjem H,Coskun O,Ciccio G,Smajda S,Labreuche J,Preda C,Ruiz Guerrero C,Decroix JP,Rodesch G,Mazighi M,Blanc R,Piotin M,Lapergue B,ETIS (Endovascular Treatment in Ischemic Stroke) Research Investigator

更新日期：2017-04-01 00:00:00

abstract：:TCD recording of flow velocities in intracranial vessels was first described by Aaslid in 1982. The utility of this instrument becomes more apparent as it is used in different clinical settings and compared with angiographic findings (Figures 1 and 2). Its importance in early detection of vasospasm in subarachnoid hem...

journal_title：Stroke

authors： DeWitt LD,Wechsler LR

更新日期：1988-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Clomethiazole is a neuroprotective drug that enhances gamma-aminobutyrate type A (GABA(A)) receptor activity. Its efficacy and safety were tested in the CLomethiazole Acute Stroke Study (CLASS). The protocol allowed a CT scan to be done after randomization but within 7 days of stroke onset to min...

journal_title：Stroke

authors： Wahlgren NG,Díez-Tejedor E,Teitelbaum J,Arboix A,Leys D,Ashwood T,Grossman E

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The neuroprotective role of mild therapeutic hypothermia was established in animal models of cerebral ischemia. Still, several issues, including optimal target temperature, remain unclear. The optimal depth of hypothermia in a rat model of focal cerebral ischemia was investigated. METHODS:Eighty...

journal_title：Stroke

authors： Kollmar R,Blank T,Han JL,Georgiadis D,Schwab S

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:One hundred twelve patients undergoing elective carotid endarterectomy for symptomatic and asymptomatic carotid artery stenosis were enrolled in a prospective study to evaluate the incidence of change in postoperative cerebral function. METHODS:Patients were evaluated preoperatively and postoper...

journal_title：Stroke

authors： Heyer EJ,Adams DC,Solomon RA,Todd GJ,Quest DO,McMahon DJ,Steneck SD,Choudhri TF,Connolly ES

更新日期：1998-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Efforts at public education to improve adults' response to stroke symptoms continue to be disappointing, and very little has been developed to improve the knowledge base of children regarding brain attacks. Children may be able to exert a positive influence on adult behavior and to learn positive...

journal_title：Stroke

authors： Dressman LA,Hunter J

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Knowledge of cerebral blood volume (CBV) is invaluable in identifying the primary cause of brain swelling in patients with stroke or severe head injury, and it might also help in clinical decision making in patients thought to have hemodynamic transient ischemic attacks (TIAs). This investigation...

journal_title：Stroke

authors： Muizelaar JP,Fatouros PP,Schröder ML

更新日期：1997-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Emergency medical services routing of patients with acute stroke to designated centers may increase the proportion of patients receiving care at facilities meeting national standards and augment recruitment for prehospital stroke research. METHODS:We analyzed consecutive patients enrolled within...

journal_title：Stroke

authors： Sanossian N,Liebeskind DS,Eckstein M,Starkman S,Stratton S,Pratt FD,Koenig W,Hamilton S,Kim-Tenser M,Conwit R,Saver JL,FAST-MAG Investigators and Coordinators.

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Glutamate receptor antagonists are protective in animal models of focal cerebral ischemia. Lamotrigine (3,5-diamino-6-[2,3-dichlorophenyl]-1,2,4-triazine) is an anticonvulsant drug that blocks voltage-gated sodium channels and inhibits the ischemia-induced release of glutamate. We describe the ce...

journal_title：Stroke

authors： Smith SE,Meldrum BS

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Despite the social, health, and economic burdens associated with cognitive impairment poststroke, there is considerable uncertainty about the types of interventions that might preserve or restore cognitive abilities. The objective of this systematic review and meta-analysis was to evaluate the ef...

journal_title：Stroke

authors： Oberlin LE,Waiwood AM,Cumming TB,Marsland AL,Bernhardt J,Erickson KI

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Previous studies have evaluated the association of body mass index (BMI) with the risk of all-cause and cardiovascular disease mortality among diabetic patients, and results were controversial. No studies have focused on the association between BMI and stroke risk among diabetic patients. We aime...

journal_title：Stroke

authors： Li W,Katzmarzyk PT,Horswell R,Zhang Y,Zhao W,Wang Y,Johnson J,Hu G

更新日期：2015-01-01 00:00:00